CN101631799A - 靶向nbs1-atm相互作用以使癌细胞对放射疗法及化学疗法敏感 - Google Patents

靶向nbs1-atm相互作用以使癌细胞对放射疗法及化学疗法敏感 Download PDF

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CN101631799A
CN101631799A CN200780048001A CN200780048001A CN101631799A CN 101631799 A CN101631799 A CN 101631799A CN 200780048001 A CN200780048001 A CN 200780048001A CN 200780048001 A CN200780048001 A CN 200780048001A CN 101631799 A CN101631799 A CN 101631799A
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seq
polypeptide
nbs1
atm
cells
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M·J·卡里维
B·徐
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Southern Research Institute
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Southern Research Institute
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C07K14/43Sweetening agents, e.g. thaumatin, monellin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200780048001A 2006-10-30 2007-10-30 靶向nbs1-atm相互作用以使癌细胞对放射疗法及化学疗法敏感 Pending CN101631799A (zh)

Applications Claiming Priority (2)

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US86345706P 2006-10-30 2006-10-30
US60/863,457 2006-10-30

Publications (1)

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CN101631799A true CN101631799A (zh) 2010-01-20

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US (1) US20100120679A1 (enExample)
EP (1) EP2091964A2 (enExample)
JP (1) JP2010508022A (enExample)
KR (1) KR20090102744A (enExample)
CN (1) CN101631799A (enExample)
AU (1) AU2007314366A1 (enExample)
CA (1) CA2674238A1 (enExample)
MX (1) MX2009004748A (enExample)
WO (1) WO2008054726A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104046644A (zh) * 2013-03-14 2014-09-17 中国科学院上海生命科学研究院 人源化小鼠模型的构建方法和应用
CN105377305A (zh) * 2013-04-16 2016-03-02 汉阳大学校产学协力团 靶向脂肪细胞的非病毒基因递送体系
CN110520108A (zh) * 2017-02-16 2019-11-29 福斯特斯特林研究公司 用于防止辐射损伤和促进组织再生的组合物和方法

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US8118754B1 (en) 2007-11-15 2012-02-21 Flynn Edward R Magnetic needle biopsy
US9964469B2 (en) 2005-02-28 2018-05-08 Imagion Biosystems, Inc. Magnetic needle separation and optical monitoring
US8841414B1 (en) * 2006-01-27 2014-09-23 University Of Mississippi Medical Center Targeted delivery of therapeutic peptides by thermally responsive biopolymers
US8447379B2 (en) 2006-11-16 2013-05-21 Senior Scientific, LLC Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof
CA2780148C (en) 2009-11-06 2017-02-28 Scientific Nanomedicine, Inc. Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof
US10194825B2 (en) 2009-11-06 2019-02-05 Imagion Biosystems Inc. Methods and apparatuses for the localization and treatment of disease such as cancer
DK2702172T3 (da) 2011-04-29 2020-04-06 Univ Aarhus Fremgangsmåde til bestemmelse af klinisk relevant hypoxi ved cancer
US9364514B2 (en) * 2011-12-27 2016-06-14 Institute Curie Anti-tumor adjuvant therapy
GB201209517D0 (en) 2012-05-29 2012-07-11 Univ Birmingham Nanoparticles
US10463880B2 (en) * 2014-02-27 2019-11-05 Koninklijke Philips N.V. Medical instrument for high dose rate brachytherapy
EP3317448B1 (en) 2015-06-30 2021-09-08 Tela Bio, Inc. Corner-lock stitch patterns
US10426587B2 (en) 2015-07-21 2019-10-01 Tela Bio, Inc. Compliance control stitching in substrate materials
WO2017189772A1 (en) 2016-04-26 2017-11-02 Tela Bio, Inc. Hernia repair grafts having anti-adhesion barriers
KR101875111B1 (ko) * 2016-04-29 2018-07-09 한국수력원자력 주식회사 저선량 방사선을 이용한 암화유전자 Ras-유도 악성 암화 억제
CA3060509A1 (en) 2017-04-21 2018-10-25 Federica Sotgia Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
WO2018195434A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
CA3063450A1 (en) 2017-05-19 2018-11-22 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
BR112019024264A2 (pt) 2017-05-19 2020-06-02 Lunella Biotech, Inc. Antimitoscinas: inibidores direcionados da biogênese mitoconcrial para erradicação de células-tronco de câncer
WO2019005698A1 (en) 2017-06-26 2019-01-03 Lunella Biotech, Inc. MITOCETOSCINES: MITOCHONDRIAL THERAPEUTIC AGENTS TARGETING THE METABOLISM OF KETONES IN CANCER CELLS
US11590262B2 (en) 2018-03-09 2023-02-28 Tela Bio, Inc. Surgical repair graft
EP4585235A3 (en) 2019-03-08 2025-08-20 Tela Bio, Inc. Textured medical textiles
WO2023069094A1 (en) * 2021-10-20 2023-04-27 Castor Trevor P Method and apparatus for inactivating pathogens in units of whole blood using superparamagnetic nanoparticles coated with chemiluminescence reagents and broad-spectrum anti-viral therapeutics
CN115300449B (zh) * 2022-02-07 2023-06-27 郑州大学第一附属医院 榄香烯在制备抑制肿瘤耐药性的控释制剂中的应用
CN118126155B (zh) * 2024-02-05 2025-04-25 中山大学附属第七医院(深圳) 一种人nbs1蛋白赖氨酸388位点乳酸化抗原、抗体及其制备方法与应用

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US6077880A (en) * 1997-08-08 2000-06-20 Cordis Corporation Highly radiopaque polyolefins and method for making the same
US7122343B1 (en) * 1998-04-27 2006-10-17 Wisconsin Alumni Research Foundation Methods to alter levels of a DNA repair protein
US7074902B1 (en) * 1998-04-27 2006-07-11 Warf Wisconsin Alumni Research Foundation Antibody specific for a DNA repair protein
US6530944B2 (en) * 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US20030104427A1 (en) * 2001-06-25 2003-06-05 Petrini John H.J. Methods to modulate telomere structure and function

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104046644A (zh) * 2013-03-14 2014-09-17 中国科学院上海生命科学研究院 人源化小鼠模型的构建方法和应用
CN105377305A (zh) * 2013-04-16 2016-03-02 汉阳大学校产学协力团 靶向脂肪细胞的非病毒基因递送体系
CN110520108A (zh) * 2017-02-16 2019-11-29 福斯特斯特林研究公司 用于防止辐射损伤和促进组织再生的组合物和方法

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Publication number Publication date
AU2007314366A1 (en) 2008-05-08
WO2008054726A3 (en) 2009-02-05
EP2091964A2 (en) 2009-08-26
US20100120679A1 (en) 2010-05-13
MX2009004748A (es) 2009-08-25
JP2010508022A (ja) 2010-03-18
KR20090102744A (ko) 2009-09-30
WO2008054726A2 (en) 2008-05-08
CA2674238A1 (en) 2008-05-08

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Application publication date: 20100120