JP2010507634A5 - - Google Patents
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- Publication number
- JP2010507634A5 JP2010507634A5 JP2009533896A JP2009533896A JP2010507634A5 JP 2010507634 A5 JP2010507634 A5 JP 2010507634A5 JP 2009533896 A JP2009533896 A JP 2009533896A JP 2009533896 A JP2009533896 A JP 2009533896A JP 2010507634 A5 JP2010507634 A5 JP 2010507634A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- groups
- alkyl
- alk
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 20
- 125000003545 alkoxy group Chemical group 0.000 description 9
- 125000004414 alkyl thio group Chemical group 0.000 description 7
- 125000004093 cyano group Chemical group *C#N 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- -1 hydroxy, mercapto, amino Chemical group 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 125000003282 alkyl amino group Chemical group 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 125000004663 dialkyl amino group Chemical group 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 2
- 150000003857 carboxamides Chemical class 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 description 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical group NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0609331A FR2907453B1 (fr) | 2006-10-24 | 2006-10-24 | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| FR0609331 | 2006-10-24 | ||
| PCT/FR2007/001703 WO2008049994A1 (fr) | 2006-10-24 | 2007-10-17 | Nouveaux derives du fluorene, compositions les contenant et utilisation comme inhibiteurs de la proteine chpaerone hsp90 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010507634A JP2010507634A (ja) | 2010-03-11 |
| JP2010507634A5 true JP2010507634A5 (enExample) | 2013-07-18 |
| JP5431944B2 JP5431944B2 (ja) | 2014-03-05 |
Family
ID=38069221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533896A Expired - Fee Related JP5431944B2 (ja) | 2006-10-24 | 2007-10-17 | 新規フルオレン誘導体、これを含む組成物、およびタンパク質シャペロンｈｓｐ９０の阻害剤としてのこれらの使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8163750B2 (enExample) |
| EP (1) | EP2078009B1 (enExample) |
| JP (1) | JP5431944B2 (enExample) |
| KR (1) | KR20090080948A (enExample) |
| CN (1) | CN101528735A (enExample) |
| AR (1) | AR063507A1 (enExample) |
| AU (1) | AU2007310767A1 (enExample) |
| BR (1) | BRPI0718202A2 (enExample) |
| CA (1) | CA2664115A1 (enExample) |
| CL (1) | CL2007003046A1 (enExample) |
| CO (1) | CO6160311A2 (enExample) |
| CR (1) | CR10690A (enExample) |
| EA (1) | EA200970400A1 (enExample) |
| FR (1) | FR2907453B1 (enExample) |
| IL (1) | IL197887A0 (enExample) |
| MA (1) | MA30904B1 (enExample) |
| MX (1) | MX2009004049A (enExample) |
| NO (1) | NO20091972L (enExample) |
| PE (1) | PE20081261A1 (enExample) |
| TN (1) | TN2009000086A1 (enExample) |
| TW (1) | TW200825083A (enExample) |
| UY (1) | UY30667A1 (enExample) |
| WO (1) | WO2008049994A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| MX336687B (es) * | 2009-06-30 | 2016-01-28 | Siga Technologies Inc | Tratamiento y prevencion de infecciones del virus del dengue. |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| DE102009054302A1 (de) * | 2009-11-23 | 2011-05-26 | Merck Patent Gmbh | Chinazolinderivate |
| CN113521394A (zh) * | 2020-04-13 | 2021-10-22 | 浙江华臻医疗器械有限公司 | 一种脱细胞血管基质及其制备方法 |
| CN119409635A (zh) * | 2024-11-04 | 2025-02-11 | 河南师范大学 | 具有抗癌活性的氟代甲基取代茚并[1,2-b]吡啶类化合物及其合成方法 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2476087A1 (fr) | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
| US7439359B2 (en) | 2000-11-02 | 2008-10-21 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to hsp90 |
| US7553979B2 (en) | 2001-11-09 | 2009-06-30 | Conforma Therapeutics Corporation | HSP90-inhibiting zearalanol compounds and methods of producing and using same |
| US7258238B2 (en) | 2002-07-11 | 2007-08-21 | Gea Energy System (India) Limited | Debris filter with a rotating debris extractor |
| GB0227948D0 (en) | 2002-11-29 | 2003-01-08 | Cipla Ltd | Pharmaceutical combinations comprising b-2 adrenoreceptor agonists and xanthines |
| GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
| GB0229618D0 (en) | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| US7160885B2 (en) | 2003-02-10 | 2007-01-09 | Cgi Pharmaceuticals, Inc. | Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity |
| US20040163196A1 (en) | 2003-02-21 | 2004-08-26 | Mckenzie Rebecca Anne | Dusting-cleaning sleeve |
| GB0309637D0 (en) | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
| US7241754B2 (en) | 2003-06-13 | 2007-07-10 | Kosan Biosciences, Inc. | 2-Desmethyl ansamycin compounds |
| KR101129215B1 (ko) | 2003-06-27 | 2012-04-13 | 교와 핫꼬 기린 가부시키가이샤 | Ｈｓｐ90 패밀리 단백질 저해제 |
| GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| AU2004200774A1 (en) | 2003-07-07 | 2005-01-27 | Holyrood Exports Pty Ltd | Padlock Protector |
| JPWO2005006322A1 (ja) | 2003-07-11 | 2006-08-24 | コニカミノルタオプト株式会社 | 光ピックアップ装置、光ピックアップ装置に用いられる光学素子、及び光学素子の製造方法 |
| EP1675861B1 (en) | 2003-08-29 | 2015-12-23 | Vernalis (R&D) Ltd. | Pyrimidothiophene compounds |
| EA010160B1 (ru) * | 2003-09-18 | 2008-06-30 | Конформа Терапьютикс Корпорейшн | Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения |
| GB0323810D0 (en) | 2003-10-10 | 2003-11-12 | Cancer Rec Tech Ltd | Pyridothiophene compounds |
| US6855705B1 (en) | 2003-11-12 | 2005-02-15 | Kosan Biosciences, Inc. | 11-O-methylgeldanamycin compounds |
| DE10354133A1 (de) | 2003-11-19 | 2005-06-23 | Phoenix Ag | Fördergurt |
| US7282493B2 (en) | 2003-12-23 | 2007-10-16 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| US20060019941A1 (en) | 2003-12-23 | 2006-01-26 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| WO2005072766A2 (en) | 2004-01-27 | 2005-08-11 | Boys Town National Research Hospital | Peptides that bind to hsp90 proteins |
| JP2005225787A (ja) | 2004-02-12 | 2005-08-25 | Nippon Kayaku Co Ltd | Ｈｓｐ９０阻害剤 |
| GB0416168D0 (en) | 2004-07-20 | 2004-08-18 | Vernalis Cambridge Ltd | Pyrmidothiophene compounds |
| US7342093B2 (en) | 2004-07-23 | 2008-03-11 | University Of Massachusetts | Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins |
| AR050084A1 (es) | 2004-07-27 | 2006-09-27 | Novartis Ag | Derivados de bencimidazolona como inhibidores de hsp90 |
| CN101027053A (zh) | 2004-07-27 | 2007-08-29 | 诺瓦提斯公司 | Hsp90抑制剂 |
| KR101045324B1 (ko) | 2004-08-11 | 2011-06-30 | 한국생명공학연구원 | 젤다나마이신 유도체 및 그 생합성 방법 |
| DE102004039280A1 (de) | 2004-08-13 | 2006-02-23 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole |
| US7208630B2 (en) | 2004-10-27 | 2007-04-24 | University Of Kansas | Heat shock protein 90 inhibitors |
| US7608594B2 (en) | 2004-11-03 | 2009-10-27 | University Of Kansas | Novobiocin analogues as anticancer agents |
| CA2585939C (en) | 2004-11-03 | 2013-06-04 | K2 Concepts, Inc. | Anti-microbial compositions and methods of making and using the same |
| EP1817295B1 (en) | 2004-11-18 | 2012-11-07 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| FR2880540B1 (fr) | 2005-01-13 | 2008-07-11 | Aventis Pharma Sa | Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90 |
| GB0501535D0 (en) | 2005-01-25 | 2005-03-02 | Vernalis R&D Ltd | Pyrimidothiophene compounds |
| WO2006084030A2 (en) | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| DE102005007304A1 (de) | 2005-02-17 | 2006-08-24 | Merck Patent Gmbh | Triazolderivate |
| FR2882361A1 (fr) | 2005-02-22 | 2006-08-25 | Aventis Pharma Sa | Nouveaux derives de 3-aryl-1,2-benzisoxazole, compositions les contenant et leur utilisation |
| TWI382015B (zh) | 2005-02-25 | 2013-01-11 | Serenex Inc | 苯、吡啶及噠嗪衍生物 |
| WO2006090094A1 (en) | 2005-02-28 | 2006-08-31 | Vernalis R & D Ltd | Pyrimidothiophene compounds for use as hsp90 inhibitors |
| DE102005009440A1 (de) | 2005-03-02 | 2006-09-07 | Merck Patent Gmbh | Thienopyridinderivate |
| CA2598899A1 (en) | 2005-03-09 | 2006-09-14 | Nippon Kayaku Kabushiki Kaisha | Novel hsp90 inhibitor |
| WO2006098761A2 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| JP2008137894A (ja) | 2005-03-22 | 2008-06-19 | Nippon Kayaku Co Ltd | 新規なアセチレン誘導体 |
| KR20080004550A (ko) | 2005-03-30 | 2008-01-09 | 콘포마 세러퓨틱스 코포레이션 | Ｈｓｐ９０-억제제로서 알키닐 피롤로피리미딘 및 관련유사체 |
| GB2423328B (en) | 2005-04-09 | 2007-02-28 | Louver Lite Ltd | Window blind system |
| DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
| FR2885904B1 (fr) * | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
-
2006
- 2006-10-24 FR FR0609331A patent/FR2907453B1/fr not_active Expired - Fee Related
-
2007
- 2007-10-17 KR KR1020097008314A patent/KR20090080948A/ko not_active Withdrawn
- 2007-10-17 WO PCT/FR2007/001703 patent/WO2008049994A1/fr not_active Ceased
- 2007-10-17 JP JP2009533896A patent/JP5431944B2/ja not_active Expired - Fee Related
- 2007-10-17 CN CNA2007800397476A patent/CN101528735A/zh active Pending
- 2007-10-17 CA CA002664115A patent/CA2664115A1/fr not_active Abandoned
- 2007-10-17 MX MX2009004049A patent/MX2009004049A/es not_active Application Discontinuation
- 2007-10-17 EA EA200970400A patent/EA200970400A1/ru unknown
- 2007-10-17 BR BRPI0718202-3A patent/BRPI0718202A2/pt not_active Application Discontinuation
- 2007-10-17 EP EP07858463.8A patent/EP2078009B1/fr active Active
- 2007-10-17 AU AU2007310767A patent/AU2007310767A1/en not_active Abandoned
- 2007-10-22 TW TW096139514A patent/TW200825083A/zh unknown
- 2007-10-23 CL CL200703046A patent/CL2007003046A1/es unknown
- 2007-10-23 AR ARP070104666A patent/AR063507A1/es unknown
- 2007-10-24 PE PE2007001446A patent/PE20081261A1/es not_active Application Discontinuation
- 2007-10-29 UY UY30667A patent/UY30667A1/es not_active Application Discontinuation
-
2009
- 2009-03-13 TN TN2009000086A patent/TN2009000086A1/fr unknown
- 2009-03-24 CR CR10690A patent/CR10690A/es not_active Application Discontinuation
- 2009-04-05 IL IL197887A patent/IL197887A0/en unknown
- 2009-04-24 CO CO09041714A patent/CO6160311A2/es unknown
- 2009-05-18 MA MA31893A patent/MA30904B1/fr unknown
- 2009-05-20 NO NO20091972A patent/NO20091972L/no not_active Application Discontinuation
- 2009-11-24 US US12/625,005 patent/US8163750B2/en not_active Expired - Fee Related
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