FR2907453B1 - Nouveaux derives du fluorene,compositions les contenant et utilisation - Google Patents

Nouveaux derives du fluorene,compositions les contenant et utilisation

Info

Publication number
FR2907453B1
FR2907453B1 FR0609331A FR0609331A FR2907453B1 FR 2907453 B1 FR2907453 B1 FR 2907453B1 FR 0609331 A FR0609331 A FR 0609331A FR 0609331 A FR0609331 A FR 0609331A FR 2907453 B1 FR2907453 B1 FR 2907453B1
Authority
FR
France
Prior art keywords
compositions containing
containing same
fluorene derivatives
novel fluorene
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0609331A
Other languages
English (en)
French (fr)
Other versions
FR2907453A1 (fr
Inventor
Fabienne Thompson
Patrick Mailliet
Jean Marie Ruxer
Helene Goulaouic
Francois Vallee
Herve Minoux
Fabienne Pilorge
Luc Bertin
Stephane Hourcade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38069221&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2907453(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0609331A priority Critical patent/FR2907453B1/fr
Priority to EA200970400A priority patent/EA200970400A1/ru
Priority to PCT/FR2007/001703 priority patent/WO2008049994A1/fr
Priority to KR1020097008314A priority patent/KR20090080948A/ko
Priority to CA002664115A priority patent/CA2664115A1/fr
Priority to BRPI0718202-3A priority patent/BRPI0718202A2/pt
Priority to MX2009004049A priority patent/MX2009004049A/es
Priority to CNA2007800397476A priority patent/CN101528735A/zh
Priority to EP07858463.8A priority patent/EP2078009B1/fr
Priority to AU2007310767A priority patent/AU2007310767A1/en
Priority to JP2009533896A priority patent/JP5431944B2/ja
Priority to TW096139514A priority patent/TW200825083A/zh
Priority to ARP070104666A priority patent/AR063507A1/es
Priority to CL200703046A priority patent/CL2007003046A1/es
Priority to PE2007001446A priority patent/PE20081261A1/es
Priority to UY30667A priority patent/UY30667A1/es
Publication of FR2907453A1 publication Critical patent/FR2907453A1/fr
Application granted granted Critical
Publication of FR2907453B1 publication Critical patent/FR2907453B1/fr
Priority to TN2009000086A priority patent/TN2009000086A1/fr
Priority to CR10690A priority patent/CR10690A/es
Priority to IL197887A priority patent/IL197887A0/en
Priority to CO09041714A priority patent/CO6160311A2/es
Priority to MA31893A priority patent/MA30904B1/fr
Priority to NO20091972A priority patent/NO20091972L/no
Priority to US12/625,005 priority patent/US8163750B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0609331A 2006-10-24 2006-10-24 Nouveaux derives du fluorene,compositions les contenant et utilisation Expired - Fee Related FR2907453B1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR0609331A FR2907453B1 (fr) 2006-10-24 2006-10-24 Nouveaux derives du fluorene,compositions les contenant et utilisation
CA002664115A CA2664115A1 (fr) 2006-10-24 2007-10-17 Nouveaux derives du fluorene, compositions les contenant et utilisation comme inhibiteurs de la proteine chaperone hsp90
PCT/FR2007/001703 WO2008049994A1 (fr) 2006-10-24 2007-10-17 Nouveaux derives du fluorene, compositions les contenant et utilisation comme inhibiteurs de la proteine chpaerone hsp90
KR1020097008314A KR20090080948A (ko) 2006-10-24 2007-10-17 신규한 플루오렌 유도체, 이를 함유하는 조성물, 및 단백질 샤페론 ｈｓｐ90의 억제제로서 그의 용도
EA200970400A EA200970400A1 (ru) 2006-10-24 2007-10-17 Новые производные флуорена, композиции, содержащие их, и их применение в качестве ингибиторов белка-шаперона hsp90
BRPI0718202-3A BRPI0718202A2 (pt) 2006-10-24 2007-10-17 Derivados do fluoreno, composições que os contêm e uso como inibidores da proteína chaperona hsp90
MX2009004049A MX2009004049A (es) 2006-10-24 2007-10-17 Nuevos derivados de fluoreno, composiciones que los contienen y sus usos como inhibidores de la proteina chaperona hsp90.
CNA2007800397476A CN101528735A (zh) 2006-10-24 2007-10-17 新的芴衍生物，包含它们的组合物和作为伴侣蛋白hsp90抑制剂的用途
EP07858463.8A EP2078009B1 (fr) 2006-10-24 2007-10-17 Nouveaux derives du fluorene, compositions les contenant et utilisation comme inhibiteurs de la proteine chpaerone hsp90
AU2007310767A AU2007310767A1 (en) 2006-10-24 2007-10-17 New fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90
JP2009533896A JP5431944B2 (ja) 2006-10-24 2007-10-17 新規フルオレン誘導体、これを含む組成物、およびタンパク質シャペロンｈｓｐ９０の阻害剤としてのこれらの使用
TW096139514A TW200825083A (en) 2006-10-24 2007-10-22 Novel fluorene derivatives, compositions containing them and use thereof
ARP070104666A AR063507A1 (es) 2006-10-24 2007-10-23 Derivados del fluoreno, composiciones que los contienen y uso como anticancerigenos
CL200703046A CL2007003046A1 (es) 2006-10-24 2007-10-23 Compuestos derivados de fluoreno; composicion farmaceutica que comprende a dicho compuesto; y uso para el tratamiento de enfermedades neurodegenerativas como parkinson, isquemia cerebral, huntington, cancer, degeneracion muscular, psoriasis, trombosi
PE2007001446A PE20081261A1 (es) 2006-10-24 2007-10-24 DERIVADOS DEL FLUORENO COMO INHIBIDORES DE LA PROTEINA CHAPERONA Hsp90 Y COMPOSICIONES QUE LOS CONTIENEN
UY30667A UY30667A1 (es) 2006-10-24 2007-10-29 Nuevos derivados del fluoreno, composiciones que los contienen y utilizacion
TN2009000086A TN2009000086A1 (en) 2006-10-24 2009-03-13 New fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone hsp 90
CR10690A CR10690A (es) 2006-10-24 2009-03-24 Nuevos derivados de fluoreno, composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90
IL197887A IL197887A0 (en) 2006-10-24 2009-04-05 New fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone hsp 90
CO09041714A CO6160311A2 (es) 2006-10-24 2009-04-24 Nuevos derivados de fluoreno composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90
MA31893A MA30904B1 (fr) 2006-10-24 2009-05-18 Nouveaux derives du fluorene, compositions les contenant et utilisation comme inhibiteurs de la proteine chpaerone hsp90
NO20091972A NO20091972L (no) 2006-10-24 2009-05-20 Nye fluorenderivater, sammensetninger inneholdende dem og anvendelse derav som inhibitorer av protein chaperone HSP 90
US12/625,005 US8163750B2 (en) 2006-10-24 2009-11-24 Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0609331A FR2907453B1 (fr) 2006-10-24 2006-10-24 Nouveaux derives du fluorene,compositions les contenant et utilisation

Publications (2)

Publication Number Publication Date
FR2907453A1 FR2907453A1 (fr) 2008-04-25
FR2907453B1 true FR2907453B1 (fr) 2008-12-26

Family

ID=38069221

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0609331A Expired - Fee Related FR2907453B1 (fr) 2006-10-24 2006-10-24 Nouveaux derives du fluorene,compositions les contenant et utilisation

Country Status (23)

Country Link
US (1) US8163750B2 (enExample)
EP (1) EP2078009B1 (enExample)
JP (1) JP5431944B2 (enExample)
KR (1) KR20090080948A (enExample)
CN (1) CN101528735A (enExample)
AR (1) AR063507A1 (enExample)
AU (1) AU2007310767A1 (enExample)
BR (1) BRPI0718202A2 (enExample)
CA (1) CA2664115A1 (enExample)
CL (1) CL2007003046A1 (enExample)
CO (1) CO6160311A2 (enExample)
CR (1) CR10690A (enExample)
EA (1) EA200970400A1 (enExample)
FR (1) FR2907453B1 (enExample)
IL (1) IL197887A0 (enExample)
MA (1) MA30904B1 (enExample)
MX (1) MX2009004049A (enExample)
NO (1) NO20091972L (enExample)
PE (1) PE20081261A1 (enExample)
TN (1) TN2009000086A1 (enExample)
TW (1) TW200825083A (enExample)
UY (1) UY30667A1 (enExample)
WO (1) WO2008049994A1 (enExample)

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US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
MX336687B (es) * 2009-06-30 2016-01-28 Siga Technologies Inc Tratamiento y prevencion de infecciones del virus del dengue.
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
DE102009054302A1 (de) * 2009-11-23 2011-05-26 Merck Patent Gmbh Chinazolinderivate
CN113521394A (zh) * 2020-04-13 2021-10-22 浙江华臻医疗器械有限公司 一种脱细胞血管基质及其制备方法
CN119409635A (zh) * 2024-11-04 2025-02-11 河南师范大学 具有抗癌活性的氟代甲基取代茚并[1,2-b]吡啶类化合物及其合成方法

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MX2009004049A (es) 2009-04-28
WO2008049994A1 (fr) 2008-05-02
FR2907453A1 (fr) 2008-04-25
UY30667A1 (es) 2008-05-31
NO20091972L (no) 2009-05-20
EA200970400A1 (ru) 2009-10-30
US8163750B2 (en) 2012-04-24
EP2078009B1 (fr) 2015-03-18
CL2007003046A1 (es) 2008-05-30
KR20090080948A (ko) 2009-07-27
MA30904B1 (fr) 2009-11-02
AU2007310767A1 (en) 2008-05-02
BRPI0718202A2 (pt) 2013-11-12
US20100130503A1 (en) 2010-05-27
CA2664115A1 (fr) 2008-05-02
JP5431944B2 (ja) 2014-03-05
TN2009000086A1 (en) 2010-08-19
EP2078009A1 (fr) 2009-07-15
CO6160311A2 (es) 2010-05-20
IL197887A0 (en) 2009-12-24
CN101528735A (zh) 2009-09-09
PE20081261A1 (es) 2008-10-15
CR10690A (es) 2009-07-23
AR063507A1 (es) 2009-01-28
TW200825083A (en) 2008-06-16

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