NO20091972L - Nye fluorenderivater, sammensetninger inneholdende dem og anvendelse derav som inhibitorer av protein chaperone HSP 90 - Google Patents
Nye fluorenderivater, sammensetninger inneholdende dem og anvendelse derav som inhibitorer av protein chaperone HSP 90Info
- Publication number
- NO20091972L NO20091972L NO20091972A NO20091972A NO20091972L NO 20091972 L NO20091972 L NO 20091972L NO 20091972 A NO20091972 A NO 20091972A NO 20091972 A NO20091972 A NO 20091972A NO 20091972 L NO20091972 L NO 20091972L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- inhibitors
- conh2
- compositions containing
- fluorene derivatives
- Prior art date
Links
- 101001016856 Homo sapiens Heat shock protein HSP 90-beta Proteins 0.000 title 1
- 101000988090 Leishmania donovani Heat shock protein 83 Proteins 0.000 title 1
- 125000003983 fluorenyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- -1 hydroxy, mercapto, amino Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0609331A FR2907453B1 (fr) | 2006-10-24 | 2006-10-24 | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| PCT/FR2007/001703 WO2008049994A1 (fr) | 2006-10-24 | 2007-10-17 | Nouveaux derives du fluorene, compositions les contenant et utilisation comme inhibiteurs de la proteine chpaerone hsp90 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20091972L true NO20091972L (no) | 2009-05-20 |
Family
ID=38069221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20091972A NO20091972L (no) | 2006-10-24 | 2009-05-20 | Nye fluorenderivater, sammensetninger inneholdende dem og anvendelse derav som inhibitorer av protein chaperone HSP 90 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8163750B2 (enExample) |
| EP (1) | EP2078009B1 (enExample) |
| JP (1) | JP5431944B2 (enExample) |
| KR (1) | KR20090080948A (enExample) |
| CN (1) | CN101528735A (enExample) |
| AR (1) | AR063507A1 (enExample) |
| AU (1) | AU2007310767A1 (enExample) |
| BR (1) | BRPI0718202A2 (enExample) |
| CA (1) | CA2664115A1 (enExample) |
| CL (1) | CL2007003046A1 (enExample) |
| CO (1) | CO6160311A2 (enExample) |
| CR (1) | CR10690A (enExample) |
| EA (1) | EA200970400A1 (enExample) |
| FR (1) | FR2907453B1 (enExample) |
| IL (1) | IL197887A0 (enExample) |
| MA (1) | MA30904B1 (enExample) |
| MX (1) | MX2009004049A (enExample) |
| NO (1) | NO20091972L (enExample) |
| PE (1) | PE20081261A1 (enExample) |
| TN (1) | TN2009000086A1 (enExample) |
| TW (1) | TW200825083A (enExample) |
| UY (1) | UY30667A1 (enExample) |
| WO (1) | WO2008049994A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| MX336687B (es) * | 2009-06-30 | 2016-01-28 | Siga Technologies Inc | Tratamiento y prevencion de infecciones del virus del dengue. |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| DE102009054302A1 (de) * | 2009-11-23 | 2011-05-26 | Merck Patent Gmbh | Chinazolinderivate |
| CN113521394A (zh) * | 2020-04-13 | 2021-10-22 | 浙江华臻医疗器械有限公司 | 一种脱细胞血管基质及其制备方法 |
| CN119409635A (zh) * | 2024-11-04 | 2025-02-11 | 河南师范大学 | 具有抗癌活性的氟代甲基取代茚并[1,2-b]吡啶类化合物及其合成方法 |
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| US7439359B2 (en) | 2000-11-02 | 2008-10-21 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to hsp90 |
| US7553979B2 (en) | 2001-11-09 | 2009-06-30 | Conforma Therapeutics Corporation | HSP90-inhibiting zearalanol compounds and methods of producing and using same |
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| EA010160B1 (ru) * | 2003-09-18 | 2008-06-30 | Конформа Терапьютикс Корпорейшн | Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения |
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| US7208630B2 (en) | 2004-10-27 | 2007-04-24 | University Of Kansas | Heat shock protein 90 inhibitors |
| US7608594B2 (en) | 2004-11-03 | 2009-10-27 | University Of Kansas | Novobiocin analogues as anticancer agents |
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2006
- 2006-10-24 FR FR0609331A patent/FR2907453B1/fr not_active Expired - Fee Related
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2007
- 2007-10-17 KR KR1020097008314A patent/KR20090080948A/ko not_active Withdrawn
- 2007-10-17 WO PCT/FR2007/001703 patent/WO2008049994A1/fr not_active Ceased
- 2007-10-17 JP JP2009533896A patent/JP5431944B2/ja not_active Expired - Fee Related
- 2007-10-17 CN CNA2007800397476A patent/CN101528735A/zh active Pending
- 2007-10-17 CA CA002664115A patent/CA2664115A1/fr not_active Abandoned
- 2007-10-17 MX MX2009004049A patent/MX2009004049A/es not_active Application Discontinuation
- 2007-10-17 EA EA200970400A patent/EA200970400A1/ru unknown
- 2007-10-17 BR BRPI0718202-3A patent/BRPI0718202A2/pt not_active Application Discontinuation
- 2007-10-17 EP EP07858463.8A patent/EP2078009B1/fr active Active
- 2007-10-17 AU AU2007310767A patent/AU2007310767A1/en not_active Abandoned
- 2007-10-22 TW TW096139514A patent/TW200825083A/zh unknown
- 2007-10-23 CL CL200703046A patent/CL2007003046A1/es unknown
- 2007-10-23 AR ARP070104666A patent/AR063507A1/es unknown
- 2007-10-24 PE PE2007001446A patent/PE20081261A1/es not_active Application Discontinuation
- 2007-10-29 UY UY30667A patent/UY30667A1/es not_active Application Discontinuation
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2009
- 2009-03-13 TN TN2009000086A patent/TN2009000086A1/fr unknown
- 2009-03-24 CR CR10690A patent/CR10690A/es not_active Application Discontinuation
- 2009-04-05 IL IL197887A patent/IL197887A0/en unknown
- 2009-04-24 CO CO09041714A patent/CO6160311A2/es unknown
- 2009-05-18 MA MA31893A patent/MA30904B1/fr unknown
- 2009-05-20 NO NO20091972A patent/NO20091972L/no not_active Application Discontinuation
- 2009-11-24 US US12/625,005 patent/US8163750B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010507634A (ja) | 2010-03-11 |
| MX2009004049A (es) | 2009-04-28 |
| WO2008049994A1 (fr) | 2008-05-02 |
| FR2907453B1 (fr) | 2008-12-26 |
| FR2907453A1 (fr) | 2008-04-25 |
| UY30667A1 (es) | 2008-05-31 |
| EA200970400A1 (ru) | 2009-10-30 |
| US8163750B2 (en) | 2012-04-24 |
| EP2078009B1 (fr) | 2015-03-18 |
| CL2007003046A1 (es) | 2008-05-30 |
| KR20090080948A (ko) | 2009-07-27 |
| MA30904B1 (fr) | 2009-11-02 |
| AU2007310767A1 (en) | 2008-05-02 |
| BRPI0718202A2 (pt) | 2013-11-12 |
| US20100130503A1 (en) | 2010-05-27 |
| CA2664115A1 (fr) | 2008-05-02 |
| JP5431944B2 (ja) | 2014-03-05 |
| TN2009000086A1 (en) | 2010-08-19 |
| EP2078009A1 (fr) | 2009-07-15 |
| CO6160311A2 (es) | 2010-05-20 |
| IL197887A0 (en) | 2009-12-24 |
| CN101528735A (zh) | 2009-09-09 |
| PE20081261A1 (es) | 2008-10-15 |
| CR10690A (es) | 2009-07-23 |
| AR063507A1 (es) | 2009-01-28 |
| TW200825083A (en) | 2008-06-16 |
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