CO6160311A2 - Nuevos derivados de fluoreno composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90 - Google Patents

Nuevos derivados de fluoreno composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90

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Publication number
CO6160311A2
CO6160311A2 CO09041714A CO09041714A CO6160311A2 CO 6160311 A2 CO6160311 A2 CO 6160311A2 CO 09041714 A CO09041714 A CO 09041714A CO 09041714 A CO09041714 A CO 09041714A CO 6160311 A2 CO6160311 A2 CO 6160311A2
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Prior art keywords
alkyl
alkoxy
alkylthio
different
conh2
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CO09041714A
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English (en)
Inventor
Fabienne Thompson
Patrick Mailliet
Jean-Marie Ruxer
Helene Goulaouic
Francois Vallee
Herve Minoux
Fabienne Pilorge
Luc Bertin
Stephane Hourcade
Maria Mendez-Perez
Peter Hamley
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Sanofi Aventis
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Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CO6160311A2 publication Critical patent/CO6160311A2/es

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    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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Abstract

1.- Productos de fórmula (I):en los que: Het representa un heterociclo aromático o parcialmente insaturado - de tipo dihidro o tetrahidro - mono o bicíclico, de 5 a 11 eslabones, que contiene de 1 a 4 heteroátomos, elegidos entre N O o S, sustituido opcionalmente con uno o varios radicales R idénticos o diferentes tales como los descritos más adelante, R está en el grupo constituido por H, halógeno, CF3, nitro, ciano, alquilo, hidroxi, mercapto, amino, alquilamino, dialquilamino, alcoxi, alquiltio, carboxi libre o esterificado por un radical alquilo, carboxamida, CO-NH(alquilo) y CON(alquilo)2, NH-CO-alquilo, NH-SO2-alquilo y heterocicloalquilo, estando todos los radicales alquilo, alcoxi, alquiltio y heterocicloalquilo sustituidos opcionalmente, R1 se elige del grupo constituido por X-(A-B)n-CONH2, X-(A-B)n-O-CONH2, X-(A-B)n-NH-CONH2, X-(CH2)m-heterocicloalquilo, X-(CH2)m-arilo y X-(CH2)m-heteroarilo con X que representa -O-C(O), -NH-C(O), NH-CS, -NH-CO-CH2-O-; -NH-CO-CH2-S-CH2-CO-NH-; -NH-CO-(CH2)2-SO2-; -NH-CO-CH2-N(CH3)-CO-; A y B idénticos o diferentes representan independientemente un enlace sencillo, CH2, CH-alquilo, CH-aralquilo, n = 1,2 y m = 0, 1, R2 y R´2, idénticos o diferentes, se seleccionan independientemente del grupo constituido por H, halógeno, CF3, nitro, ciano, alquilo, hidroxi, mercapto, amino, alquilamino, dialquilamino, alcoxi, alquiltio (metiltio), carboxi libre o esterificado por un radical alquilo, carboxamida, CO-NH(alquilo) y NH-CO-alquilo, estando todos los radicales alquilo, alcoxi y alquiltio sustituidos opcionalmente, p y p' idénticos o diferentes representan respectivamente los números enteros 1 a 4 y 1 a 3; L se elige entre enlace sencillo, CH2, C(O), O, S o NH, estando dichos productos de fórmula (I) en todas las formas tautómeras e isómeras posibles racémicas, enantiómeras y diastereoisómeras, así como las sales de adición con los ácidos minerales y orgánicos o con las bases minerales y orgánicas de dichos productos de fórmula (I).
CO09041714A 2006-10-24 2009-04-24 Nuevos derivados de fluoreno composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90 CO6160311A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0609331A FR2907453B1 (fr) 2006-10-24 2006-10-24 Nouveaux derives du fluorene,compositions les contenant et utilisation

Publications (1)

Publication Number Publication Date
CO6160311A2 true CO6160311A2 (es) 2010-05-20

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CO09041714A CO6160311A2 (es) 2006-10-24 2009-04-24 Nuevos derivados de fluoreno composiciones que los contienen y utilizacion como inhibidores de la proteina chaperona hsp90

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Country Link
US (1) US8163750B2 (es)
EP (1) EP2078009B1 (es)
JP (1) JP5431944B2 (es)
KR (1) KR20090080948A (es)
CN (1) CN101528735A (es)
AR (1) AR063507A1 (es)
AU (1) AU2007310767A1 (es)
BR (1) BRPI0718202A2 (es)
CA (1) CA2664115A1 (es)
CL (1) CL2007003046A1 (es)
CO (1) CO6160311A2 (es)
CR (1) CR10690A (es)
EA (1) EA200970400A1 (es)
FR (1) FR2907453B1 (es)
IL (1) IL197887A0 (es)
MA (1) MA30904B1 (es)
MX (1) MX2009004049A (es)
NO (1) NO20091972L (es)
PE (1) PE20081261A1 (es)
TN (1) TN2009000086A1 (es)
TW (1) TW200825083A (es)
UY (1) UY30667A1 (es)
WO (1) WO2008049994A1 (es)

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EP2078009B1 (fr) 2015-03-18
CR10690A (es) 2009-07-23
US20100130503A1 (en) 2010-05-27
CN101528735A (zh) 2009-09-09
US8163750B2 (en) 2012-04-24
MA30904B1 (fr) 2009-11-02
EP2078009A1 (fr) 2009-07-15
AU2007310767A1 (en) 2008-05-02
TW200825083A (en) 2008-06-16
JP5431944B2 (ja) 2014-03-05
FR2907453A1 (fr) 2008-04-25
IL197887A0 (en) 2009-12-24
UY30667A1 (es) 2008-05-31
BRPI0718202A2 (pt) 2013-11-12
PE20081261A1 (es) 2008-10-15
FR2907453B1 (fr) 2008-12-26
EA200970400A1 (ru) 2009-10-30
NO20091972L (no) 2009-05-20
CA2664115A1 (fr) 2008-05-02
WO2008049994A1 (fr) 2008-05-02
CL2007003046A1 (es) 2008-05-30
JP2010507634A (ja) 2010-03-11
KR20090080948A (ko) 2009-07-27
AR063507A1 (es) 2009-01-28
MX2009004049A (es) 2009-04-28
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