WO2009122034A8 - Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation - Google Patents
Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation Download PDFInfo
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- WO2009122034A8 WO2009122034A8 PCT/FR2009/000267 FR2009000267W WO2009122034A8 WO 2009122034 A8 WO2009122034 A8 WO 2009122034A8 FR 2009000267 W FR2009000267 W FR 2009000267W WO 2009122034 A8 WO2009122034 A8 WO 2009122034A8
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- WIPO (PCT)
- Prior art keywords
- alkyl
- compositions containing
- containing same
- carbazole derivatives
- optionally substituted
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
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- A61P31/10—Antimycotics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Neurology (AREA)
- Communicable Diseases (AREA)
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- Biotechnology (AREA)
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- Urology & Nephrology (AREA)
- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009801174385A CN102026992A (zh) | 2008-03-14 | 2009-03-13 | 新的hsp90抑制性咔唑衍生物和含有该咔唑衍生物的组合物及其用途 |
BRPI0909731-7A BRPI0909731A2 (pt) | 2008-03-14 | 2009-03-13 | derivados de carbazol inibidores de hsp90, composições que os contêm e a respectiva utilização |
AU2009232121A AU2009232121A1 (en) | 2008-03-14 | 2009-03-13 | Novel HSP90 inhibitory carbazole derivatives, compositions containing same, and use thereof |
CA2718488A CA2718488A1 (fr) | 2008-03-14 | 2009-03-13 | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
JP2010550234A JP5674483B2 (ja) | 2008-03-14 | 2009-03-13 | 新規なhsp90阻害性カルバゾール誘導体、同誘導体を含む組成物およびその使用 |
EA201071078A EA201071078A1 (ru) | 2008-03-14 | 2009-03-13 | Новые производные карбазола, являющиеся ингибиторами hsp90, содержащие их композиции и их применение |
MX2010010018A MX2010010018A (es) | 2008-03-14 | 2009-03-13 | Nuevos derivados de carbazol inhibidores de hsp90, composiciones que los contienen y su uso. |
EP09728587A EP2265598A2 (fr) | 2008-03-14 | 2009-03-13 | Nouveaux derives de carbazole inhibiteurs d' hsp90, compositions les contenant et utilisation |
TNP2010000351A TN2010000351A1 (en) | 2009-03-13 | 2010-07-27 | Novel hsp90 inhibitory carbazole derivatives compositions containing same and use thereof |
IL208059A IL208059A0 (en) | 2008-03-14 | 2010-09-07 | Novel hsp90 inhibitory carbazole derivatives, compositions containing same and use thereof |
US12/881,414 US8309721B2 (en) | 2008-03-14 | 2010-09-14 | HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof |
MA33221A MA32206B1 (fr) | 2008-03-14 | 2010-10-06 | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR08/01394 | 2008-03-14 | ||
FR0801394A FR2928645A1 (fr) | 2008-03-14 | 2008-03-14 | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/881,414 Continuation US8309721B2 (en) | 2008-03-14 | 2010-09-14 | HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009122034A2 WO2009122034A2 (fr) | 2009-10-08 |
WO2009122034A3 WO2009122034A3 (fr) | 2009-12-03 |
WO2009122034A8 true WO2009122034A8 (fr) | 2010-08-19 |
Family
ID=39930567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2009/000267 WO2009122034A2 (fr) | 2008-03-14 | 2009-03-13 | Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation |
Country Status (24)
Country | Link |
---|---|
US (1) | US8309721B2 (fr) |
EP (1) | EP2265598A2 (fr) |
JP (1) | JP5674483B2 (fr) |
KR (1) | KR20100130603A (fr) |
CN (1) | CN102026992A (fr) |
AR (1) | AR070836A1 (fr) |
AU (1) | AU2009232121A1 (fr) |
BR (1) | BRPI0909731A2 (fr) |
CA (1) | CA2718488A1 (fr) |
CL (1) | CL2009000619A1 (fr) |
CO (1) | CO6251295A2 (fr) |
CR (1) | CR11653A (fr) |
DO (1) | DOP2010000272A (fr) |
EA (1) | EA201071078A1 (fr) |
EC (1) | ECSP10010473A (fr) |
FR (1) | FR2928645A1 (fr) |
IL (1) | IL208059A0 (fr) |
MA (1) | MA32206B1 (fr) |
MX (1) | MX2010010018A (fr) |
NI (1) | NI201000150A (fr) |
PE (1) | PE20091673A1 (fr) |
TW (1) | TW200938541A (fr) |
UY (1) | UY31711A (fr) |
WO (1) | WO2009122034A2 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011035416A1 (fr) * | 2009-09-25 | 2011-03-31 | Aegera Therapeutics Inc. | Composés modulateurs de la hsp90, compositions, procédés et utilisations correspondants |
KR20140025327A (ko) | 2011-01-07 | 2014-03-04 | 다이호야쿠힌고교 가부시키가이샤 | 신규 2 고리형 화합물 또는 그 염 |
RU2013136861A (ru) | 2011-01-07 | 2015-02-20 | Тайхо Фармасьютикал Ко., Лтд. | Новое производное индола или индазола или его соль |
JP5842630B2 (ja) * | 2011-03-16 | 2016-01-13 | 株式会社リコー | カルバゾール誘導体、及び半導体ナノ結晶 |
JP2014075556A (ja) * | 2012-10-05 | 2014-04-24 | Idemitsu Kosan Co Ltd | 有機エレクトロルミネッセンス素子用材料、及びそれを用いた有機エレクトロルミネッセンス素子 |
ES2723888T3 (es) * | 2013-01-10 | 2019-09-03 | Merck Patent Gmbh | Piperidinilcarbazol como antipalúdico |
WO2015056782A1 (fr) | 2013-10-17 | 2015-04-23 | 塩野義製薬株式会社 | Nouveau dérivé d'alkylène |
JP6345786B2 (ja) | 2013-12-05 | 2018-06-20 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼの阻害剤 |
WO2016008010A1 (fr) * | 2014-07-16 | 2016-01-21 | Novogen ltd | Carbazoles fonctionnalisés et substitués utilisés en tant qu'agents anti-cancéreux |
MA40769B1 (fr) * | 2014-10-01 | 2019-03-29 | Janssen Pharmaceuticals Inc | Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue |
JOP20150335B1 (ar) * | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
ES2784316T3 (es) * | 2015-04-29 | 2020-09-24 | Arena Pharm Inc | 1-Heteroaril-indolin-4-carboxamidas como moduladores de GPR52 útiles para el tratamiento o la prevención de trastornos relacionados con el mismo |
JOP20160086B1 (ar) * | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JO3633B1 (ar) * | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
DE102016122122B4 (de) * | 2015-11-18 | 2021-02-11 | Cynora Gmbh | Organische Moleküle, insbesondere zur Verwendung in organischen optoelektronischen Vorrichtungen |
US9966542B2 (en) * | 2016-06-02 | 2018-05-08 | E I Du Pont De Nemours And Company | Electroactive materials |
DE102017008073A1 (de) * | 2017-08-28 | 2019-02-28 | Henkel Ag & Co. Kgaa | Neue anionische Tenside und Wasch- und Reinigungsmittel, welche diese enthalten |
CN111217741B (zh) * | 2019-03-01 | 2022-03-15 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | 氟取代单咔唑类衍生物、其制备方法及应用 |
CN117157299B (zh) * | 2022-04-28 | 2024-05-28 | 北京丹擎医药科技有限公司 | 三环杂环衍生物及其组合物和应用 |
CN117159570B (zh) * | 2023-11-01 | 2024-01-23 | 云南中医药大学 | 6-酰氧基甘露糖叠氮乙苷衍生物与氟康唑联合在制备抗耐药白念珠菌药物中的应用 |
CN117486782A (zh) * | 2023-12-29 | 2024-02-02 | 中国医学科学院药用植物研究所 | 一种n-取代咔唑衍生物及其制备方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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IT1317926B1 (it) * | 2000-11-03 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
CN101072759B (zh) * | 2004-11-18 | 2013-06-19 | Synta医药公司 | 调节hsp90活性的三唑化合物 |
WO2007035620A2 (fr) * | 2005-09-16 | 2007-03-29 | Serenex, Inc. | Derives de carbazole |
US8405508B2 (en) * | 2006-08-09 | 2013-03-26 | Emd Millipore Corporation | Use of gamma hardened RFID tags in pharmaceutical devices |
-
2008
- 2008-03-14 FR FR0801394A patent/FR2928645A1/fr not_active Withdrawn
-
2009
- 2009-03-12 TW TW098108083A patent/TW200938541A/zh unknown
- 2009-03-12 AR ARP090100879A patent/AR070836A1/es unknown
- 2009-03-12 PE PE2009000368A patent/PE20091673A1/es not_active Application Discontinuation
- 2009-03-13 WO PCT/FR2009/000267 patent/WO2009122034A2/fr active Application Filing
- 2009-03-13 CL CL2009000619A patent/CL2009000619A1/es unknown
- 2009-03-13 BR BRPI0909731-7A patent/BRPI0909731A2/pt not_active IP Right Cessation
- 2009-03-13 JP JP2010550234A patent/JP5674483B2/ja not_active Expired - Fee Related
- 2009-03-13 EP EP09728587A patent/EP2265598A2/fr not_active Withdrawn
- 2009-03-13 KR KR1020107020403A patent/KR20100130603A/ko not_active Application Discontinuation
- 2009-03-13 UY UY0001031711A patent/UY31711A/es not_active Application Discontinuation
- 2009-03-13 MX MX2010010018A patent/MX2010010018A/es unknown
- 2009-03-13 CN CN2009801174385A patent/CN102026992A/zh active Pending
- 2009-03-13 EA EA201071078A patent/EA201071078A1/ru unknown
- 2009-03-13 CA CA2718488A patent/CA2718488A1/fr not_active Abandoned
- 2009-03-13 AU AU2009232121A patent/AU2009232121A1/en not_active Abandoned
-
2010
- 2010-08-26 CR CR11653A patent/CR11653A/es not_active Application Discontinuation
- 2010-09-01 CO CO10108118A patent/CO6251295A2/es not_active Application Discontinuation
- 2010-09-07 IL IL208059A patent/IL208059A0/en unknown
- 2010-09-09 NI NI201000150A patent/NI201000150A/es unknown
- 2010-09-10 EC EC2010010473A patent/ECSP10010473A/es unknown
- 2010-09-10 DO DO2010000272A patent/DOP2010000272A/es unknown
- 2010-09-14 US US12/881,414 patent/US8309721B2/en not_active Expired - Fee Related
- 2010-10-06 MA MA33221A patent/MA32206B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
US20110166169A1 (en) | 2011-07-07 |
WO2009122034A2 (fr) | 2009-10-08 |
NI201000150A (es) | 2011-03-29 |
CN102026992A (zh) | 2011-04-20 |
EP2265598A2 (fr) | 2010-12-29 |
CO6251295A2 (es) | 2011-02-21 |
AU2009232121A1 (en) | 2009-10-08 |
EA201071078A1 (ru) | 2011-04-29 |
MA32206B1 (fr) | 2011-04-01 |
JP2011513473A (ja) | 2011-04-28 |
MX2010010018A (es) | 2010-12-15 |
BRPI0909731A2 (pt) | 2019-03-06 |
JP5674483B2 (ja) | 2015-02-25 |
AR070836A1 (es) | 2010-05-05 |
CL2009000619A1 (es) | 2011-02-18 |
TW200938541A (en) | 2009-09-16 |
PE20091673A1 (es) | 2009-11-14 |
ECSP10010473A (es) | 2010-10-30 |
DOP2010000272A (es) | 2010-10-15 |
CA2718488A1 (fr) | 2009-10-08 |
CR11653A (es) | 2010-11-22 |
UY31711A (es) | 2009-11-10 |
KR20100130603A (ko) | 2010-12-13 |
US8309721B2 (en) | 2012-11-13 |
WO2009122034A3 (fr) | 2009-12-03 |
FR2928645A1 (fr) | 2009-09-18 |
IL208059A0 (en) | 2010-12-30 |
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