WO2009122034A8 - Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation - Google Patents

Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation Download PDF

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Publication number
WO2009122034A8
WO2009122034A8 PCT/FR2009/000267 FR2009000267W WO2009122034A8 WO 2009122034 A8 WO2009122034 A8 WO 2009122034A8 FR 2009000267 W FR2009000267 W FR 2009000267W WO 2009122034 A8 WO2009122034 A8 WO 2009122034A8
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WIPO (PCT)
Prior art keywords
alkyl
compositions containing
containing same
carbazole derivatives
optionally substituted
Prior art date
Application number
PCT/FR2009/000267
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English (en)
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WO2009122034A2 (fr
WO2009122034A3 (fr
Inventor
Marcel Alasia
Luc Bertin
Victor Certal
Frank Halley
Patrick Mailliet
Maria Mendez Perez
Hervé MINOUX
Jean-Marie Ruxer
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Sanofi-Aventis
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39930567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009122034(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP09728587A priority Critical patent/EP2265598A2/fr
Priority to AU2009232121A priority patent/AU2009232121A1/en
Priority to CA2718488A priority patent/CA2718488A1/fr
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Priority to EA201071078A priority patent/EA201071078A1/ru
Priority to BRPI0909731-7A priority patent/BRPI0909731A2/pt
Priority to MX2010010018A priority patent/MX2010010018A/es
Priority to JP2010550234A priority patent/JP5674483B2/ja
Priority to CN2009801174385A priority patent/CN102026992A/zh
Publication of WO2009122034A2 publication Critical patent/WO2009122034A2/fr
Publication of WO2009122034A3 publication Critical patent/WO2009122034A3/fr
Priority to TNP2010000351A priority patent/TN2010000351A1/fr
Publication of WO2009122034A8 publication Critical patent/WO2009122034A8/fr
Priority to IL208059A priority patent/IL208059A0/en
Priority to US12/881,414 priority patent/US8309721B2/en
Priority to MA33221A priority patent/MA32206B1/fr

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    • C—CHEMISTRY; METALLURGY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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Abstract

L'invention concerne les nouveaux produits de formule (I) dans lesquels Het représente un hétérocycle éventuellement substitué par un ou plusieurs radicaux R1 ou R'1, R est choisi dans le groupe constitué par (A'), (B), (C), (D) et (E) avec R1 et/ou R'1, choisis parmi H, halogène, CF3, nitro, cyano, alkyle, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, phénylalcoxy, alkylthio, carboxy libre ou estérifié par un radical alkyle, carboxamide, CO-NH(alkyl), CON(alkyl)2, NH-CO- alkyl, sulfonamide, NH-S02-alkyl, S(0)2-NHalkyl, S(O2)-N(alkyl)2; tous ces radicaux éventuellement substitués; W1, W2, W3 représentent indépendemment CH ou N, X représente O, S, NR2, C(O), S(O) ou S(0)2; Z représente H, HaI, -0-R2 ou -NH-R2 avec R2 représente H, alkyle, cycloalkyle ou hétérocycloalkyle éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.
PCT/FR2009/000267 2008-03-14 2009-03-13 Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation WO2009122034A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN2009801174385A CN102026992A (zh) 2008-03-14 2009-03-13 新的hsp90抑制性咔唑衍生物和含有该咔唑衍生物的组合物及其用途
BRPI0909731-7A BRPI0909731A2 (pt) 2008-03-14 2009-03-13 derivados de carbazol inibidores de hsp90, composições que os contêm e a respectiva utilização
AU2009232121A AU2009232121A1 (en) 2008-03-14 2009-03-13 Novel HSP90 inhibitory carbazole derivatives, compositions containing same, and use thereof
CA2718488A CA2718488A1 (fr) 2008-03-14 2009-03-13 Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
JP2010550234A JP5674483B2 (ja) 2008-03-14 2009-03-13 新規なｈｓｐ９０阻害性カルバゾール誘導体、同誘導体を含む組成物およびその使用
EA201071078A EA201071078A1 (ru) 2008-03-14 2009-03-13 Новые производные карбазола, являющиеся ингибиторами hsp90, содержащие их композиции и их применение
MX2010010018A MX2010010018A (es) 2008-03-14 2009-03-13 Nuevos derivados de carbazol inhibidores de hsp90, composiciones que los contienen y su uso.
EP09728587A EP2265598A2 (fr) 2008-03-14 2009-03-13 Nouveaux derives de carbazole inhibiteurs d' hsp90, compositions les contenant et utilisation
TNP2010000351A TN2010000351A1 (en) 2009-03-13 2010-07-27 Novel hsp90 inhibitory carbazole derivatives compositions containing same and use thereof
IL208059A IL208059A0 (en) 2008-03-14 2010-09-07 Novel hsp90 inhibitory carbazole derivatives, compositions containing same and use thereof
US12/881,414 US8309721B2 (en) 2008-03-14 2010-09-14 HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof
MA33221A MA32206B1 (fr) 2008-03-14 2010-10-06 Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR08/01394 2008-03-14
FR0801394A FR2928645A1 (fr) 2008-03-14 2008-03-14 Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/881,414 Continuation US8309721B2 (en) 2008-03-14 2010-09-14 HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof

Publications (3)

Publication Number Publication Date
WO2009122034A2 WO2009122034A2 (fr) 2009-10-08
WO2009122034A3 WO2009122034A3 (fr) 2009-12-03
WO2009122034A8 true WO2009122034A8 (fr) 2010-08-19

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PCT/FR2009/000267 WO2009122034A2 (fr) 2008-03-14 2009-03-13 Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation

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Country Link
US (1) US8309721B2 (fr)
EP (1) EP2265598A2 (fr)
JP (1) JP5674483B2 (fr)
KR (1) KR20100130603A (fr)
CN (1) CN102026992A (fr)
AR (1) AR070836A1 (fr)
AU (1) AU2009232121A1 (fr)
BR (1) BRPI0909731A2 (fr)
CA (1) CA2718488A1 (fr)
CL (1) CL2009000619A1 (fr)
CO (1) CO6251295A2 (fr)
CR (1) CR11653A (fr)
DO (1) DOP2010000272A (fr)
EA (1) EA201071078A1 (fr)
EC (1) ECSP10010473A (fr)
FR (1) FR2928645A1 (fr)
IL (1) IL208059A0 (fr)
MA (1) MA32206B1 (fr)
MX (1) MX2010010018A (fr)
NI (1) NI201000150A (fr)
PE (1) PE20091673A1 (fr)
TW (1) TW200938541A (fr)
UY (1) UY31711A (fr)
WO (1) WO2009122034A2 (fr)

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WO2011035416A1 (fr) * 2009-09-25 2011-03-31 Aegera Therapeutics Inc. Composés modulateurs de la hsp90, compositions, procédés et utilisations correspondants
KR20140025327A (ko) 2011-01-07 2014-03-04 다이호야쿠힌고교 가부시키가이샤 신규 2 고리형 화합물 또는 그 염
RU2013136861A (ru) 2011-01-07 2015-02-20 Тайхо Фармасьютикал Ко., Лтд. Новое производное индола или индазола или его соль
JP5842630B2 (ja) * 2011-03-16 2016-01-13 株式会社リコー カルバゾール誘導体、及び半導体ナノ結晶
JP2014075556A (ja) * 2012-10-05 2014-04-24 Idemitsu Kosan Co Ltd 有機エレクトロルミネッセンス素子用材料、及びそれを用いた有機エレクトロルミネッセンス素子
ES2723888T3 (es) * 2013-01-10 2019-09-03 Merck Patent Gmbh Piperidinilcarbazol como antipalúdico
WO2015056782A1 (fr) 2013-10-17 2015-04-23 塩野義製薬株式会社 Nouveau dérivé d'alkylène
JP6345786B2 (ja) 2013-12-05 2018-06-20 ファーマサイクリックス エルエルシー ブルトン型チロシンキナーゼの阻害剤
WO2016008010A1 (fr) * 2014-07-16 2016-01-21 Novogen ltd Carbazoles fonctionnalisés et substitués utilisés en tant qu'agents anti-cancéreux
MA40769B1 (fr) * 2014-10-01 2019-03-29 Janssen Pharmaceuticals Inc Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue
JOP20150335B1 (ar) * 2015-01-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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EP2265598A2 (fr) 2010-12-29
CO6251295A2 (es) 2011-02-21
AU2009232121A1 (en) 2009-10-08
EA201071078A1 (ru) 2011-04-29
MA32206B1 (fr) 2011-04-01
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MX2010010018A (es) 2010-12-15
BRPI0909731A2 (pt) 2019-03-06
JP5674483B2 (ja) 2015-02-25
AR070836A1 (es) 2010-05-05
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US8309721B2 (en) 2012-11-13
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