BRPI0718202A2 - Derivados do fluoreno, composições que os contêm e uso como inibidores da proteína chaperona hsp90 - Google Patents
Derivados do fluoreno, composições que os contêm e uso como inibidores da proteína chaperona hsp90 Download PDFInfo
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- BRPI0718202A2 BRPI0718202A2 BRPI0718202-3A BRPI0718202A BRPI0718202A2 BR PI0718202 A2 BRPI0718202 A2 BR PI0718202A2 BR PI0718202 A BRPI0718202 A BR PI0718202A BR PI0718202 A2 BRPI0718202 A2 BR PI0718202A2
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- fluoren
- pyridine
- amide
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- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 title claims description 33
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical class C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 title claims description 3
- 239000000203 mixture Substances 0.000 title description 105
- 239000003112 inhibitor Substances 0.000 title description 11
- 101710113864 Heat shock protein 90 Proteins 0.000 title description 4
- -1 hydroxy, mercapto, amino Chemical group 0.000 claims description 169
- 239000007787 solid Substances 0.000 claims description 70
- 150000003254 radicals Chemical class 0.000 claims description 64
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims description 41
- 239000003814 drug Substances 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 38
- 239000002253 acid Substances 0.000 claims description 35
- 239000003481 heat shock protein 90 inhibitor Substances 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 32
- 239000011707 mineral Substances 0.000 claims description 32
- MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical compound C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 claims description 29
- 206010028980 Neoplasm Diseases 0.000 claims description 27
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 230000000694 effects Effects 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 19
- HPPPHDPVSYYWCH-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine-4-carboxylic acid Chemical compound OC(=O)C1=CC=NC2=C1C=CN2 HPPPHDPVSYYWCH-UHFFFAOYSA-N 0.000 claims description 18
- 201000011510 cancer Diseases 0.000 claims description 18
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims description 18
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 17
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 15
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- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 13
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- FMUPBLXDBFTANV-UHFFFAOYSA-N 6-bromo-1h-imidazo[4,5-b]pyridine-7-carboxylic acid Chemical compound OC(=O)C1=C(Br)C=NC2=C1NC=N2 FMUPBLXDBFTANV-UHFFFAOYSA-N 0.000 claims description 5
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- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- YPOXGDJGKBXRFP-UHFFFAOYSA-N pyrimidine-4-carboxylic acid Chemical compound OC(=O)C1=CC=NC=N1 YPOXGDJGKBXRFP-UHFFFAOYSA-N 0.000 claims description 4
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- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Landscapes
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| FR0609331A FR2907453B1 (fr) | 2006-10-24 | 2006-10-24 | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| FR0609331 | 2006-10-24 | ||
| PCT/FR2007/001703 WO2008049994A1 (fr) | 2006-10-24 | 2007-10-17 | Nouveaux derives du fluorene, compositions les contenant et utilisation comme inhibiteurs de la proteine chpaerone hsp90 |
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| BRPI0718202A2 true BRPI0718202A2 (pt) | 2013-11-12 |
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| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| MX336687B (es) * | 2009-06-30 | 2016-01-28 | Siga Technologies Inc | Tratamiento y prevencion de infecciones del virus del dengue. |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| DE102009054302A1 (de) * | 2009-11-23 | 2011-05-26 | Merck Patent Gmbh | Chinazolinderivate |
| CN113521394A (zh) * | 2020-04-13 | 2021-10-22 | 浙江华臻医疗器械有限公司 | 一种脱细胞血管基质及其制备方法 |
| CN119409635A (zh) * | 2024-11-04 | 2025-02-11 | 河南师范大学 | 具有抗癌活性的氟代甲基取代茚并[1,2-b]吡啶类化合物及其合成方法 |
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| US7439359B2 (en) | 2000-11-02 | 2008-10-21 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to hsp90 |
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| AU2004200774A1 (en) | 2003-07-07 | 2005-01-27 | Holyrood Exports Pty Ltd | Padlock Protector |
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| EA010160B1 (ru) * | 2003-09-18 | 2008-06-30 | Конформа Терапьютикс Корпорейшн | Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения |
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| US7342093B2 (en) | 2004-07-23 | 2008-03-11 | University Of Massachusetts | Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins |
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| CN101027053A (zh) | 2004-07-27 | 2007-08-29 | 诺瓦提斯公司 | Hsp90抑制剂 |
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| CA2598899A1 (en) | 2005-03-09 | 2006-09-14 | Nippon Kayaku Kabushiki Kaisha | Novel hsp90 inhibitor |
| WO2006098761A2 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| JP2008137894A (ja) | 2005-03-22 | 2008-06-19 | Nippon Kayaku Co Ltd | 新規なアセチレン誘導体 |
| KR20080004550A (ko) | 2005-03-30 | 2008-01-09 | 콘포마 세러퓨틱스 코포레이션 | Ｈｓｐ９０-억제제로서 알키닐 피롤로피리미딘 및 관련유사체 |
| GB2423328B (en) | 2005-04-09 | 2007-02-28 | Louver Lite Ltd | Window blind system |
| DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
| FR2885904B1 (fr) * | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
-
2006
- 2006-10-24 FR FR0609331A patent/FR2907453B1/fr not_active Expired - Fee Related
-
2007
- 2007-10-17 KR KR1020097008314A patent/KR20090080948A/ko not_active Withdrawn
- 2007-10-17 WO PCT/FR2007/001703 patent/WO2008049994A1/fr not_active Ceased
- 2007-10-17 JP JP2009533896A patent/JP5431944B2/ja not_active Expired - Fee Related
- 2007-10-17 CN CNA2007800397476A patent/CN101528735A/zh active Pending
- 2007-10-17 CA CA002664115A patent/CA2664115A1/fr not_active Abandoned
- 2007-10-17 MX MX2009004049A patent/MX2009004049A/es not_active Application Discontinuation
- 2007-10-17 EA EA200970400A patent/EA200970400A1/ru unknown
- 2007-10-17 BR BRPI0718202-3A patent/BRPI0718202A2/pt not_active Application Discontinuation
- 2007-10-17 EP EP07858463.8A patent/EP2078009B1/fr active Active
- 2007-10-17 AU AU2007310767A patent/AU2007310767A1/en not_active Abandoned
- 2007-10-22 TW TW096139514A patent/TW200825083A/zh unknown
- 2007-10-23 CL CL200703046A patent/CL2007003046A1/es unknown
- 2007-10-23 AR ARP070104666A patent/AR063507A1/es unknown
- 2007-10-24 PE PE2007001446A patent/PE20081261A1/es not_active Application Discontinuation
- 2007-10-29 UY UY30667A patent/UY30667A1/es not_active Application Discontinuation
-
2009
- 2009-03-13 TN TN2009000086A patent/TN2009000086A1/fr unknown
- 2009-03-24 CR CR10690A patent/CR10690A/es not_active Application Discontinuation
- 2009-04-05 IL IL197887A patent/IL197887A0/en unknown
- 2009-04-24 CO CO09041714A patent/CO6160311A2/es unknown
- 2009-05-18 MA MA31893A patent/MA30904B1/fr unknown
- 2009-05-20 NO NO20091972A patent/NO20091972L/no not_active Application Discontinuation
- 2009-11-24 US US12/625,005 patent/US8163750B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010507634A (ja) | 2010-03-11 |
| MX2009004049A (es) | 2009-04-28 |
| WO2008049994A1 (fr) | 2008-05-02 |
| FR2907453B1 (fr) | 2008-12-26 |
| FR2907453A1 (fr) | 2008-04-25 |
| UY30667A1 (es) | 2008-05-31 |
| NO20091972L (no) | 2009-05-20 |
| EA200970400A1 (ru) | 2009-10-30 |
| US8163750B2 (en) | 2012-04-24 |
| EP2078009B1 (fr) | 2015-03-18 |
| CL2007003046A1 (es) | 2008-05-30 |
| KR20090080948A (ko) | 2009-07-27 |
| MA30904B1 (fr) | 2009-11-02 |
| AU2007310767A1 (en) | 2008-05-02 |
| US20100130503A1 (en) | 2010-05-27 |
| CA2664115A1 (fr) | 2008-05-02 |
| JP5431944B2 (ja) | 2014-03-05 |
| TN2009000086A1 (en) | 2010-08-19 |
| EP2078009A1 (fr) | 2009-07-15 |
| CO6160311A2 (es) | 2010-05-20 |
| IL197887A0 (en) | 2009-12-24 |
| CN101528735A (zh) | 2009-09-09 |
| PE20081261A1 (es) | 2008-10-15 |
| CR10690A (es) | 2009-07-23 |
| AR063507A1 (es) | 2009-01-28 |
| TW200825083A (en) | 2008-06-16 |
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