TW200825083A - Novel fluorene derivatives, compositions containing them and use thereof - Google Patents
Novel fluorene derivatives, compositions containing them and use thereof Download PDFInfo
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- TW200825083A TW200825083A TW096139514A TW96139514A TW200825083A TW 200825083 A TW200825083 A TW 200825083A TW 096139514 A TW096139514 A TW 096139514A TW 96139514 A TW96139514 A TW 96139514A TW 200825083 A TW200825083 A TW 200825083A
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- 125000003983 fluorenyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 title claims description 8
- 239000000203 mixture Substances 0.000 title description 119
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 19
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 8
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- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims description 69
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- YPOXGDJGKBXRFP-UHFFFAOYSA-N pyrimidine-4-carboxylic acid Chemical compound OC(=O)C1=CC=NC=N1 YPOXGDJGKBXRFP-UHFFFAOYSA-N 0.000 claims description 3
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- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims 2
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Classifications
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| MX336687B (es) * | 2009-06-30 | 2016-01-28 | Siga Technologies Inc | Tratamiento y prevencion de infecciones del virus del dengue. |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| DE102009054302A1 (de) * | 2009-11-23 | 2011-05-26 | Merck Patent Gmbh | Chinazolinderivate |
| CN113521394A (zh) * | 2020-04-13 | 2021-10-22 | 浙江华臻医疗器械有限公司 | 一种脱细胞血管基质及其制备方法 |
| CN119409635A (zh) * | 2024-11-04 | 2025-02-11 | 河南师范大学 | 具有抗癌活性的氟代甲基取代茚并[1,2-b]吡啶类化合物及其合成方法 |
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| US7439359B2 (en) | 2000-11-02 | 2008-10-21 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to hsp90 |
| US7553979B2 (en) | 2001-11-09 | 2009-06-30 | Conforma Therapeutics Corporation | HSP90-inhibiting zearalanol compounds and methods of producing and using same |
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| US7160885B2 (en) | 2003-02-10 | 2007-01-09 | Cgi Pharmaceuticals, Inc. | Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity |
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| GB0309637D0 (en) | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
| US7241754B2 (en) | 2003-06-13 | 2007-07-10 | Kosan Biosciences, Inc. | 2-Desmethyl ansamycin compounds |
| KR101129215B1 (ko) | 2003-06-27 | 2012-04-13 | 교와 핫꼬 기린 가부시키가이샤 | Ｈｓｐ90 패밀리 단백질 저해제 |
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| AU2004200774A1 (en) | 2003-07-07 | 2005-01-27 | Holyrood Exports Pty Ltd | Padlock Protector |
| JPWO2005006322A1 (ja) | 2003-07-11 | 2006-08-24 | コニカミノルタオプト株式会社 | 光ピックアップ装置、光ピックアップ装置に用いられる光学素子、及び光学素子の製造方法 |
| EP1675861B1 (en) | 2003-08-29 | 2015-12-23 | Vernalis (R&D) Ltd. | Pyrimidothiophene compounds |
| EA010160B1 (ru) * | 2003-09-18 | 2008-06-30 | Конформа Терапьютикс Корпорейшн | Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения |
| GB0323810D0 (en) | 2003-10-10 | 2003-11-12 | Cancer Rec Tech Ltd | Pyridothiophene compounds |
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| DE10354133A1 (de) | 2003-11-19 | 2005-06-23 | Phoenix Ag | Fördergurt |
| US7282493B2 (en) | 2003-12-23 | 2007-10-16 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| US20060019941A1 (en) | 2003-12-23 | 2006-01-26 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| WO2005072766A2 (en) | 2004-01-27 | 2005-08-11 | Boys Town National Research Hospital | Peptides that bind to hsp90 proteins |
| JP2005225787A (ja) | 2004-02-12 | 2005-08-25 | Nippon Kayaku Co Ltd | Ｈｓｐ９０阻害剤 |
| GB0416168D0 (en) | 2004-07-20 | 2004-08-18 | Vernalis Cambridge Ltd | Pyrmidothiophene compounds |
| US7342093B2 (en) | 2004-07-23 | 2008-03-11 | University Of Massachusetts | Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins |
| AR050084A1 (es) | 2004-07-27 | 2006-09-27 | Novartis Ag | Derivados de bencimidazolona como inhibidores de hsp90 |
| CN101027053A (zh) | 2004-07-27 | 2007-08-29 | 诺瓦提斯公司 | Hsp90抑制剂 |
| KR101045324B1 (ko) | 2004-08-11 | 2011-06-30 | 한국생명공학연구원 | 젤다나마이신 유도체 및 그 생합성 방법 |
| DE102004039280A1 (de) | 2004-08-13 | 2006-02-23 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole |
| US7208630B2 (en) | 2004-10-27 | 2007-04-24 | University Of Kansas | Heat shock protein 90 inhibitors |
| US7608594B2 (en) | 2004-11-03 | 2009-10-27 | University Of Kansas | Novobiocin analogues as anticancer agents |
| CA2585939C (en) | 2004-11-03 | 2013-06-04 | K2 Concepts, Inc. | Anti-microbial compositions and methods of making and using the same |
| EP1817295B1 (en) | 2004-11-18 | 2012-11-07 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| FR2880540B1 (fr) | 2005-01-13 | 2008-07-11 | Aventis Pharma Sa | Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90 |
| GB0501535D0 (en) | 2005-01-25 | 2005-03-02 | Vernalis R&D Ltd | Pyrimidothiophene compounds |
| WO2006084030A2 (en) | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| DE102005007304A1 (de) | 2005-02-17 | 2006-08-24 | Merck Patent Gmbh | Triazolderivate |
| FR2882361A1 (fr) | 2005-02-22 | 2006-08-25 | Aventis Pharma Sa | Nouveaux derives de 3-aryl-1,2-benzisoxazole, compositions les contenant et leur utilisation |
| TWI382015B (zh) | 2005-02-25 | 2013-01-11 | Serenex Inc | 苯、吡啶及噠嗪衍生物 |
| WO2006090094A1 (en) | 2005-02-28 | 2006-08-31 | Vernalis R & D Ltd | Pyrimidothiophene compounds for use as hsp90 inhibitors |
| DE102005009440A1 (de) | 2005-03-02 | 2006-09-07 | Merck Patent Gmbh | Thienopyridinderivate |
| CA2598899A1 (en) | 2005-03-09 | 2006-09-14 | Nippon Kayaku Kabushiki Kaisha | Novel hsp90 inhibitor |
| WO2006098761A2 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| JP2008137894A (ja) | 2005-03-22 | 2008-06-19 | Nippon Kayaku Co Ltd | 新規なアセチレン誘導体 |
| KR20080004550A (ko) | 2005-03-30 | 2008-01-09 | 콘포마 세러퓨틱스 코포레이션 | Ｈｓｐ９０-억제제로서 알키닐 피롤로피리미딘 및 관련유사체 |
| GB2423328B (en) | 2005-04-09 | 2007-02-28 | Louver Lite Ltd | Window blind system |
| DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
| FR2885904B1 (fr) * | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
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2006
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2007
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2010507634A (ja) | 2010-03-11 |
| MX2009004049A (es) | 2009-04-28 |
| WO2008049994A1 (fr) | 2008-05-02 |
| FR2907453B1 (fr) | 2008-12-26 |
| FR2907453A1 (fr) | 2008-04-25 |
| UY30667A1 (es) | 2008-05-31 |
| NO20091972L (no) | 2009-05-20 |
| EA200970400A1 (ru) | 2009-10-30 |
| US8163750B2 (en) | 2012-04-24 |
| EP2078009B1 (fr) | 2015-03-18 |
| CL2007003046A1 (es) | 2008-05-30 |
| KR20090080948A (ko) | 2009-07-27 |
| MA30904B1 (fr) | 2009-11-02 |
| AU2007310767A1 (en) | 2008-05-02 |
| BRPI0718202A2 (pt) | 2013-11-12 |
| US20100130503A1 (en) | 2010-05-27 |
| CA2664115A1 (fr) | 2008-05-02 |
| JP5431944B2 (ja) | 2014-03-05 |
| TN2009000086A1 (en) | 2010-08-19 |
| EP2078009A1 (fr) | 2009-07-15 |
| CO6160311A2 (es) | 2010-05-20 |
| IL197887A0 (en) | 2009-12-24 |
| CN101528735A (zh) | 2009-09-09 |
| PE20081261A1 (es) | 2008-10-15 |
| CR10690A (es) | 2009-07-23 |
| AR063507A1 (es) | 2009-01-28 |
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