JP2010506853A - 疼痛などのナトリウムチャネル媒介性の疾患の処置のための、スピロ（［３，２−フロ］ピリジン−３，３’−インドール）−２’（１’ｈ）−オン誘導体および関連化合物 - Google Patents
疼痛などのナトリウムチャネル媒介性の疾患の処置のための、スピロ（［３，２−フロ］ピリジン−３，３’−インドール）−２’（１’ｈ）−オン誘導体および関連化合物 Download PDFInfo
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- JP2010506853A JP2010506853A JP2009532605A JP2009532605A JP2010506853A JP 2010506853 A JP2010506853 A JP 2010506853A JP 2009532605 A JP2009532605 A JP 2009532605A JP 2009532605 A JP2009532605 A JP 2009532605A JP 2010506853 A JP2010506853 A JP 2010506853A
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Landscapes
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| US85123706P | 2006-10-12 | 2006-10-12 | |
| US95558207P | 2007-08-13 | 2007-08-13 | |
| PCT/US2007/081244 WO2008046049A1 (en) | 2006-10-12 | 2007-10-12 | Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
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| Publication Number | Publication Date |
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| JP2010506853A true JP2010506853A (ja) | 2010-03-04 |
| JP2010506853A5 JP2010506853A5 (enExample) | 2011-11-24 |
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| JP2009532605A Withdrawn JP2010506853A (ja) | 2006-10-12 | 2007-10-12 | 疼痛などのナトリウムチャネル媒介性の疾患の処置のための、スピロ（［３，２−フロ］ピリジン−３，３’−インドール）−２’（１’ｈ）−オン誘導体および関連化合物 |
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| US (1) | US20110294842A9 (enExample) |
| EP (1) | EP2076514A1 (enExample) |
| JP (1) | JP2010506853A (enExample) |
| AR (1) | AR063278A1 (enExample) |
| AU (1) | AU2007307638A1 (enExample) |
| BR (1) | BRPI0719857A2 (enExample) |
| CA (1) | CA2666143A1 (enExample) |
| CL (1) | CL2007002953A1 (enExample) |
| MX (1) | MX2009003875A (enExample) |
| RU (1) | RU2009117605A (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012505895A (ja) * | 2008-10-17 | 2012-03-08 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 治療剤としてのスピロオキシインドール化合物およびそれらの使用 |
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| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| MX2009003876A (es) | 2006-10-12 | 2009-05-11 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos. |
| WO2010045197A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| WO2010078307A1 (en) | 2008-12-29 | 2010-07-08 | Xenon Pharmaceuticals Inc. | Spiro-oxindole-derivatives as sodium channel blockers |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| PE20121350A1 (es) | 2009-10-14 | 2012-10-20 | Xenon Pharmaceuticals Inc | Metodos sinteticos para compuestos espiro-oxoindol |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| PE20121699A1 (es) | 2010-02-26 | 2012-12-22 | Xenon Pharmaceuticals Inc | Composiciones farmaceuticas del compuesto espiro-oxindol para administracion topica |
| WO2012049555A1 (en) | 2010-10-13 | 2012-04-19 | Lupin Limited | Spirocyclic compounds as voltage-gated sodium channel modulators |
| KR101880966B1 (ko) * | 2011-06-10 | 2018-07-23 | 메르크 파텐트 게엠베하 | Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법 |
| WO2013154712A1 (en) | 2012-04-12 | 2013-10-17 | Xenon Pharmaceuticals Inc. | Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| US20170137415A1 (en) | 2014-03-29 | 2017-05-18 | Lupin Limited | Sulfonamide compounds as voltage gated sodium channel modulators |
| BR112016028888A2 (pt) | 2014-06-12 | 2017-08-22 | Adamed Sp Zoo | compostos que compreendem o sistema 1,1',2,5'-tetra hidro espiro [indol-3,2'-pirrol]-2,5'-diona como inibidores de interação proteína-proteína p53-mdm2 |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| TW201722938A (zh) | 2015-09-04 | 2017-07-01 | 魯賓有限公司 | 作為電位閘控鈉通道調節子之磺醯胺化合物 |
| WO2017218920A1 (en) | 2016-06-16 | 2017-12-21 | Teva Pharmaceuticals International Gmbh | Asymmetric synthesis of funapide |
| WO2018163077A1 (en) | 2017-03-08 | 2018-09-13 | Lupin Limited | Indanyl compounds as voltage gated sodium channel modulators |
| WO2019075073A2 (en) | 2017-10-10 | 2019-04-18 | Biogen Inc. | PROCESS FOR THE PREPARATION OF SPIRO DERIVATIVES |
| CN108299451B (zh) * | 2018-04-04 | 2020-11-24 | 四川理工学院 | 一种螺[吲哚啉-3,3’-吡喃[2,3-b]芳杂环]-2-酮化合物及其制备方法 |
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2007
- 2007-10-12 MX MX2009003875A patent/MX2009003875A/es not_active Application Discontinuation
- 2007-10-12 EP EP07844225A patent/EP2076514A1/en not_active Withdrawn
- 2007-10-12 CA CA002666143A patent/CA2666143A1/en not_active Abandoned
- 2007-10-12 CL CL200702953A patent/CL2007002953A1/es unknown
- 2007-10-12 TW TW096138359A patent/TW200825091A/zh unknown
- 2007-10-12 JP JP2009532605A patent/JP2010506853A/ja not_active Withdrawn
- 2007-10-12 AU AU2007307638A patent/AU2007307638A1/en not_active Abandoned
- 2007-10-12 RU RU2009117605/04A patent/RU2009117605A/ru not_active Application Discontinuation
- 2007-10-12 AR ARP070104539A patent/AR063278A1/es unknown
- 2007-10-12 US US12/445,270 patent/US20110294842A9/en not_active Abandoned
- 2007-10-12 BR BRPI0719857-4A patent/BRPI0719857A2/pt not_active IP Right Cessation
- 2007-10-12 WO PCT/US2007/081244 patent/WO2008046049A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012505895A (ja) * | 2008-10-17 | 2012-03-08 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 治療剤としてのスピロオキシインドール化合物およびそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200825091A (en) | 2008-06-16 |
| BRPI0719857A2 (pt) | 2014-06-03 |
| EP2076514A1 (en) | 2009-07-08 |
| MX2009003875A (es) | 2009-04-22 |
| WO2008046049A1 (en) | 2008-04-17 |
| CL2007002953A1 (es) | 2008-02-01 |
| AR063278A1 (es) | 2009-01-14 |
| RU2009117605A (ru) | 2010-11-20 |
| US20110294842A9 (en) | 2011-12-01 |
| AU2007307638A1 (en) | 2008-04-17 |
| CA2666143A1 (en) | 2008-04-17 |
| US20100160362A1 (en) | 2010-06-24 |
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