JP2010504530A - Raf阻害剤の標的調節、効果、診断、および/または予後診断のためのバイオマーカー - Google Patents

Raf阻害剤の標的調節、効果、診断、および/または予後診断のためのバイオマーカー Download PDF

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JP2010504530A
JP2010504530A JP2009529376A JP2009529376A JP2010504530A JP 2010504530 A JP2010504530 A JP 2010504530A JP 2009529376 A JP2009529376 A JP 2009529376A JP 2009529376 A JP2009529376 A JP 2009529376A JP 2010504530 A JP2010504530 A JP 2010504530A
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biomarker
gene expression
patient
raf
biomarkers
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JP2010504530A5 (enExample
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ナターシャ・アジーズ
エドワード・モウラー
ダリン・スチュアート
カーラ・ハイセ
キム・アーダレン
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ノバルティス アーゲー
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/5743Specifically defined cancers of skin, e.g. melanoma
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
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  • Cell Biology (AREA)
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  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2009529376A 2006-09-19 2007-09-19 Raf阻害剤の標的調節、効果、診断、および/または予後診断のためのバイオマーカー Pending JP2010504530A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84560106P 2006-09-19 2006-09-19
PCT/US2007/078946 WO2008082730A2 (en) 2006-09-19 2007-09-19 Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors

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JP2013015294A Division JP2013128487A (ja) 2006-09-19 2013-01-30 Raf阻害剤の標的調節、効果、診断、および/または予後診断のためのバイオマーカー

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JP2010504530A5 JP2010504530A5 (enExample) 2010-10-28

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JP2009529376A Pending JP2010504530A (ja) 2006-09-19 2007-09-19 Raf阻害剤の標的調節、効果、診断、および/または予後診断のためのバイオマーカー
JP2013015294A Withdrawn JP2013128487A (ja) 2006-09-19 2013-01-30 Raf阻害剤の標的調節、効果、診断、および/または予後診断のためのバイオマーカー

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US (1) US20100004253A1 (enExample)
EP (1) EP2074226A2 (enExample)
JP (2) JP2010504530A (enExample)
KR (1) KR20090071603A (enExample)
CN (1) CN101541977A (enExample)
AU (1) AU2007340265B2 (enExample)
BR (1) BRPI0716944A2 (enExample)
CA (1) CA2662508A1 (enExample)
IL (1) IL197450A0 (enExample)
MX (1) MX2009002936A (enExample)
RU (1) RU2009114745A (enExample)
SG (1) SG174826A1 (enExample)
WO (1) WO2008082730A2 (enExample)

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JP2013537544A (ja) * 2010-08-17 2013-10-03 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 抗癌剤併用療法
JP2015502958A (ja) * 2011-12-09 2015-01-29 オンコメッド ファーマシューティカルズ インコーポレイテッド がんの処置のための併用療法
JP2015536667A (ja) * 2012-12-03 2015-12-24 アルマック・ダイアグノスティクス・リミテッドAlmac Diagnostics Limited 癌のための分子診断検査
JP2016528914A (ja) * 2013-08-28 2016-09-23 クラウン バイオサイエンス インコーポレイテッド(タイカン) 対象のマルチキナーゼ阻害剤に対する応答性を予測する遺伝子発現シグネチャ、及びその使用
JP2017533727A (ja) * 2014-10-13 2017-11-16 セルジーン コーポレイション 固形腫瘍の治療方法及び免疫調節療法への臨床的感度の予測因子としてのバイオマーカーの使用
US10260097B2 (en) 2011-06-02 2019-04-16 Almac Diagnostics Limited Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent
US10280468B2 (en) 2014-02-07 2019-05-07 Almac Diagnostics Limited Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer
JP2019518426A (ja) * 2016-04-15 2019-07-04 ジェネンテック, インコーポレイテッド がんの診断及び治療方法
JP2019216716A (ja) * 2013-12-06 2019-12-26 セルジーン コーポレイション びまん性大細胞型b細胞リンパ腫、多発性骨髄腫、及び骨髄癌の治療の薬効を決定するための方法

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