CA2662508A1 - Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors - Google Patents

Info

Publication number

CA2662508A1

CA2662508A1 CA002662508A CA2662508A CA2662508A1 CA 2662508 A1 CA2662508 A1 CA 2662508A1 CA 002662508 A CA002662508 A CA 002662508A CA 2662508 A CA2662508 A CA 2662508A CA 2662508 A1 CA2662508 A1 CA 2662508A1

Authority

CA

Canada

Prior art keywords

protein

factor

alpha

kinase

receptor

Prior art date

2006-09-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 239000000090 biomarker Substances 0.000 title claims abstract description 86
• 239000003112 inhibitor Substances 0.000 title claims description 21
• 238000004393 prognosis Methods 0.000 title description 4
• 238000003745 diagnosis Methods 0.000 title description 2
• 230000014509 gene expression Effects 0.000 claims abstract description 72
• 238000000034 method Methods 0.000 claims abstract description 69
• 238000011282 treatment Methods 0.000 claims abstract description 44
• 230000004044 response Effects 0.000 claims abstract description 32
• 230000004075 alteration Effects 0.000 claims abstract description 21
• 108090000623 proteins and genes Proteins 0.000 claims description 198
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 83
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 75
• 229920001184 polypeptide Polymers 0.000 claims description 73
• 102000004169 proteins and genes Human genes 0.000 claims description 67
• 206010028980 Neoplasm Diseases 0.000 claims description 43
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
• 201000011510 cancer Diseases 0.000 claims description 18
• 239000003795 chemical substances by application Substances 0.000 claims description 18
• 229940123690 Raf kinase inhibitor Drugs 0.000 claims description 16
• 102000051624 phosphatidylethanolamine binding protein Human genes 0.000 claims description 16
• 108700021017 phosphatidylethanolamine binding protein Proteins 0.000 claims description 16
• 208000035475 disorder Diseases 0.000 claims description 15
• 201000001441 melanoma Diseases 0.000 claims description 15
• 230000035772 mutation Effects 0.000 claims description 15
• 230000002062 proliferating effect Effects 0.000 claims description 14
• 210000001519 tissue Anatomy 0.000 claims description 14
• KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 claims description 11
• 101100381978 Mus musculus Braf gene Proteins 0.000 claims description 11
• 239000012472 biological sample Substances 0.000 claims description 10
• YABJJWZLRMPFSI-UHFFFAOYSA-N 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine Chemical group N=1C2=CC(OC=3C=C(N=CC=3)C=3NC(=CN=3)C(F)(F)F)=CC=C2N(C)C=1NC1=CC=C(C(F)(F)F)C=C1 YABJJWZLRMPFSI-UHFFFAOYSA-N 0.000 claims description 8
• 238000001514 detection method Methods 0.000 claims description 5
• 238000012544 monitoring process Methods 0.000 claims description 5
• 102000001788 Proto-Oncogene Proteins c-raf Human genes 0.000 claims description 4
• 108010029869 Proto-Oncogene Proteins c-raf Proteins 0.000 claims description 4
• 210000000481 breast Anatomy 0.000 claims description 4
• 210000004185 liver Anatomy 0.000 claims description 4
• 210000001072 colon Anatomy 0.000 claims description 3
• 210000004072 lung Anatomy 0.000 claims description 3
• 238000005259 measurement Methods 0.000 claims description 3
• 230000001613 neoplastic effect Effects 0.000 claims description 3
• 210000001672 ovary Anatomy 0.000 claims description 3
• 210000000496 pancreas Anatomy 0.000 claims description 3
• 210000002307 prostate Anatomy 0.000 claims description 3
• 238000012360 testing method Methods 0.000 claims description 3
• 210000001685 thyroid gland Anatomy 0.000 claims description 3
• 210000003932 urinary bladder Anatomy 0.000 claims description 3
• MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims description 2
• 238000004113 cell culture Methods 0.000 claims description 2
• OMEUGRCNAZNQLN-UHFFFAOYSA-N isis 5132 Chemical compound O=C1NC(=O)C(C)=CN1C1OC(COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(S)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)CO)C(O)C1 OMEUGRCNAZNQLN-UHFFFAOYSA-N 0.000 claims description 2
• 229960003787 sorafenib Drugs 0.000 claims description 2
• YZDJQTHVDDOVHR-UHFFFAOYSA-N PLX-4720 Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(Cl)=CN=C3NC=2)=C1F YZDJQTHVDDOVHR-UHFFFAOYSA-N 0.000 claims 1
• BOJDCYLXQYKJPO-UHFFFAOYSA-N n-[3-[6-[(3-oxo-1h-2-benzofuran-5-yl)amino]pyrazin-2-yl]phenyl]acetamide Chemical compound CC(=O)NC1=CC=CC(C=2N=C(NC=3C=C4C(=O)OCC4=CC=3)C=NC=2)=C1 BOJDCYLXQYKJPO-UHFFFAOYSA-N 0.000 claims 1
• GCZVDUHEMXEXOO-UHFFFAOYSA-N n-[5-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-2-methylphenyl]-3-methyl-4-oxoquinazoline-6-carboxamide Chemical compound C1=C(NC(=O)C=2C=C3C(=O)N(C)C=NC3=CC=2)C(C)=CC=C1NC(=O)C1=CC=CC(C(C)(C)C#N)=C1 GCZVDUHEMXEXOO-UHFFFAOYSA-N 0.000 claims 1
• OIZCAAMXVVUUIZ-UHFFFAOYSA-N n-[5-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-2-methylphenyl]-4-oxo-1h-quinazoline-6-carboxamide Chemical compound C1=C(NC(=O)C=2C=C3C(=O)NC=NC3=CC=2)C(C)=CC=C1NC(=O)C1=CC=CC(C(C)(C)C#N)=C1 OIZCAAMXVVUUIZ-UHFFFAOYSA-N 0.000 claims 1
• 238000010839 reverse transcription Methods 0.000 claims 1
• 229960003862 vemurafenib Drugs 0.000 claims 1
• GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 1
• 102000009929 raf Kinases Human genes 0.000 abstract description 29
• 108010077182 raf Kinases Proteins 0.000 abstract description 29
• 230000005764 inhibitory process Effects 0.000 abstract description 10
• 235000018102 proteins Nutrition 0.000 description 65
• 210000004027 cell Anatomy 0.000 description 50
• 102000040430 polynucleotide Human genes 0.000 description 39
• 108091033319 polynucleotide Proteins 0.000 description 39
• 239000002157 polynucleotide Substances 0.000 description 39
• 230000027455 binding Effects 0.000 description 28
• 102000008013 Electron Transport Complex I Human genes 0.000 description 26
• 108010089760 Electron Transport Complex I Proteins 0.000 description 26
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 22
• 108700020796 Oncogene Proteins 0.000 description 21
• 239000000427 antigen Substances 0.000 description 20
• 102000036639 antigens Human genes 0.000 description 20
• 108091007433 antigens Proteins 0.000 description 20
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 20
• 230000003612 virological effect Effects 0.000 description 19
• 102000001708 Protein Isoforms Human genes 0.000 description 17
• 108010029485 Protein Isoforms Proteins 0.000 description 17
• 239000003814 drug Substances 0.000 description 17
• 230000001105 regulatory effect Effects 0.000 description 17
• 230000002438 mitochondrial effect Effects 0.000 description 16
• 102100021866 Hepatocyte growth factor Human genes 0.000 description 15
• 108090000581 Leukemia inhibitory factor Proteins 0.000 description 15
• 102000043136 MAP kinase family Human genes 0.000 description 15
• 108091054455 MAP kinase family Proteins 0.000 description 15
• -1 antibody Substances 0.000 description 15
• 241000271566 Aves Species 0.000 description 14
• 230000012010 growth Effects 0.000 description 14
• 239000000047 product Substances 0.000 description 14
• 102000016914 ras Proteins Human genes 0.000 description 14
• 108010014186 ras Proteins Proteins 0.000 description 14
• 230000014621 translational initiation Effects 0.000 description 13
• 102100022749 Aminopeptidase N Human genes 0.000 description 12
• 108091000080 Phosphotransferase Proteins 0.000 description 12
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 12
• 201000010099 disease Diseases 0.000 description 12
• 229940079593 drug Drugs 0.000 description 12
• 125000003729 nucleotide group Chemical group 0.000 description 12
• 102000020233 phosphotransferase Human genes 0.000 description 12
• 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 description 11
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 11
• 229940024606 amino acid Drugs 0.000 description 11
• 235000001014 amino acid Nutrition 0.000 description 11
• 150000001413 amino acids Chemical class 0.000 description 11
• 230000001419 dependent effect Effects 0.000 description 11
• 108020004999 messenger RNA Proteins 0.000 description 11
• 239000011591 potassium Substances 0.000 description 11
• 229910052700 potassium Inorganic materials 0.000 description 11
• 239000000523 sample Substances 0.000 description 11
• OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 10
• 108091006146 Channels Proteins 0.000 description 10
• 108020004414 DNA Proteins 0.000 description 10
• 108091006027 G proteins Proteins 0.000 description 10
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 10
• 238000006243 chemical reaction Methods 0.000 description 10
• 230000000694 effects Effects 0.000 description 10
• 229960003692 gamma aminobutyric acid Drugs 0.000 description 10
• 238000009396 hybridization Methods 0.000 description 10
• 239000003446 ligand Substances 0.000 description 10
• 230000037361 pathway Effects 0.000 description 10
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 10
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 9
• 101710088194 Dehydrogenase Proteins 0.000 description 9
• 102100024640 Low-density lipoprotein receptor Human genes 0.000 description 9
• 102100026632 Mimecan Human genes 0.000 description 9
• 102000004389 Ribonucleoproteins Human genes 0.000 description 9
• 108010081734 Ribonucleoproteins Proteins 0.000 description 9
• 101710186200 CCAAT/enhancer-binding protein Proteins 0.000 description 8
• 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 8
• 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 8
• 108010042283 HSP40 Heat-Shock Proteins Proteins 0.000 description 8
• 101000608772 Homo sapiens Galectin-7 Proteins 0.000 description 8
• 102100027004 Inhibin beta A chain Human genes 0.000 description 8
• 102000004058 Leukemia inhibitory factor Human genes 0.000 description 8
• 102000003960 Ligases Human genes 0.000 description 8
• 108090000364 Ligases Proteins 0.000 description 8
• 241001529936 Murinae Species 0.000 description 8
• 102000040945 Transcription factor Human genes 0.000 description 8
• 108091023040 Transcription factor Proteins 0.000 description 8
• 230000006870 function Effects 0.000 description 8
• 239000002773 nucleotide Substances 0.000 description 8
• 102000005962 receptors Human genes 0.000 description 8
• 108020003175 receptors Proteins 0.000 description 8
• 102100022640 Collagen alpha-1(XV) chain Human genes 0.000 description 7
• 102000034286 G proteins Human genes 0.000 description 7
• 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 description 7
• 101000899935 Homo sapiens Collagen alpha-1(XV) chain Proteins 0.000 description 7
• 102000004890 Interleukin-8 Human genes 0.000 description 7
• 108090001007 Interleukin-8 Proteins 0.000 description 7
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 7
• 102100032352 Leukemia inhibitory factor Human genes 0.000 description 7
• 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 description 7
• 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 description 7
• 230000003213 activating effect Effects 0.000 description 7
• 238000013459 approach Methods 0.000 description 7
• 150000001875 compounds Chemical class 0.000 description 7
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 7
• 235000018417 cysteine Nutrition 0.000 description 7
• 239000012634 fragment Substances 0.000 description 7
• 150000008195 galaktosides Chemical class 0.000 description 7
• 230000002068 genetic effect Effects 0.000 description 7
• 230000002401 inhibitory effect Effects 0.000 description 7
• 230000002132 lysosomal effect Effects 0.000 description 7
• 210000003205 muscle Anatomy 0.000 description 7
• 238000003752 polymerase chain reaction Methods 0.000 description 7
• 102100022002 CD59 glycoprotein Human genes 0.000 description 6
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
• 102100023580 Cyclic AMP-dependent transcription factor ATF-4 Human genes 0.000 description 6
• 102100039523 Cytoskeleton-associated protein 2-like Human genes 0.000 description 6
• 102100029109 Endothelin-3 Human genes 0.000 description 6
• 102100031968 Ephrin type-B receptor 2 Human genes 0.000 description 6
• 102100026116 Follicular dendritic cell secreted peptide Human genes 0.000 description 6
• 102100021735 Galectin-2 Human genes 0.000 description 6
• 101000888538 Homo sapiens Cytoskeleton-associated protein 2-like Proteins 0.000 description 6
• 101000841213 Homo sapiens Endothelin-3 Proteins 0.000 description 6
• 101000912993 Homo sapiens Follicular dendritic cell secreted peptide Proteins 0.000 description 6
• 101000972488 Homo sapiens Laminin subunit alpha-4 Proteins 0.000 description 6
• 101000701440 Homo sapiens Stanniocalcin-1 Proteins 0.000 description 6
• 101000692109 Homo sapiens Syndecan-2 Proteins 0.000 description 6
• 102100022743 Laminin subunit alpha-4 Human genes 0.000 description 6
• 102000004856 Lectins Human genes 0.000 description 6
• 108090001090 Lectins Proteins 0.000 description 6
• 108010064209 Phosphoribosylglycinamide formyltransferase Proteins 0.000 description 6
• 108010039518 Proton-Translocating ATPases Proteins 0.000 description 6
• 102000015176 Proton-Translocating ATPases Human genes 0.000 description 6
• 102000037054 SLC-Transporter Human genes 0.000 description 6
• 108091006207 SLC-Transporter Proteins 0.000 description 6
• 206010039491 Sarcoma Diseases 0.000 description 6
• 102100030511 Stanniocalcin-1 Human genes 0.000 description 6
• 102100026087 Syndecan-2 Human genes 0.000 description 6
• 208000021841 acute erythroid leukemia Diseases 0.000 description 6
• 239000002585 base Substances 0.000 description 6
• 239000011575 calcium Substances 0.000 description 6
• 229910052791 calcium Inorganic materials 0.000 description 6
• 230000000295 complement effect Effects 0.000 description 6
• 239000002299 complementary DNA Substances 0.000 description 6
• 230000002950 deficient Effects 0.000 description 6
• 239000002523 lectin Substances 0.000 description 6
• 238000012423 maintenance Methods 0.000 description 6
• 239000002777 nucleoside Substances 0.000 description 6
• 238000011160 research Methods 0.000 description 6
• 102000055046 tissue-factor-pathway inhibitor 2 Human genes 0.000 description 6
• 108010016054 tissue-factor-pathway inhibitor 2 Proteins 0.000 description 6
• 101150019464 ARAF gene Proteins 0.000 description 5
• 102000007299 Amphiregulin Human genes 0.000 description 5
• 102100038778 Amphiregulin Human genes 0.000 description 5
• 108010033760 Amphiregulin Proteins 0.000 description 5
• 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 5
• 102100020999 Argininosuccinate synthase Human genes 0.000 description 5
• 102100023927 Asparagine synthetase [glutamine-hydrolyzing] Human genes 0.000 description 5
• 108010078791 Carrier Proteins Proteins 0.000 description 5
• 102100025621 Cytochrome b-245 heavy chain Human genes 0.000 description 5
• 102100027641 DNA-binding protein inhibitor ID-1 Human genes 0.000 description 5
• 102000004190 Enzymes Human genes 0.000 description 5
• 108090000790 Enzymes Proteins 0.000 description 5
• 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 description 5
• 102100030875 Gastricsin Human genes 0.000 description 5
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 5
• 102100022103 Histone-lysine N-methyltransferase 2A Human genes 0.000 description 5
• 102100022107 Holliday junction recognition protein Human genes 0.000 description 5
• 101001045907 Homo sapiens Holliday junction recognition protein Proteins 0.000 description 5
• 101001018100 Homo sapiens Lysozyme C Proteins 0.000 description 5
• 101000896657 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Proteins 0.000 description 5
• 101001014610 Homo sapiens Neuroendocrine secretory protein 55 Proteins 0.000 description 5
• 101000979249 Homo sapiens Neuromodulin Proteins 0.000 description 5
• 101001082142 Homo sapiens Pentraxin-related protein PTX3 Proteins 0.000 description 5
• 101000892360 Homo sapiens Protein AF-17 Proteins 0.000 description 5
• 101000801270 Homo sapiens Protein O-mannosyl-transferase TMTC2 Proteins 0.000 description 5
• 101000612671 Homo sapiens Pulmonary surfactant-associated protein C Proteins 0.000 description 5
• 101000697510 Homo sapiens Stathmin-2 Proteins 0.000 description 5
• 102100027735 Hyaluronan mediated motility receptor Human genes 0.000 description 5
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 5
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 5
• 102100035692 Importin subunit alpha-1 Human genes 0.000 description 5
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 5
• 102100036157 Interferon gamma receptor 2 Human genes 0.000 description 5
• 102000014150 Interferons Human genes 0.000 description 5
• 108010050904 Interferons Proteins 0.000 description 5
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 5
• 102100033468 Lysozyme C Human genes 0.000 description 5
• 102100021691 Mitotic checkpoint serine/threonine-protein kinase BUB1 Human genes 0.000 description 5
• 102100023206 Neuromodulin Human genes 0.000 description 5
• 102100027351 Pentraxin-related protein PTX3 Human genes 0.000 description 5
• 102100039654 Phosphoribosylglycinamide formyltransferase Human genes 0.000 description 5
• 102100026651 Pro-adrenomedullin Human genes 0.000 description 5
• 102100040638 Protein AF-17 Human genes 0.000 description 5
• 102000001253 Protein Kinase Human genes 0.000 description 5
• 102100033745 Protein O-mannosyl-transferase TMTC2 Human genes 0.000 description 5
• 102100040971 Pulmonary surfactant-associated protein C Human genes 0.000 description 5
• 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 description 5
• 101710141955 RAF proto-oncogene serine/threonine-protein kinase Proteins 0.000 description 5
• 102100023843 Selenoprotein P Human genes 0.000 description 5
• 102100028051 Stathmin-2 Human genes 0.000 description 5
• 108010002687 Survivin Proteins 0.000 description 5
• 230000009286 beneficial effect Effects 0.000 description 5
• 230000022131 cell cycle Effects 0.000 description 5
• 102000005352 centromere protein F Human genes 0.000 description 5
• 108010031377 centromere protein F Proteins 0.000 description 5
• 239000005516 coenzyme A Substances 0.000 description 5
• 229940093530 coenzyme a Drugs 0.000 description 5
• 239000003623 enhancer Substances 0.000 description 5
• 229940088598 enzyme Drugs 0.000 description 5
• 238000002474 experimental method Methods 0.000 description 5
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 5
• 229940079322 interferon Drugs 0.000 description 5
• 239000000546 pharmaceutical excipient Substances 0.000 description 5
• 230000002974 pharmacogenomic effect Effects 0.000 description 5
• 239000002243 precursor Substances 0.000 description 5
• 230000008569 process Effects 0.000 description 5
• 108060006633 protein kinase Proteins 0.000 description 5
• 239000011347 resin Substances 0.000 description 5
• 229920005989 resin Polymers 0.000 description 5
• CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 5
• 208000011580 syndromic disease Diseases 0.000 description 5
• 230000035897 transcription Effects 0.000 description 5
• 238000013518 transcription Methods 0.000 description 5
• 238000013519 translation Methods 0.000 description 5
• 230000014616 translation Effects 0.000 description 5
• 102100027518 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Human genes 0.000 description 4
• 102100028734 1,4-alpha-glucan-branching enzyme Human genes 0.000 description 4
• KVUXYQHEESDGIJ-UHFFFAOYSA-N 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-3,16-diol Chemical compound C1CC2CC(O)CCC2(C)C2C1C1CC(O)CC1(C)CC2 KVUXYQHEESDGIJ-UHFFFAOYSA-N 0.000 description 4
• 102100028704 Acetyl-CoA acetyltransferase, cytosolic Human genes 0.000 description 4
• 102100029470 Apolipoprotein E Human genes 0.000 description 4
• 108091012583 BCL2 Proteins 0.000 description 4
• 102100026437 Branched-chain-amino-acid aminotransferase, cytosolic Human genes 0.000 description 4
• 108010049990 CD13 Antigens Proteins 0.000 description 4
• 102000014914 Carrier Proteins Human genes 0.000 description 4
• 102100023344 Centromere protein F Human genes 0.000 description 4
• 102100023321 Ceruloplasmin Human genes 0.000 description 4
• 102000016950 Chemokine CXCL1 Human genes 0.000 description 4
• 108010014419 Chemokine CXCL1 Proteins 0.000 description 4
• 102100024338 Collagen alpha-3(VI) chain Human genes 0.000 description 4
• 102100033775 Collagen alpha-5(IV) chain Human genes 0.000 description 4
• 108010043471 Core Binding Factor Alpha 2 Subunit Proteins 0.000 description 4
• 102100034976 Cystathionine beta-synthase Human genes 0.000 description 4
• 108010073644 Cystathionine beta-synthase Proteins 0.000 description 4
• 102100028036 Cystatin-S Human genes 0.000 description 4
• 102100037579 D-3-phosphoglycerate dehydrogenase Human genes 0.000 description 4
• 102100024829 DNA polymerase delta catalytic subunit Human genes 0.000 description 4
• 102100029721 DnaJ homolog subfamily B member 1 Human genes 0.000 description 4
• 102100030421 Fatty acid-binding protein 5 Human genes 0.000 description 4
• 102000030782 GTP binding Human genes 0.000 description 4
• 108091000058 GTP-Binding Proteins 0.000 description 4
• 102100025626 GTP-binding protein GEM Human genes 0.000 description 4
• 108010001496 Galectin 2 Proteins 0.000 description 4
• 102000044465 Galectin-7 Human genes 0.000 description 4
• 102100039555 Galectin-7 Human genes 0.000 description 4
• 102100034176 Glutathione-specific gamma-glutamylcyclotransferase 1 Human genes 0.000 description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• 102100034221 Growth-regulated alpha protein Human genes 0.000 description 4
• 102100032610 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Human genes 0.000 description 4
• 102000004447 HSP40 Heat-Shock Proteins Human genes 0.000 description 4
• 102100027685 Hemoglobin subunit alpha Human genes 0.000 description 4
• 108050002855 Histone-lysine N-methyltransferase 2A Proteins 0.000 description 4
• 101000837584 Homo sapiens Acetyl-CoA acetyltransferase, cytosolic Proteins 0.000 description 4
• 101000896234 Homo sapiens Baculoviral IAP repeat-containing protein 5 Proteins 0.000 description 4
• 101000766268 Homo sapiens Branched-chain-amino-acid aminotransferase, cytosolic Proteins 0.000 description 4
• 101000907941 Homo sapiens Centromere protein F Proteins 0.000 description 4
• 101000908019 Homo sapiens Ceruloplasmin Proteins 0.000 description 4
• 101000909506 Homo sapiens Collagen alpha-3(VI) chain Proteins 0.000 description 4
• 101000710886 Homo sapiens Collagen alpha-5(IV) chain Proteins 0.000 description 4
• 101000905743 Homo sapiens Cyclic AMP-dependent transcription factor ATF-4 Proteins 0.000 description 4
• 101000868333 Homo sapiens Cyclin-dependent kinase 1 Proteins 0.000 description 4
• 101000722966 Homo sapiens Cystatin-S Proteins 0.000 description 4
• 101000909198 Homo sapiens DNA polymerase delta catalytic subunit Proteins 0.000 description 4
• 101001018431 Homo sapiens DNA replication licensing factor MCM7 Proteins 0.000 description 4
• 101001081590 Homo sapiens DNA-binding protein inhibitor ID-1 Proteins 0.000 description 4
• 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 description 4
• 101000856606 Homo sapiens GTP-binding protein GEM Proteins 0.000 description 4
• 101000943584 Homo sapiens Glutathione-specific gamma-glutamylcyclotransferase 1 Proteins 0.000 description 4
• 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 description 4
• 101001014590 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Proteins 0.000 description 4
• 101001014594 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Proteins 0.000 description 4
• 101001009007 Homo sapiens Hemoglobin subunit alpha Proteins 0.000 description 4
• 101001091371 Homo sapiens Kallikrein-8 Proteins 0.000 description 4
• 101001051093 Homo sapiens Low-density lipoprotein receptor Proteins 0.000 description 4
• 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 description 4
• 101001043352 Homo sapiens Lysyl oxidase homolog 2 Proteins 0.000 description 4
• 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 4
• 101000959028 Homo sapiens Mitochondrial 10-formyltetrahydrofolate dehydrogenase Proteins 0.000 description 4
• 101000794228 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Proteins 0.000 description 4
• 101000957259 Homo sapiens Mitotic spindle assembly checkpoint protein MAD2A Proteins 0.000 description 4
• 101001000104 Homo sapiens Myosin-11 Proteins 0.000 description 4
• 101000615933 Homo sapiens Phosphoserine aminotransferase Proteins 0.000 description 4
• 101001068552 Homo sapiens Proline-rich protein 15-like protein Proteins 0.000 description 4
• 101001001272 Homo sapiens Prostatic acid phosphatase Proteins 0.000 description 4
• 101000797903 Homo sapiens Protein ALEX Proteins 0.000 description 4
• 101001123332 Homo sapiens Proteoglycan 4 Proteins 0.000 description 4
• 101000575639 Homo sapiens Ribonucleoside-diphosphate reductase subunit M2 Proteins 0.000 description 4
• 101000617099 Homo sapiens Scrapie-responsive protein 1 Proteins 0.000 description 4
• 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 4
• 101000750321 Homo sapiens Synaptic vesicle membrane protein VAT-1 homolog-like Proteins 0.000 description 4
• 101000820490 Homo sapiens Syntaxin-binding protein 6 Proteins 0.000 description 4
• 101000653455 Homo sapiens Transcriptional and immune response regulator Proteins 0.000 description 4
• 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 description 4
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 4
• 102100034870 Kallikrein-8 Human genes 0.000 description 4
• 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 description 4
• 102100021948 Lysyl oxidase homolog 2 Human genes 0.000 description 4
• 102100039809 Matrix Gla protein Human genes 0.000 description 4
• 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 4
• 206010054949 Metaplasia Diseases 0.000 description 4
• 102100028687 Methenyltetrahydrofolate cyclohydrolase Human genes 0.000 description 4
• 108060004795 Methyltransferase Proteins 0.000 description 4
• 102100039076 Mitochondrial 10-formyltetrahydrofolate dehydrogenase Human genes 0.000 description 4
• 102100030144 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Human genes 0.000 description 4
• 102100038792 Mitotic spindle assembly checkpoint protein MAD2A Human genes 0.000 description 4
• 102000003505 Myosin Human genes 0.000 description 4
• 108060008487 Myosin Proteins 0.000 description 4
• 102100036639 Myosin-11 Human genes 0.000 description 4
• 102100023057 Neurofilament light polypeptide Human genes 0.000 description 4
• 102100021768 Phosphoserine aminotransferase Human genes 0.000 description 4
• 102100035846 Pigment epithelium-derived factor Human genes 0.000 description 4
• 108010066816 Polypeptide N-acetylgalactosaminyltransferase Proteins 0.000 description 4
• 102100033950 Proline-rich protein 15-like protein Human genes 0.000 description 4
• 102100035703 Prostatic acid phosphatase Human genes 0.000 description 4
• 102100028965 Proteoglycan 4 Human genes 0.000 description 4
• 102100026006 Ribonucleoside-diphosphate reductase subunit M2 Human genes 0.000 description 4
• 102100025373 Runt-related transcription factor 1 Human genes 0.000 description 4
• 102100021675 Scrapie-responsive protein 1 Human genes 0.000 description 4
• 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 4
• 102000013275 Somatomedins Human genes 0.000 description 4
• 102100021165 Synaptic vesicle membrane protein VAT-1 homolog-like Human genes 0.000 description 4
• 102100021681 Syntaxin-binding protein 6 Human genes 0.000 description 4
• 102100030666 Transcriptional and immune response regulator Human genes 0.000 description 4
• 102000004357 Transferases Human genes 0.000 description 4
• 108090000992 Transferases Proteins 0.000 description 4
• 206010045261 Type IIa hyperlipidaemia Diseases 0.000 description 4
• 102100039094 Tyrosinase Human genes 0.000 description 4
• 102100031929 UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit Human genes 0.000 description 4
• 241000700605 Viruses Species 0.000 description 4
• 238000004458 analytical method Methods 0.000 description 4
• 230000006907 apoptotic process Effects 0.000 description 4
• 108091008324 binding proteins Proteins 0.000 description 4
• 239000000872 buffer Substances 0.000 description 4
• 150000001720 carbohydrates Chemical class 0.000 description 4
• 235000014633 carbohydrates Nutrition 0.000 description 4
• 239000000969 carrier Substances 0.000 description 4
• 230000004663 cell proliferation Effects 0.000 description 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
• 239000013256 coordination polymer Substances 0.000 description 4
• 230000001086 cytosolic effect Effects 0.000 description 4
• 201000001386 familial hypercholesterolemia Diseases 0.000 description 4
• 230000004190 glucose uptake Effects 0.000 description 4
• 230000001939 inductive effect Effects 0.000 description 4
• 229960000367 inositol Drugs 0.000 description 4
• CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 4
• 230000015689 metaplastic ossification Effects 0.000 description 4
• 239000000203 mixture Substances 0.000 description 4
• 108010034343 phosphoribosylamine-glycine ligase Proteins 0.000 description 4
• 229920001223 polyethylene glycol Polymers 0.000 description 4
• 230000019491 signal transduction Effects 0.000 description 4
• 239000007787 solid Substances 0.000 description 4
• 239000007790 solid phase Substances 0.000 description 4
• 239000000758 substrate Substances 0.000 description 4
• 235000000346 sugar Nutrition 0.000 description 4
• 230000002103 transcriptional effect Effects 0.000 description 4
• 210000004881 tumor cell Anatomy 0.000 description 4
• 108091064702 1 family Proteins 0.000 description 3
• 102100031236 11-beta-hydroxysteroid dehydrogenase type 2 Human genes 0.000 description 3
• 102100028550 40S ribosomal protein S4, Y isoform 1 Human genes 0.000 description 3
• 101150092476 ABCA1 gene Proteins 0.000 description 3
• 108700005241 ATP Binding Cassette Transporter 1 Proteins 0.000 description 3
• 108091006112 ATPases Proteins 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 description 3
• 102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 description 3
• 108010077852 Adaptor Protein Complex 2 Proteins 0.000 description 3
• 102000010650 Adaptor Protein Complex 2 Human genes 0.000 description 3
• 229930024421 Adenine Natural products 0.000 description 3
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 3
• 102000057290 Adenosine Triphosphatases Human genes 0.000 description 3
• 102100036601 Aggrecan core protein Human genes 0.000 description 3
• 102100037399 Alanine-tRNA ligase, cytoplasmic Human genes 0.000 description 3
• 102100024089 Aldo-keto reductase family 1 member C2 Human genes 0.000 description 3
• 102100034561 Alpha-N-acetylglucosaminidase Human genes 0.000 description 3
• 102100039160 Amiloride-sensitive amine oxidase [copper-containing] Human genes 0.000 description 3
• 108010090849 Amyloid beta-Peptides Proteins 0.000 description 3
• 102000013455 Amyloid beta-Peptides Human genes 0.000 description 3
• 102100034594 Angiopoietin-1 Human genes 0.000 description 3
• 108010048154 Angiopoietin-1 Proteins 0.000 description 3
• 102100025674 Angiopoietin-related protein 4 Human genes 0.000 description 3
• 102100033393 Anillin Human genes 0.000 description 3
• 102100021253 Antileukoproteinase Human genes 0.000 description 3
• 102100023771 Aquaporin-1 Human genes 0.000 description 3
• 102100036608 Aspartate aminotransferase, cytoplasmic Human genes 0.000 description 3
• 102100035656 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 Human genes 0.000 description 3
• 102100022544 Bone morphogenetic protein 7 Human genes 0.000 description 3
• 102100037675 CCAAT/enhancer-binding protein gamma Human genes 0.000 description 3
• 102100024155 Cadherin-11 Human genes 0.000 description 3
• 102000003922 Calcium Channels Human genes 0.000 description 3
• 108090000312 Calcium Channels Proteins 0.000 description 3
• 108010033547 Carbonic Anhydrase I Proteins 0.000 description 3
• 102100025518 Carbonic anhydrase 1 Human genes 0.000 description 3
• 102100028003 Catenin alpha-1 Human genes 0.000 description 3
• 101710106619 Catenin alpha-3 Proteins 0.000 description 3
• 102000016362 Catenins Human genes 0.000 description 3
• 108010067316 Catenins Proteins 0.000 description 3
• 102100035654 Cathepsin S Human genes 0.000 description 3
• 102100032346 Cell cycle progression protein 1 Human genes 0.000 description 3
• 102100038099 Cell division cycle protein 20 homolog Human genes 0.000 description 3
• 102100034786 Cell migration-inducing and hyaluronan-binding protein Human genes 0.000 description 3
• 108010014421 Chemokine CXCL5 Proteins 0.000 description 3
• 102000016948 Chemokine CXCL5 Human genes 0.000 description 3
• 102000017589 Chromo domains Human genes 0.000 description 3
• 108050005811 Chromo domains Proteins 0.000 description 3
• 102100038445 Claudin-2 Human genes 0.000 description 3
• 102100037529 Coagulation factor V Human genes 0.000 description 3
• 102000005870 Coenzyme A Ligases Human genes 0.000 description 3
• 102100033825 Collagen alpha-1(XI) chain Human genes 0.000 description 3
• 102100027995 Collagenase 3 Human genes 0.000 description 3
• 102000016917 Complement C1 Human genes 0.000 description 3
• 108010028774 Complement C1 Proteins 0.000 description 3
• 102100025680 Complement decay-accelerating factor Human genes 0.000 description 3
• 102100040132 Complement factor H-related protein 1 Human genes 0.000 description 3
• 206010053138 Congenital aplastic anaemia Diseases 0.000 description 3
• 102000006311 Cyclin D1 Human genes 0.000 description 3
• 108010058546 Cyclin D1 Proteins 0.000 description 3
• 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 description 3
• 102100032522 Cyclin-dependent kinases regulatory subunit 2 Human genes 0.000 description 3
• 102100038695 Cysteine-rich secretory protein LCCL domain-containing 1 Human genes 0.000 description 3
• 101710155020 Cysteine-rich secretory protein LCCL domain-containing 1 Proteins 0.000 description 3
• 102400000011 Cytochrome b-c1 complex subunit 9 Human genes 0.000 description 3
• 101800000778 Cytochrome b-c1 complex subunit 9 Proteins 0.000 description 3
• 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 3
• 108010070977 Cytoplasmic Dyneins Proteins 0.000 description 3
• 102000005362 Cytoplasmic Dyneins Human genes 0.000 description 3
• 102100031866 DNA excision repair protein ERCC-5 Human genes 0.000 description 3
• 102100030960 DNA replication licensing factor MCM2 Human genes 0.000 description 3
• 102100033587 DNA topoisomerase 2-alpha Human genes 0.000 description 3
• 230000004568 DNA-binding Effects 0.000 description 3
• 102100039439 DNA-binding protein inhibitor ID-4 Human genes 0.000 description 3
• 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 3
• 102100036723 Discoidin domain-containing receptor 2 Human genes 0.000 description 3
• 101710127786 Discoidin domain-containing receptor 2 Proteins 0.000 description 3
• 102000017944 Dishevelled Human genes 0.000 description 3
• 108050007016 Dishevelled Proteins 0.000 description 3
• 102100023965 Dynein light chain Tctex-type 3 Human genes 0.000 description 3
• 101710150624 Dynein light chain Tctex-type 3 Proteins 0.000 description 3
• 101000600890 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) G2-specific protein kinase nimA Proteins 0.000 description 3
• 102100029327 FERM domain-containing protein 4A Human genes 0.000 description 3
• 108010014172 Factor V Proteins 0.000 description 3
• 201000004939 Fanconi anemia Diseases 0.000 description 3
• 102100035111 Farnesyl pyrophosphate synthase Human genes 0.000 description 3
• 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 description 3
• 102000017177 Fibromodulin Human genes 0.000 description 3
• 108010013996 Fibromodulin Proteins 0.000 description 3
• 102100022627 Fructose-2,6-bisphosphatase Human genes 0.000 description 3
• 102000053334 GRB10 Adaptor Human genes 0.000 description 3
• 102100028652 Gamma-enolase Human genes 0.000 description 3
• 102100021023 Gamma-glutamyl hydrolase Human genes 0.000 description 3
• 102100030540 Gap junction alpha-5 protein Human genes 0.000 description 3
• 102100030426 Gastrotropin Human genes 0.000 description 3
• 102000006395 Globulins Human genes 0.000 description 3
• 108010044091 Globulins Proteins 0.000 description 3
• 102000016354 Glucuronosyltransferase Human genes 0.000 description 3
• 108010092364 Glucuronosyltransferase Proteins 0.000 description 3
• 102100033424 Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 2 Human genes 0.000 description 3
• 102100025783 Glutamyl aminopeptidase Human genes 0.000 description 3
• 108010051724 Glycine-tRNA Ligase Proteins 0.000 description 3
• 206010053249 Glycogen Storage Disease Type IV Diseases 0.000 description 3
• 208000011123 Glycogen storage disease due to glycogen branching enzyme deficiency Diseases 0.000 description 3
• 102000019220 Glycyl-tRNA synthetases Human genes 0.000 description 3
• 102100036243 HLA class II histocompatibility antigen, DQ alpha 1 chain Human genes 0.000 description 3
• 102100030500 Heparin cofactor 2 Human genes 0.000 description 3
• SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 3
• 102100029009 High mobility group protein HMG-I/HMG-Y Human genes 0.000 description 3
• 102100028993 Hippocalcin-like protein 1 Human genes 0.000 description 3
• 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 3
• 108700005087 Homeobox Genes Proteins 0.000 description 3
• 102100022377 Homeobox protein DLX-2 Human genes 0.000 description 3
• 101000861278 Homo sapiens 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Proteins 0.000 description 3
• 101001058479 Homo sapiens 1,4-alpha-glucan-branching enzyme Proteins 0.000 description 3
• 101000845090 Homo sapiens 11-beta-hydroxysteroid dehydrogenase type 2 Proteins 0.000 description 3
• 101000696103 Homo sapiens 40S ribosomal protein S4, Y isoform 1 Proteins 0.000 description 3
• 101000768000 Homo sapiens AP-1 complex subunit sigma-1A Proteins 0.000 description 3
• 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 description 3
• 101000693076 Homo sapiens Angiopoietin-related protein 4 Proteins 0.000 description 3
• 101000732632 Homo sapiens Anillin Proteins 0.000 description 3
• 101000615334 Homo sapiens Antileukoproteinase Proteins 0.000 description 3
• 101000684063 Homo sapiens Aquaporin-1 Proteins 0.000 description 3
• 101000803294 Homo sapiens BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 Proteins 0.000 description 3
• 101000880590 Homo sapiens CCAAT/enhancer-binding protein gamma Proteins 0.000 description 3
• 101000868629 Homo sapiens Cell cycle progression protein 1 Proteins 0.000 description 3
• 101000945881 Homo sapiens Cell migration-inducing and hyaluronan-binding protein Proteins 0.000 description 3
• 101000882901 Homo sapiens Claudin-2 Proteins 0.000 description 3
• 101000710623 Homo sapiens Collagen alpha-1(XI) chain Proteins 0.000 description 3
• 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 description 3
• 101000890732 Homo sapiens Complement factor H-related protein 1 Proteins 0.000 description 3
• 101000942317 Homo sapiens Cyclin-dependent kinases regulatory subunit 2 Proteins 0.000 description 3
• 101000583807 Homo sapiens DNA replication licensing factor MCM2 Proteins 0.000 description 3
• 101000801505 Homo sapiens DNA topoisomerase 2-alpha Proteins 0.000 description 3
• 101000924017 Homo sapiens Dual specificity protein phosphatase 1 Proteins 0.000 description 3
• 101001062454 Homo sapiens FERM domain-containing protein 4A Proteins 0.000 description 3
• 101001062855 Homo sapiens Fatty acid-binding protein 5 Proteins 0.000 description 3
• 101000823456 Homo sapiens Fructose-2,6-bisphosphatase Proteins 0.000 description 3
• 101001058231 Homo sapiens Gamma-enolase Proteins 0.000 description 3
• 101000997966 Homo sapiens Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 2 Proteins 0.000 description 3
• 101001082432 Homo sapiens Heparin cofactor 2 Proteins 0.000 description 3
• 101000986380 Homo sapiens High mobility group protein HMG-I/HMG-Y Proteins 0.000 description 3
• 101000838883 Homo sapiens Hippocalcin-like protein 1 Proteins 0.000 description 3
• 101000901635 Homo sapiens Homeobox protein DLX-2 Proteins 0.000 description 3
• 101001081176 Homo sapiens Hyaluronan mediated motility receptor Proteins 0.000 description 3
• 101001047912 Homo sapiens Hydroxymethylglutaryl-CoA lyase, mitochondrial Proteins 0.000 description 3
• 101000988834 Homo sapiens Hypoxanthine-guanine phosphoribosyltransferase Proteins 0.000 description 3
• 101000839066 Homo sapiens Hypoxia-inducible lipid droplet-associated protein Proteins 0.000 description 3
• 101001054725 Homo sapiens Inhibin beta B chain Proteins 0.000 description 3
• 101001076680 Homo sapiens Insulin-induced gene 1 protein Proteins 0.000 description 3
• 101000840566 Homo sapiens Insulin-like growth factor-binding protein 5 Proteins 0.000 description 3
• 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 description 3
• 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 3
• 101000997670 Homo sapiens Integrin beta-8 Proteins 0.000 description 3
• 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 3
• 101001026236 Homo sapiens Intermediate conductance calcium-activated potassium channel protein 4 Proteins 0.000 description 3
• 101000875582 Homo sapiens Isoleucine-tRNA ligase, cytoplasmic Proteins 0.000 description 3
• 101000590482 Homo sapiens Kinetochore protein Nuf2 Proteins 0.000 description 3
• 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 description 3
• 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 description 3
• 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 description 3
• 101000645293 Homo sapiens Metalloproteinase inhibitor 3 Proteins 0.000 description 3
• 101001027945 Homo sapiens Metallothionein-1E Proteins 0.000 description 3
• 101001013799 Homo sapiens Metallothionein-1X Proteins 0.000 description 3
• 101000985328 Homo sapiens Methenyltetrahydrofolate cyclohydrolase Proteins 0.000 description 3
• 101000577126 Homo sapiens Monocarboxylate transporter 4 Proteins 0.000 description 3
• 101000829992 Homo sapiens N-acetylglucosamine-6-sulfatase Proteins 0.000 description 3
• 101000672316 Homo sapiens Netrin receptor UNC5B Proteins 0.000 description 3
• 101001128694 Homo sapiens Neuroendocrine convertase 1 Proteins 0.000 description 3
• 101000655246 Homo sapiens Neutral amino acid transporter A Proteins 0.000 description 3
• 101000591187 Homo sapiens Notch homolog 2 N-terminal-like protein A Proteins 0.000 description 3
• 101000969031 Homo sapiens Nuclear protein 1 Proteins 0.000 description 3
• 101000585555 Homo sapiens PCNA-associated factor Proteins 0.000 description 3
• 101000728117 Homo sapiens Plasma membrane calcium-transporting ATPase 4 Proteins 0.000 description 3
• 101000605127 Homo sapiens Prostaglandin G/H synthase 2 Proteins 0.000 description 3
• 101000831616 Homo sapiens Protachykinin-1 Proteins 0.000 description 3
• 101000891842 Homo sapiens Protein FAM3B Proteins 0.000 description 3
• 101000999079 Homo sapiens Radiation-inducible immediate-early gene IEX-1 Proteins 0.000 description 3
• 101001106523 Homo sapiens Regulator of G-protein signaling 1 Proteins 0.000 description 3
• 101001106672 Homo sapiens Regulator of G-protein signaling 2 Proteins 0.000 description 3
• 101000752221 Homo sapiens Rho guanine nucleotide exchange factor 2 Proteins 0.000 description 3
• 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 description 3
• 101000899739 Homo sapiens Solute carrier family 2, facilitated glucose transporter member 3 Proteins 0.000 description 3
• 101000868422 Homo sapiens Sushi, nidogen and EGF-like domain-containing protein 1 Proteins 0.000 description 3
• 101000658115 Homo sapiens Synaptotagmin-like protein 5 Proteins 0.000 description 3
• 101000596277 Homo sapiens TSC22 domain family protein 3 Proteins 0.000 description 3
• 101000800055 Homo sapiens Testican-1 Proteins 0.000 description 3
• 101000796022 Homo sapiens Thioredoxin-interacting protein Proteins 0.000 description 3
• 101000766345 Homo sapiens Tribbles homolog 3 Proteins 0.000 description 3
• 101000847952 Homo sapiens Trypsin-3 Proteins 0.000 description 3
• 101000625727 Homo sapiens Tubulin beta chain Proteins 0.000 description 3
• 101000788517 Homo sapiens Tubulin beta-2A chain Proteins 0.000 description 3
• 101000830603 Homo sapiens Tumor necrosis factor ligand superfamily member 11 Proteins 0.000 description 3
• 101000847156 Homo sapiens Tumor necrosis factor-inducible gene 6 protein Proteins 0.000 description 3
• 101000807354 Homo sapiens Ubiquitin-conjugating enzyme E2 C Proteins 0.000 description 3
• 101000760337 Homo sapiens Urokinase plasminogen activator surface receptor Proteins 0.000 description 3
• 101000708573 Homo sapiens Y+L amino acid transporter 2 Proteins 0.000 description 3
• 102000008100 Human Serum Albumin Human genes 0.000 description 3
• 108091006905 Human Serum Albumin Proteins 0.000 description 3
• 102100024004 Hydroxymethylglutaryl-CoA lyase, mitochondrial Human genes 0.000 description 3
• 102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 3
• 206010021143 Hypoxia Diseases 0.000 description 3
• 102100028891 Hypoxia-inducible lipid droplet-associated protein Human genes 0.000 description 3
• GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 description 3
• 102100029199 Iduronate 2-sulfatase Human genes 0.000 description 3
• 102100027411 Immunoglobulin kappa variable 1D-13 Human genes 0.000 description 3
• 101710087632 Immunoglobulin kappa variable 1D-13 Proteins 0.000 description 3
• 102100027003 Inhibin beta B chain Human genes 0.000 description 3
• 102100025887 Insulin-induced gene 1 protein Human genes 0.000 description 3
• 102100037852 Insulin-like growth factor I Human genes 0.000 description 3
• 102100029225 Insulin-like growth factor-binding protein 5 Human genes 0.000 description 3
• 102100025305 Integrin alpha-2 Human genes 0.000 description 3
• 102100032817 Integrin alpha-5 Human genes 0.000 description 3
• 102100022337 Integrin alpha-V Human genes 0.000 description 3
• 102100025304 Integrin beta-1 Human genes 0.000 description 3
• 102100033336 Integrin beta-8 Human genes 0.000 description 3
• 102100024064 Interferon-inducible protein AIM2 Human genes 0.000 description 3
• 102100037441 Intermediate conductance calcium-activated potassium channel protein 4 Human genes 0.000 description 3
• 102100036015 Isoleucine-tRNA ligase, cytoplasmic Human genes 0.000 description 3
• 102100032431 Kinetochore protein Nuf2 Human genes 0.000 description 3
• 102100031413 L-dopachrome tautomerase Human genes 0.000 description 3
• 208000009625 Lesch-Nyhan syndrome Diseases 0.000 description 3
• 102100035131 Lipopolysaccharide-binding protein Human genes 0.000 description 3
• 108010013563 Lipoprotein Lipase Proteins 0.000 description 3
• 102100022119 Lipoprotein lipase Human genes 0.000 description 3
• 108091080011 Long-chain family Proteins 0.000 description 3
• 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 description 3
• 102100026753 Lymphokine-activated killer T-cell-originated protein kinase Human genes 0.000 description 3
• 102100038560 Maleylacetoacetate isomerase Human genes 0.000 description 3
• 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 3
• 102100039373 Membrane cofactor protein Human genes 0.000 description 3
• 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 3
• 102100026261 Metalloproteinase inhibitor 3 Human genes 0.000 description 3
• 102100037510 Metallothionein-1E Human genes 0.000 description 3
• 102100031781 Metallothionein-1X Human genes 0.000 description 3
• 102100031347 Metallothionein-2 Human genes 0.000 description 3
• 108091013859 Mimecan Proteins 0.000 description 3
• 102100025276 Monocarboxylate transporter 4 Human genes 0.000 description 3
• 102100038750 Myc-associated zinc finger protein Human genes 0.000 description 3
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 3
• 102100023282 N-acetylglucosamine-6-sulfatase Human genes 0.000 description 3
• BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 3
• 102100040289 Netrin receptor UNC5B Human genes 0.000 description 3
• 102100032132 Neuroendocrine convertase 1 Human genes 0.000 description 3
• 102100032884 Neutral amino acid transporter A Human genes 0.000 description 3
• 102100034093 Notch homolog 2 N-terminal-like protein A Human genes 0.000 description 3
• 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 description 3
• 102100021133 Nuclear protein 1 Human genes 0.000 description 3
• 108091028043 Nucleic acid sequence Proteins 0.000 description 3
• 102100030991 Nucleolar and spindle-associated protein 1 Human genes 0.000 description 3
• 101710182831 Nucleolar and spindle-associated protein 1 Proteins 0.000 description 3
• 108091034117 Oligonucleotide Proteins 0.000 description 3
• 108010084438 Oncogene Protein v-maf Proteins 0.000 description 3
• 108010054076 Oncogene Proteins v-myb Proteins 0.000 description 3
• 102100025909 Opsin-3 Human genes 0.000 description 3
• 101800002327 Osteoinductive factor Proteins 0.000 description 3
• 102000004316 Oxidoreductases Human genes 0.000 description 3
• 108090000854 Oxidoreductases Proteins 0.000 description 3
• 102100029879 PCNA-associated factor Human genes 0.000 description 3
• 102100033616 Phospholipid-transporting ATPase ABCA1 Human genes 0.000 description 3
• 102100029743 Plasma membrane calcium-transporting ATPase 4 Human genes 0.000 description 3
• 102100020950 Polypeptide N-acetylgalactosaminyltransferase 2 Human genes 0.000 description 3
• 102100030284 Prosaposin receptor GPR37 Human genes 0.000 description 3
• 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 3
• 102100024304 Protachykinin-1 Human genes 0.000 description 3
• 102100031227 Protein Dr1 Human genes 0.000 description 3
• 102100040307 Protein FAM3B Human genes 0.000 description 3
• 102100033947 Protein regulator of cytokinesis 1 Human genes 0.000 description 3
• 102000052575 Proto-Oncogene Human genes 0.000 description 3
• 108700020978 Proto-Oncogene Proteins 0.000 description 3
• 102100036900 Radiation-inducible immediate-early gene IEX-1 Human genes 0.000 description 3
• 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 description 3
• 102100021269 Regulator of G-protein signaling 1 Human genes 0.000 description 3
• 102100021258 Regulator of G-protein signaling 2 Human genes 0.000 description 3
• 102100039977 Regulator of chromosome condensation Human genes 0.000 description 3
• 102100021707 Rho guanine nucleotide exchange factor 2 Human genes 0.000 description 3
• 102100029989 SHC SH2 domain-binding protein 1 Human genes 0.000 description 3
• 101710140556 SHC SH2 domain-binding protein 1 Proteins 0.000 description 3
• 108091006241 SLC7A11 Proteins 0.000 description 3
• 241000252141 Semionotiformes Species 0.000 description 3
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
• 102100040516 Serine-tRNA ligase, cytoplasmic Human genes 0.000 description 3
• 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 description 3
• FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 3
• 102100039672 Solute carrier family 2, facilitated glucose transporter member 14 Human genes 0.000 description 3
• 102100022722 Solute carrier family 2, facilitated glucose transporter member 3 Human genes 0.000 description 3
• 208000022758 Sorsby fundus dystrophy Diseases 0.000 description 3
• 102100038021 Steryl-sulfatase Human genes 0.000 description 3
• 102000004896 Sulfotransferases Human genes 0.000 description 3
• 108090001033 Sulfotransferases Proteins 0.000 description 3
• 102100032891 Superoxide dismutase [Mn], mitochondrial Human genes 0.000 description 3
• 101710202572 Superoxide dismutase [Mn], mitochondrial Proteins 0.000 description 3
• 102100032853 Sushi, nidogen and EGF-like domain-containing protein 1 Human genes 0.000 description 3
• 102100035003 Synaptotagmin-like protein 5 Human genes 0.000 description 3
• 108090000054 Syndecan-2 Proteins 0.000 description 3
• 102000003711 Syndecan-2 Human genes 0.000 description 3
• 102100035260 TSC22 domain family protein 3 Human genes 0.000 description 3
• 102100033390 Testican-1 Human genes 0.000 description 3
• 102100031344 Thioredoxin-interacting protein Human genes 0.000 description 3
• 208000035317 Total hypoxanthine-guanine phosphoribosyl transferase deficiency Diseases 0.000 description 3
• 102000003929 Transaminases Human genes 0.000 description 3
• 108090000340 Transaminases Proteins 0.000 description 3
• 102000004887 Transforming Growth Factor beta Human genes 0.000 description 3
• 108090001012 Transforming Growth Factor beta Proteins 0.000 description 3
• 102100026390 Tribbles homolog 3 Human genes 0.000 description 3
• 102100034396 Trypsin-3 Human genes 0.000 description 3
• 102100024717 Tubulin beta chain Human genes 0.000 description 3
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 3
• 102100024568 Tumor necrosis factor ligand superfamily member 11 Human genes 0.000 description 3
• 102100032807 Tumor necrosis factor-inducible gene 6 protein Human genes 0.000 description 3
• 102100034298 Tyrosine-tRNA ligase, cytoplasmic Human genes 0.000 description 3
• 102100029152 UDP-glucuronosyltransferase 1A1 Human genes 0.000 description 3
• 101710205316 UDP-glucuronosyltransferase 1A1 Proteins 0.000 description 3
• 102100037256 Ubiquitin-conjugating enzyme E2 C Human genes 0.000 description 3
• 102100024689 Urokinase plasminogen activator surface receptor Human genes 0.000 description 3
• 102100032803 Y+L amino acid transporter 2 Human genes 0.000 description 3
• XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 230000004913 activation Effects 0.000 description 3
• 229960000643 adenine Drugs 0.000 description 3
• 239000002671 adjuvant Substances 0.000 description 3
• 238000003556 assay Methods 0.000 description 3
• 210000003719 b-lymphocyte Anatomy 0.000 description 3
• 230000031018 biological processes and functions Effects 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 230000001413 cellular effect Effects 0.000 description 3
• 210000000349 chromosome Anatomy 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• 230000001747 exhibiting effect Effects 0.000 description 3
• 102000003684 fibroblast growth factor 13 Human genes 0.000 description 3
• 108090000047 fibroblast growth factor 13 Proteins 0.000 description 3
• 239000011521 glass Substances 0.000 description 3
• 239000001257 hydrogen Substances 0.000 description 3
• 229910052739 hydrogen Inorganic materials 0.000 description 3
• 235000013902 inosinic acid Nutrition 0.000 description 3
• NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 description 3
• 229940043355 kinase inhibitor Drugs 0.000 description 3
• 231100000518 lethal Toxicity 0.000 description 3
• 230000001665 lethal effect Effects 0.000 description 3
• 208000032839 leukemia Diseases 0.000 description 3
• 210000004379 membrane Anatomy 0.000 description 3
• 239000012528 membrane Substances 0.000 description 3
• 230000009826 neoplastic cell growth Effects 0.000 description 3
• 230000001537 neural effect Effects 0.000 description 3
• 150000003833 nucleoside derivatives Chemical class 0.000 description 3
• 210000000056 organ Anatomy 0.000 description 3
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 3
• 239000003757 phosphotransferase inhibitor Substances 0.000 description 3
• 238000006116 polymerization reaction Methods 0.000 description 3
• 229920001282 polysaccharide Polymers 0.000 description 3
• 102000027426 receptor tyrosine kinases Human genes 0.000 description 3
• 108091008598 receptor tyrosine kinases Proteins 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• 239000003001 serine protease inhibitor Substances 0.000 description 3
• 210000002966 serum Anatomy 0.000 description 3
• 229910001415 sodium ion Inorganic materials 0.000 description 3
• 239000003381 stabilizer Substances 0.000 description 3
• 150000008163 sugars Chemical class 0.000 description 3
• 230000004083 survival effect Effects 0.000 description 3
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 3
• 229940124597 therapeutic agent Drugs 0.000 description 3
• 230000001131 transforming effect Effects 0.000 description 3
• 230000004614 tumor growth Effects 0.000 description 3
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 3
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 3
• 239000013598 vector Substances 0.000 description 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
• AJIQWLVEPGOJRR-FPVNRPTNSA-N (2S)-2-[[4-[(2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid (2S)-2-amino-4-sulfanylbutanoic acid Chemical compound OC(=O)[C@@H](N)CCS.C1NC=2N=C(N)NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 AJIQWLVEPGOJRR-FPVNRPTNSA-N 0.000 description 2
• CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 description 2
• 102000003925 1,4-alpha-Glucan Branching Enzyme Human genes 0.000 description 2
• 108090000344 1,4-alpha-Glucan Branching Enzyme Proteins 0.000 description 2
• 102100024341 10 kDa heat shock protein, mitochondrial Human genes 0.000 description 2
• QZDDFQLIQRYMBV-UHFFFAOYSA-N 2-[3-nitro-2-(2-nitrophenyl)-4-oxochromen-8-yl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C(C=2[N+]([O-])=O)=O)=C1OC=2C1=CC=CC=C1[N+]([O-])=O QZDDFQLIQRYMBV-UHFFFAOYSA-N 0.000 description 2
• KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 2
• 102100034510 2-phosphoxylose phosphatase 1 Human genes 0.000 description 2
• 108010046716 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) Proteins 0.000 description 2
• 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 description 2
• 102100022464 5'-nucleotidase Human genes 0.000 description 2
• 108050000246 AAA domains Proteins 0.000 description 2
• 102100022886 ADP-ribosylation factor-like protein 4C Human genes 0.000 description 2
• 102100032897 AMP deaminase 2 Human genes 0.000 description 2
• 102100025339 ATP-dependent DNA helicase DDX11 Human genes 0.000 description 2
• 102100034402 ATP-dependent RNA helicase DDX39A Human genes 0.000 description 2
• 102100033391 ATP-dependent RNA helicase DDX3X Human genes 0.000 description 2
• 102100022117 Abnormal spindle-like microcephaly-associated protein Human genes 0.000 description 2
• 108010085376 Activating Transcription Factor 4 Proteins 0.000 description 2
• 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 description 2
• 108010077847 Adaptor Protein Complex 1 Proteins 0.000 description 2
• 102000010651 Adaptor Protein Complex 1 Human genes 0.000 description 2
• 108090001079 Adenine Nucleotide Translocator 1 Proteins 0.000 description 2
• 108010087905 Adenovirus E1B Proteins Proteins 0.000 description 2
• 102100020775 Adenylosuccinate lyase Human genes 0.000 description 2
• 102100022455 Adrenocorticotropic hormone receptor Human genes 0.000 description 2
• 102100039702 Alcohol dehydrogenase class-3 Human genes 0.000 description 2
• 108010003133 Aldo-Keto Reductase Family 1 Member C2 Proteins 0.000 description 2
• 102000005602 Aldo-Keto Reductases Human genes 0.000 description 2
• 108010084469 Aldo-Keto Reductases Proteins 0.000 description 2
• 102100026446 Aldo-keto reductase family 1 member C1 Human genes 0.000 description 2
• 102100021266 Alpha-(1,6)-fucosyltransferase Human genes 0.000 description 2
• 102100033312 Alpha-2-macroglobulin Human genes 0.000 description 2
• 102100022815 Alpha-2A adrenergic receptor Human genes 0.000 description 2
• 102100024075 Alpha-internexin Human genes 0.000 description 2
• 102100040410 Alpha-methylacyl-CoA racemase Human genes 0.000 description 2
• 108010044434 Alpha-methylacyl-CoA racemase Proteins 0.000 description 2
• 208000024985 Alport syndrome Diseases 0.000 description 2
• 102100039338 Aminomethyltransferase, mitochondrial Human genes 0.000 description 2
• 102100036439 Amyloid beta precursor protein binding family B member 1 Human genes 0.000 description 2
• 102100036438 Amyloid beta precursor protein binding family B member 2 Human genes 0.000 description 2
• 102100036441 Amyloid-beta A4 precursor protein-binding family A member 2 Human genes 0.000 description 2
• 102100033307 Ankyrin repeat domain-containing protein 37 Human genes 0.000 description 2
• 102100030949 Apelin receptor Human genes 0.000 description 2
• 102000004888 Aquaporin 1 Human genes 0.000 description 2
• 108090001004 Aquaporin 1 Proteins 0.000 description 2
• 102000004363 Aquaporin 3 Human genes 0.000 description 2
• 108090000991 Aquaporin 3 Proteins 0.000 description 2
• 102100030356 Arginase-2, mitochondrial Human genes 0.000 description 2
• 102100023943 Arylsulfatase L Human genes 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical class OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• 102100034193 Aspartate aminotransferase, mitochondrial Human genes 0.000 description 2
• 102100027705 Astrotactin-2 Human genes 0.000 description 2
• 102100032306 Aurora kinase B Human genes 0.000 description 2
• 102100021631 B-cell lymphoma 6 protein Human genes 0.000 description 2
• 108010021800 B7-2 Antigen Proteins 0.000 description 2
• 102000007697 B7-2 Antigen Human genes 0.000 description 2
• 102100037140 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Human genes 0.000 description 2
• 102000008836 BTB/POZ domains Human genes 0.000 description 2
• 108050000749 BTB/POZ domains Proteins 0.000 description 2
• 102100021971 Bcl-2-interacting killer Human genes 0.000 description 2
• 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 description 2
• 108091005539 Brain-specific angiogenesis inhibitors Proteins 0.000 description 2
• 102000001967 Branched-chain aminotransferases Human genes 0.000 description 2
• 108050009223 Branched-chain aminotransferases Proteins 0.000 description 2
• 206010006187 Breast cancer Diseases 0.000 description 2
• 208000026310 Breast neoplasm Diseases 0.000 description 2
• 102100036301 C-C chemokine receptor type 7 Human genes 0.000 description 2
• 102100037084 C4b-binding protein alpha chain Human genes 0.000 description 2
• 102100034799 CCAAT/enhancer-binding protein delta Human genes 0.000 description 2
• 102100032912 CD44 antigen Human genes 0.000 description 2
• 102100027221 CD81 antigen Human genes 0.000 description 2
• 108700020472 CDC20 Proteins 0.000 description 2
• 101150047144 CDC28 gene Proteins 0.000 description 2
• 102100021975 CREB-binding protein Human genes 0.000 description 2
• 102000000905 Cadherin Human genes 0.000 description 2
• 108050007957 Cadherin Proteins 0.000 description 2
• 102100035671 Cadherin EGF LAG seven-pass G-type receptor 3 Human genes 0.000 description 2
• 102100024154 Cadherin-13 Human genes 0.000 description 2
• 102000055006 Calcitonin Human genes 0.000 description 2
• 108060001064 Calcitonin Proteins 0.000 description 2
• 102100038518 Calcitonin Human genes 0.000 description 2
• 102100032583 Calcium-dependent secretion activator 2 Human genes 0.000 description 2
• 102100035632 Calcyphosin Human genes 0.000 description 2
• 101710085913 Calcyphosin Proteins 0.000 description 2
• 102000000584 Calmodulin Human genes 0.000 description 2
• 108010041952 Calmodulin Proteins 0.000 description 2
• 102100025580 Calmodulin-1 Human genes 0.000 description 2
• 102100025926 Calmodulin-3 Human genes 0.000 description 2
• 102100032539 Calpain-3 Human genes 0.000 description 2
• 102100026422 Carbamoyl-phosphate synthase [ammonia], mitochondrial Human genes 0.000 description 2
• 102100038781 Carbohydrate sulfotransferase 2 Human genes 0.000 description 2
• 108010018424 Carnitine O-palmitoyltransferase Proteins 0.000 description 2
• 102000002666 Carnitine O-palmitoyltransferase Human genes 0.000 description 2
• 102100027947 Carnitine O-palmitoyltransferase 1, muscle isoform Human genes 0.000 description 2
• 108090000397 Caspase 3 Proteins 0.000 description 2
• 102100032616 Caspase-2 Human genes 0.000 description 2
• 102100026550 Caspase-9 Human genes 0.000 description 2
• 108090000994 Catalytic RNA Proteins 0.000 description 2
• 102000053642 Catalytic RNA Human genes 0.000 description 2
• 102100037182 Cation-independent mannose-6-phosphate receptor Human genes 0.000 description 2
• 102100027047 Cell division control protein 6 homolog Human genes 0.000 description 2
• 102100032860 Cell division cycle 5-like protein Human genes 0.000 description 2
• 102100037633 Centrin-3 Human genes 0.000 description 2
• 102100035366 Centromere protein M Human genes 0.000 description 2
• 102100037635 Centromere protein U Human genes 0.000 description 2
• 101710084081 Centromere protein U Proteins 0.000 description 2
• 102100034888 Centrosomal protein kizuna Human genes 0.000 description 2
• 102100031219 Centrosomal protein of 55 kDa Human genes 0.000 description 2
• 108050001186 Chaperonin Cpn60 Proteins 0.000 description 2
• 102000052603 Chaperonins Human genes 0.000 description 2
• 102100028758 Chondroitin sulfate proteoglycan 5 Human genes 0.000 description 2
• 102100020736 Chromosome-associated kinesin KIF4A Human genes 0.000 description 2
• 102100026191 Class E basic helix-loop-helix protein 40 Human genes 0.000 description 2
• 108010081236 Cleavage Stimulation Factor Proteins 0.000 description 2
• 102000005221 Cleavage Stimulation Factor Human genes 0.000 description 2
• 102100040996 Cochlin Human genes 0.000 description 2
• 102100027466 Cofilin-1 Human genes 0.000 description 2
• 102100036045 Colipase Human genes 0.000 description 2
• 102100031611 Collagen alpha-1(III) chain Human genes 0.000 description 2
• 102100040995 Collagen alpha-1(XXI) chain Human genes 0.000 description 2
• 206010009944 Colon cancer Diseases 0.000 description 2
• 108020004635 Complementary DNA Proteins 0.000 description 2
• 102100032952 Condensin complex subunit 3 Human genes 0.000 description 2
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
• 102100037313 Core-binding factor subunit beta Human genes 0.000 description 2
• 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 description 2
• 108010009367 Cyclin-Dependent Kinase Inhibitor p18 Proteins 0.000 description 2
• 102100036239 Cyclin-dependent kinase 2 Human genes 0.000 description 2
• 102100024465 Cyclin-dependent kinase 4 inhibitor C Human genes 0.000 description 2
• 102100026810 Cyclin-dependent kinase 7 Human genes 0.000 description 2
• 102100024457 Cyclin-dependent kinase 9 Human genes 0.000 description 2
• 229920000858 Cyclodextrin Polymers 0.000 description 2
• 102100026897 Cystatin-C Human genes 0.000 description 2
• 102100041024 Cytochrome c oxidase assembly protein COX11, mitochondrial Human genes 0.000 description 2
• 102100029079 Cytochrome c oxidase assembly protein COX15 homolog Human genes 0.000 description 2
• 102100031649 Cytochrome c oxidase subunit 6B1 Human genes 0.000 description 2
• 108090000365 Cytochrome-c oxidases Proteins 0.000 description 2
• RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
• 102100021246 DDIT3 upstream open reading frame protein Human genes 0.000 description 2
• 102100037753 DEP domain-containing protein 1A Human genes 0.000 description 2
• 102100021122 DNA damage-binding protein 2 Human genes 0.000 description 2
• 102100034157 DNA mismatch repair protein Msh2 Human genes 0.000 description 2
• 102100033072 DNA replication ATP-dependent helicase DNA2 Human genes 0.000 description 2
• 102100027564 DNA replication complex GINS protein PSF1 Human genes 0.000 description 2
• 102100039606 DNA replication licensing factor MCM3 Human genes 0.000 description 2
• 102100021389 DNA replication licensing factor MCM4 Human genes 0.000 description 2
• 102100034001 DNA replication licensing factor MCM5 Human genes 0.000 description 2
• 102100033720 DNA replication licensing factor MCM6 Human genes 0.000 description 2
• 102100033711 DNA replication licensing factor MCM7 Human genes 0.000 description 2
• 102100039436 DNA-binding protein inhibitor ID-3 Human genes 0.000 description 2
• 102100029588 Deoxycytidine kinase Human genes 0.000 description 2
• 102100034577 Desmoglein-3 Human genes 0.000 description 2
• 102100038199 Desmoplakin Human genes 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• 102100028572 Disabled homolog 2 Human genes 0.000 description 2
• 102100033996 Double-strand break repair protein MRE11 Human genes 0.000 description 2
• 102100024673 Dual specificity protein phosphatase 3 Human genes 0.000 description 2
• 102100027088 Dual specificity protein phosphatase 5 Human genes 0.000 description 2
• 102100025682 Dystroglycan 1 Human genes 0.000 description 2
• 102100024108 Dystrophin Human genes 0.000 description 2
• 108010069091 Dystrophin Proteins 0.000 description 2
• 102100023227 E3 SUMO-protein ligase EGR2 Human genes 0.000 description 2
• 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 description 2
• 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 description 2
• 102100024739 E3 ubiquitin-protein ligase UHRF1 Human genes 0.000 description 2
• 102000017914 EDNRA Human genes 0.000 description 2
• 102000001301 EGF receptor Human genes 0.000 description 2
• 108060006698 EGF receptor Proteins 0.000 description 2
• 102100029652 EH domain-binding protein 1 Human genes 0.000 description 2
• 102100029994 ERO1-like protein alpha Human genes 0.000 description 2
• 102100023226 Early growth response protein 1 Human genes 0.000 description 2
• 102100036437 Ectonucleoside triphosphate diphosphohydrolase 6 Human genes 0.000 description 2
• 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 description 2
• 102000012737 Electron-Transferring Flavoproteins Human genes 0.000 description 2
• 108010079426 Electron-Transferring Flavoproteins Proteins 0.000 description 2
• 102100030801 Elongation factor 1-alpha 1 Human genes 0.000 description 2
• 102100030808 Elongation factor 1-delta Human genes 0.000 description 2
• 102100023362 Elongation factor 1-gamma Human genes 0.000 description 2
• 102100031780 Endonuclease Human genes 0.000 description 2
• 102100030770 Enhancer of rudimentary homolog Human genes 0.000 description 2
• 102100023721 Ephrin-B2 Human genes 0.000 description 2
• 102100025403 Epoxide hydrolase 1 Human genes 0.000 description 2
• 102100029091 Exportin-2 Human genes 0.000 description 2
• 102100039207 Exportin-T Human genes 0.000 description 2
• 102100023077 Extracellular matrix protein 2 Human genes 0.000 description 2
• 101710191461 F420-dependent glucose-6-phosphate dehydrogenase Proteins 0.000 description 2
• 102100037733 Fatty acid-binding protein, brain Human genes 0.000 description 2
• 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 description 2
• 102100038647 Fibroleukin Human genes 0.000 description 2
• 102100037362 Fibronectin Human genes 0.000 description 2
• 201000008808 Fibrosarcoma Diseases 0.000 description 2
• 102100026559 Filamin-B Human genes 0.000 description 2
• 102100027944 Flavin reductase (NADPH) Human genes 0.000 description 2
• 102100037854 G1/S-specific cyclin-E2 Human genes 0.000 description 2
• 102100033201 G2/mitotic-specific cyclin-B2 Human genes 0.000 description 2
• 108010045298 GA-Binding Protein Transcription Factor Proteins 0.000 description 2
• 102000005664 GA-Binding Protein Transcription Factor Human genes 0.000 description 2
• 102000001534 GDP dissociation inhibitor Human genes 0.000 description 2
• 102100036080 GPI mannosyltransferase 3 Human genes 0.000 description 2
• 102100039835 Galactoside alpha-(1,2)-fucosyltransferase 1 Human genes 0.000 description 2
• 108010001517 Galectin 3 Proteins 0.000 description 2
• 102100039554 Galectin-8 Human genes 0.000 description 2
• 102100025444 Gamma-butyrobetaine dioxygenase Human genes 0.000 description 2
• 206010051066 Gastrointestinal stromal tumour Diseases 0.000 description 2
• 102100031885 General transcription and DNA repair factor IIH helicase subunit XPB Human genes 0.000 description 2
• 108010026318 Geranyltranstransferase Proteins 0.000 description 2
• 102100033299 Glia-derived nexin Human genes 0.000 description 2
• 102100039632 Glioma pathogenesis-related protein 1 Human genes 0.000 description 2
• 102100033417 Glucocorticoid receptor Human genes 0.000 description 2
• 102100035902 Glutamate decarboxylase 1 Human genes 0.000 description 2
• 102100035857 Glutamate decarboxylase 2 Human genes 0.000 description 2
• 102100030651 Glutamate receptor 2 Human genes 0.000 description 2
• 102000004263 Glutamate-Cysteine Ligase Human genes 0.000 description 2
• 108010081687 Glutamate-cysteine ligase Proteins 0.000 description 2
• 102100033398 Glutamate-cysteine ligase regulatory subunit Human genes 0.000 description 2
• 108010058940 Glutamyl Aminopeptidase Proteins 0.000 description 2
• 102100030395 Glycerol-3-phosphate dehydrogenase, mitochondrial Human genes 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 102100025506 Glycine cleavage system H protein, mitochondrial Human genes 0.000 description 2
• 102100033495 Glycine dehydrogenase (decarboxylating), mitochondrial Human genes 0.000 description 2
• 102000003886 Glycoproteins Human genes 0.000 description 2
• 108090000288 Glycoproteins Proteins 0.000 description 2
• 102000018884 Golgi Matrix Proteins Human genes 0.000 description 2
• 108010052778 Golgi Matrix Proteins Proteins 0.000 description 2
• 108010092964 Guanine Nucleotide Dissociation Inhibitors Proteins 0.000 description 2
• 102100035786 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Human genes 0.000 description 2
• 102100035688 Guanylate-binding protein 1 Human genes 0.000 description 2
• 102100028541 Guanylate-binding protein 2 Human genes 0.000 description 2
• 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 2
• 108010024164 HLA-G Antigens Proteins 0.000 description 2
• 101150088682 HMT-1 gene Proteins 0.000 description 2
• 102100028893 Hemicentin-1 Human genes 0.000 description 2
• 102100031000 Hepatoma-derived growth factor Human genes 0.000 description 2
• 102100033985 Heterogeneous nuclear ribonucleoprotein D0 Human genes 0.000 description 2
• 102100033997 Heterogeneous nuclear ribonucleoprotein H3 Human genes 0.000 description 2
• 102100024002 Heterogeneous nuclear ribonucleoprotein U Human genes 0.000 description 2
• 108010019372 Heterogeneous-Nuclear Ribonucleoproteins Proteins 0.000 description 2
• 102000006479 Heterogeneous-Nuclear Ribonucleoproteins Human genes 0.000 description 2
• 102100022128 High mobility group protein B2 Human genes 0.000 description 2
• 102100029076 Histamine N-methyltransferase Human genes 0.000 description 2
• 102100024501 Histone H3-like centromeric protein A Human genes 0.000 description 2
• 102100039236 Histone H3.3 Human genes 0.000 description 2
• 102100034523 Histone H4 Human genes 0.000 description 2
• 108010033040 Histones Proteins 0.000 description 2
• 102100035009 Holocytochrome c-type synthase Human genes 0.000 description 2
• 102100037102 Homeobox protein MOX-2 Human genes 0.000 description 2
• 101000980303 Homo sapiens 10 kDa heat shock protein, mitochondrial Proteins 0.000 description 2
• 101001132150 Homo sapiens 2-phosphoxylose phosphatase 1 Proteins 0.000 description 2
• 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 description 2
• 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 2
• 101000974390 Homo sapiens ADP-ribosylation factor-like protein 4C Proteins 0.000 description 2
• 101100490834 Homo sapiens ALG1 gene Proteins 0.000 description 2
• 101000797458 Homo sapiens AMP deaminase 2 Proteins 0.000 description 2
• 101000722210 Homo sapiens ATP-dependent DNA helicase DDX11 Proteins 0.000 description 2
• 101000923749 Homo sapiens ATP-dependent RNA helicase DDX39A Proteins 0.000 description 2
• 101000870662 Homo sapiens ATP-dependent RNA helicase DDX3X Proteins 0.000 description 2
• 101000887284 Homo sapiens ATPase family AAA domain-containing protein 2 Proteins 0.000 description 2
• 101000900939 Homo sapiens Abnormal spindle-like microcephaly-associated protein Proteins 0.000 description 2
• 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 description 2
• 101000999998 Homo sapiens Aggrecan core protein Proteins 0.000 description 2
• 101000756842 Homo sapiens Alpha-2A adrenergic receptor Proteins 0.000 description 2
• 101000833549 Homo sapiens Alpha-internexin Proteins 0.000 description 2
• 101000928670 Homo sapiens Amyloid beta precursor protein binding family B member 1 Proteins 0.000 description 2
• 101000928680 Homo sapiens Amyloid beta precursor protein binding family B member 2 Proteins 0.000 description 2
• 101000928677 Homo sapiens Amyloid-beta A4 precursor protein-binding family A member 2 Proteins 0.000 description 2
• 101000732539 Homo sapiens Ankyrin repeat domain-containing protein 37 Proteins 0.000 description 2
• 101000793362 Homo sapiens Apelin receptor Proteins 0.000 description 2
• 101000792835 Homo sapiens Arginase-2, mitochondrial Proteins 0.000 description 2
• 101000929698 Homo sapiens Aspartate aminotransferase, cytoplasmic Proteins 0.000 description 2
• 101000799549 Homo sapiens Aspartate aminotransferase, mitochondrial Proteins 0.000 description 2
• 101000936743 Homo sapiens Astrotactin-2 Proteins 0.000 description 2
• 101000798306 Homo sapiens Aurora kinase B Proteins 0.000 description 2
• 101000740545 Homo sapiens BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Proteins 0.000 description 2
• 101000970576 Homo sapiens Bcl-2-interacting killer Proteins 0.000 description 2
• 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 description 2
• 101000740685 Homo sapiens C4b-binding protein alpha chain Proteins 0.000 description 2
• 101000945965 Homo sapiens CCAAT/enhancer-binding protein delta Proteins 0.000 description 2
• 101000715671 Homo sapiens Cadherin EGF LAG seven-pass G-type receptor 3 Proteins 0.000 description 2
• 101000741445 Homo sapiens Calcitonin Proteins 0.000 description 2
• 101000932890 Homo sapiens Calcitonin gene-related peptide 1 Proteins 0.000 description 2
• 101000867778 Homo sapiens Calcium-dependent secretion activator 2 Proteins 0.000 description 2
• 101000867715 Homo sapiens Calpain-3 Proteins 0.000 description 2
• 101000855412 Homo sapiens Carbamoyl-phosphate synthase [ammonia], mitochondrial Proteins 0.000 description 2
• 101000883009 Homo sapiens Carbohydrate sulfotransferase 2 Proteins 0.000 description 2
• 101000910843 Homo sapiens Carboxypeptidase N catalytic chain Proteins 0.000 description 2
• 101000761509 Homo sapiens Cathepsin K Proteins 0.000 description 2
• 101000914465 Homo sapiens Cell division control protein 6 homolog Proteins 0.000 description 2
• 101000868318 Homo sapiens Cell division cycle 5-like protein Proteins 0.000 description 2
• 101000884317 Homo sapiens Cell division cycle protein 20 homolog Proteins 0.000 description 2
• 101000880522 Homo sapiens Centrin-3 Proteins 0.000 description 2
• 101000737696 Homo sapiens Centromere protein M Proteins 0.000 description 2
• 101001091251 Homo sapiens Centrosomal protein kizuna Proteins 0.000 description 2
• 101000776447 Homo sapiens Centrosomal protein of 55 kDa Proteins 0.000 description 2
• 101000916485 Homo sapiens Chondroitin sulfate proteoglycan 5 Proteins 0.000 description 2
• 101001139157 Homo sapiens Chromosome-associated kinesin KIF4A Proteins 0.000 description 2
• 101001027836 Homo sapiens Coagulation factor V Proteins 0.000 description 2
• 101000876022 Homo sapiens Colipase Proteins 0.000 description 2
• 101000993285 Homo sapiens Collagen alpha-1(III) chain Proteins 0.000 description 2
• 101000748976 Homo sapiens Collagen alpha-1(XXI) chain Proteins 0.000 description 2
• 101000942622 Homo sapiens Condensin complex subunit 3 Proteins 0.000 description 2
• 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 2
• 101000748842 Homo sapiens Cytochrome c oxidase assembly protein COX11, mitochondrial Proteins 0.000 description 2
• 101000770637 Homo sapiens Cytochrome c oxidase assembly protein COX15 homolog Proteins 0.000 description 2
• 101000922367 Homo sapiens Cytochrome c oxidase subunit 6B1 Proteins 0.000 description 2
• 101000950642 Homo sapiens DEP domain-containing protein 1A Proteins 0.000 description 2
• 101000920784 Homo sapiens DNA excision repair protein ERCC-5 Proteins 0.000 description 2
• 101000927313 Homo sapiens DNA replication ATP-dependent helicase DNA2 Proteins 0.000 description 2
• 101001080484 Homo sapiens DNA replication complex GINS protein PSF1 Proteins 0.000 description 2
• 101000963174 Homo sapiens DNA replication licensing factor MCM3 Proteins 0.000 description 2
• 101000615280 Homo sapiens DNA replication licensing factor MCM4 Proteins 0.000 description 2
• 101001017545 Homo sapiens DNA replication licensing factor MCM5 Proteins 0.000 description 2
• 101001018484 Homo sapiens DNA replication licensing factor MCM6 Proteins 0.000 description 2
• 101001036276 Homo sapiens DNA-binding protein inhibitor ID-4 Proteins 0.000 description 2
• 101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 description 2
• 101001057612 Homo sapiens Dual specificity protein phosphatase 5 Proteins 0.000 description 2
• 101001049692 Homo sapiens E3 SUMO-protein ligase EGR2 Proteins 0.000 description 2
• 101000760417 Homo sapiens E3 ubiquitin-protein ligase UHRF1 Proteins 0.000 description 2
• 101001012951 Homo sapiens EH domain-binding protein 1 Proteins 0.000 description 2
• 101001010853 Homo sapiens ERO1-like protein alpha Proteins 0.000 description 2
• 101001049697 Homo sapiens Early growth response protein 1 Proteins 0.000 description 2
• 101000920078 Homo sapiens Elongation factor 1-alpha 1 Proteins 0.000 description 2
• 101000920062 Homo sapiens Elongation factor 1-delta Proteins 0.000 description 2
• 101001050451 Homo sapiens Elongation factor 1-gamma Proteins 0.000 description 2
• 101001049392 Homo sapiens Ephrin-B2 Proteins 0.000 description 2
• 101000745703 Homo sapiens Exportin-T Proteins 0.000 description 2
• 101001027674 Homo sapiens Fatty acid-binding protein, brain Proteins 0.000 description 2
• 101001031613 Homo sapiens Fibroleukin Proteins 0.000 description 2
• 101000913551 Homo sapiens Filamin-B Proteins 0.000 description 2
• 101000738575 Homo sapiens G1/S-specific cyclin-E2 Proteins 0.000 description 2
• 101000713023 Homo sapiens G2/mitotic-specific cyclin-B2 Proteins 0.000 description 2
• 101000595504 Homo sapiens GPI mannosyltransferase 3 Proteins 0.000 description 2
• 101001042446 Homo sapiens Galectin-2 Proteins 0.000 description 2
• 101000608769 Homo sapiens Galectin-8 Proteins 0.000 description 2
• 101000934612 Homo sapiens Gamma-butyrobetaine dioxygenase Proteins 0.000 description 2
• 101001075374 Homo sapiens Gamma-glutamyl hydrolase Proteins 0.000 description 2
• 101000726548 Homo sapiens Gap junction alpha-5 protein Proteins 0.000 description 2
• 101001062849 Homo sapiens Gastrotropin Proteins 0.000 description 2
• 101000920748 Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPB Proteins 0.000 description 2
• 101000997803 Homo sapiens Glia-derived nexin Proteins 0.000 description 2
• 101000888759 Homo sapiens Glioma pathogenesis-related protein 1 Proteins 0.000 description 2
• 101001010449 Homo sapiens Glutamate receptor 2 Proteins 0.000 description 2
• 101000870644 Homo sapiens Glutamate-cysteine ligase regulatory subunit Proteins 0.000 description 2
• 101000719019 Homo sapiens Glutamyl aminopeptidase Proteins 0.000 description 2
• 101000856845 Homo sapiens Glycine cleavage system H protein, mitochondrial Proteins 0.000 description 2
• 101001073247 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Proteins 0.000 description 2
• 101000839060 Homo sapiens Hemicentin-1 Proteins 0.000 description 2
• 101001066435 Homo sapiens Hepatocyte growth factor-like protein Proteins 0.000 description 2
• 101001017561 Homo sapiens Heterogeneous nuclear ribonucleoprotein H3 Proteins 0.000 description 2
• 101001045791 Homo sapiens High mobility group protein B2 Proteins 0.000 description 2
• 101000988655 Homo sapiens Histamine N-methyltransferase Proteins 0.000 description 2
• 101000981071 Homo sapiens Histone H3-like centromeric protein A Proteins 0.000 description 2
• 101001067880 Homo sapiens Histone H4 Proteins 0.000 description 2
• 101001046967 Homo sapiens Histone acetyltransferase KAT2A Proteins 0.000 description 2
• 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 2
• 101000809239 Homo sapiens Inactive ubiquitin carboxyl-terminal hydrolase 53 Proteins 0.000 description 2
• 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 2
• 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 description 2
• 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 description 2
• 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 description 2
• 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 description 2
• 101000976697 Homo sapiens Inter-alpha-trypsin inhibitor heavy chain H1 Proteins 0.000 description 2
• 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 description 2
• 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 2
• 101001003132 Homo sapiens Interleukin-13 receptor subunit alpha-2 Proteins 0.000 description 2
• 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 description 2
• 101001046633 Homo sapiens Junctional adhesion molecule A Proteins 0.000 description 2
• 101001008949 Homo sapiens Kinesin-like protein KIF14 Proteins 0.000 description 2
• 101001027621 Homo sapiens Kinesin-like protein KIF20A Proteins 0.000 description 2
• 101000605743 Homo sapiens Kinesin-like protein KIF23 Proteins 0.000 description 2
• 101000711455 Homo sapiens Kinetochore protein Spc25 Proteins 0.000 description 2
• 101000971521 Homo sapiens Kinetochore scaffold 1 Proteins 0.000 description 2
• 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 description 2
• 101001054649 Homo sapiens Latent-transforming growth factor beta-binding protein 2 Proteins 0.000 description 2
• 101001054646 Homo sapiens Latent-transforming growth factor beta-binding protein 3 Proteins 0.000 description 2
• 101001039189 Homo sapiens Leucine-rich repeat-containing protein 17 Proteins 0.000 description 2
• 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 description 2
• 101000942133 Homo sapiens Leupaxin Proteins 0.000 description 2
• 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 2
• 101001039207 Homo sapiens Low-density lipoprotein receptor-related protein 8 Proteins 0.000 description 2
• 101001115419 Homo sapiens MAGUK p55 subfamily member 7 Proteins 0.000 description 2
• 101000956314 Homo sapiens Maleylacetoacetate isomerase Proteins 0.000 description 2
• 101000968916 Homo sapiens Methylsterol monooxygenase 1 Proteins 0.000 description 2
• 101000928479 Homo sapiens Microtubule organization protein AKNA Proteins 0.000 description 2
• 101000573513 Homo sapiens Muskelin Proteins 0.000 description 2
• 101001018552 Homo sapiens MyoD family inhibitor domain-containing protein Proteins 0.000 description 2
• 101001030173 Homo sapiens Myozenin-2 Proteins 0.000 description 2
• 101001108246 Homo sapiens Neuronal pentraxin-2 Proteins 0.000 description 2
• 101001112224 Homo sapiens Neutrophil cytosol factor 2 Proteins 0.000 description 2
• 101000998855 Homo sapiens Nicotinamide phosphoribosyltransferase Proteins 0.000 description 2
• 101000711744 Homo sapiens Non-secretory ribonuclease Proteins 0.000 description 2
• 101000988395 Homo sapiens PDZ and LIM domain protein 4 Proteins 0.000 description 2
• 101000988394 Homo sapiens PDZ and LIM domain protein 5 Proteins 0.000 description 2
• 101100216116 Homo sapiens PRMT2 gene Proteins 0.000 description 2
• 101000904196 Homo sapiens Pancreatic secretory granule membrane major glycoprotein GP2 Proteins 0.000 description 2
• 101000876782 Homo sapiens Phenylalanine-tRNA ligase alpha subunit Proteins 0.000 description 2
• 101000734579 Homo sapiens Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Proteins 0.000 description 2
• 101000579123 Homo sapiens Phosphoglycerate kinase 1 Proteins 0.000 description 2
• 101000600387 Homo sapiens Phosphoglycerate mutase 1 Proteins 0.000 description 2
• 101001045704 Homo sapiens Phosphoribosyl pyrophosphate synthase-associated protein 1 Proteins 0.000 description 2
• 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 description 2
• 101000728125 Homo sapiens Plasma membrane calcium-transporting ATPase 2 Proteins 0.000 description 2
• 101001009547 Homo sapiens Prosaposin receptor GPR37 Proteins 0.000 description 2
• 101000605534 Homo sapiens Prostate-specific antigen Proteins 0.000 description 2
• 101000710074 Homo sapiens Protein CFAP20DC Proteins 0.000 description 2
• 101000979748 Homo sapiens Protein NDRG1 Proteins 0.000 description 2
• 101000979460 Homo sapiens Protein Niban 1 Proteins 0.000 description 2
• 101000620365 Homo sapiens Protein TMEPAI Proteins 0.000 description 2
• 101000716310 Homo sapiens Protein sidekick-2 Proteins 0.000 description 2
• 101000685923 Homo sapiens Protein transport protein Sec24A Proteins 0.000 description 2
• 101001098557 Homo sapiens Proteinase-activated receptor 3 Proteins 0.000 description 2
• 101000655540 Homo sapiens Protransforming growth factor alpha Proteins 0.000 description 2
• 101001136671 Homo sapiens Putative phosphoserine phosphatase-like protein Proteins 0.000 description 2
• 101000795018 Homo sapiens Putative trypsin-6 Proteins 0.000 description 2
• 101000684323 Homo sapiens Putative uncharacterized protein ARHGAP5-AS1 Proteins 0.000 description 2
• 101000848721 Homo sapiens Rap guanine nucleotide exchange factor 4 Proteins 0.000 description 2
• 101001075453 Homo sapiens Regulator of G-protein signaling 17 Proteins 0.000 description 2
• 101001096355 Homo sapiens Replication factor C subunit 3 Proteins 0.000 description 2
• 101001078082 Homo sapiens Reticulocalbin-3 Proteins 0.000 description 2
• 101000936731 Homo sapiens Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Proteins 0.000 description 2
• 101000709099 Homo sapiens Schlafen family member 5 Proteins 0.000 description 2
• 101001087372 Homo sapiens Securin Proteins 0.000 description 2
• 101000739754 Homo sapiens Semenogelin-1 Proteins 0.000 description 2
• 101001067604 Homo sapiens Serine hydroxymethyltransferase, mitochondrial Proteins 0.000 description 2
• 101000655897 Homo sapiens Serine protease 1 Proteins 0.000 description 2
• 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 2
• 101000739905 Homo sapiens Sestrin-2 Proteins 0.000 description 2
• 101000702081 Homo sapiens Small proline-rich protein 2G Proteins 0.000 description 2
• 101000639970 Homo sapiens Sodium- and chloride-dependent GABA transporter 1 Proteins 0.000 description 2
• 101000617818 Homo sapiens Solute carrier organic anion transporter family member 4A1 Proteins 0.000 description 2
• 101000714470 Homo sapiens Synaptotagmin-1 Proteins 0.000 description 2
• 101000634846 Homo sapiens T-cell receptor-associated transmembrane adapter 1 Proteins 0.000 description 2
• 101000738413 Homo sapiens T-cell surface glycoprotein CD3 gamma chain Proteins 0.000 description 2
• 101000738335 Homo sapiens T-cell surface glycoprotein CD3 zeta chain Proteins 0.000 description 2
• 101000830894 Homo sapiens Targeting protein for Xklp2 Proteins 0.000 description 2
• 101001027052 Homo sapiens Thymidylate kinase Proteins 0.000 description 2
• 101000809797 Homo sapiens Thymidylate synthase Proteins 0.000 description 2
• 101000635804 Homo sapiens Tissue factor Proteins 0.000 description 2
• 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 description 2
• 101000835720 Homo sapiens Transcription elongation factor A protein 1 Proteins 0.000 description 2
• 101000891649 Homo sapiens Transcription elongation factor A protein-like 1 Proteins 0.000 description 2
• 101000658574 Homo sapiens Transmembrane 4 L6 family member 1 Proteins 0.000 description 2
• 101000831866 Homo sapiens Transmembrane protein 45A Proteins 0.000 description 2
• 101000838411 Homo sapiens Tubulin epsilon chain Proteins 0.000 description 2
• 101000606090 Homo sapiens Tyrosinase Proteins 0.000 description 2
• 101000992235 Homo sapiens UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit Proteins 0.000 description 2
• 101000837581 Homo sapiens Ubiquitin-conjugating enzyme E2 T Proteins 0.000 description 2
• 101000906698 Homo sapiens Uncharacterized protein C12orf50 Proteins 0.000 description 2
• 101001000116 Homo sapiens Unconventional myosin-Ig Proteins 0.000 description 2
• 101000583031 Homo sapiens Unconventional myosin-Va Proteins 0.000 description 2
• 101000934581 Homo sapiens Valacyclovir hydrolase Proteins 0.000 description 2
• 101000743863 Homo sapiens ZW10 interactor Proteins 0.000 description 2
• 102100028084 Hyaluronan and proteoglycan link protein 1 Human genes 0.000 description 2
• 101710191341 Hyaluronan and proteoglycan link protein 1 Proteins 0.000 description 2
• 108010007666 IMP cyclohydrolase Proteins 0.000 description 2
• 102100038425 Inactive ubiquitin carboxyl-terminal hydrolase 53 Human genes 0.000 description 2
• 102100020796 Inosine 5'-monophosphate cyclohydrolase Human genes 0.000 description 2
• 102100025458 Inosine triphosphate pyrophosphatase Human genes 0.000 description 2
• 108010032354 Inositol 1,4,5-Trisphosphate Receptors Proteins 0.000 description 2
• 102000007640 Inositol 1,4,5-Trisphosphate Receptors Human genes 0.000 description 2
• 101710144867 Inositol monophosphatase Proteins 0.000 description 2
• 102100026819 Inositol polyphosphate 1-phosphatase Human genes 0.000 description 2
• 102100032819 Integrin alpha-3 Human genes 0.000 description 2
• 102100032818 Integrin alpha-4 Human genes 0.000 description 2
• 102100032999 Integrin beta-3 Human genes 0.000 description 2
• 102100023490 Inter-alpha-trypsin inhibitor heavy chain H1 Human genes 0.000 description 2
• 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 description 2
• 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 description 2
• 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 2
• 102100039060 Interleukin enhancer-binding factor 2 Human genes 0.000 description 2
• 102000006940 Interleukin-1 Receptor-Associated Kinases Human genes 0.000 description 2
• 108010072621 Interleukin-1 Receptor-Associated Kinases Proteins 0.000 description 2
• 102000019223 Interleukin-1 receptor Human genes 0.000 description 2
• 108050006617 Interleukin-1 receptor Proteins 0.000 description 2
• 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 description 2
• 102000004195 Isomerases Human genes 0.000 description 2
• 108090000769 Isomerases Proteins 0.000 description 2
• 102100022304 Junctional adhesion molecule A Human genes 0.000 description 2
• 102100023133 Jupiter microtubule associated homolog 1 Human genes 0.000 description 2
• 102100023970 Keratin, type I cytoskeletal 10 Human genes 0.000 description 2
• 101710172072 Kexin Proteins 0.000 description 2
• 102100027631 Kinesin-like protein KIF14 Human genes 0.000 description 2
• 102100037694 Kinesin-like protein KIF20A Human genes 0.000 description 2
• 102100038406 Kinesin-like protein KIF23 Human genes 0.000 description 2
• 102100023426 Kinesin-like protein KIF2A Human genes 0.000 description 2
• 102100034037 Kinetochore protein Spc25 Human genes 0.000 description 2
• 102100021464 Kinetochore scaffold 1 Human genes 0.000 description 2
• 102100020677 Krueppel-like factor 4 Human genes 0.000 description 2
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
• 108010007622 LDL Lipoproteins Proteins 0.000 description 2
• 102000007330 LDL Lipoproteins Human genes 0.000 description 2
• 102100032011 Lanosterol synthase Human genes 0.000 description 2
• 102000052922 Large Neutral Amino Acid-Transporter 1 Human genes 0.000 description 2
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
• 102100040690 Leucine-rich repeat-containing protein 17 Human genes 0.000 description 2
• 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 description 2
• 102100032755 Leupaxin Human genes 0.000 description 2
• 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 description 2
• 102100040705 Low-density lipoprotein receptor-related protein 8 Human genes 0.000 description 2
• 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 description 2
• 102100033448 Lysosomal alpha-glucosidase Human genes 0.000 description 2
• 102100023259 MAGUK p55 subfamily member 7 Human genes 0.000 description 2
• 102100037791 Macrophage migration inhibitory factor Human genes 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 2
• 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 description 2
• 102100030216 Matrix metalloproteinase-14 Human genes 0.000 description 2
• 102100030201 Matrix metalloproteinase-15 Human genes 0.000 description 2
• 102100030200 Matrix metalloproteinase-16 Human genes 0.000 description 2
• 101710159527 Maturation protein A Proteins 0.000 description 2
• 101710091157 Maturation protein A2 Proteins 0.000 description 2
• 102100034216 Melanocyte-stimulating hormone receptor Human genes 0.000 description 2
• 102000018697 Membrane Proteins Human genes 0.000 description 2
• 108010052285 Membrane Proteins Proteins 0.000 description 2
• 241001465754 Metazoa Species 0.000 description 2
• 108010010685 Methenyltetrahydrofolate cyclohydrolase Proteins 0.000 description 2
• 102100039124 Methyl-CpG-binding protein 2 Human genes 0.000 description 2
• 102100021091 Methylsterol monooxygenase 1 Human genes 0.000 description 2
• 102100030335 Midkine Human genes 0.000 description 2
• 102100038738 Mitochondrial carnitine/acylcarnitine carrier protein Human genes 0.000 description 2
• 102100037984 Mitoferrin-1 Human genes 0.000 description 2
• 102100025748 Mothers against decapentaplegic homolog 3 Human genes 0.000 description 2
• 101710143111 Mothers against decapentaplegic homolog 3 Proteins 0.000 description 2
• 102100030608 Mothers against decapentaplegic homolog 7 Human genes 0.000 description 2
• 101000596402 Mus musculus Neuronal vesicle trafficking-associated protein 1 Proteins 0.000 description 2
• 101000800539 Mus musculus Translationally-controlled tumor protein Proteins 0.000 description 2
• 102100026301 Muskelin Human genes 0.000 description 2
• 101710146400 Myc-associated zinc finger protein Proteins 0.000 description 2
• 102000047918 Myelin Basic Human genes 0.000 description 2
• 101710107068 Myelin basic protein Proteins 0.000 description 2
• 102100033699 MyoD family inhibitor domain-containing protein Human genes 0.000 description 2
• 102100038900 Myozenin-2 Human genes 0.000 description 2
• OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
• MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
• 102100023175 NADP-dependent malic enzyme Human genes 0.000 description 2
• 102100031911 NEDD8 Human genes 0.000 description 2
• 108700004934 NEDD8 Proteins 0.000 description 2
• 102100030407 NGFI-A-binding protein 1 Human genes 0.000 description 2
• 102100034434 Nebulin Human genes 0.000 description 2
• 102100021878 Neuronal pentraxin-2 Human genes 0.000 description 2
• 102000004213 Neuropilin-2 Human genes 0.000 description 2
• 108090000770 Neuropilin-2 Proteins 0.000 description 2
• 102100023618 Neutrophil cytosol factor 2 Human genes 0.000 description 2
• 102100033223 Nicotinamide phosphoribosyltransferase Human genes 0.000 description 2
• 102100034217 Non-secretory ribonuclease Human genes 0.000 description 2
• 102000015863 Nuclear Factor 90 Proteins Human genes 0.000 description 2
• 108010010424 Nuclear Factor 90 Proteins Proteins 0.000 description 2
• 102100023904 Nuclear autoantigenic sperm protein Human genes 0.000 description 2
• 101710149564 Nuclear autoantigenic sperm protein Proteins 0.000 description 2
• 102100024372 Nuclear cap-binding protein subunit 1 Human genes 0.000 description 2
• 108700026244 Open Reading Frames Proteins 0.000 description 2
• 101710130961 Opsin-3 Proteins 0.000 description 2
• 102100029178 PDZ and LIM domain protein 4 Human genes 0.000 description 2
• 102100029181 PDZ and LIM domain protein 5 Human genes 0.000 description 2
• 102000002125 PDZK1-interacting protein 1 Human genes 0.000 description 2
• 108050009474 PDZK1-interacting protein 1 Proteins 0.000 description 2
• 102100024019 Pancreatic secretory granule membrane major glycoprotein GP2 Human genes 0.000 description 2
• 229940122344 Peptidase inhibitor Drugs 0.000 description 2
• 102100035215 Phenylalanine-tRNA ligase alpha subunit Human genes 0.000 description 2
• 102100034792 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Human genes 0.000 description 2
• 102100028251 Phosphoglycerate kinase 1 Human genes 0.000 description 2
• 102100037389 Phosphoglycerate mutase 1 Human genes 0.000 description 2
• 102100023410 Phospholipid hydroperoxide glutathione peroxidase Human genes 0.000 description 2
• 102100022063 Phosphoribosyl pyrophosphate synthase-associated protein 1 Human genes 0.000 description 2
• 108010064071 Phosphorylase Kinase Proteins 0.000 description 2
• 102000014750 Phosphorylase Kinase Human genes 0.000 description 2
• 102100035194 Placenta growth factor Human genes 0.000 description 2
• 108010077971 Plasminogen Inactivators Proteins 0.000 description 2
• 102100039419 Plasminogen activator inhibitor 2 Human genes 0.000 description 2
• 102100020947 Polypeptide N-acetylgalactosaminyltransferase 1 Human genes 0.000 description 2
• 102100038358 Prostate-specific antigen Human genes 0.000 description 2
• 102100034625 Protein CFAP20DC Human genes 0.000 description 2
• 102100034479 Protein CLN8 Human genes 0.000 description 2
• 102100023788 Protein FAM162A Human genes 0.000 description 2
• 101710106671 Protein FAM162A Proteins 0.000 description 2
• 102100024980 Protein NDRG1 Human genes 0.000 description 2
• 102100023076 Protein Niban 1 Human genes 0.000 description 2
• 102100022429 Protein TMEPAI Human genes 0.000 description 2
• 102100022988 Protein arginine N-methyltransferase 2 Human genes 0.000 description 2
• 102100021005 Protein sidekick-2 Human genes 0.000 description 2
• 102100023368 Protein transport protein Sec24A Human genes 0.000 description 2
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 2
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
• 102100037133 Proteinase-activated receptor 3 Human genes 0.000 description 2
• 102000016611 Proteoglycans Human genes 0.000 description 2
• 108010067787 Proteoglycans Proteins 0.000 description 2
• 102100032350 Protransforming growth factor alpha Human genes 0.000 description 2
• 102100036656 Putative phosphoserine phosphatase-like protein Human genes 0.000 description 2
• 102100029629 Putative trypsin-6 Human genes 0.000 description 2
• 102100023819 Putative uncharacterized protein ARHGAP5-AS1 Human genes 0.000 description 2
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
• 102100037414 Rac GTPase-activating protein 1 Human genes 0.000 description 2
• 101710196218 Rac GTPase-activating protein 1 Proteins 0.000 description 2
• 102100034591 Rap guanine nucleotide exchange factor 4 Human genes 0.000 description 2
• 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 description 2
• 102100020982 Regulator of G-protein signaling 17 Human genes 0.000 description 2
• 101710150974 Regulator of chromosome condensation Proteins 0.000 description 2
• 102100037855 Replication factor C subunit 3 Human genes 0.000 description 2
• 102100025343 Reticulocalbin-3 Human genes 0.000 description 2
• 101710202172 Rho GDP-dissociation inhibitor Proteins 0.000 description 2
• 102100035947 S-adenosylmethionine synthase isoform type-2 Human genes 0.000 description 2
• 108091006229 SLC7A1 Proteins 0.000 description 2
• 108091006232 SLC7A5 Proteins 0.000 description 2
• 101700026522 SMAD7 Proteins 0.000 description 2
• 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 description 2
• 102100027697 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Human genes 0.000 description 2
• 101000781972 Schizosaccharomyces pombe (strain 972 / ATCC 24843) Protein wos2 Proteins 0.000 description 2
• 102100032668 Schlafen family member 5 Human genes 0.000 description 2
• 102100033004 Securin Human genes 0.000 description 2
• 102100032758 Segment polarity protein dishevelled homolog DVL-1 Human genes 0.000 description 2
• 102100032753 Segment polarity protein dishevelled homolog DVL-2 Human genes 0.000 description 2
• 102100032754 Segment polarity protein dishevelled homolog DVL-3 Human genes 0.000 description 2
• 102100037550 Semenogelin-1 Human genes 0.000 description 2
• 102100034606 Serine hydroxymethyltransferase, mitochondrial Human genes 0.000 description 2
• 102100032491 Serine protease 1 Human genes 0.000 description 2
• 102000008847 Serpin Human genes 0.000 description 2
• 108050000761 Serpin Proteins 0.000 description 2
• 108010005113 Serpin E2 Proteins 0.000 description 2
• 102000005821 Serpin E2 Human genes 0.000 description 2
• 102100037576 Sestrin-2 Human genes 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• 102100033927 Sodium- and chloride-dependent GABA transporter 1 Human genes 0.000 description 2
• 102000006633 Sodium-Bicarbonate Symporters Human genes 0.000 description 2
• 102100035088 Sodium/calcium exchanger 1 Human genes 0.000 description 2
• 102100022004 Solute carrier organic anion transporter family member 4A1 Human genes 0.000 description 2
• 102100026718 StAR-related lipid transfer protein 4 Human genes 0.000 description 2
• 108010087999 Steryl-Sulfatase Proteins 0.000 description 2
• 108090000787 Subtilisin Proteins 0.000 description 2
• 102100036417 Synaptotagmin-1 Human genes 0.000 description 2
• 102100029453 T-cell receptor-associated transmembrane adapter 1 Human genes 0.000 description 2
• 102100037911 T-cell surface glycoprotein CD3 gamma chain Human genes 0.000 description 2
• 102100037906 T-cell surface glycoprotein CD3 zeta chain Human genes 0.000 description 2
• 102100024813 Targeting protein for Xklp2 Human genes 0.000 description 2
• 102100037357 Thymidylate kinase Human genes 0.000 description 2
• 102100038618 Thymidylate synthase Human genes 0.000 description 2
• 102100030859 Tissue factor Human genes 0.000 description 2
• 101001009610 Toxoplasma gondii Dense granule protein 5 Proteins 0.000 description 2
• 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 description 2
• 108010057666 Transcription Factor CHOP Proteins 0.000 description 2
• 108010083256 Transcription Factor TFIIH Proteins 0.000 description 2
• 102000006288 Transcription Factor TFIIH Human genes 0.000 description 2
• 102100026430 Transcription elongation factor A protein 1 Human genes 0.000 description 2
• 102100040250 Transcription elongation factor A protein-like 1 Human genes 0.000 description 2
• 102100030798 Transcription factor HES-1 Human genes 0.000 description 2
• 102100023931 Transcriptional regulator ATRX Human genes 0.000 description 2
• 102100034902 Transmembrane 4 L6 family member 1 Human genes 0.000 description 2
• 102100024186 Transmembrane protein 45A Human genes 0.000 description 2
• 102100028984 Tubulin epsilon chain Human genes 0.000 description 2
• 108700025716 Tumor Suppressor Genes Proteins 0.000 description 2
• 102000044209 Tumor Suppressor Genes Human genes 0.000 description 2
• 102000001742 Tumor Suppressor Proteins Human genes 0.000 description 2
• 108010040002 Tumor Suppressor Proteins Proteins 0.000 description 2
• 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 description 2
• 108060008724 Tyrosinase Proteins 0.000 description 2
• 101710098624 Tyrosine-protein kinase ABL1 Proteins 0.000 description 2
• LFTYTUAZOPRMMI-NESSUJCYSA-N UDP-N-acetyl-alpha-D-galactosamine Chemical compound O1[C@H](CO)[C@H](O)[C@H](O)[C@@H](NC(=O)C)[C@H]1O[P@](O)(=O)O[P@](O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-NESSUJCYSA-N 0.000 description 2
• 101710117112 UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit Proteins 0.000 description 2
• LFTYTUAZOPRMMI-UHFFFAOYSA-N UNPD164450 Natural products O1C(CO)C(O)C(O)C(NC(=O)C)C1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-UHFFFAOYSA-N 0.000 description 2
• 102000044159 Ubiquitin Human genes 0.000 description 2
• 108090000848 Ubiquitin Proteins 0.000 description 2
• 102100028705 Ubiquitin-conjugating enzyme E2 T Human genes 0.000 description 2
• 102100023748 Uncharacterized protein C12orf50 Human genes 0.000 description 2
• 102100035824 Unconventional myosin-Ig Human genes 0.000 description 2
• 102100030409 Unconventional myosin-Va Human genes 0.000 description 2
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
• 102100025139 Valacyclovir hydrolase Human genes 0.000 description 2
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
• 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 2
• 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 2
• 102100028437 Versican core protein Human genes 0.000 description 2
• 102100037814 Vigilin Human genes 0.000 description 2
• 102100036976 X-ray repair cross-complementing protein 6 Human genes 0.000 description 2
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
• 102100039102 ZW10 interactor Human genes 0.000 description 2
• 108091006088 activator proteins Proteins 0.000 description 2
• 235000004279 alanine Nutrition 0.000 description 2
• 108090000183 alpha-2-Antiplasmin Proteins 0.000 description 2
• 108010009380 alpha-N-acetyl-D-glucosaminidase Proteins 0.000 description 2
• 210000004102 animal cell Anatomy 0.000 description 2
• 230000000692 anti-sense effect Effects 0.000 description 2
• 239000011324 bead Substances 0.000 description 2
• 150000001556 benzimidazoles Chemical class 0.000 description 2
• 230000008236 biological pathway Effects 0.000 description 2
• 210000004556 brain Anatomy 0.000 description 2
• BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 2
• 229960004015 calcitonin Drugs 0.000 description 2
• 108010051348 cdc42 GTP-Binding Protein Proteins 0.000 description 2
• 230000034303 cell budding Effects 0.000 description 2
• 230000032823 cell division Effects 0.000 description 2
• 230000010261 cell growth Effects 0.000 description 2
• 210000000170 cell membrane Anatomy 0.000 description 2
• 230000008859 change Effects 0.000 description 2
• 239000003153 chemical reaction reagent Substances 0.000 description 2
• 235000012000 cholesterol Nutrition 0.000 description 2
• 230000002759 chromosomal effect Effects 0.000 description 2
• 208000016532 chronic granulomatous disease Diseases 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2
• RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 2
• 229910052802 copper Inorganic materials 0.000 description 2
• 239000010949 copper Substances 0.000 description 2
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 2
• 238000013461 design Methods 0.000 description 2
• 238000002405 diagnostic procedure Methods 0.000 description 2
• 238000009826 distribution Methods 0.000 description 2
• 108010038305 down-regulator of transcription 1 Proteins 0.000 description 2
• 230000003828 downregulation Effects 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 230000009977 dual effect Effects 0.000 description 2
• 230000008482 dysregulation Effects 0.000 description 2
• 239000012636 effector Substances 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 230000009762 endothelial cell differentiation Effects 0.000 description 2
• 210000002919 epithelial cell Anatomy 0.000 description 2
• 210000003617 erythrocyte membrane Anatomy 0.000 description 2
• 230000000925 erythroid effect Effects 0.000 description 2
• 210000003527 eukaryotic cell Anatomy 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 201000011243 gastrointestinal stromal tumor Diseases 0.000 description 2
• 239000000499 gel Substances 0.000 description 2
• 231100000118 genetic alteration Toxicity 0.000 description 2
• 230000004077 genetic alteration Effects 0.000 description 2
• 210000004602 germ cell Anatomy 0.000 description 2
• 239000004220 glutamic acid Substances 0.000 description 2
• 150000004676 glycans Chemical class 0.000 description 2
• 208000007345 glycogen storage disease Diseases 0.000 description 2
• 230000034659 glycolysis Effects 0.000 description 2
• 230000013595 glycosylation Effects 0.000 description 2
• 238000006206 glycosylation reaction Methods 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• 210000003494 hepatocyte Anatomy 0.000 description 2
• 108010052188 hepatoma-derived growth factor Proteins 0.000 description 2
• 208000003215 hereditary nephritis Diseases 0.000 description 2
• 102000048712 human AKNA Human genes 0.000 description 2
• 108010003425 hyaluronan-mediated motility receptor Proteins 0.000 description 2
• 206010020718 hyperplasia Diseases 0.000 description 2
• 206010021198 ichthyosis Diseases 0.000 description 2
• YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 2
• 102000018358 immunoglobulin Human genes 0.000 description 2
• 238000001727 in vivo Methods 0.000 description 2
• 230000000977 initiatory effect Effects 0.000 description 2
• 102000006029 inositol monophosphatase Human genes 0.000 description 2
• 230000010354 integration Effects 0.000 description 2
• 108010085650 interferon gamma receptor Proteins 0.000 description 2
• 230000003834 intracellular effect Effects 0.000 description 2
• 108010011989 karyopherin alpha 2 Proteins 0.000 description 2
• 210000004901 leucine-rich repeat Anatomy 0.000 description 2
• 150000002632 lipids Chemical class 0.000 description 2
• 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
• 230000001394 metastastic effect Effects 0.000 description 2
• 206010061289 metastatic neoplasm Diseases 0.000 description 2
• 230000003228 microsomal effect Effects 0.000 description 2
• 239000003226 mitogen Substances 0.000 description 2
• 150000002772 monosaccharides Chemical class 0.000 description 2
• 229950006780 n-acetylglucosamine Drugs 0.000 description 2
• 108010054130 nebulin Proteins 0.000 description 2
• 210000005170 neoplastic cell Anatomy 0.000 description 2
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
• 239000003921 oil Substances 0.000 description 2
• 108010000953 osteoblast cadherin Proteins 0.000 description 2
• 201000008968 osteosarcoma Diseases 0.000 description 2
• 102000022032 p53 binding proteins Human genes 0.000 description 2
• 108091012362 p53 binding proteins Proteins 0.000 description 2
• 239000000816 peptidomimetic Substances 0.000 description 2
• 150000003904 phospholipids Chemical class 0.000 description 2
• XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
• 108090000102 pigment epithelium-derived factor Proteins 0.000 description 2
• 239000002797 plasminogen activator inhibitor Substances 0.000 description 2
• 102000054765 polymorphisms of proteins Human genes 0.000 description 2
• 239000005017 polysaccharide Substances 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2
• 229940121649 protein inhibitor Drugs 0.000 description 2
• 239000012268 protein inhibitor Substances 0.000 description 2
• MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 2
• 108700042226 ras Genes Proteins 0.000 description 2
• 230000001177 retroviral effect Effects 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• 108091092562 ribozyme Proteins 0.000 description 2
• 230000007017 scission Effects 0.000 description 2
• 101150015999 sec24 gene Proteins 0.000 description 2
• 230000028327 secretion Effects 0.000 description 2
• 230000011664 signaling Effects 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 230000004960 subcellular localization Effects 0.000 description 2
• 150000005846 sugar alcohols Chemical class 0.000 description 2
• 239000013589 supplement Substances 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• XQTLDIFVVHJORV-UHFFFAOYSA-N tecnazene Chemical compound [O-][N+](=O)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl XQTLDIFVVHJORV-UHFFFAOYSA-N 0.000 description 2
• 208000011317 telomere syndrome Diseases 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• 238000002560 therapeutic procedure Methods 0.000 description 2
• 238000011285 therapeutic regimen Methods 0.000 description 2
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
• 108010029377 transcription factor TFIIIC Proteins 0.000 description 2
• 230000005945 translocation Effects 0.000 description 2
• 239000001226 triphosphate Substances 0.000 description 2
• 235000011178 triphosphate Nutrition 0.000 description 2
• UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 2
• 230000004565 tumor cell growth Effects 0.000 description 2
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
• 241000712461 unidentified influenza virus Species 0.000 description 2
• 230000003827 upregulation Effects 0.000 description 2
• 238000011144 upstream manufacturing Methods 0.000 description 2
• 239000000811 xylitol Substances 0.000 description 2
• 235000010447 xylitol Nutrition 0.000 description 2
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
• 229960002675 xylitol Drugs 0.000 description 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
• WKZGKZQVLRQTCT-ABLWVSNPSA-N (2S)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-formyloxy-5-oxopentanoic acid Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(=O)OC=O)C(O)=O)C=C1 WKZGKZQVLRQTCT-ABLWVSNPSA-N 0.000 description 1
• UJCHIZDEQZMODR-BYPYZUCNSA-N (2r)-2-acetamido-3-sulfanylpropanamide Chemical compound CC(=O)N[C@@H](CS)C(N)=O UJCHIZDEQZMODR-BYPYZUCNSA-N 0.000 description 1
• YUXKOWPNKJSTPQ-AXWWPMSFSA-N (2s,3r)-2-amino-3-hydroxybutanoic acid;(2s)-2-amino-3-hydroxypropanoic acid Chemical compound OC[C@H](N)C(O)=O.C[C@@H](O)[C@H](N)C(O)=O YUXKOWPNKJSTPQ-AXWWPMSFSA-N 0.000 description 1
• XJBQVBPGIOOPMP-HNNXBMFYSA-N (3s)-3-[[6-[[[3-(methylsulfonylcarbamoyl)phenyl]sulfonylamino]methyl]pyridine-3-carbonyl]amino]-4-oxobutanoic acid Chemical compound CS(=O)(=O)NC(=O)C1=CC=CC(S(=O)(=O)NCC=2N=CC(=CC=2)C(=O)N[C@@H](CC(O)=O)C=O)=C1 XJBQVBPGIOOPMP-HNNXBMFYSA-N 0.000 description 1
• USVOMZAPZHSFMM-FQEVSTJZSA-N (3s)-5-[(2-chlorophenyl)methylsulfanyl]-4-oxo-3-[[5-[[[3-(5-oxo-2h-1,2,4-oxadiazol-3-yl)phenyl]sulfonylamino]methyl]thiophene-2-carbonyl]amino]pentanoic acid Chemical compound N([C@@H](CC(=O)O)C(=O)CSCC=1C(=CC=CC=1)Cl)C(=O)C(S1)=CC=C1CNS(=O)(=O)C(C=1)=CC=CC=1C1=NC(=O)ON1 USVOMZAPZHSFMM-FQEVSTJZSA-N 0.000 description 1
• LXJXRIRHZLFYRP-VKHMYHEASA-L (R)-2-Hydroxy-3-(phosphonooxy)-propanal Natural products O=C[C@H](O)COP([O-])([O-])=O LXJXRIRHZLFYRP-VKHMYHEASA-L 0.000 description 1
• CDKIEBFIMCSCBB-UHFFFAOYSA-N 1-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride Chemical compound Cl.C1C=2C=C(OC)C(OC)=CC=2CCN1C(=O)C=CC(C1=CC=CN=C1N1C)=C1C1=CC=CC=C1 CDKIEBFIMCSCBB-UHFFFAOYSA-N 0.000 description 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
• 102100030489 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Human genes 0.000 description 1
• 102100037426 17-beta-hydroxysteroid dehydrogenase type 1 Human genes 0.000 description 1
• 102100022585 17-beta-hydroxysteroid dehydrogenase type 3 Human genes 0.000 description 1
• 102100031599 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 Human genes 0.000 description 1
• 102100024830 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 Human genes 0.000 description 1
• GXAFMKJFWWBYNW-OWHBQTKESA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-3-cyclopropyl-2-(3,4,5-trimethoxyphenyl)propanoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC2CC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GXAFMKJFWWBYNW-OWHBQTKESA-N 0.000 description 1
• 101710186714 2-acylglycerol O-acyltransferase 1 Proteins 0.000 description 1
• 102100025271 2-acylglycerol O-acyltransferase 2 Human genes 0.000 description 1
• 101710186725 2-acylglycerol O-acyltransferase 2 Proteins 0.000 description 1
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
• AOYNUTHNTBLRMT-SLPGGIOYSA-N 2-deoxy-2-fluoro-aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](F)C=O AOYNUTHNTBLRMT-SLPGGIOYSA-N 0.000 description 1
• 108010030844 2-methylcitrate synthase Proteins 0.000 description 1
• KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 1
• 102100035352 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Human genes 0.000 description 1
• VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 description 1
• 108010073030 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Proteins 0.000 description 1
• 102100036285 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Human genes 0.000 description 1
• 102100036659 26S proteasome non-ATPase regulatory subunit 9 Human genes 0.000 description 1
• 208000024801 3-hydroxy-3-methylglutaric aciduria Diseases 0.000 description 1
• 102100021908 3-mercaptopyruvate sulfurtransferase Human genes 0.000 description 1
• 102100033751 39S ribosomal protein L49, mitochondrial Human genes 0.000 description 1
• 238000010600 3H thymidine incorporation assay Methods 0.000 description 1
• 101710172561 3alpha-hydroxysteroid dehydrogenase Proteins 0.000 description 1
• KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 description 1
• 102100023912 40S ribosomal protein S12 Human genes 0.000 description 1
• 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 1
• PDACUKOKVHBVHJ-XVFCMESISA-N 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole Chemical compound NC1=CN=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 PDACUKOKVHBVHJ-XVFCMESISA-N 0.000 description 1
• 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
• 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
• 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 description 1
• 102100036512 7-dehydrocholesterol reductase Human genes 0.000 description 1
• 108091007504 ADAM10 Proteins 0.000 description 1
• 108010016281 ADP-Ribosylation Factor 1 Proteins 0.000 description 1
• 108090000067 ADP-Ribosylation Factor 6 Proteins 0.000 description 1
• 102000034257 ADP-Ribosylation Factor 6 Human genes 0.000 description 1
• 102100034341 ADP-ribosylation factor 1 Human genes 0.000 description 1
• 102100023818 ADP-ribosylation factor 3 Human genes 0.000 description 1
• 102100023826 ADP-ribosylation factor 4 Human genes 0.000 description 1
• 102100022908 ADP-ribosylation factor-like protein 1 Human genes 0.000 description 1
• 102100039646 ADP-ribosylation factor-like protein 3 Human genes 0.000 description 1
• 102100034119 ADP-ribosylhydrolase ARH1 Human genes 0.000 description 1
• 102100032533 ADP/ATP translocase 1 Human genes 0.000 description 1
• 102100026396 ADP/ATP translocase 2 Human genes 0.000 description 1
• 102100033793 ALK tyrosine kinase receptor Human genes 0.000 description 1
• 102100032898 AMP deaminase 3 Human genes 0.000 description 1
• 102100033938 AP-1 complex subunit gamma-1 Human genes 0.000 description 1
• 102100034531 AP-1 complex subunit mu-2 Human genes 0.000 description 1
• 102100028777 AP-1 complex subunit sigma-1A Human genes 0.000 description 1
• 102100022984 AP-2 complex subunit alpha-1 Human genes 0.000 description 1
• 102100022974 AP-2 complex subunit alpha-2 Human genes 0.000 description 1
• 102100031315 AP-2 complex subunit mu Human genes 0.000 description 1
• 102100037651 AP-2 complex subunit sigma Human genes 0.000 description 1
• 102100040009 AP-3 complex subunit sigma-1 Human genes 0.000 description 1
• 101150037123 APOE gene Proteins 0.000 description 1
• 102100023619 ATP synthase F(0) complex subunit B1, mitochondrial Human genes 0.000 description 1
• 102100023568 ATP synthase F(0) complex subunit C1, mitochondrial Human genes 0.000 description 1
• 102100023587 ATP synthase F(0) complex subunit C2, mitochondrial Human genes 0.000 description 1
• 102100022994 ATP synthase F(0) complex subunit C3, mitochondrial Human genes 0.000 description 1
• 102100022890 ATP synthase subunit beta, mitochondrial Human genes 0.000 description 1
• 102100025581 ATP synthase subunit delta, mitochondrial Human genes 0.000 description 1
• 102100027782 ATP synthase-coupling factor 6, mitochondrial Human genes 0.000 description 1
• 102100033618 ATP-binding cassette sub-family A member 2 Human genes 0.000 description 1
• 102100020979 ATP-binding cassette sub-family F member 1 Human genes 0.000 description 1
• 102100035623 ATP-citrate synthase Human genes 0.000 description 1
• 102100030088 ATP-dependent RNA helicase A Human genes 0.000 description 1
• 102100033392 ATP-dependent RNA helicase DDX3Y Human genes 0.000 description 1
• 102100023388 ATP-dependent RNA helicase DHX15 Human genes 0.000 description 1
• 102100021176 ATP-sensitive inward rectifier potassium channel 10 Human genes 0.000 description 1
• 108020005176 AU Rich Elements Proteins 0.000 description 1
• 208000002618 Aarskog syndrome Diseases 0.000 description 1
• 208000033745 Aarskog-Scott syndrome Diseases 0.000 description 1
• 241000208140 Acer Species 0.000 description 1
• 102100039164 Acetyl-CoA carboxylase 1 Human genes 0.000 description 1
• 102100021641 Acetyl-CoA carboxylase 2 Human genes 0.000 description 1
• 102100024005 Acid ceramidase Human genes 0.000 description 1
• 102100033404 Acidic leucine-rich nuclear phosphoprotein 32 family member E Human genes 0.000 description 1
• 206010069754 Acquired gene mutation Diseases 0.000 description 1
• 201000010028 Acrocephalosyndactylia Diseases 0.000 description 1
• 102100030374 Actin, cytoplasmic 2 Human genes 0.000 description 1
• 101710093498 Actin, gamma Proteins 0.000 description 1
• 102100034064 Actin-like protein 6A Human genes 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 102000007469 Actins Human genes 0.000 description 1
• 108010085371 Activating Transcription Factor 3 Proteins 0.000 description 1
• 102100034111 Activin receptor type-1 Human genes 0.000 description 1
• 102100034134 Activin receptor type-1B Human genes 0.000 description 1
• 102100021886 Activin receptor type-2A Human genes 0.000 description 1
• 108010059616 Activins Proteins 0.000 description 1
• 102000005606 Activins Human genes 0.000 description 1
• 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 description 1
• 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 description 1
• 102100035785 Acyl-CoA-binding protein Human genes 0.000 description 1
• 101710106492 Acyl-CoA-binding protein Proteins 0.000 description 1
• 101710169323 Acyl-CoA-binding protein homolog Proteins 0.000 description 1
• 102100032488 Acylamino-acid-releasing enzyme Human genes 0.000 description 1
• 108010077835 Adaptor Protein Complex 3 Proteins 0.000 description 1
• 102000010646 Adaptor Protein Complex 3 Human genes 0.000 description 1
• 102000004875 Adenine Nucleotide Translocator 1 Human genes 0.000 description 1
• 208000003200 Adenoma Diseases 0.000 description 1
• 102100034540 Adenomatous polyposis coli protein Human genes 0.000 description 1
• 102100036664 Adenosine deaminase Human genes 0.000 description 1
• 102100032534 Adenosine kinase Human genes 0.000 description 1
• 108010076278 Adenosine kinase Proteins 0.000 description 1
• 102100039677 Adenylate cyclase type 1 Human genes 0.000 description 1
• 102100039675 Adenylate cyclase type 2 Human genes 0.000 description 1
• 102100032161 Adenylate cyclase type 5 Human genes 0.000 description 1
• 102100032158 Adenylate cyclase type 6 Human genes 0.000 description 1
• 102100032152 Adenylate cyclase type 7 Human genes 0.000 description 1
• 102100032153 Adenylate cyclase type 8 Human genes 0.000 description 1
• 102100032156 Adenylate cyclase type 9 Human genes 0.000 description 1
• 108090000115 Adenylate kinase 2 Proteins 0.000 description 1
• 102000003829 Adenylate kinase 2 Human genes 0.000 description 1
• 102100027236 Adenylate kinase isoenzyme 1 Human genes 0.000 description 1
• 108700040193 Adenylosuccinate lyases Proteins 0.000 description 1
• 102100020786 Adenylosuccinate synthetase isozyme 2 Human genes 0.000 description 1
• 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 description 1
• 239000000275 Adrenocorticotropic Hormone Substances 0.000 description 1
• 102100024396 Adrenodoxin, mitochondrial Human genes 0.000 description 1
• 102100036775 Afadin Human genes 0.000 description 1
• 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
• 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
• 102000052030 Aldehyde Dehydrogenase 1 Family Human genes 0.000 description 1
• 108700041701 Aldehyde Dehydrogenase 1 Family Proteins 0.000 description 1
• 102100039075 Aldehyde dehydrogenase family 1 member A3 Human genes 0.000 description 1
• 101710192173 Aldehyde dehydrogenase family 1 member A3 Proteins 0.000 description 1
• 102100026608 Aldehyde dehydrogenase family 3 member A2 Human genes 0.000 description 1
• 102100026609 Aldehyde dehydrogenase family 3 member B1 Human genes 0.000 description 1
• 101710130543 Aldehyde dehydrogenase family 3 member B1 Proteins 0.000 description 1
• 102100026605 Aldehyde dehydrogenase, dimeric NADP-preferring Human genes 0.000 description 1
• 102100036826 Aldehyde oxidase Human genes 0.000 description 1
• 101710131969 Aldehyde oxidase 1 Proteins 0.000 description 1
• 101710117294 Aldo-keto reductase family 1 member C1 Proteins 0.000 description 1
• 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 description 1
• 102100040121 Allograft inflammatory factor 1 Human genes 0.000 description 1
• 101710146120 Alpha-(1,6)-fucosyltransferase Proteins 0.000 description 1
• 102100022622 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Human genes 0.000 description 1
• 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 102100029233 Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Human genes 0.000 description 1
• 102100034033 Alpha-adducin Human genes 0.000 description 1
• 102100024085 Alpha-aminoadipic semialdehyde dehydrogenase Human genes 0.000 description 1
• 102100040743 Alpha-crystallin B chain Human genes 0.000 description 1
• 102100036092 Alpha-endosulfine Human genes 0.000 description 1
• 102100038910 Alpha-enolase Human genes 0.000 description 1
• 102100021763 Alpha-mannosidase 2x Human genes 0.000 description 1
• 201000002434 Alpha-thalassemia-X-linked intellectual disability syndrome Diseases 0.000 description 1
• 208000024827 Alzheimer disease Diseases 0.000 description 1
• 101710181557 Amiloride-sensitive amine oxidase [copper-containing] Proteins 0.000 description 1
• 102100028116 Amine oxidase [flavin-containing] B Human genes 0.000 description 1
• 101710191958 Amino-acid acetyltransferase Proteins 0.000 description 1
• 102100025981 Aminoacylase-1 Human genes 0.000 description 1
• 101710113777 Aminoacylase-1A Proteins 0.000 description 1
• 108010058065 Aminomethyltransferase Proteins 0.000 description 1
• 101710099461 Aminopeptidase N Proteins 0.000 description 1
• 102100040181 Aminopeptidase Q Human genes 0.000 description 1
• 102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 description 1
• 102000014303 Amyloid beta-Protein Precursor Human genes 0.000 description 1
• 108010079054 Amyloid beta-Protein Precursor Proteins 0.000 description 1
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 1
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 1
• 102100040356 Angio-associated migratory cell protein Human genes 0.000 description 1
• 206010059245 Angiopathy Diseases 0.000 description 1
• 102100035765 Angiotensin-converting enzyme 2 Human genes 0.000 description 1
• 102100034566 Ankyrin repeat domain-containing protein 36B Human genes 0.000 description 1
• 102100031366 Ankyrin-1 Human genes 0.000 description 1
• 102100036818 Ankyrin-2 Human genes 0.000 description 1
• 102100036817 Ankyrin-3 Human genes 0.000 description 1
• 102100028118 Annexin A11 Human genes 0.000 description 1
• 102100034613 Annexin A2 Human genes 0.000 description 1
• 102100034612 Annexin A4 Human genes 0.000 description 1
• 102100034278 Annexin A6 Human genes 0.000 description 1
• 101710081722 Antitrypsin Proteins 0.000 description 1
• 102100039998 Apolipoprotein C-II Human genes 0.000 description 1
• 102100027308 Apoptosis regulator BAX Human genes 0.000 description 1
• 102100034524 Apoptotic protease-activating factor 1 Human genes 0.000 description 1
• 108010036280 Aquaporin 4 Proteins 0.000 description 1
• 102000004392 Aquaporin 5 Human genes 0.000 description 1
• 108090000976 Aquaporin 5 Proteins 0.000 description 1
• 102100037276 Aquaporin-4 Human genes 0.000 description 1
• 102100029464 Aquaporin-9 Human genes 0.000 description 1
• 101001099507 Arabidopsis thaliana Peroxidase 19 Proteins 0.000 description 1
• 108010076676 Arachidonate 12-lipoxygenase Proteins 0.000 description 1
• 108010048907 Arachidonate 15-lipoxygenase Proteins 0.000 description 1
• 102100024365 Arf-GAP domain and FG repeat-containing protein 1 Human genes 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 102100028449 Arginine-glutamic acid dipeptide repeats protein Human genes 0.000 description 1
• 102000009042 Argininosuccinate Lyase Human genes 0.000 description 1
• 108090000448 Aryl Hydrocarbon Receptors Proteins 0.000 description 1
• 102100026792 Aryl hydrocarbon receptor Human genes 0.000 description 1
• 102100033887 Arylsulfatase D Human genes 0.000 description 1
• 101710115246 Arylsulfatase L Proteins 0.000 description 1
• 102100023245 Asparagine-tRNA ligase, cytoplasmic Human genes 0.000 description 1
• 108010011485 Aspartame Proteins 0.000 description 1
• 101710203251 Aspartate aminotransferase 1 Proteins 0.000 description 1
• 102100028820 Aspartate-tRNA ligase, cytoplasmic Human genes 0.000 description 1
• 102100022108 Aspartyl/asparaginyl beta-hydroxylase Human genes 0.000 description 1
• 108010023546 Aspartylglucosylaminase Proteins 0.000 description 1
• 102100035029 Ataxin-1 Human genes 0.000 description 1
• 102100021321 Ataxin-3 Human genes 0.000 description 1
• 108010032947 Ataxin-3 Proteins 0.000 description 1
• 102100020741 Atrophin-1 Human genes 0.000 description 1
• 208000023275 Autoimmune disease Diseases 0.000 description 1
• 208000023095 Autosomal dominant epidermolytic ichthyosis Diseases 0.000 description 1
• 102100032481 B-cell CLL/lymphoma 9 protein Human genes 0.000 description 1
• 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 description 1
• 101710111825 B-cell lymphoma 6 protein Proteins 0.000 description 1
• 108700000712 BH3 Interacting Domain Death Agonist Proteins 0.000 description 1
• 102100035740 BH3-interacting domain death agonist Human genes 0.000 description 1
• 108091007065 BIRCs Proteins 0.000 description 1
• 102100021531 BPI fold-containing family B member 1 Human genes 0.000 description 1
• 102100028048 BRCA1-associated RING domain protein 1 Human genes 0.000 description 1
• 101001074429 Bacillus subtilis (strain 168) Polyketide biosynthesis acyltransferase homolog PksD Proteins 0.000 description 1
• 101000936617 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) Polyketide biosynthesis acyltransferase homolog BaeD Proteins 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• 108700003785 Baculoviral IAP Repeat-Containing 3 Proteins 0.000 description 1
• 102100021676 Baculoviral IAP repeat-containing protein 1 Human genes 0.000 description 1
• 102100021677 Baculoviral IAP repeat-containing protein 2 Human genes 0.000 description 1
• 102100021662 Baculoviral IAP repeat-containing protein 3 Human genes 0.000 description 1
• 102100024747 Band 4.1-like protein 1 Human genes 0.000 description 1
• 102100023045 Band 4.1-like protein 2 Human genes 0.000 description 1
• 102100021295 Bardet-Biedl syndrome 1 protein Human genes 0.000 description 1
• 201000009187 Bardet-Biedl syndrome 2 Diseases 0.000 description 1
• 102100027883 Bardet-Biedl syndrome 2 protein Human genes 0.000 description 1
• 102100022440 Battenin Human genes 0.000 description 1
• 102100032305 Bcl-2 homologous antagonist/killer Human genes 0.000 description 1
• 102100021334 Bcl-2-related protein A1 Human genes 0.000 description 1
• 102100031403 Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe Human genes 0.000 description 1
• 102100026349 Beta-1,4-galactosyltransferase 1 Human genes 0.000 description 1
• 102100027314 Beta-2-microglobulin Human genes 0.000 description 1
• 102100031006 Beta-Ala-His dipeptidase Human genes 0.000 description 1
• 102100021738 Beta-adrenergic receptor kinase 1 Human genes 0.000 description 1
• 102100029648 Beta-arrestin-2 Human genes 0.000 description 1
• 102100035388 Beta-enolase Human genes 0.000 description 1
• 102100026031 Beta-glucuronidase Human genes 0.000 description 1
• 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 description 1
• 102100022549 Beta-hexosaminidase subunit beta Human genes 0.000 description 1
• KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
• 102100025991 Betaine-homocysteine S-methyltransferase 1 Human genes 0.000 description 1
• 102100030401 Biglycan Human genes 0.000 description 1
• 102100035752 Biliverdin reductase A Human genes 0.000 description 1
• 102100026044 Biotinidase Human genes 0.000 description 1
• 102100036200 Bisphosphoglycerate mutase Human genes 0.000 description 1
• 102100027058 Bleomycin hydrolase Human genes 0.000 description 1
• 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
• 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
• 208000005692 Bloom Syndrome Diseases 0.000 description 1
• 101100396232 Bombyx mori EN03 gene Proteins 0.000 description 1
• 102000001893 Bone Morphogenetic Protein Receptors Human genes 0.000 description 1
• 108010040422 Bone Morphogenetic Protein Receptors Proteins 0.000 description 1
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 1
• 102100024505 Bone morphogenetic protein 4 Human genes 0.000 description 1
• 102100022525 Bone morphogenetic protein 6 Human genes 0.000 description 1
• 102100025422 Bone morphogenetic protein receptor type-2 Human genes 0.000 description 1
• 108700025148 Bos taurus AP2A1 Proteins 0.000 description 1
• 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 description 1
• 208000003174 Brain Neoplasms Diseases 0.000 description 1
• 102100026413 Branched-chain-amino-acid aminotransferase, mitochondrial Human genes 0.000 description 1
• 102100026008 Breakpoint cluster region protein Human genes 0.000 description 1
• 102100025401 Breast cancer type 1 susceptibility protein Human genes 0.000 description 1
• 102100025399 Breast cancer type 2 susceptibility protein Human genes 0.000 description 1
• 102100021714 Bystin Human genes 0.000 description 1
• 102100031174 C-C chemokine receptor type 10 Human genes 0.000 description 1
• 102100021411 C-terminal-binding protein 2 Human genes 0.000 description 1
• 102100026194 C-type lectin domain family 2 member B Human genes 0.000 description 1
• 102100034808 CCAAT/enhancer-binding protein alpha Human genes 0.000 description 1
• 102100034798 CCAAT/enhancer-binding protein beta Human genes 0.000 description 1
• 102100031168 CCN family member 2 Human genes 0.000 description 1
• 102100037917 CD109 antigen Human genes 0.000 description 1
• 102100035893 CD151 antigen Human genes 0.000 description 1
• 108010062433 CD28 Antigens Proteins 0.000 description 1
• 102000010910 CD28 Antigens Human genes 0.000 description 1
• 108010063916 CD40 Antigens Proteins 0.000 description 1
• 101150013553 CD40 gene Proteins 0.000 description 1
• 108091016585 CD44 antigen Proteins 0.000 description 1
• 108010058590 CD47 Antigen Proteins 0.000 description 1
• 102000006355 CD47 Antigen Human genes 0.000 description 1
• 108010009575 CD55 Antigens Proteins 0.000 description 1
• 108010084313 CD58 Antigens Proteins 0.000 description 1
• 102100025221 CD70 antigen Human genes 0.000 description 1
• 108010001445 CD79 Antigens Proteins 0.000 description 1
• 102000000796 CD79 Antigens Human genes 0.000 description 1
• 102100027217 CD82 antigen Human genes 0.000 description 1
• 102100037904 CD9 antigen Human genes 0.000 description 1
• 229940126074 CDK kinase inhibitor Drugs 0.000 description 1
• 102100030933 CDK-activating kinase assembly factor MAT1 Human genes 0.000 description 1
• 208000033527 CLN3 disease Diseases 0.000 description 1
• 108010040163 CREB-Binding Protein Proteins 0.000 description 1
• 108010021064 CTLA-4 Antigen Proteins 0.000 description 1
• 102000008203 CTLA-4 Antigen Human genes 0.000 description 1
• 102100039866 CTP synthase 1 Human genes 0.000 description 1
• 102100025659 Cadherin EGF LAG seven-pass G-type receptor 1 Human genes 0.000 description 1
• 102100036360 Cadherin-3 Human genes 0.000 description 1
• 108010042955 Calcineurin Proteins 0.000 description 1
• 102000004631 Calcineurin Human genes 0.000 description 1
• 102100036431 Calcineurin subunit B type 1 Human genes 0.000 description 1
• 102100027557 Calcipressin-1 Human genes 0.000 description 1
• 102100025228 Calcium/calmodulin-dependent protein kinase type II subunit delta Human genes 0.000 description 1
• 102100022789 Calcium/calmodulin-dependent protein kinase type IV Human genes 0.000 description 1
• 102100024436 Caldesmon Human genes 0.000 description 1
• 101710164735 Calmodulin-1 Proteins 0.000 description 1
• 101710164738 Calmodulin-3 Proteins 0.000 description 1
• 102100036339 Calmodulin-like protein 3 Human genes 0.000 description 1
• 102100021868 Calnexin Human genes 0.000 description 1
• 102100035037 Calpastatin Human genes 0.000 description 1
• 102100029968 Calreticulin Human genes 0.000 description 1
• 102100021848 Calumenin Human genes 0.000 description 1
• 101710191075 Calumenin Proteins 0.000 description 1
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
• 102100029949 Caprin-1 Human genes 0.000 description 1
• 102100033040 Carbonic anhydrase 12 Human genes 0.000 description 1
• 102100021973 Carbonyl reductase [NADPH] 1 Human genes 0.000 description 1
• 102100035249 Carbonyl reductase [NADPH] 3 Human genes 0.000 description 1
• 102100026678 Carboxypeptidase N catalytic chain Human genes 0.000 description 1
• 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 description 1
• 101710190843 Carcinoembryonic antigen-related cell adhesion molecule 1 Proteins 0.000 description 1
• 208000005623 Carcinogenesis Diseases 0.000 description 1
• 201000009030 Carcinoma Diseases 0.000 description 1
• 102100028892 Cardiotrophin-1 Human genes 0.000 description 1
• 102100027943 Carnitine O-palmitoyltransferase 1, liver isoform Human genes 0.000 description 1
• 101710108984 Carnitine O-palmitoyltransferase 1, muscle isoform Proteins 0.000 description 1
• 102100024853 Carnitine O-palmitoyltransferase 2, mitochondrial Human genes 0.000 description 1
• 102100034357 Casein kinase I isoform alpha Human genes 0.000 description 1
• 102100037402 Casein kinase I isoform delta Human genes 0.000 description 1
• 102100037398 Casein kinase I isoform epsilon Human genes 0.000 description 1
• 102100040753 Casein kinase II subunit alpha' Human genes 0.000 description 1
• 108010076119 Caseins Proteins 0.000 description 1
• 102000011632 Caseins Human genes 0.000 description 1
• 108090000567 Caspase 7 Proteins 0.000 description 1
• 102100024931 Caspase-14 Human genes 0.000 description 1
• 108090000552 Caspase-2 Proteins 0.000 description 1
• 102100029855 Caspase-3 Human genes 0.000 description 1
• 102100038902 Caspase-7 Human genes 0.000 description 1
• 102100035882 Catalase Human genes 0.000 description 1
• 108010053835 Catalase Proteins 0.000 description 1
• 108020002739 Catechol O-methyltransferase Proteins 0.000 description 1
• 102100040999 Catechol O-methyltransferase Human genes 0.000 description 1
• 102100028002 Catenin alpha-2 Human genes 0.000 description 1
• 102100021633 Cathepsin B Human genes 0.000 description 1
• 102100024940 Cathepsin K Human genes 0.000 description 1
• 102100026657 Cathepsin Z Human genes 0.000 description 1
• 101710145225 Cation-independent mannose-6-phosphate receptor Proteins 0.000 description 1
• 102100035888 Caveolin-1 Human genes 0.000 description 1
• 102100038909 Caveolin-2 Human genes 0.000 description 1
• 102100032212 Caveolin-3 Human genes 0.000 description 1
• ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 description 1
• 101150023302 Cdc20 gene Proteins 0.000 description 1
• 102100025051 Cell division control protein 42 homolog Human genes 0.000 description 1
• 102100034929 Cell division cycle protein 27 homolog Human genes 0.000 description 1
• 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 description 1
• 108010091675 Cellular Apoptosis Susceptibility Protein Proteins 0.000 description 1
• 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 1
• 102100037631 Centrin-2 Human genes 0.000 description 1
• 102100025828 Centromere protein C Human genes 0.000 description 1
• 102100023343 Centromere protein I Human genes 0.000 description 1
• 102100025832 Centromere-associated protein E Human genes 0.000 description 1
• 102000004201 Ceramidases Human genes 0.000 description 1
• 108090000751 Ceramidases Proteins 0.000 description 1
• 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 description 1
• 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
• 102100034505 Ceroid-lipofuscinosis neuronal protein 5 Human genes 0.000 description 1
• 108010010706 Chaperonin Containing TCP-1 Proteins 0.000 description 1
• 102100028487 Checkpoint protein HUS1 Human genes 0.000 description 1
• 102100031011 Chemerin-like receptor 1 Human genes 0.000 description 1
• 108700038876 Chemerin-like receptor 1 Proteins 0.000 description 1
• 102000016951 Chemokine CXCL2 Human genes 0.000 description 1
• 108010014414 Chemokine CXCL2 Proteins 0.000 description 1
• 102100038196 Chitinase-3-like protein 1 Human genes 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
• 102100034667 Chloride intracellular channel protein 1 Human genes 0.000 description 1
• 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 description 1
• 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 description 1
• 102100037637 Cholesteryl ester transfer protein Human genes 0.000 description 1
• 102100031065 Choline kinase alpha Human genes 0.000 description 1
• 102100031082 Choline/ethanolamine kinase Human genes 0.000 description 1
• 108010009685 Cholinergic Receptors Proteins 0.000 description 1
• 208000033810 Choroidal dystrophy Diseases 0.000 description 1
• 102100031265 Chromodomain-helicase-DNA-binding protein 2 Human genes 0.000 description 1
• 102100031266 Chromodomain-helicase-DNA-binding protein 3 Human genes 0.000 description 1
• 102100038214 Chromodomain-helicase-DNA-binding protein 4 Human genes 0.000 description 1
• 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 description 1
• 102100031614 Ciliary neurotrophic factor Human genes 0.000 description 1
• 108010071536 Citrate (Si)-synthase Proteins 0.000 description 1
• 102000006732 Citrate synthase Human genes 0.000 description 1
• 102100034467 Clathrin light chain A Human genes 0.000 description 1
• 102100040269 Cleavage stimulation factor subunit 2 Human genes 0.000 description 1
• 102100040267 Cleavage stimulation factor subunit 3 Human genes 0.000 description 1
• 101150001828 Cmklr1 gene Proteins 0.000 description 1
• 102100026735 Coagulation factor VIII Human genes 0.000 description 1
• 108700022408 Coatomer Proteins 0.000 description 1
• 102000057710 Coatomer Human genes 0.000 description 1
• 102100028289 Coatomer subunit delta Human genes 0.000 description 1
• 101710152347 Cochlin Proteins 0.000 description 1
• 208000010200 Cockayne syndrome Diseases 0.000 description 1
• UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 description 1
• 101000916659 Coffea arabica Probable caffeine synthase 3 Proteins 0.000 description 1
• 101000895742 Coffea canephora Probable caffeine synthase MTL2 Proteins 0.000 description 1
• 102100027440 Cofilin-2 Human genes 0.000 description 1
• 102100023774 Cold-inducible RNA-binding protein Human genes 0.000 description 1
• 108010048623 Collagen Receptors Proteins 0.000 description 1
• 102100022145 Collagen alpha-1(IV) chain Human genes 0.000 description 1
• 102100031519 Collagen alpha-1(VI) chain Human genes 0.000 description 1
• 102100027442 Collagen alpha-1(XII) chain Human genes 0.000 description 1
• 102100028257 Collagen alpha-1(XVI) chain Human genes 0.000 description 1
• 102100036213 Collagen alpha-2(I) chain Human genes 0.000 description 1
• 102100030976 Collagen alpha-2(IX) chain Human genes 0.000 description 1
• 102100031502 Collagen alpha-2(V) chain Human genes 0.000 description 1
• 102100040496 Collagen alpha-2(VIII) chain Human genes 0.000 description 1
• 102100033885 Collagen alpha-2(XI) chain Human genes 0.000 description 1
• 206010048832 Colon adenoma Diseases 0.000 description 1
• 102100032778 Colorectal mutant cancer protein Human genes 0.000 description 1
• 101710190564 Colorectal mutant cancer protein Proteins 0.000 description 1
• 102100037085 Complement C1q subcomponent subunit B Human genes 0.000 description 1
• 102100025849 Complement C1q subcomponent subunit C Human genes 0.000 description 1
• 108010028773 Complement C5 Proteins 0.000 description 1
• 102100031506 Complement C5 Human genes 0.000 description 1
• 102100037078 Complement component 1 Q subcomponent-binding protein, mitochondrial Human genes 0.000 description 1
• 102100035432 Complement factor H Human genes 0.000 description 1
• 102100040451 Connector enhancer of kinase suppressor of ras 3 Human genes 0.000 description 1
• 102100024326 Contactin-1 Human genes 0.000 description 1
• 241000761389 Copa Species 0.000 description 1
• 102100032636 Copine-1 Human genes 0.000 description 1
• 102100029767 Copper transport protein ATOX1 Human genes 0.000 description 1
• 102000012437 Copper-Transporting ATPases Human genes 0.000 description 1
• 102100027591 Copper-transporting ATPase 2 Human genes 0.000 description 1
• 108010079362 Core Binding Factor Alpha 3 Subunit Proteins 0.000 description 1
• 108010060313 Core Binding Factor beta Subunit Proteins 0.000 description 1
• 102400000739 Corticotropin Human genes 0.000 description 1
• 101800000414 Corticotropin Proteins 0.000 description 1
• 229920000742 Cotton Polymers 0.000 description 1
• 241000709687 Coxsackievirus Species 0.000 description 1
• 102100025278 Coxsackievirus and adenovirus receptor Human genes 0.000 description 1
• 102100029376 Cryptochrome-1 Human genes 0.000 description 1
• 102100026280 Cryptochrome-2 Human genes 0.000 description 1
• 102100025571 Cutaneous T-cell lymphoma-associated antigen 1 Human genes 0.000 description 1
• 102100023026 Cyclic AMP-dependent transcription factor ATF-1 Human genes 0.000 description 1
• 102100023032 Cyclic AMP-dependent transcription factor ATF-3 Human genes 0.000 description 1
• 102100026359 Cyclic AMP-responsive element-binding protein 1 Human genes 0.000 description 1
• 102000003910 Cyclin D Human genes 0.000 description 1
• 108090000259 Cyclin D Proteins 0.000 description 1
• 102100025191 Cyclin-A2 Human genes 0.000 description 1
• 102100024170 Cyclin-C Human genes 0.000 description 1
• 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 1
• 108010025454 Cyclin-Dependent Kinase 5 Proteins 0.000 description 1
• 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 description 1
• 108010025461 Cyclin-Dependent Kinase 9 Proteins 0.000 description 1
• 108010016777 Cyclin-Dependent Kinase Inhibitor p27 Proteins 0.000 description 1
• 102000000577 Cyclin-Dependent Kinase Inhibitor p27 Human genes 0.000 description 1
• 108010017222 Cyclin-Dependent Kinase Inhibitor p57 Proteins 0.000 description 1
• 102000004480 Cyclin-Dependent Kinase Inhibitor p57 Human genes 0.000 description 1
• 102100038254 Cyclin-F Human genes 0.000 description 1
• 102100039683 Cyclin-G-associated kinase Human genes 0.000 description 1
• 102100036883 Cyclin-H Human genes 0.000 description 1
• 102100024109 Cyclin-T1 Human genes 0.000 description 1
• 102100036329 Cyclin-dependent kinase 3 Human genes 0.000 description 1
• 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 1
• 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 description 1
• 101710106276 Cyclin-dependent kinase 7 Proteins 0.000 description 1
• 101710157591 Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 1
• 102100034501 Cyclin-dependent kinases regulatory subunit 1 Human genes 0.000 description 1
• 102100026805 Cyclin-dependent-like kinase 5 Human genes 0.000 description 1
• YPWSLBHSMIKTPR-UHFFFAOYSA-N Cystathionine Natural products OC(=O)C(N)CCSSCC(N)C(O)=O YPWSLBHSMIKTPR-UHFFFAOYSA-N 0.000 description 1
• 102000020018 Cystathionine gamma-Lyase Human genes 0.000 description 1
• 108010045283 Cystathionine gamma-lyase Proteins 0.000 description 1
• 108010061642 Cystatin C Proteins 0.000 description 1
• 102100031237 Cystatin-A Human genes 0.000 description 1
• 102100026891 Cystatin-B Human genes 0.000 description 1
• 102100038387 Cystatin-SN Human genes 0.000 description 1
• 102100031051 Cysteine and glycine-rich protein 1 Human genes 0.000 description 1
• 102100031621 Cysteine and glycine-rich protein 2 Human genes 0.000 description 1
• 102000005889 Cysteine-Rich Protein 61 Human genes 0.000 description 1
• 108010019961 Cysteine-Rich Protein 61 Proteins 0.000 description 1
• 102100031089 Cystinosin Human genes 0.000 description 1
• 108010001202 Cytochrome P-450 CYP2E1 Proteins 0.000 description 1
• 102100039282 Cytochrome P450 26A1 Human genes 0.000 description 1
• 102100036194 Cytochrome P450 2A6 Human genes 0.000 description 1
• 102100038739 Cytochrome P450 2B6 Human genes 0.000 description 1
• 102100024889 Cytochrome P450 2E1 Human genes 0.000 description 1
• 102100027419 Cytochrome P450 4B1 Human genes 0.000 description 1
• 102100025620 Cytochrome b-245 light chain Human genes 0.000 description 1
• 102100031655 Cytochrome b5 Human genes 0.000 description 1
• 102100024638 Cytochrome c oxidase subunit 5B, mitochondrial Human genes 0.000 description 1
• 102100038835 Cytochrome c oxidase subunit 7B, mitochondrial Human genes 0.000 description 1
• 102100030512 Cytochrome c oxidase subunit 7C, mitochondrial Human genes 0.000 description 1
• 108050008072 Cytochrome c oxidase subunit IV Proteins 0.000 description 1
• 102000018832 Cytochromes Human genes 0.000 description 1
• 108010052832 Cytochromes Proteins 0.000 description 1
• 108010007167 Cytochromes b5 Proteins 0.000 description 1
• 102100032218 Cytokine-inducible SH2-containing protein Human genes 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• 102100031635 Cytoplasmic dynein 1 heavy chain 1 Human genes 0.000 description 1
• 102100036318 Cytoplasmic phosphatidylinositol transfer protein 1 Human genes 0.000 description 1
• 102100036952 Cytoplasmic protein NCK2 Human genes 0.000 description 1
• GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
• ILRYLPWNYFXEMH-UHFFFAOYSA-N D-cystathionine Natural products OC(=O)C(N)CCSCC(N)C(O)=O ILRYLPWNYFXEMH-UHFFFAOYSA-N 0.000 description 1
• 102100033133 D-dopachrome decarboxylase Human genes 0.000 description 1
• 101710119398 D-dopachrome decarboxylase Proteins 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Chemical class OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
• LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 description 1
• NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 description 1
• 108010009540 DNA (Cytosine-5-)-Methyltransferase 1 Proteins 0.000 description 1
• 102100036279 DNA (cytosine-5)-methyltransferase 1 Human genes 0.000 description 1
• 102100040262 DNA dC->dU-editing enzyme APOBEC-3B Human genes 0.000 description 1
• 101710137105 DNA damage-binding protein 2 Proteins 0.000 description 1
• 102100035186 DNA excision repair protein ERCC-1 Human genes 0.000 description 1
• 108010035476 DNA excision repair protein ERCC-5 Proteins 0.000 description 1
• 102100038026 DNA fragmentation factor subunit alpha Human genes 0.000 description 1
• 102100033195 DNA ligase 4 Human genes 0.000 description 1
• 102100037700 DNA mismatch repair protein Msh3 Human genes 0.000 description 1
• 102100021147 DNA mismatch repair protein Msh6 Human genes 0.000 description 1
• 102100033484 DNA repair and recombination protein RAD54-like Human genes 0.000 description 1
• 101710179332 DNA repair and recombination protein RAD54-like Proteins 0.000 description 1
• 102100030380 DNA replication complex GINS protein SLD5 Human genes 0.000 description 1
• 101710179497 DNA replication helicase Proteins 0.000 description 1
• 102100024607 DNA topoisomerase 1 Human genes 0.000 description 1
• 102100038694 DNA-binding protein SMUBP-2 Human genes 0.000 description 1
• 101710152088 DNA-binding protein inhibitor ID-1 Proteins 0.000 description 1
• 101710152064 DNA-binding protein inhibitor ID-3 Proteins 0.000 description 1
• 101710152058 DNA-binding protein inhibitor ID-4 Proteins 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 102100039886 DNA-directed RNA polymerase III subunit RPC4 Human genes 0.000 description 1
• 102100028559 Death domain-associated protein 6 Human genes 0.000 description 1
• 102100039694 Death-associated protein 1 Human genes 0.000 description 1
• 102100037618 Decapping and exoribonuclease protein Human genes 0.000 description 1
• 102100031598 Dedicator of cytokinesis protein 1 Human genes 0.000 description 1
• 102100024347 Dedicator of cytokinesis protein 5 Human genes 0.000 description 1
• 102100034690 Delta(14)-sterol reductase LBR Human genes 0.000 description 1
• 102100035890 Delta(24)-sterol reductase Human genes 0.000 description 1
• 102100040515 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Human genes 0.000 description 1
• 108010033174 Deoxycytidine kinase Proteins 0.000 description 1
• 108010058222 Deoxyguanosine kinase Proteins 0.000 description 1
• 102100036853 Deoxyguanosine kinase, mitochondrial Human genes 0.000 description 1
• 102100031242 Deoxyhypusine synthase Human genes 0.000 description 1
• 102100022872 Deoxyribonuclease-1-like 1 Human genes 0.000 description 1
• 101710094552 Deoxyribonuclease-1-like 1 Proteins 0.000 description 1
• 102100022882 Deoxyribonuclease-2-alpha Human genes 0.000 description 1
• 102100023933 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Human genes 0.000 description 1
• 102100040481 Desmocollin-2 Human genes 0.000 description 1
• 108010032035 Desmoglein 3 Proteins 0.000 description 1
• 102100034578 Desmoglein-2 Human genes 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• 102100022735 Diacylglycerol kinase alpha Human genes 0.000 description 1
• 102100030221 Diacylglycerol kinase theta Human genes 0.000 description 1
• 108010039287 Diazepam Binding Inhibitor Proteins 0.000 description 1
• 102100024746 Dihydrofolate reductase Human genes 0.000 description 1
• 102000028526 Dihydrolipoamide Dehydrogenase Human genes 0.000 description 1
• 108010028127 Dihydrolipoamide Dehydrogenase Proteins 0.000 description 1
• 108010073112 Dihydrolipoyllysine-residue acetyltransferase Proteins 0.000 description 1
• 102000009093 Dihydrolipoyllysine-residue acetyltransferase Human genes 0.000 description 1
• 102100027152 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Human genes 0.000 description 1
• 102100031920 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Human genes 0.000 description 1
• 102100022188 Dihydropyrimidinase-related protein 1 Human genes 0.000 description 1
• 102100024425 Dihydropyrimidinase-related protein 3 Human genes 0.000 description 1
• 102100022334 Dihydropyrimidine dehydrogenase [NADP(+)] Human genes 0.000 description 1
• 108010006731 Dimethylallyltranstransferase Proteins 0.000 description 1
• 102100032788 Dimethylaniline monooxygenase [N-oxide-forming] 1 Human genes 0.000 description 1
• 102100035046 Dimethylaniline monooxygenase [N-oxide-forming] 4 Human genes 0.000 description 1
• 108010016626 Dipeptides Proteins 0.000 description 1
• 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 description 1
• 102100029921 Dipeptidyl peptidase 1 Human genes 0.000 description 1
• 101710197163 Disabled homolog 2 Proteins 0.000 description 1
• 102000002706 Discoidin Domain Receptors Human genes 0.000 description 1
• 108010043648 Discoidin Domain Receptors Proteins 0.000 description 1
• 102100027043 Discoidin, CUB and LCCL domain-containing protein 2 Human genes 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• 101800001224 Disintegrin Proteins 0.000 description 1
• 102100039673 Disintegrin and metalloproteinase domain-containing protein 10 Human genes 0.000 description 1
• 102100024099 Disks large homolog 1 Human genes 0.000 description 1
• 102100037980 Disks large-associated protein 5 Human genes 0.000 description 1
• 102100035372 DmX-like protein 1 Human genes 0.000 description 1
• 102100029714 DnaJ homolog subfamily B member 2 Human genes 0.000 description 1
• 102100031682 DnaJ homolog subfamily C member 4 Human genes 0.000 description 1
• 108010042091 Dodecenoyl-CoA Isomerase Proteins 0.000 description 1
• 102000004334 Dodecenoyl-CoA Isomerase Human genes 0.000 description 1
• 102100039104 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Human genes 0.000 description 1
• 102100038002 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A Human genes 0.000 description 1
• 241001669680 Dormitator maculatus Species 0.000 description 1
• 102100038191 Double-stranded RNA-specific editase 1 Human genes 0.000 description 1
• 102100028952 Drebrin Human genes 0.000 description 1
• 101710167313 Drebrin-like protein Proteins 0.000 description 1
• 101100015729 Drosophila melanogaster drk gene Proteins 0.000 description 1
• 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
• 108010038536 Dual Specificity Phosphatase 3 Proteins 0.000 description 1
• 102100028987 Dual specificity protein phosphatase 2 Human genes 0.000 description 1
• 102100027085 Dual specificity protein phosphatase 4 Human genes 0.000 description 1
• 102100027274 Dual specificity protein phosphatase 6 Human genes 0.000 description 1
• 108010044191 Dynamin II Proteins 0.000 description 1
• 102100021238 Dynamin-2 Human genes 0.000 description 1
• 102100040610 Dynein regulatory complex subunit 4 Human genes 0.000 description 1
• 102100032249 Dystonin Human genes 0.000 description 1
• 102100024074 Dystrobrevin alpha Human genes 0.000 description 1
• 108010071885 Dystroglycans Proteins 0.000 description 1
• 102100035374 Dystrophia myotonica WD repeat-containing protein Human genes 0.000 description 1
• 108010036466 E2F2 Transcription Factor Proteins 0.000 description 1
• 102100032045 E3 ubiquitin-protein ligase AMFR Human genes 0.000 description 1
• 102100035273 E3 ubiquitin-protein ligase CBL-B Human genes 0.000 description 1
• 102100033991 E3 ubiquitin-protein ligase DTX1 Human genes 0.000 description 1
• 102100031788 E3 ubiquitin-protein ligase MYLIP Human genes 0.000 description 1
• 102100031918 E3 ubiquitin-protein ligase NEDD4 Human genes 0.000 description 1
• 102100039812 E3 ubiquitin-protein ligase RNF182 Human genes 0.000 description 1
• 102100040322 E3 ubiquitin-protein ligase RNF183 Human genes 0.000 description 1
• 102100034596 E3 ubiquitin-protein ligase TRIM23 Human genes 0.000 description 1
• 102100040068 E3 ubiquitin-protein ligase TRIM37 Human genes 0.000 description 1
• 102100037024 E3 ubiquitin-protein ligase XIAP Human genes 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 101150059401 EGR2 gene Proteins 0.000 description 1
• 102100032057 ETS domain-containing protein Elk-1 Human genes 0.000 description 1
• 102100030768 ETS domain-containing transcription factor ERF Human genes 0.000 description 1
• 102000040848 ETS family Human genes 0.000 description 1
• 108091071901 ETS family Proteins 0.000 description 1
• 102100039563 ETS translocation variant 1 Human genes 0.000 description 1
• 102100039562 ETS translocation variant 3 Human genes 0.000 description 1
• 102100039577 ETS translocation variant 5 Human genes 0.000 description 1
• 102100035075 ETS-related transcription factor Elf-1 Human genes 0.000 description 1
• 101710131938 ETS-related transcription factor Elf-1 Proteins 0.000 description 1
• 102100035078 ETS-related transcription factor Elf-2 Human genes 0.000 description 1
• 101710131939 ETS-related transcription factor Elf-2 Proteins 0.000 description 1
• 102100039244 ETS-related transcription factor Elf-5 Human genes 0.000 description 1
• 108700037660 ETS-related transcription factor Elf-5 Proteins 0.000 description 1
• 102100021717 Early growth response protein 3 Human genes 0.000 description 1
• 102100027094 Echinoderm microtubule-associated protein-like 1 Human genes 0.000 description 1
• 241000258955 Echinodermata Species 0.000 description 1
• 101710116079 Ectonucleoside triphosphate diphosphohydrolase 6 Proteins 0.000 description 1
• 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 description 1
• 102100037249 Egl nine homolog 1 Human genes 0.000 description 1
• 102100030695 Electron transfer flavoprotein subunit alpha, mitochondrial Human genes 0.000 description 1
• 102100031804 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial Human genes 0.000 description 1
• 102100029108 Elongation factor 1-alpha 2 Human genes 0.000 description 1
• 102100032050 Elongation of very long chain fatty acids protein 2 Human genes 0.000 description 1
• 108700041152 Endoplasmic Reticulum Chaperone BiP Proteins 0.000 description 1
• 102100021451 Endoplasmic reticulum chaperone BiP Human genes 0.000 description 1
• 102100031702 Endoplasmic reticulum membrane sensor NFE2L1 Human genes 0.000 description 1
• 102100036448 Endothelial PAS domain-containing protein 1 Human genes 0.000 description 1
• 102100040611 Endothelin receptor type B Human genes 0.000 description 1
• 102100021579 Enhancer of filamentation 1 Human genes 0.000 description 1
• 101710128765 Enhancer of filamentation 1 Proteins 0.000 description 1
• 101710184324 Enhancer of rudimentary homolog Proteins 0.000 description 1
• 102100021821 Enoyl-CoA delta isomerase 1, mitochondrial Human genes 0.000 description 1
• 102100021822 Enoyl-CoA hydratase, mitochondrial Human genes 0.000 description 1
• 101710180035 Enoyl-CoA hydratase, mitochondrial Proteins 0.000 description 1
• 102100030324 Ephrin type-A receptor 3 Human genes 0.000 description 1
• 102100021616 Ephrin type-A receptor 4 Human genes 0.000 description 1
• 102100031982 Ephrin type-B receptor 3 Human genes 0.000 description 1
• 108010043945 Ephrin-A1 Proteins 0.000 description 1
• 102000020086 Ephrin-A1 Human genes 0.000 description 1
• 102100023733 Ephrin-B3 Human genes 0.000 description 1
• 108010044085 Ephrin-B3 Proteins 0.000 description 1
• 102100039369 Epidermal growth factor receptor substrate 15 Human genes 0.000 description 1
• 201000009040 Epidermolytic Hyperkeratosis Diseases 0.000 description 1
• 102100036725 Epithelial discoidin domain-containing receptor 1 Human genes 0.000 description 1
• 101710131668 Epithelial discoidin domain-containing receptor 1 Proteins 0.000 description 1
• 102100033183 Epithelial membrane protein 1 Human genes 0.000 description 1
• 102100033176 Epithelial membrane protein 2 Human genes 0.000 description 1
• 102100030146 Epithelial membrane protein 3 Human genes 0.000 description 1
• 101710167546 Epoxide hydrolase 1 Proteins 0.000 description 1
• 102000044972 Equilibrative nucleoside transporter 1 Human genes 0.000 description 1
• 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 description 1
• 206010049466 Erythroblastosis Diseases 0.000 description 1
• 208000036566 Erythroleukaemia Diseases 0.000 description 1
• 241000588724 Escherichia coli Species 0.000 description 1
• 241000701959 Escherichia virus Lambda Species 0.000 description 1
• 108010082945 Eukaryotic Initiation Factor-2B Proteins 0.000 description 1
• 102000005233 Eukaryotic Initiation Factor-4E Human genes 0.000 description 1
• 108060002636 Eukaryotic Initiation Factor-4E Proteins 0.000 description 1
• 102100039950 Eukaryotic initiation factor 4A-I Human genes 0.000 description 1
• 102100022462 Eukaryotic initiation factor 4A-II Human genes 0.000 description 1
• 102100036816 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Human genes 0.000 description 1
• 102100030667 Eukaryotic peptide chain release factor subunit 1 Human genes 0.000 description 1
• 102100035549 Eukaryotic translation initiation factor 2 subunit 1 Human genes 0.000 description 1
• 102100040015 Eukaryotic translation initiation factor 2 subunit 3 Human genes 0.000 description 1
• 102100038075 Eukaryotic translation initiation factor 2D Human genes 0.000 description 1
• 102100039737 Eukaryotic translation initiation factor 4 gamma 2 Human genes 0.000 description 1
• 101710190709 Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 description 1
• 102100029602 Eukaryotic translation initiation factor 4B Human genes 0.000 description 1
• 102100022466 Eukaryotic translation initiation factor 4E-binding protein 1 Human genes 0.000 description 1
• 102100022447 Eukaryotic translation initiation factor 4E-binding protein 2 Human genes 0.000 description 1
• 102100020987 Eukaryotic translation initiation factor 5 Human genes 0.000 description 1
• 102100026761 Eukaryotic translation initiation factor 5A-1 Human genes 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 108060002716 Exonuclease Proteins 0.000 description 1
• 102100029055 Exostosin-1 Human genes 0.000 description 1
• 102100035977 Exostosin-like 2 Human genes 0.000 description 1
• 102100031758 Extracellular matrix protein 1 Human genes 0.000 description 1
• 101710127932 Extracellular matrix protein 2 Proteins 0.000 description 1
• 102100030863 Eyes absent homolog 1 Human genes 0.000 description 1
• 102100030861 Eyes absent homolog 3 Human genes 0.000 description 1
• 102100029956 F-actin-capping protein subunit beta Human genes 0.000 description 1
• 101150064015 FAS gene Proteins 0.000 description 1
• 102100035261 FYN-binding protein 1 Human genes 0.000 description 1
• 102100038635 FYVE, RhoGEF and PH domain-containing protein 1 Human genes 0.000 description 1
• 108010054218 Factor VIII Proteins 0.000 description 1
• 102000001690 Factor VIII Human genes 0.000 description 1
• 201000003542 Factor VIII deficiency Diseases 0.000 description 1
• 108010074105 Factor Va Proteins 0.000 description 1
• 108010080865 Factor XII Proteins 0.000 description 1
• 102000000429 Factor XII Human genes 0.000 description 1
• VWFJDQUYCIWHTN-FBXUGWQNSA-N Farnesyl diphosphate Natural products CC(C)=CCC\C(C)=C/CC\C(C)=C/COP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-FBXUGWQNSA-N 0.000 description 1
• 108010007508 Farnesyltranstransferase Proteins 0.000 description 1
• 102000007317 Farnesyltranstransferase Human genes 0.000 description 1
• 102100036089 Fascin Human genes 0.000 description 1
• 102100034334 Fatty acid CoA ligase Acsl3 Human genes 0.000 description 1
• 102100034543 Fatty acid desaturase 3 Human genes 0.000 description 1
• 101710083187 Fatty acid-binding protein 5 Proteins 0.000 description 1
• 102100020760 Ferritin heavy chain Human genes 0.000 description 1
• 102100021062 Ferritin light chain Human genes 0.000 description 1
• 102100030771 Ferrochelatase, mitochondrial Human genes 0.000 description 1
• 102100031509 Fibrillin-1 Human genes 0.000 description 1
• 102100038664 Fibrinogen-like protein 1 Human genes 0.000 description 1
• 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 1
• 108010067306 Fibronectins Proteins 0.000 description 1
• 102100031812 Fibulin-1 Human genes 0.000 description 1
• 229920001917 Ficoll Polymers 0.000 description 1
• 102100026121 Flap endonuclease 1 Human genes 0.000 description 1
• 101710115821 Flavin reductase (NADPH) Proteins 0.000 description 1
• 102100023513 Flotillin-2 Human genes 0.000 description 1
• 108090000852 Forkhead Transcription Factors Proteins 0.000 description 1
• 102000004315 Forkhead Transcription Factors Human genes 0.000 description 1
• 102100037057 Forkhead box protein D1 Human genes 0.000 description 1
• 102100035129 Forkhead box protein K2 Human genes 0.000 description 1
• 102100023359 Forkhead box protein N3 Human genes 0.000 description 1
• 102100025413 Formyltetrahydrofolate synthetase Human genes 0.000 description 1
• 102100030334 Friend leukemia integration 1 transcription factor Human genes 0.000 description 1
• 102100021265 Frizzled-2 Human genes 0.000 description 1
• 102100039676 Frizzled-7 Human genes 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 102100037181 Fructose-1,6-bisphosphatase 1 Human genes 0.000 description 1
• 102100022277 Fructose-bisphosphate aldolase A Human genes 0.000 description 1
• 102100027269 Fructose-bisphosphate aldolase C Human genes 0.000 description 1
• 108010019236 Fucosyltransferases Proteins 0.000 description 1
• 102000006471 Fucosyltransferases Human genes 0.000 description 1
• 108010036781 Fumarate Hydratase Proteins 0.000 description 1
• 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 description 1
• 102100039709 G antigen 2A Human genes 0.000 description 1
• 102100033063 G protein-activated inward rectifier potassium channel 1 Human genes 0.000 description 1
• 102100023734 G protein-coupled receptor kinase 4 Human genes 0.000 description 1
• 102100023685 G protein-coupled receptor kinase 5 Human genes 0.000 description 1
• 102100033864 G-protein coupled receptor 84 Human genes 0.000 description 1
• 102100033506 G-rich sequence factor 1 Human genes 0.000 description 1
• 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 description 1
• 102100037859 G1/S-specific cyclin-D3 Human genes 0.000 description 1
• 102100037488 G2 and S phase-expressed protein 1 Human genes 0.000 description 1
• 102100035237 GA-binding protein alpha chain Human genes 0.000 description 1
• 102100035205 GA-binding protein subunit beta-1 Human genes 0.000 description 1
• 108010005551 GABA Receptors Proteins 0.000 description 1
• 102000005915 GABA Receptors Human genes 0.000 description 1
• 102000017707 GABRB3 Human genes 0.000 description 1
• 102000017703 GABRG2 Human genes 0.000 description 1
• 102000017700 GABRP Human genes 0.000 description 1
• 102000019448 GART Human genes 0.000 description 1
• 108010003163 GDP dissociation inhibitor 1 Proteins 0.000 description 1
• 108700031835 GRB10 Adaptor Proteins 0.000 description 1
• 102100037740 GRB2-associated-binding protein 1 Human genes 0.000 description 1
• 102100033512 GTP:AMP phosphotransferase AK3, mitochondrial Human genes 0.000 description 1
• 102100039788 GTPase NRas Human genes 0.000 description 1
• 102100028496 Galactocerebrosidase Human genes 0.000 description 1
• 102100037777 Galactokinase Human genes 0.000 description 1
• 102000030902 Galactosyltransferase Human genes 0.000 description 1
• 108060003306 Galactosyltransferase Proteins 0.000 description 1
• 108010001498 Galectin 1 Proteins 0.000 description 1
• 102000000802 Galectin 3 Human genes 0.000 description 1
• 102100021736 Galectin-1 Human genes 0.000 description 1
• 102100039558 Galectin-3 Human genes 0.000 description 1
• 102100040510 Galectin-3-binding protein Human genes 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 102100034004 Gamma-adducin Human genes 0.000 description 1
• 102100023364 Ganglioside GM2 activator Human genes 0.000 description 1
• 102100037156 Gap junction beta-2 protein Human genes 0.000 description 1
• 102100037391 Gasdermin-E Human genes 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 102100028953 Gelsolin Human genes 0.000 description 1
• 230000010558 Gene Alterations Effects 0.000 description 1
• 102100036529 General transcription factor 3C polypeptide 1 Human genes 0.000 description 1
• 102100036536 General transcription factor 3C polypeptide 2 Human genes 0.000 description 1
• 102100038073 General transcription factor II-I Human genes 0.000 description 1
• 102100033840 General transcription factor IIF subunit 1 Human genes 0.000 description 1
• 102100038308 General transcription factor IIH subunit 1 Human genes 0.000 description 1
• 102100032864 General transcription factor IIH subunit 2 Human genes 0.000 description 1
• 102000013404 Geranyltranstransferase Human genes 0.000 description 1
• 102100041013 Glia maturation factor beta Human genes 0.000 description 1
• 108090000079 Glucocorticoid Receptors Proteins 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 102100035172 Glucose-6-phosphate 1-dehydrogenase Human genes 0.000 description 1
• 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 1
• 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
• 102100034009 Glutamate dehydrogenase 1, mitochondrial Human genes 0.000 description 1
• 102100039696 Glutamate-cysteine ligase catalytic subunit Human genes 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 108010073324 Glutaminase Proteins 0.000 description 1
• 102000009127 Glutaminase Human genes 0.000 description 1
• 102000006485 Glutamyl Aminopeptidase Human genes 0.000 description 1
• 102100025945 Glutaredoxin-1 Human genes 0.000 description 1
• 102100037473 Glutathione S-transferase A1 Human genes 0.000 description 1
• 102100033369 Glutathione S-transferase A4 Human genes 0.000 description 1
• 102100036528 Glutathione S-transferase Mu 3 Human genes 0.000 description 1
• 102100023523 Glutathione S-transferase Mu 4 Human genes 0.000 description 1
• 102100038055 Glutathione S-transferase theta-1 Human genes 0.000 description 1
• 102100023469 Glutathione S-transferase theta-2 Human genes 0.000 description 1
• 102100033366 Glutathione hydrolase 1 proenzyme Human genes 0.000 description 1
• 102100033039 Glutathione peroxidase 1 Human genes 0.000 description 1
• 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 1
• 108010036164 Glutathione synthase Proteins 0.000 description 1
• 102100034294 Glutathione synthetase Human genes 0.000 description 1
• 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
• 101710086809 Glycerol-3-phosphate dehydrogenase 2 Proteins 0.000 description 1
• 108010036684 Glycine Dehydrogenase Proteins 0.000 description 1
• 102000004327 Glycine dehydrogenase (decarboxylating) Human genes 0.000 description 1
• 108090000826 Glycine dehydrogenase (decarboxylating) Proteins 0.000 description 1
• 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 description 1
• 102100039264 Glycogen [starch] synthase, liver Human genes 0.000 description 1
• 102100039262 Glycogen [starch] synthase, muscle Human genes 0.000 description 1
• 208000032007 Glycogen storage disease due to acid maltase deficiency Diseases 0.000 description 1
• 206010053185 Glycogen storage disease type II Diseases 0.000 description 1
• 102100038104 Glycogen synthase kinase-3 beta Human genes 0.000 description 1
• 102100036430 Glycophorin-B Human genes 0.000 description 1
• 102100023849 Glycophorin-C Human genes 0.000 description 1
• 108091005250 Glycophorins Proteins 0.000 description 1
• 102000028180 Glycophorins Human genes 0.000 description 1
• 102100024404 Glycosyltransferase 8 domain-containing protein 2 Human genes 0.000 description 1
• 102100034190 Glypican-1 Human genes 0.000 description 1
• 102100032527 Glypican-4 Human genes 0.000 description 1
• 102100034223 Golgi apparatus protein 1 Human genes 0.000 description 1
• 102100032564 Golgin subfamily A member 2 Human genes 0.000 description 1
• 102100032565 Golgin subfamily A member 3 Human genes 0.000 description 1
• 101150090959 Grb10 gene Proteins 0.000 description 1
• 102000009465 Growth Factor Receptors Human genes 0.000 description 1
• 108010009202 Growth Factor Receptors Proteins 0.000 description 1
• 102100031150 Growth arrest and DNA damage-inducible protein GADD45 alpha Human genes 0.000 description 1
• 102100031153 Growth arrest and DNA damage-inducible protein GADD45 beta Human genes 0.000 description 1
• 102100036683 Growth arrest-specific protein 1 Human genes 0.000 description 1
• 102100031487 Growth arrest-specific protein 6 Human genes 0.000 description 1
• 102100033067 Growth factor receptor-bound protein 2 Human genes 0.000 description 1
• 102100020948 Growth hormone receptor Human genes 0.000 description 1
• 102000016285 Guanine Nucleotide Exchange Factors Human genes 0.000 description 1
• 108010067218 Guanine Nucleotide Exchange Factors Proteins 0.000 description 1
• 102100033321 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Human genes 0.000 description 1
• 102100035913 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Human genes 0.000 description 1
• 102100035354 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Human genes 0.000 description 1
• 102100036738 Guanine nucleotide-binding protein subunit alpha-11 Human genes 0.000 description 1
• 102100036733 Guanine nucleotide-binding protein subunit alpha-12 Human genes 0.000 description 1
• 102100036703 Guanine nucleotide-binding protein subunit alpha-13 Human genes 0.000 description 1
• 102100040468 Guanylate kinase Human genes 0.000 description 1
• 101710110781 Guanylate-binding protein 1 Proteins 0.000 description 1
• 101710110789 Guanylate-binding protein 2 Proteins 0.000 description 1
• 102100034477 H(+)/Cl(-) exchange transporter 3 Human genes 0.000 description 1
• 102100028685 H(+)/Cl(-) exchange transporter 7 Human genes 0.000 description 1
• 102100031249 H/ACA ribonucleoprotein complex subunit DKC1 Human genes 0.000 description 1
• 108010010234 HDL Lipoproteins Proteins 0.000 description 1
• 102000015779 HDL Lipoproteins Human genes 0.000 description 1
• 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 1
• 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 1
• 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 1
• 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 description 1
• 102100031618 HLA class II histocompatibility antigen, DP beta 1 chain Human genes 0.000 description 1
• 102100028636 HLA class II histocompatibility antigen, DR beta 4 chain Human genes 0.000 description 1
• 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 description 1
• 108010075704 HLA-A Antigens Proteins 0.000 description 1
• 108010058607 HLA-B Antigens Proteins 0.000 description 1
• 108010052199 HLA-C Antigens Proteins 0.000 description 1
• 108010045483 HLA-DPB1 antigen Proteins 0.000 description 1
• 108010086786 HLA-DQA1 antigen Proteins 0.000 description 1
• 108010039343 HLA-DRB1 Chains Proteins 0.000 description 1
• 108010040960 HLA-DRB4 Chains Proteins 0.000 description 1
• 108010009907 HLA-DRB6 antigen Proteins 0.000 description 1
• 101150112743 HSPA5 gene Proteins 0.000 description 1
• 101001056976 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) Catalase-peroxidase Proteins 0.000 description 1
• 102100040408 Heat shock 70 kDa protein 1-like Human genes 0.000 description 1
• 102100040352 Heat shock 70 kDa protein 1A Human genes 0.000 description 1
• 102100040407 Heat shock 70 kDa protein 1B Human genes 0.000 description 1
• 102100028765 Heat shock 70 kDa protein 4 Human genes 0.000 description 1
• 101710089250 Heat shock 70 kDa protein 5 Proteins 0.000 description 1
• 102100028761 Heat shock 70 kDa protein 6 Human genes 0.000 description 1
• 102100034049 Heat shock factor protein 2 Human genes 0.000 description 1
• 102100027529 Heat shock factor-binding protein 1 Human genes 0.000 description 1
• 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 description 1
• 102100032510 Heat shock protein HSP 90-beta Human genes 0.000 description 1
• 102100037174 Helicase MOV-10 Human genes 0.000 description 1
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
• 102100028006 Heme oxygenase 1 Human genes 0.000 description 1
• 102100028008 Heme oxygenase 2 Human genes 0.000 description 1
• 208000009292 Hemophilia A Diseases 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 1
• 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 description 1
• 102000006752 Hepatocyte Nuclear Factor 4 Human genes 0.000 description 1
• 102100034676 Hepatocyte cell adhesion molecule Human genes 0.000 description 1
• 102100022623 Hepatocyte growth factor receptor Human genes 0.000 description 1
• 102100032813 Hepatocyte growth factor-like protein Human genes 0.000 description 1
• 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 description 1
• 102100022054 Hepatocyte nuclear factor 4-alpha Human genes 0.000 description 1
• 208000002972 Hepatolenticular Degeneration Diseases 0.000 description 1
• 102000004989 Hepsin Human genes 0.000 description 1
• 108090001101 Hepsin Proteins 0.000 description 1
• 201000005379 Hermansky-Pudlak syndrome 1 Diseases 0.000 description 1
• 102100028902 Hermansky-Pudlak syndrome 1 protein Human genes 0.000 description 1
• 102100035617 Heterogeneous nuclear ribonucleoprotein A/B Human genes 0.000 description 1
• 102100027703 Heterogeneous nuclear ribonucleoprotein H2 Human genes 0.000 description 1
• 102100028909 Heterogeneous nuclear ribonucleoprotein K Human genes 0.000 description 1
• 102100028895 Heterogeneous nuclear ribonucleoprotein M Human genes 0.000 description 1
• 102100035616 Heterogeneous nuclear ribonucleoproteins A2/B1 Human genes 0.000 description 1
• 102100033994 Heterogeneous nuclear ribonucleoproteins C1/C2 Human genes 0.000 description 1
• 108010085241 Heterogeneous-Nuclear Ribonucleoprotein D Proteins 0.000 description 1
• 108010085697 Heterogeneous-Nuclear Ribonucleoprotein U Proteins 0.000 description 1
• 102100030338 Hexokinase-1 Human genes 0.000 description 1
• 101710121996 Hexon protein p72 Proteins 0.000 description 1
• 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 description 1
• 102100037907 High mobility group protein B1 Human genes 0.000 description 1
• 102100022130 High mobility group protein B3 Human genes 0.000 description 1
• 102100031004 Histidine-tRNA ligase, cytoplasmic Human genes 0.000 description 1
• 108010023981 Histone Deacetylase 2 Proteins 0.000 description 1
• 102000011423 Histone Deacetylase 2 Human genes 0.000 description 1
• 102100037487 Histone H1.0 Human genes 0.000 description 1
• 102100039266 Histone H2A type 1-B/E Human genes 0.000 description 1
• 102100023919 Histone H2A.Z Human genes 0.000 description 1
• 102100034533 Histone H2AX Human genes 0.000 description 1
• 102100030689 Histone H2B type 1-D Human genes 0.000 description 1
• 102100022901 Histone acetyltransferase KAT2A Human genes 0.000 description 1
• 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 description 1
• 102100037164 Histone-lysine N-methyltransferase EZH1 Human genes 0.000 description 1
• 108050001949 Histone-lysine N-methyltransferase EZH1 Proteins 0.000 description 1
• 101710196274 Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 1
• 108030003910 Holocytochrome-c synthases Proteins 0.000 description 1
• 102100031672 Homeobox protein CDX-1 Human genes 0.000 description 1
• 102100030087 Homeobox protein DLX-1 Human genes 0.000 description 1
• 102100030309 Homeobox protein Hox-A1 Human genes 0.000 description 1
• 102100030339 Homeobox protein Hox-A10 Human genes 0.000 description 1
• 102100039541 Homeobox protein Hox-A3 Human genes 0.000 description 1
• 102100034862 Homeobox protein Hox-B2 Human genes 0.000 description 1
• 102100025061 Homeobox protein Hox-B7 Human genes 0.000 description 1
• 102100029433 Homeobox protein Hox-B9 Human genes 0.000 description 1
• 102100022599 Homeobox protein Hox-C6 Human genes 0.000 description 1
• 102100040227 Homeobox protein Hox-D13 Human genes 0.000 description 1
• 102100040228 Homeobox protein Hox-D3 Human genes 0.000 description 1
• 102100034858 Homeobox protein Hox-D8 Human genes 0.000 description 1
• 101710142888 Homeobox protein MOX-2 Proteins 0.000 description 1
• 102100040615 Homeobox protein MSX-2 Human genes 0.000 description 1
• 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 description 1
• 102100028092 Homeobox protein Nkx-3.1 Human genes 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 241000282414 Homo sapiens Species 0.000 description 1
• 101001126430 Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Proteins 0.000 description 1
• 101000806242 Homo sapiens 17-beta-hydroxysteroid dehydrogenase type 1 Proteins 0.000 description 1
• 101001045211 Homo sapiens 17-beta-hydroxysteroid dehydrogenase type 3 Proteins 0.000 description 1
• 101000866191 Homo sapiens 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 Proteins 0.000 description 1
• 101000909233 Homo sapiens 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 Proteins 0.000 description 1
• 101000597665 Homo sapiens 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Proteins 0.000 description 1
• 101000988577 Homo sapiens 3-hydroxy-3-methylglutaryl-coenzyme A reductase Proteins 0.000 description 1
• 101000753843 Homo sapiens 3-mercaptopyruvate sulfurtransferase Proteins 0.000 description 1
• 101000733904 Homo sapiens 39S ribosomal protein L49, mitochondrial Proteins 0.000 description 1
• 101000883686 Homo sapiens 60 kDa heat shock protein, mitochondrial Proteins 0.000 description 1
• 101000928720 Homo sapiens 7-dehydrocholesterol reductase Proteins 0.000 description 1
• 101000890611 Homo sapiens A-kinase anchor protein 6 Proteins 0.000 description 1
• 101000684275 Homo sapiens ADP-ribosylation factor 3 Proteins 0.000 description 1
• 101000684189 Homo sapiens ADP-ribosylation factor 4 Proteins 0.000 description 1
• 101000974500 Homo sapiens ADP-ribosylation factor-like protein 1 Proteins 0.000 description 1
• 101000886004 Homo sapiens ADP-ribosylation factor-like protein 3 Proteins 0.000 description 1
• 101000780532 Homo sapiens ADP-ribosylhydrolase ARH1 Proteins 0.000 description 1
• 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 description 1
• 101000797462 Homo sapiens AMP deaminase 3 Proteins 0.000 description 1
• 101000779234 Homo sapiens AP-1 complex subunit gamma-1 Proteins 0.000 description 1
• 101000924636 Homo sapiens AP-1 complex subunit mu-2 Proteins 0.000 description 1
• 101000757299 Homo sapiens AP-2 complex subunit alpha-1 Proteins 0.000 description 1
• 101000757394 Homo sapiens AP-2 complex subunit alpha-2 Proteins 0.000 description 1
• 101000796047 Homo sapiens AP-2 complex subunit mu Proteins 0.000 description 1
• 101000806914 Homo sapiens AP-2 complex subunit sigma Proteins 0.000 description 1
• 101000959710 Homo sapiens AP-3 complex subunit sigma-1 Proteins 0.000 description 1
• 101000905623 Homo sapiens ATP synthase F(0) complex subunit B1, mitochondrial Proteins 0.000 description 1
• 101000905799 Homo sapiens ATP synthase F(0) complex subunit C1, mitochondrial Proteins 0.000 description 1
• 101000905797 Homo sapiens ATP synthase F(0) complex subunit C2, mitochondrial Proteins 0.000 description 1
• 101000974901 Homo sapiens ATP synthase F(0) complex subunit C3, mitochondrial Proteins 0.000 description 1
• 101000903027 Homo sapiens ATP synthase subunit beta, mitochondrial Proteins 0.000 description 1
• 101000766510 Homo sapiens ATP synthase subunit delta, mitochondrial Proteins 0.000 description 1
• 101000936965 Homo sapiens ATP synthase-coupling factor 6, mitochondrial Proteins 0.000 description 1
• 101000801645 Homo sapiens ATP-binding cassette sub-family A member 2 Proteins 0.000 description 1
• 101000783783 Homo sapiens ATP-binding cassette sub-family F member 1 Proteins 0.000 description 1
• 101000782969 Homo sapiens ATP-citrate synthase Proteins 0.000 description 1
• 101000864670 Homo sapiens ATP-dependent RNA helicase A Proteins 0.000 description 1
• 101000870664 Homo sapiens ATP-dependent RNA helicase DDX3Y Proteins 0.000 description 1
• 101000907886 Homo sapiens ATP-dependent RNA helicase DHX15 Proteins 0.000 description 1
• 101000614696 Homo sapiens ATP-sensitive inward rectifier potassium channel 10 Proteins 0.000 description 1
• 101000598552 Homo sapiens Acetyl-CoA acetyltransferase, mitochondrial Proteins 0.000 description 1
• 101000963424 Homo sapiens Acetyl-CoA carboxylase 1 Proteins 0.000 description 1
• 101000677540 Homo sapiens Acetyl-CoA carboxylase 2 Proteins 0.000 description 1
• 101000975753 Homo sapiens Acid ceramidase Proteins 0.000 description 1
• 101000732665 Homo sapiens Acidic leucine-rich nuclear phosphoprotein 32 family member E Proteins 0.000 description 1
• 101000773237 Homo sapiens Actin, cytoplasmic 2 Proteins 0.000 description 1
• 101000798882 Homo sapiens Actin-like protein 6A Proteins 0.000 description 1
• 101000799140 Homo sapiens Activin receptor type-1 Proteins 0.000 description 1
• 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 description 1
• 101000970954 Homo sapiens Activin receptor type-2A Proteins 0.000 description 1
• 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 description 1
• 101000959343 Homo sapiens Adenylate cyclase type 1 Proteins 0.000 description 1
• 101000959347 Homo sapiens Adenylate cyclase type 2 Proteins 0.000 description 1
• 101000775478 Homo sapiens Adenylate cyclase type 5 Proteins 0.000 description 1
• 101000775483 Homo sapiens Adenylate cyclase type 7 Proteins 0.000 description 1
• 101000775481 Homo sapiens Adenylate cyclase type 8 Proteins 0.000 description 1
• 101000614487 Homo sapiens Adenylate kinase 4, mitochondrial Proteins 0.000 description 1
• 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 description 1
• 101000678419 Homo sapiens Adrenocorticotropic hormone receptor Proteins 0.000 description 1
• 101000833098 Homo sapiens Adrenodoxin, mitochondrial Proteins 0.000 description 1
• 101000928246 Homo sapiens Afadin Proteins 0.000 description 1
• 101000879354 Homo sapiens Alanine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
• 101000959452 Homo sapiens Alcohol dehydrogenase class-3 Proteins 0.000 description 1
• 101000717967 Homo sapiens Aldehyde dehydrogenase family 3 member A2 Proteins 0.000 description 1
• 101000718028 Homo sapiens Aldo-keto reductase family 1 member C1 Proteins 0.000 description 1
• 101000780453 Homo sapiens All-trans-retinol dehydrogenase [NAD(+)] ADH1B Proteins 0.000 description 1
• 101000890626 Homo sapiens Allograft inflammatory factor 1 Proteins 0.000 description 1
• 101000819490 Homo sapiens Alpha-(1,6)-fucosyltransferase Proteins 0.000 description 1
• 101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 description 1
• 101001019502 Homo sapiens Alpha-L-iduronidase Proteins 0.000 description 1
• 101000924350 Homo sapiens Alpha-N-acetylglucosaminidase Proteins 0.000 description 1
• 101000634075 Homo sapiens Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Proteins 0.000 description 1
• 101000799406 Homo sapiens Alpha-actinin-1 Proteins 0.000 description 1
• 101000797282 Homo sapiens Alpha-actinin-4 Proteins 0.000 description 1
• 101000799076 Homo sapiens Alpha-adducin Proteins 0.000 description 1
• 101000690235 Homo sapiens Alpha-aminoadipic semialdehyde dehydrogenase Proteins 0.000 description 1
• 101000891982 Homo sapiens Alpha-crystallin B chain Proteins 0.000 description 1
• 101000876352 Homo sapiens Alpha-endosulfine Proteins 0.000 description 1
• 101000882335 Homo sapiens Alpha-enolase Proteins 0.000 description 1
• 101000615966 Homo sapiens Alpha-mannosidase 2x Proteins 0.000 description 1
• 101000924727 Homo sapiens Alternative prion protein Proteins 0.000 description 1
• 101000720039 Homo sapiens Aminoacylase-1 Proteins 0.000 description 1
• 101000889673 Homo sapiens Aminopeptidase Q Proteins 0.000 description 1
• 101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 description 1
• 101000964180 Homo sapiens Angio-associated migratory cell protein Proteins 0.000 description 1
• 101000929928 Homo sapiens Angiotensin-converting enzyme 2 Proteins 0.000 description 1
• 101000924345 Homo sapiens Ankyrin repeat domain-containing protein 36B Proteins 0.000 description 1
• 101000796140 Homo sapiens Ankyrin-1 Proteins 0.000 description 1
• 101000928344 Homo sapiens Ankyrin-2 Proteins 0.000 description 1
• 101000928342 Homo sapiens Ankyrin-3 Proteins 0.000 description 1
• 101000768066 Homo sapiens Annexin A11 Proteins 0.000 description 1
• 101000924474 Homo sapiens Annexin A2 Proteins 0.000 description 1
• 101000924461 Homo sapiens Annexin A4 Proteins 0.000 description 1
• 101000780137 Homo sapiens Annexin A6 Proteins 0.000 description 1
• 101000928628 Homo sapiens Apolipoprotein C-I Proteins 0.000 description 1
• 101000924629 Homo sapiens Apoptotic protease-activating factor 1 Proteins 0.000 description 1
• 101000771413 Homo sapiens Aquaporin-9 Proteins 0.000 description 1
• 101000833314 Homo sapiens Arf-GAP domain and FG repeat-containing protein 1 Proteins 0.000 description 1
• 101001061654 Homo sapiens Arginine-glutamic acid dipeptide repeats protein Proteins 0.000 description 1
• 101000925559 Homo sapiens Arylsulfatase D Proteins 0.000 description 1
• 101000624939 Homo sapiens Asparagine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
• 101000901030 Homo sapiens Aspartyl/asparaginyl beta-hydroxylase Proteins 0.000 description 1
• 101000873082 Homo sapiens Ataxin-1 Proteins 0.000 description 1
• 101000785083 Homo sapiens Atrophin-1 Proteins 0.000 description 1
• 101000798495 Homo sapiens B-cell CLL/lymphoma 9 protein Proteins 0.000 description 1
• 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 description 1
• 101000971234 Homo sapiens B-cell lymphoma 6 protein Proteins 0.000 description 1
• 101000899079 Homo sapiens BPI fold-containing family B member 1 Proteins 0.000 description 1
• 101000697486 Homo sapiens BRCA1-associated RING domain protein 1 Proteins 0.000 description 1
• 101000896156 Homo sapiens Baculoviral IAP repeat-containing protein 1 Proteins 0.000 description 1
• 101001049977 Homo sapiens Band 4.1-like protein 2 Proteins 0.000 description 1
• 101000894722 Homo sapiens Bardet-Biedl syndrome 1 protein Proteins 0.000 description 1
• 101000697700 Homo sapiens Bardet-Biedl syndrome 2 protein Proteins 0.000 description 1
• 101000901683 Homo sapiens Battenin Proteins 0.000 description 1
• 101000798320 Homo sapiens Bcl-2 homologous antagonist/killer Proteins 0.000 description 1
• 101000894929 Homo sapiens Bcl-2-related protein A1 Proteins 0.000 description 1
• 101001130526 Homo sapiens Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe Proteins 0.000 description 1
• 101000766145 Homo sapiens Beta-1,4-galactosyltransferase 1 Proteins 0.000 description 1
• 101000919694 Homo sapiens Beta-Ala-His dipeptidase Proteins 0.000 description 1
• 101000751445 Homo sapiens Beta-adrenergic receptor kinase 1 Proteins 0.000 description 1
• 101000877537 Homo sapiens Beta-enolase Proteins 0.000 description 1
• 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 description 1
• 101001045440 Homo sapiens Beta-hexosaminidase subunit alpha Proteins 0.000 description 1
• 101001045433 Homo sapiens Beta-hexosaminidase subunit beta Proteins 0.000 description 1
• 101000859448 Homo sapiens Beta/gamma crystallin domain-containing protein 1 Proteins 0.000 description 1
• 101000933413 Homo sapiens Betaine-homocysteine S-methyltransferase 1 Proteins 0.000 description 1
• 101000802825 Homo sapiens Biliverdin reductase A Proteins 0.000 description 1
• 101000594702 Homo sapiens Bisphosphoglycerate mutase Proteins 0.000 description 1
• 101000984541 Homo sapiens Bleomycin hydrolase Proteins 0.000 description 1
• 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 1
• 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 description 1
• 101000899390 Homo sapiens Bone morphogenetic protein 6 Proteins 0.000 description 1
• 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 description 1
• 101000934635 Homo sapiens Bone morphogenetic protein receptor type-2 Proteins 0.000 description 1
• 101000766294 Homo sapiens Branched-chain-amino-acid aminotransferase, mitochondrial Proteins 0.000 description 1
• 101000934870 Homo sapiens Breast cancer type 1 susceptibility protein Proteins 0.000 description 1
• 101000934858 Homo sapiens Breast cancer type 2 susceptibility protein Proteins 0.000 description 1
• 101000896419 Homo sapiens Bystin Proteins 0.000 description 1
• 101000777558 Homo sapiens C-C chemokine receptor type 10 Proteins 0.000 description 1
• 101001076862 Homo sapiens C-Jun-amino-terminal kinase-interacting protein 4 Proteins 0.000 description 1
• 101000912618 Homo sapiens C-type lectin domain family 2 member B Proteins 0.000 description 1
• 101000945515 Homo sapiens CCAAT/enhancer-binding protein alpha Proteins 0.000 description 1
• 101000945963 Homo sapiens CCAAT/enhancer-binding protein beta Proteins 0.000 description 1
• 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 description 1
• 101000738399 Homo sapiens CD109 antigen Proteins 0.000 description 1
• 101000946874 Homo sapiens CD151 antigen Proteins 0.000 description 1
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
• 101000934356 Homo sapiens CD70 antigen Proteins 0.000 description 1
• 101000914479 Homo sapiens CD81 antigen Proteins 0.000 description 1
• 101000914469 Homo sapiens CD82 antigen Proteins 0.000 description 1
• 101000738354 Homo sapiens CD9 antigen Proteins 0.000 description 1
• 101000583935 Homo sapiens CDK-activating kinase assembly factor MAT1 Proteins 0.000 description 1
• 101000896987 Homo sapiens CREB-binding protein Proteins 0.000 description 1
• 101000914155 Homo sapiens Cadherin EGF LAG seven-pass G-type receptor 1 Proteins 0.000 description 1
• 101000762236 Homo sapiens Cadherin-11 Proteins 0.000 description 1
• 101000762243 Homo sapiens Cadherin-13 Proteins 0.000 description 1
• 101000762242 Homo sapiens Cadherin-15 Proteins 0.000 description 1
• 101000714553 Homo sapiens Cadherin-3 Proteins 0.000 description 1
• 101000714321 Homo sapiens Calcineurin subunit B type 1 Proteins 0.000 description 1
• 101000580357 Homo sapiens Calcipressin-1 Proteins 0.000 description 1
• 101001077338 Homo sapiens Calcium/calmodulin-dependent protein kinase type II subunit delta Proteins 0.000 description 1
• 101000974816 Homo sapiens Calcium/calmodulin-dependent protein kinase type IV Proteins 0.000 description 1
• 101000910297 Homo sapiens Caldesmon Proteins 0.000 description 1
• 101000984164 Homo sapiens Calmodulin-1 Proteins 0.000 description 1
• 101000933777 Homo sapiens Calmodulin-3 Proteins 0.000 description 1
• 101000714692 Homo sapiens Calmodulin-like protein 3 Proteins 0.000 description 1
• 101000898052 Homo sapiens Calnexin Proteins 0.000 description 1
• 101000793651 Homo sapiens Calreticulin Proteins 0.000 description 1
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
• 101000793727 Homo sapiens Caprin-1 Proteins 0.000 description 1
• 101000737274 Homo sapiens Carbonyl reductase [NADPH] 3 Proteins 0.000 description 1
• 101000916283 Homo sapiens Cardiotrophin-1 Proteins 0.000 description 1
• 101000859570 Homo sapiens Carnitine O-palmitoyltransferase 1, liver isoform Proteins 0.000 description 1
• 101000859574 Homo sapiens Carnitine O-palmitoyltransferase 1, muscle isoform Proteins 0.000 description 1
• 101000994700 Homo sapiens Casein kinase I isoform alpha Proteins 0.000 description 1
• 101001026336 Homo sapiens Casein kinase I isoform delta Proteins 0.000 description 1
• 101001026376 Homo sapiens Casein kinase I isoform epsilon Proteins 0.000 description 1
• 101000892026 Homo sapiens Casein kinase II subunit alpha Proteins 0.000 description 1
• 101000892015 Homo sapiens Casein kinase II subunit alpha' Proteins 0.000 description 1
• 101000761467 Homo sapiens Caspase-14 Proteins 0.000 description 1
• 101000867612 Homo sapiens Caspase-2 Proteins 0.000 description 1
• 101000741014 Homo sapiens Caspase-7 Proteins 0.000 description 1
• 101000983523 Homo sapiens Caspase-9 Proteins 0.000 description 1
• 101000859073 Homo sapiens Catenin alpha-2 Proteins 0.000 description 1
• 101000898449 Homo sapiens Cathepsin B Proteins 0.000 description 1
• 101000740970 Homo sapiens Cathepsin O Proteins 0.000 description 1
• 101000910979 Homo sapiens Cathepsin Z Proteins 0.000 description 1
• 101001028831 Homo sapiens Cation-independent mannose-6-phosphate receptor Proteins 0.000 description 1
• 101000715467 Homo sapiens Caveolin-1 Proteins 0.000 description 1
• 101000740981 Homo sapiens Caveolin-2 Proteins 0.000 description 1
• 101000869042 Homo sapiens Caveolin-3 Proteins 0.000 description 1
• 101000946837 Homo sapiens Cell division cycle protein 27 homolog Proteins 0.000 description 1
• 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 description 1
• 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 1
• 101000880516 Homo sapiens Centrin-2 Proteins 0.000 description 1
• 101000907944 Homo sapiens Centromere protein I Proteins 0.000 description 1
• 101000914247 Homo sapiens Centromere-associated protein E Proteins 0.000 description 1
• 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 description 1
• 101000839968 Homo sapiens Checkpoint protein HUS1 Proteins 0.000 description 1
• 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 description 1
• 101000946430 Homo sapiens Chloride intracellular channel protein 1 Proteins 0.000 description 1
• 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 description 1
• 101000777314 Homo sapiens Choline kinase alpha Proteins 0.000 description 1
• 101000777313 Homo sapiens Choline/ethanolamine kinase Proteins 0.000 description 1
• 101000777079 Homo sapiens Chromodomain-helicase-DNA-binding protein 2 Proteins 0.000 description 1
• 101000777071 Homo sapiens Chromodomain-helicase-DNA-binding protein 3 Proteins 0.000 description 1
• 101000883749 Homo sapiens Chromodomain-helicase-DNA-binding protein 4 Proteins 0.000 description 1
• 101000710244 Homo sapiens Clathrin light chain A Proteins 0.000 description 1
• 101000891793 Homo sapiens Cleavage stimulation factor subunit 2 Proteins 0.000 description 1
• 101000891801 Homo sapiens Cleavage stimulation factor subunit 3 Proteins 0.000 description 1
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
• 101000860881 Homo sapiens Coatomer subunit delta Proteins 0.000 description 1
• 101000725583 Homo sapiens Cofilin-1 Proteins 0.000 description 1
• 101000725605 Homo sapiens Cofilin-2 Proteins 0.000 description 1
• 101000906744 Homo sapiens Cold-inducible RNA-binding protein Proteins 0.000 description 1
• 101000901150 Homo sapiens Collagen alpha-1(IV) chain Proteins 0.000 description 1
• 101000941581 Homo sapiens Collagen alpha-1(VI) chain Proteins 0.000 description 1
• 101000861874 Homo sapiens Collagen alpha-1(XII) chain Proteins 0.000 description 1
• 101000860648 Homo sapiens Collagen alpha-1(XVI) chain Proteins 0.000 description 1
• 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 description 1
• 101000710876 Homo sapiens Collagen alpha-2(IV) chain Proteins 0.000 description 1
• 101000919645 Homo sapiens Collagen alpha-2(IX) chain Proteins 0.000 description 1
• 101000941594 Homo sapiens Collagen alpha-2(V) chain Proteins 0.000 description 1
• 101000941585 Homo sapiens Collagen alpha-2(VI) chain Proteins 0.000 description 1
• 101000749886 Homo sapiens Collagen alpha-2(VIII) chain Proteins 0.000 description 1
• 101000710619 Homo sapiens Collagen alpha-2(XI) chain Proteins 0.000 description 1
• 101000577887 Homo sapiens Collagenase 3 Proteins 0.000 description 1
• 101000740680 Homo sapiens Complement C1q subcomponent subunit B Proteins 0.000 description 1
• 101000933636 Homo sapiens Complement C1q subcomponent subunit C Proteins 0.000 description 1
• 101000749829 Homo sapiens Connector enhancer of kinase suppressor of ras 3 Proteins 0.000 description 1
• 101000909520 Homo sapiens Contactin-1 Proteins 0.000 description 1
• 101000941754 Homo sapiens Copine-1 Proteins 0.000 description 1
• 101000727865 Homo sapiens Copper transport protein ATOX1 Proteins 0.000 description 1
• 101000936280 Homo sapiens Copper-transporting ATPase 2 Proteins 0.000 description 1
• 101000601012 Homo sapiens Core-binding factor subunit beta Proteins 0.000 description 1
• 101000858031 Homo sapiens Coxsackievirus and adenovirus receptor Proteins 0.000 description 1
• 101000919351 Homo sapiens Cryptochrome-1 Proteins 0.000 description 1
• 101000855613 Homo sapiens Cryptochrome-2 Proteins 0.000 description 1
• 101000856239 Homo sapiens Cutaneous T-cell lymphoma-associated antigen 1 Proteins 0.000 description 1
• 101000855516 Homo sapiens Cyclic AMP-responsive element-binding protein 1 Proteins 0.000 description 1
• 101000934320 Homo sapiens Cyclin-A2 Proteins 0.000 description 1
• 101000980770 Homo sapiens Cyclin-C Proteins 0.000 description 1
• 101000884183 Homo sapiens Cyclin-F Proteins 0.000 description 1
• 101000713120 Homo sapiens Cyclin-H Proteins 0.000 description 1
• 101000910488 Homo sapiens Cyclin-T1 Proteins 0.000 description 1
• 101000715946 Homo sapiens Cyclin-dependent kinase 3 Proteins 0.000 description 1
• 101000911952 Homo sapiens Cyclin-dependent kinase 7 Proteins 0.000 description 1
• 101000980930 Homo sapiens Cyclin-dependent kinase 9 Proteins 0.000 description 1
• 101000710200 Homo sapiens Cyclin-dependent kinases regulatory subunit 1 Proteins 0.000 description 1
• 101000737584 Homo sapiens Cystathionine gamma-lyase Proteins 0.000 description 1
• 101000921786 Homo sapiens Cystatin-A Proteins 0.000 description 1
• 101000912191 Homo sapiens Cystatin-B Proteins 0.000 description 1
• 101000912205 Homo sapiens Cystatin-C Proteins 0.000 description 1
• 101000884768 Homo sapiens Cystatin-SN Proteins 0.000 description 1
• 101000922020 Homo sapiens Cysteine and glycine-rich protein 1 Proteins 0.000 description 1
• 101000940752 Homo sapiens Cysteine and glycine-rich protein 2 Proteins 0.000 description 1
• 101000922034 Homo sapiens Cystinosin Proteins 0.000 description 1
• 101000761960 Homo sapiens Cytochrome P450 11B1, mitochondrial Proteins 0.000 description 1
• 101000875170 Homo sapiens Cytochrome P450 2A6 Proteins 0.000 description 1
• 101000957383 Homo sapiens Cytochrome P450 2B6 Proteins 0.000 description 1
• 101000856695 Homo sapiens Cytochrome b-245 heavy chain Proteins 0.000 description 1
• 101000856723 Homo sapiens Cytochrome b-245 light chain Proteins 0.000 description 1
• 101000908835 Homo sapiens Cytochrome c oxidase subunit 5B, mitochondrial Proteins 0.000 description 1
• 101000957492 Homo sapiens Cytochrome c oxidase subunit 7B, mitochondrial Proteins 0.000 description 1
• 101000919491 Homo sapiens Cytochrome c oxidase subunit 7C, mitochondrial Proteins 0.000 description 1
• 101000943420 Homo sapiens Cytokine-inducible SH2-containing protein Proteins 0.000 description 1
• 101000866326 Homo sapiens Cytoplasmic dynein 1 heavy chain 1 Proteins 0.000 description 1
• 101001074657 Homo sapiens Cytoplasmic phosphatidylinositol transfer protein 1 Proteins 0.000 description 1
• 101001024712 Homo sapiens Cytoplasmic protein NCK2 Proteins 0.000 description 1
• 101000964385 Homo sapiens DNA dC->dU-editing enzyme APOBEC-3B Proteins 0.000 description 1
• 101001041466 Homo sapiens DNA damage-binding protein 2 Proteins 0.000 description 1
• 101000876529 Homo sapiens DNA excision repair protein ERCC-1 Proteins 0.000 description 1
• 101000950906 Homo sapiens DNA fragmentation factor subunit alpha Proteins 0.000 description 1
• 101000927810 Homo sapiens DNA ligase 4 Proteins 0.000 description 1
• 101001134036 Homo sapiens DNA mismatch repair protein Msh2 Proteins 0.000 description 1
• 101001027762 Homo sapiens DNA mismatch repair protein Msh3 Proteins 0.000 description 1
• 101000968658 Homo sapiens DNA mismatch repair protein Msh6 Proteins 0.000 description 1
• 101000702463 Homo sapiens DNA replication complex GINS protein SLD5 Proteins 0.000 description 1
• 101000830681 Homo sapiens DNA topoisomerase 1 Proteins 0.000 description 1
• 101000665135 Homo sapiens DNA-binding protein SMUBP-2 Proteins 0.000 description 1
• 101001036287 Homo sapiens DNA-binding protein inhibitor ID-3 Proteins 0.000 description 1
• 101000669237 Homo sapiens DNA-directed RNA polymerase III subunit RPC4 Proteins 0.000 description 1
• 101000881223 Homo sapiens Decapping and exoribonuclease protein Proteins 0.000 description 1
• 101000866235 Homo sapiens Dedicator of cytokinesis protein 1 Proteins 0.000 description 1
• 101001052956 Homo sapiens Dedicator of cytokinesis protein 5 Proteins 0.000 description 1
• 101000929877 Homo sapiens Delta(24)-sterol reductase Proteins 0.000 description 1
• 101000966982 Homo sapiens Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Proteins 0.000 description 1
• 101000928003 Homo sapiens Deoxyguanosine kinase, mitochondrial Proteins 0.000 description 1
• 101000844963 Homo sapiens Deoxyhypusine synthase Proteins 0.000 description 1
• 101000902850 Homo sapiens Deoxyribonuclease-2-alpha Proteins 0.000 description 1
• 101000968042 Homo sapiens Desmocollin-2 Proteins 0.000 description 1
• 101000924314 Homo sapiens Desmoglein-2 Proteins 0.000 description 1
• 101000924311 Homo sapiens Desmoglein-3 Proteins 0.000 description 1
• 101000838507 Homo sapiens Developmentally-regulated GTP-binding protein 1 Proteins 0.000 description 1
• 101001044817 Homo sapiens Diacylglycerol kinase alpha Proteins 0.000 description 1
• 101000864574 Homo sapiens Diacylglycerol kinase theta Proteins 0.000 description 1
• 101001122360 Homo sapiens Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Proteins 0.000 description 1
• 101000992065 Homo sapiens Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Proteins 0.000 description 1
• 101001053503 Homo sapiens Dihydropyrimidinase-related protein 2 Proteins 0.000 description 1
• 101001053501 Homo sapiens Dihydropyrimidinase-related protein 3 Proteins 0.000 description 1
• 101000793922 Homo sapiens Dipeptidyl peptidase 1 Proteins 0.000 description 1
• 101000915391 Homo sapiens Disabled homolog 2 Proteins 0.000 description 1
• 101000911787 Homo sapiens Discoidin, CUB and LCCL domain-containing protein 2 Proteins 0.000 description 1
• 101001053984 Homo sapiens Disks large homolog 1 Proteins 0.000 description 1
• 101000951365 Homo sapiens Disks large-associated protein 5 Proteins 0.000 description 1
• 101000804531 Homo sapiens DmX-like protein 1 Proteins 0.000 description 1
• 101000866020 Homo sapiens DnaJ homolog subfamily B member 2 Proteins 0.000 description 1
• 101000845897 Homo sapiens DnaJ homolog subfamily C member 4 Proteins 0.000 description 1
• 101000884921 Homo sapiens Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Proteins 0.000 description 1
• 101000661592 Homo sapiens Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A Proteins 0.000 description 1
• 101000591400 Homo sapiens Double-strand break repair protein MRE11 Proteins 0.000 description 1
• 101000742223 Homo sapiens Double-stranded RNA-specific editase 1 Proteins 0.000 description 1
• 101000880945 Homo sapiens Down syndrome cell adhesion molecule Proteins 0.000 description 1
• 101000838600 Homo sapiens Drebrin Proteins 0.000 description 1
• 101000838335 Homo sapiens Dual specificity protein phosphatase 2 Proteins 0.000 description 1
• 101000908482 Homo sapiens Dual specificity protein phosphatase 3 Proteins 0.000 description 1
• 101001057621 Homo sapiens Dual specificity protein phosphatase 4 Proteins 0.000 description 1
• 101001057587 Homo sapiens Dual specificity protein phosphatase 6 Proteins 0.000 description 1
• 101000816970 Homo sapiens Dynein regulatory complex subunit 4 Proteins 0.000 description 1
• 101001053689 Homo sapiens Dystrobrevin alpha Proteins 0.000 description 1
• 101000855983 Homo sapiens Dystroglycan 1 Proteins 0.000 description 1
• 101000804521 Homo sapiens Dystrophia myotonica WD repeat-containing protein Proteins 0.000 description 1
• 101000776154 Homo sapiens E3 ubiquitin-protein ligase AMFR Proteins 0.000 description 1
• 101000737265 Homo sapiens E3 ubiquitin-protein ligase CBL-B Proteins 0.000 description 1
• 101001017463 Homo sapiens E3 ubiquitin-protein ligase DTX1 Proteins 0.000 description 1
• 101001128447 Homo sapiens E3 ubiquitin-protein ligase MYLIP Proteins 0.000 description 1
• 101000636713 Homo sapiens E3 ubiquitin-protein ligase NEDD4 Proteins 0.000 description 1
• 101000667703 Homo sapiens E3 ubiquitin-protein ligase RNF182 Proteins 0.000 description 1
• 101001104297 Homo sapiens E3 ubiquitin-protein ligase RNF183 Proteins 0.000 description 1
• 101000848625 Homo sapiens E3 ubiquitin-protein ligase TRIM23 Proteins 0.000 description 1
• 101000610400 Homo sapiens E3 ubiquitin-protein ligase TRIM37 Proteins 0.000 description 1
• 101000804865 Homo sapiens E3 ubiquitin-protein ligase XIAP Proteins 0.000 description 1
• 101000938776 Homo sapiens ETS domain-containing transcription factor ERF Proteins 0.000 description 1
• 101000813729 Homo sapiens ETS translocation variant 1 Proteins 0.000 description 1
• 101000813726 Homo sapiens ETS translocation variant 3 Proteins 0.000 description 1
• 101000813745 Homo sapiens ETS translocation variant 5 Proteins 0.000 description 1
• 101000877377 Homo sapiens ETS-related transcription factor Elf-2 Proteins 0.000 description 1
• 101000813141 Homo sapiens ETS-related transcription factor Elf-5 Proteins 0.000 description 1
• 101000896450 Homo sapiens Early growth response protein 3 Proteins 0.000 description 1
• 101001057941 Homo sapiens Echinoderm microtubule-associated protein-like 1 Proteins 0.000 description 1
• 101000851972 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 6 Proteins 0.000 description 1
• 101000897035 Homo sapiens Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 description 1
• 101000881648 Homo sapiens Egl nine homolog 1 Proteins 0.000 description 1
• 101001010541 Homo sapiens Electron transfer flavoprotein subunit alpha, mitochondrial Proteins 0.000 description 1
• 101001057122 Homo sapiens Electron transfer flavoprotein subunit beta Proteins 0.000 description 1
• 101000920874 Homo sapiens Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial Proteins 0.000 description 1
• 101000841231 Homo sapiens Elongation factor 1-alpha 2 Proteins 0.000 description 1
• 101000921368 Homo sapiens Elongation of very long chain fatty acids protein 2 Proteins 0.000 description 1
• 101000851937 Homo sapiens Endothelial PAS domain-containing protein 1 Proteins 0.000 description 1
• 101001066265 Homo sapiens Endothelial transcription factor GATA-2 Proteins 0.000 description 1
• 101000967299 Homo sapiens Endothelin receptor type B Proteins 0.000 description 1
• 101000898310 Homo sapiens Enhancer of filamentation 1 Proteins 0.000 description 1
• 101001064458 Homo sapiens Ephrin type-B receptor 3 Proteins 0.000 description 1
• 101000812517 Homo sapiens Epidermal growth factor receptor substrate 15 Proteins 0.000 description 1
• 101000850989 Homo sapiens Epithelial membrane protein 1 Proteins 0.000 description 1
• 101000851002 Homo sapiens Epithelial membrane protein 2 Proteins 0.000 description 1
• 101001011788 Homo sapiens Epithelial membrane protein 3 Proteins 0.000 description 1
• 101001077852 Homo sapiens Epoxide hydrolase 1 Proteins 0.000 description 1
• 101000959666 Homo sapiens Eukaryotic initiation factor 4A-I Proteins 0.000 description 1
• 101001044475 Homo sapiens Eukaryotic initiation factor 4A-II Proteins 0.000 description 1
• 101000851788 Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Proteins 0.000 description 1
• 101000938790 Homo sapiens Eukaryotic peptide chain release factor subunit 1 Proteins 0.000 description 1
• 101001020112 Homo sapiens Eukaryotic translation initiation factor 2 subunit 1 Proteins 0.000 description 1
• 101000959829 Homo sapiens Eukaryotic translation initiation factor 2 subunit 3 Proteins 0.000 description 1
• 101000896557 Homo sapiens Eukaryotic translation initiation factor 3 subunit B Proteins 0.000 description 1
• 101001034811 Homo sapiens Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 description 1
• 101000840282 Homo sapiens Eukaryotic translation initiation factor 4B Proteins 0.000 description 1
• 101000678280 Homo sapiens Eukaryotic translation initiation factor 4E-binding protein 1 Proteins 0.000 description 1
• 101000678283 Homo sapiens Eukaryotic translation initiation factor 4E-binding protein 2 Proteins 0.000 description 1
• 101001002481 Homo sapiens Eukaryotic translation initiation factor 5 Proteins 0.000 description 1
• 101001054354 Homo sapiens Eukaryotic translation initiation factor 5A-1 Proteins 0.000 description 1
• 101000959746 Homo sapiens Eukaryotic translation initiation factor 6 Proteins 0.000 description 1
• 101000918311 Homo sapiens Exostosin-1 Proteins 0.000 description 1
• 101000875558 Homo sapiens Exostosin-like 2 Proteins 0.000 description 1
• 101000770958 Homo sapiens Exportin-2 Proteins 0.000 description 1
• 101000866526 Homo sapiens Extracellular matrix protein 1 Proteins 0.000 description 1
• 101001050211 Homo sapiens Extracellular matrix protein 2 Proteins 0.000 description 1
• 101000938435 Homo sapiens Eyes absent homolog 1 Proteins 0.000 description 1
• 101000938441 Homo sapiens Eyes absent homolog 3 Proteins 0.000 description 1
• 101000793778 Homo sapiens F-actin-capping protein subunit beta Proteins 0.000 description 1
• 101001022163 Homo sapiens FYN-binding protein 1 Proteins 0.000 description 1
• 101000848171 Homo sapiens Fanconi anemia group J protein Proteins 0.000 description 1
• 101001021925 Homo sapiens Fascin Proteins 0.000 description 1
• 101000780194 Homo sapiens Fatty acid CoA ligase Acsl3 Proteins 0.000 description 1
• 101001002987 Homo sapiens Ferritin heavy chain Proteins 0.000 description 1
• 101000818390 Homo sapiens Ferritin light chain Proteins 0.000 description 1
• 101000843611 Homo sapiens Ferrochelatase, mitochondrial Proteins 0.000 description 1
• 101000846893 Homo sapiens Fibrillin-1 Proteins 0.000 description 1
• 101001031635 Homo sapiens Fibrinogen-like protein 1 Proteins 0.000 description 1
• 101000846416 Homo sapiens Fibroblast growth factor 1 Proteins 0.000 description 1
• 101001052035 Homo sapiens Fibroblast growth factor 2 Proteins 0.000 description 1
• 101000827746 Homo sapiens Fibroblast growth factor receptor 1 Proteins 0.000 description 1
• 101001027128 Homo sapiens Fibronectin Proteins 0.000 description 1
• 101001065276 Homo sapiens Fibulin-1 Proteins 0.000 description 1
• 101000935587 Homo sapiens Flavin reductase (NADPH) Proteins 0.000 description 1
• 101000828609 Homo sapiens Flotillin-2 Proteins 0.000 description 1
• 101000931494 Homo sapiens Forkhead box protein F1 Proteins 0.000 description 1
• 101001023393 Homo sapiens Forkhead box protein K2 Proteins 0.000 description 1
• 101000907594 Homo sapiens Forkhead box protein N3 Proteins 0.000 description 1
• 101001031607 Homo sapiens Four and a half LIM domains protein 1 Proteins 0.000 description 1
• 101001062996 Homo sapiens Friend leukemia integration 1 transcription factor Proteins 0.000 description 1
• 101000819477 Homo sapiens Frizzled-2 Proteins 0.000 description 1
• 101000885797 Homo sapiens Frizzled-7 Proteins 0.000 description 1
• 101001028852 Homo sapiens Fructose-1,6-bisphosphatase 1 Proteins 0.000 description 1
• 101000755879 Homo sapiens Fructose-bisphosphate aldolase A Proteins 0.000 description 1
• 101000836545 Homo sapiens Fructose-bisphosphate aldolase C Proteins 0.000 description 1
• 101000886151 Homo sapiens G antigen 2A Proteins 0.000 description 1
• 101000944266 Homo sapiens G protein-activated inward rectifier potassium channel 1 Proteins 0.000 description 1
• 101000829481 Homo sapiens G protein-coupled receptor kinase 4 Proteins 0.000 description 1
• 101000829476 Homo sapiens G protein-coupled receptor kinase 5 Proteins 0.000 description 1
• 101001069589 Homo sapiens G-protein coupled receptor 84 Proteins 0.000 description 1
• 101000870806 Homo sapiens G-rich sequence factor 1 Proteins 0.000 description 1
• 101000980741 Homo sapiens G1/S-specific cyclin-D2 Proteins 0.000 description 1
• 101000738559 Homo sapiens G1/S-specific cyclin-D3 Proteins 0.000 description 1
• 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 description 1
• 101001026457 Homo sapiens G2 and S phase-expressed protein 1 Proteins 0.000 description 1
• 101001022105 Homo sapiens GA-binding protein alpha chain Proteins 0.000 description 1
• 101001022098 Homo sapiens GA-binding protein subunit beta-1 Proteins 0.000 description 1
• 101001022101 Homo sapiens GA-binding protein subunit beta-2 Proteins 0.000 description 1
• 101001024897 Homo sapiens GRB2-associated-binding protein 1 Proteins 0.000 description 1
• 101000998053 Homo sapiens GTP:AMP phosphotransferase AK3, mitochondrial Proteins 0.000 description 1
• 101000584633 Homo sapiens GTPase HRas Proteins 0.000 description 1
• 101000744505 Homo sapiens GTPase NRas Proteins 0.000 description 1
• 101000860395 Homo sapiens Galactocerebrosidase Proteins 0.000 description 1
• 101001024874 Homo sapiens Galactokinase Proteins 0.000 description 1
• 101000885616 Homo sapiens Galactoside alpha-(1,2)-fucosyltransferase 1 Proteins 0.000 description 1
• 101000967904 Homo sapiens Galectin-3-binding protein Proteins 0.000 description 1
• 101000799011 Homo sapiens Gamma-adducin Proteins 0.000 description 1
• 101001073597 Homo sapiens Gamma-aminobutyric acid receptor subunit beta-3 Proteins 0.000 description 1
• 101000926813 Homo sapiens Gamma-aminobutyric acid receptor subunit gamma-2 Proteins 0.000 description 1
• 101000822394 Homo sapiens Gamma-aminobutyric acid receptor subunit pi Proteins 0.000 description 1
• 101000685969 Homo sapiens Ganglioside GM2 activator Proteins 0.000 description 1
• 101000954092 Homo sapiens Gap junction beta-2 protein Proteins 0.000 description 1
• 101001026269 Homo sapiens Gasdermin-E Proteins 0.000 description 1
• 101001059150 Homo sapiens Gelsolin Proteins 0.000 description 1
• 101000714249 Homo sapiens General transcription factor 3C polypeptide 1 Proteins 0.000 description 1
• 101000714246 Homo sapiens General transcription factor 3C polypeptide 2 Proteins 0.000 description 1
• 101001032427 Homo sapiens General transcription factor II-I Proteins 0.000 description 1
• 101000640758 Homo sapiens General transcription factor IIF subunit 1 Proteins 0.000 description 1
• 101000666405 Homo sapiens General transcription factor IIH subunit 1 Proteins 0.000 description 1
• 101000655398 Homo sapiens General transcription factor IIH subunit 2 Proteins 0.000 description 1
• 101001039387 Homo sapiens Glia maturation factor beta Proteins 0.000 description 1
• 101000926939 Homo sapiens Glucocorticoid receptor Proteins 0.000 description 1
• 101000873546 Homo sapiens Glutamate decarboxylase 1 Proteins 0.000 description 1
• 101000873786 Homo sapiens Glutamate decarboxylase 2 Proteins 0.000 description 1
• 101001034527 Homo sapiens Glutamate-cysteine ligase catalytic subunit Proteins 0.000 description 1
• 101001002170 Homo sapiens Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial Proteins 0.000 description 1
• 101000997929 Homo sapiens Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 1 Proteins 0.000 description 1
• 101000856983 Homo sapiens Glutaredoxin-1 Proteins 0.000 description 1
• 101001026125 Homo sapiens Glutathione S-transferase A1 Proteins 0.000 description 1
• 101000870514 Homo sapiens Glutathione S-transferase A4 Proteins 0.000 description 1
• 101001071716 Homo sapiens Glutathione S-transferase Mu 3 Proteins 0.000 description 1
• 101000906399 Homo sapiens Glutathione S-transferase Mu 4 Proteins 0.000 description 1
• 101000905982 Homo sapiens Glutathione S-transferase theta-2 Proteins 0.000 description 1
• 101000997558 Homo sapiens Glutathione hydrolase 1 proenzyme Proteins 0.000 description 1
• 101001009678 Homo sapiens Glycerol-3-phosphate dehydrogenase, mitochondrial Proteins 0.000 description 1
• 101000998096 Homo sapiens Glycine dehydrogenase (decarboxylating), mitochondrial Proteins 0.000 description 1
• 101001036117 Homo sapiens Glycogen [starch] synthase, liver Proteins 0.000 description 1
• 101001036130 Homo sapiens Glycogen [starch] synthase, muscle Proteins 0.000 description 1
• 101001071776 Homo sapiens Glycophorin-B Proteins 0.000 description 1
• 101000905336 Homo sapiens Glycophorin-C Proteins 0.000 description 1
• 101000833040 Homo sapiens Glycosyltransferase 8 domain-containing protein 2 Proteins 0.000 description 1
• 101001070736 Homo sapiens Glypican-1 Proteins 0.000 description 1
• 101001014682 Homo sapiens Glypican-4 Proteins 0.000 description 1
• 101001014629 Homo sapiens Golgin subfamily A member 2 Proteins 0.000 description 1
• 101001014634 Homo sapiens Golgin subfamily A member 3 Proteins 0.000 description 1
• 101001066158 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 alpha Proteins 0.000 description 1
• 101001066164 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 beta Proteins 0.000 description 1
• 101001072723 Homo sapiens Growth arrest-specific protein 1 Proteins 0.000 description 1
• 101000923005 Homo sapiens Growth arrest-specific protein 6 Proteins 0.000 description 1
• 101000871017 Homo sapiens Growth factor receptor-bound protein 2 Proteins 0.000 description 1
• 101000926795 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Proteins 0.000 description 1
• 101001073261 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Proteins 0.000 description 1
• 101001024316 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Proteins 0.000 description 1
• 101001072407 Homo sapiens Guanine nucleotide-binding protein subunit alpha-11 Proteins 0.000 description 1
• 101001072398 Homo sapiens Guanine nucleotide-binding protein subunit alpha-12 Proteins 0.000 description 1
• 101001072481 Homo sapiens Guanine nucleotide-binding protein subunit alpha-13 Proteins 0.000 description 1
• 101000614191 Homo sapiens Guanylate kinase Proteins 0.000 description 1
• 101001001336 Homo sapiens Guanylate-binding protein 1 Proteins 0.000 description 1
• 101001058858 Homo sapiens Guanylate-binding protein 2 Proteins 0.000 description 1
• 101000766971 Homo sapiens H(+)/Cl(-) exchange transporter 7 Proteins 0.000 description 1
• 101000844866 Homo sapiens H/ACA ribonucleoprotein complex subunit DKC1 Proteins 0.000 description 1
• 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 description 1
• 101001037977 Homo sapiens Heat shock 70 kDa protein 1-like Proteins 0.000 description 1
• 101001037759 Homo sapiens Heat shock 70 kDa protein 1A Proteins 0.000 description 1
• 101001037968 Homo sapiens Heat shock 70 kDa protein 1B Proteins 0.000 description 1
• 101001078692 Homo sapiens Heat shock 70 kDa protein 4 Proteins 0.000 description 1
• 101001078680 Homo sapiens Heat shock 70 kDa protein 6 Proteins 0.000 description 1
• 101001080568 Homo sapiens Heat shock cognate 71 kDa protein Proteins 0.000 description 1
• 101001016883 Homo sapiens Heat shock factor protein 2 Proteins 0.000 description 1
• 101001080298 Homo sapiens Heat shock factor-binding protein 1 Proteins 0.000 description 1
• 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 description 1
• 101001016856 Homo sapiens Heat shock protein HSP 90-beta Proteins 0.000 description 1
• 101001028696 Homo sapiens Helicase MOV-10 Proteins 0.000 description 1
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 1
• 101001079623 Homo sapiens Heme oxygenase 1 Proteins 0.000 description 1
• 101001079615 Homo sapiens Heme oxygenase 2 Proteins 0.000 description 1
• 101000872875 Homo sapiens Hepatocyte cell adhesion molecule Proteins 0.000 description 1
• 101000972946 Homo sapiens Hepatocyte growth factor receptor Proteins 0.000 description 1
• 101001045740 Homo sapiens Hepatocyte nuclear factor 4-alpha Proteins 0.000 description 1
• 101000838926 Homo sapiens Hermansky-Pudlak syndrome 1 protein Proteins 0.000 description 1
• 101000854036 Homo sapiens Heterogeneous nuclear ribonucleoprotein A/B Proteins 0.000 description 1
• 101001017535 Homo sapiens Heterogeneous nuclear ribonucleoprotein D0 Proteins 0.000 description 1
• 101001081143 Homo sapiens Heterogeneous nuclear ribonucleoprotein H2 Proteins 0.000 description 1
• 101000838964 Homo sapiens Heterogeneous nuclear ribonucleoprotein K Proteins 0.000 description 1
• 101000839078 Homo sapiens Heterogeneous nuclear ribonucleoprotein L Proteins 0.000 description 1
• 101000839073 Homo sapiens Heterogeneous nuclear ribonucleoprotein M Proteins 0.000 description 1
• 101001047854 Homo sapiens Heterogeneous nuclear ribonucleoprotein U Proteins 0.000 description 1
• 101000854026 Homo sapiens Heterogeneous nuclear ribonucleoproteins A2/B1 Proteins 0.000 description 1
• 101001017574 Homo sapiens Heterogeneous nuclear ribonucleoproteins C1/C2 Proteins 0.000 description 1
• 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 description 1
• 101001025337 Homo sapiens High mobility group protein B1 Proteins 0.000 description 1
• 101001045794 Homo sapiens High mobility group protein B3 Proteins 0.000 description 1
• 101001016841 Homo sapiens Histamine H1 receptor Proteins 0.000 description 1
• 101000843187 Homo sapiens Histidine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
• 101001026554 Homo sapiens Histone H1.0 Proteins 0.000 description 1
• 101001036111 Homo sapiens Histone H2A type 1-B/E Proteins 0.000 description 1
• 101000905054 Homo sapiens Histone H2A.Z Proteins 0.000 description 1
• 101001067891 Homo sapiens Histone H2AX Proteins 0.000 description 1
• 101001084684 Homo sapiens Histone H2B type 1-D Proteins 0.000 description 1
• 101001035966 Homo sapiens Histone H3.3 Proteins 0.000 description 1
• 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 description 1
• 101001045846 Homo sapiens Histone-lysine N-methyltransferase 2A Proteins 0.000 description 1
• 101001028782 Homo sapiens Histone-lysine N-methyltransferase EZH1 Proteins 0.000 description 1
• 101000946589 Homo sapiens Holocytochrome c-type synthase Proteins 0.000 description 1
• 101000777808 Homo sapiens Homeobox protein CDX-1 Proteins 0.000 description 1
• 101000864690 Homo sapiens Homeobox protein DLX-1 Proteins 0.000 description 1
• 101001083156 Homo sapiens Homeobox protein Hox-A1 Proteins 0.000 description 1
• 101001083164 Homo sapiens Homeobox protein Hox-A10 Proteins 0.000 description 1
• 101000962622 Homo sapiens Homeobox protein Hox-A3 Proteins 0.000 description 1
• 101001019752 Homo sapiens Homeobox protein Hox-B2 Proteins 0.000 description 1
• 101001077539 Homo sapiens Homeobox protein Hox-B7 Proteins 0.000 description 1
• 101000989000 Homo sapiens Homeobox protein Hox-B9 Proteins 0.000 description 1
• 101001045154 Homo sapiens Homeobox protein Hox-C6 Proteins 0.000 description 1
• 101001037168 Homo sapiens Homeobox protein Hox-D13 Proteins 0.000 description 1
• 101001037158 Homo sapiens Homeobox protein Hox-D3 Proteins 0.000 description 1
• 101001019776 Homo sapiens Homeobox protein Hox-D8 Proteins 0.000 description 1
• 101000955037 Homo sapiens Homeobox protein MOX-2 Proteins 0.000 description 1
• 101000967222 Homo sapiens Homeobox protein MSX-2 Proteins 0.000 description 1
• 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 description 1
• 101000578249 Homo sapiens Homeobox protein Nkx-3.1 Proteins 0.000 description 1
• 101001083553 Homo sapiens Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Proteins 0.000 description 1
• 101000913079 Homo sapiens IgG receptor FcRn large subunit p51 Proteins 0.000 description 1
• 101000840257 Homo sapiens Immunoglobulin kappa constant Proteins 0.000 description 1
• 101000977638 Homo sapiens Immunoglobulin superfamily containing leucine-rich repeat protein Proteins 0.000 description 1
• 101001001331 Homo sapiens Importin subunit alpha-1 Proteins 0.000 description 1
• 101001001478 Homo sapiens Importin subunit alpha-3 Proteins 0.000 description 1
• 101001001473 Homo sapiens Importin subunit alpha-4 Proteins 0.000 description 1
• 101001001462 Homo sapiens Importin subunit alpha-5 Proteins 0.000 description 1
• 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 description 1
• 101001054732 Homo sapiens Inhibin beta A chain Proteins 0.000 description 1
• 101001053708 Homo sapiens Inhibitor of growth protein 2 Proteins 0.000 description 1
• 101001056794 Homo sapiens Inosine triphosphate pyrophosphatase Proteins 0.000 description 1
• 101001076642 Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Proteins 0.000 description 1
• 101000975428 Homo sapiens Inositol 1,4,5-trisphosphate receptor type 1 Proteins 0.000 description 1
• 101000975401 Homo sapiens Inositol 1,4,5-trisphosphate receptor type 3 Proteins 0.000 description 1
• 101001001429 Homo sapiens Inositol monophosphatase 1 Proteins 0.000 description 1
• 101000950718 Homo sapiens Inositol oxygenase Proteins 0.000 description 1
• 101001054823 Homo sapiens Inositol polyphosphate 1-phosphatase Proteins 0.000 description 1
• 101001046674 Homo sapiens Inositol-tetrakisphosphate 1-kinase Proteins 0.000 description 1
• 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 description 1
• 101000840572 Homo sapiens Insulin-like growth factor-binding protein 4 Proteins 0.000 description 1
• 101000840577 Homo sapiens Insulin-like growth factor-binding protein 7 Proteins 0.000 description 1
• 101000994369 Homo sapiens Integrin alpha-5 Proteins 0.000 description 1
• 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 description 1
• 101001015059 Homo sapiens Integrin beta-5 Proteins 0.000 description 1
• 101000609396 Homo sapiens Inter-alpha-trypsin inhibitor heavy chain H2 Proteins 0.000 description 1
• 101000609406 Homo sapiens Inter-alpha-trypsin inhibitor heavy chain H3 Proteins 0.000 description 1
• 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 description 1
• 101001001496 Homo sapiens Interferon gamma receptor 2 Proteins 0.000 description 1
• 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 description 1
• 101001011393 Homo sapiens Interferon regulatory factor 2 Proteins 0.000 description 1
• 101001011441 Homo sapiens Interferon regulatory factor 4 Proteins 0.000 description 1
• 101001011442 Homo sapiens Interferon regulatory factor 5 Proteins 0.000 description 1
• 101000998500 Homo sapiens Interferon-induced 35 kDa protein Proteins 0.000 description 1
• 101001082058 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 2 Proteins 0.000 description 1
• 101000999377 Homo sapiens Interferon-related developmental regulator 1 Proteins 0.000 description 1
• 101001003149 Homo sapiens Interleukin-10 receptor subunit beta Proteins 0.000 description 1
• 101001003135 Homo sapiens Interleukin-13 receptor subunit alpha-1 Proteins 0.000 description 1
• 101001003140 Homo sapiens Interleukin-15 receptor subunit alpha Proteins 0.000 description 1
• 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 description 1
• 101001047190 Homo sapiens Inward rectifier potassium channel 16 Proteins 0.000 description 1
• 101001053430 Homo sapiens Iroquois-class homeodomain protein IRX-3 Proteins 0.000 description 1
• 101001081606 Homo sapiens Islet cell autoantigen 1 Proteins 0.000 description 1
• 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 description 1
• 101001042038 Homo sapiens Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 description 1
• 101000960245 Homo sapiens Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Proteins 0.000 description 1
• 101000614609 Homo sapiens Junctophilin-1 Proteins 0.000 description 1
• 101000975474 Homo sapiens Keratin, type I cytoskeletal 10 Proteins 0.000 description 1
• 101000998027 Homo sapiens Keratin, type I cytoskeletal 17 Proteins 0.000 description 1
• 101001056452 Homo sapiens Keratin, type II cytoskeletal 6A Proteins 0.000 description 1
• 101000975502 Homo sapiens Keratin, type II cytoskeletal 7 Proteins 0.000 description 1
• 101001091205 Homo sapiens KiSS-1 receptor Proteins 0.000 description 1
• 101001139019 Homo sapiens Kin of IRRE-like protein 1 Proteins 0.000 description 1
• 101001090172 Homo sapiens Kinectin Proteins 0.000 description 1
• 101001139062 Homo sapiens Kinesin heavy chain isoform 5A Proteins 0.000 description 1
• 101001006789 Homo sapiens Kinesin heavy chain isoform 5C Proteins 0.000 description 1
• 101001008953 Homo sapiens Kinesin-like protein KIF11 Proteins 0.000 description 1
• 101001091231 Homo sapiens Kinesin-like protein KIF18A Proteins 0.000 description 1
• 101000605734 Homo sapiens Kinesin-like protein KIF22 Proteins 0.000 description 1
• 101001050577 Homo sapiens Kinesin-like protein KIF2A Proteins 0.000 description 1
• 101001139162 Homo sapiens Kinesin-like protein KIF3C Proteins 0.000 description 1
• 101001006776 Homo sapiens Kinesin-like protein KIFC1 Proteins 0.000 description 1
• 101000716729 Homo sapiens Kit ligand Proteins 0.000 description 1
• 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 description 1
• 101001139126 Homo sapiens Krueppel-like factor 6 Proteins 0.000 description 1
• 101000796203 Homo sapiens L-dopachrome tautomerase Proteins 0.000 description 1
• 101001042351 Homo sapiens LIM and senescent cell antigen-like-containing domain protein 1 Proteins 0.000 description 1
• 101001005128 Homo sapiens LIM domain kinase 1 Proteins 0.000 description 1
• 101001047511 Homo sapiens LLGL scribble cell polarity complex component 2 Proteins 0.000 description 1
• 101001034314 Homo sapiens Lactadherin Proteins 0.000 description 1
• 101001004946 Homo sapiens Lactoylglutathione lyase Proteins 0.000 description 1
• 101001003581 Homo sapiens Lamin-B1 Proteins 0.000 description 1
• 101001008527 Homo sapiens Laminin subunit alpha-5 Proteins 0.000 description 1
• 101001008558 Homo sapiens Laminin subunit beta-2 Proteins 0.000 description 1
• 101000896726 Homo sapiens Lanosterol 14-alpha demethylase Proteins 0.000 description 1
• 101001054659 Homo sapiens Latent-transforming growth factor beta-binding protein 1 Proteins 0.000 description 1
• 101001047515 Homo sapiens Lethal(2) giant larvae protein homolog 1 Proteins 0.000 description 1
• 101000941892 Homo sapiens Leucine-rich repeat and calponin homology domain-containing protein 4 Proteins 0.000 description 1
• 101001063463 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 4 Proteins 0.000 description 1
• 101001137975 Homo sapiens Leucyl-cystinyl aminopeptidase Proteins 0.000 description 1
• 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 description 1
• 101000980823 Homo sapiens Leukocyte surface antigen CD53 Proteins 0.000 description 1
• 101001017968 Homo sapiens Leukotriene B4 receptor 1 Proteins 0.000 description 1
• 101000697929 Homo sapiens Lipid droplet-regulating VLDL assembly factor AUP1 Proteins 0.000 description 1
• 101001077840 Homo sapiens Lipid-phosphate phosphatase Proteins 0.000 description 1
• 101001003687 Homo sapiens Lipoma-preferred partner Proteins 0.000 description 1
• 101001017764 Homo sapiens Lipopolysaccharide-responsive and beige-like anchor protein Proteins 0.000 description 1
• 101000677545 Homo sapiens Long-chain specific acyl-CoA dehydrogenase, mitochondrial Proteins 0.000 description 1
• 101000799318 Homo sapiens Long-chain-fatty-acid-CoA ligase 1 Proteins 0.000 description 1
• 101000780208 Homo sapiens Long-chain-fatty-acid-CoA ligase 4 Proteins 0.000 description 1
• 101000611240 Homo sapiens Low molecular weight phosphotyrosine protein phosphatase Proteins 0.000 description 1
• 101001043596 Homo sapiens Low-density lipoprotein receptor-related protein 3 Proteins 0.000 description 1
• 101001065568 Homo sapiens Lymphocyte antigen 6E Proteins 0.000 description 1
• 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 description 1
• 101000899339 Homo sapiens Lymphoid-specific helicase Proteins 0.000 description 1
• 101000966782 Homo sapiens Lysophosphatidic acid receptor 1 Proteins 0.000 description 1
• 101001001294 Homo sapiens Lysosomal acid phosphatase Proteins 0.000 description 1
• 101001018026 Homo sapiens Lysosomal alpha-glucosidase Proteins 0.000 description 1
• 101000979046 Homo sapiens Lysosomal alpha-mannosidase Proteins 0.000 description 1
• 101001018064 Homo sapiens Lysosomal-trafficking regulator Proteins 0.000 description 1
• 101001043321 Homo sapiens Lysyl oxidase homolog 1 Proteins 0.000 description 1
• 101000624625 Homo sapiens M-phase inducer phosphatase 1 Proteins 0.000 description 1
• 101000624631 Homo sapiens M-phase inducer phosphatase 2 Proteins 0.000 description 1
• 101000624643 Homo sapiens M-phase inducer phosphatase 3 Proteins 0.000 description 1
• 101001018978 Homo sapiens MAP kinase-interacting serine/threonine-protein kinase 2 Proteins 0.000 description 1
• 101001059429 Homo sapiens MAP/microtubule affinity-regulating kinase 3 Proteins 0.000 description 1
• 101000914251 Homo sapiens Major centromere autoantigen B Proteins 0.000 description 1
• 101000573901 Homo sapiens Major prion protein Proteins 0.000 description 1
• 101001056308 Homo sapiens Malate dehydrogenase, cytoplasmic Proteins 0.000 description 1
• 101000575041 Homo sapiens Male-enhanced antigen 1 Proteins 0.000 description 1
• 101001011906 Homo sapiens Matrix metalloproteinase-14 Proteins 0.000 description 1
• 101001011884 Homo sapiens Matrix metalloproteinase-15 Proteins 0.000 description 1
• 101001011886 Homo sapiens Matrix metalloproteinase-16 Proteins 0.000 description 1
• 101000962483 Homo sapiens Max dimerization protein 1 Proteins 0.000 description 1
• 101000576320 Homo sapiens Max-binding protein MNT Proteins 0.000 description 1
• 101001134060 Homo sapiens Melanocyte-stimulating hormone receptor Proteins 0.000 description 1
• 101001012669 Homo sapiens Melanoma inhibitory activity protein 2 Proteins 0.000 description 1
• 101001005717 Homo sapiens Melanoma-associated antigen 12 Proteins 0.000 description 1
• 101001005718 Homo sapiens Melanoma-associated antigen 2 Proteins 0.000 description 1
• 101001005719 Homo sapiens Melanoma-associated antigen 3 Proteins 0.000 description 1
• 101001005720 Homo sapiens Melanoma-associated antigen 4 Proteins 0.000 description 1
• 101000798109 Homo sapiens Melanotransferrin Proteins 0.000 description 1
• 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 description 1
• 101000967073 Homo sapiens Metal regulatory transcription factor 1 Proteins 0.000 description 1
• 101000969792 Homo sapiens Metallophosphoesterase MPPED2 Proteins 0.000 description 1
• 101000880398 Homo sapiens Metalloreductase STEAP3 Proteins 0.000 description 1
• 101001027943 Homo sapiens Metallothionein-1F Proteins 0.000 description 1
• 101001027938 Homo sapiens Metallothionein-1G Proteins 0.000 description 1
• 101001013794 Homo sapiens Metallothionein-1H Proteins 0.000 description 1
• 101001116314 Homo sapiens Methionine synthase reductase Proteins 0.000 description 1
• 101000581507 Homo sapiens Methyl-CpG-binding domain protein 1 Proteins 0.000 description 1
• 101001013097 Homo sapiens Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial Proteins 0.000 description 1
• 101000575381 Homo sapiens Microfibril-associated glycoprotein 3 Proteins 0.000 description 1
• 101000947699 Homo sapiens Microfibril-associated glycoprotein 4 Proteins 0.000 description 1
• 101000575376 Homo sapiens Microfibrillar-associated protein 1 Proteins 0.000 description 1
• 101000575378 Homo sapiens Microfibrillar-associated protein 2 Proteins 0.000 description 1
• 101001055794 Homo sapiens Microfibrillar-associated protein 3-like Proteins 0.000 description 1
• 101000628785 Homo sapiens Microsomal glutathione S-transferase 3 Proteins 0.000 description 1
• 101000616438 Homo sapiens Microtubule-associated protein 4 Proteins 0.000 description 1
• 101000616432 Homo sapiens Microtubule-associated protein 6 Proteins 0.000 description 1
• 101000628925 Homo sapiens Mitochondrial intermediate peptidase Proteins 0.000 description 1
• 101000958409 Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Proteins 0.000 description 1
• 101001018147 Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Proteins 0.000 description 1
• 101001055085 Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Proteins 0.000 description 1
• 101000972273 Homo sapiens Mucin-7 Proteins 0.000 description 1
• 101000955249 Homo sapiens Multiple epidermal growth factor-like domains protein 8 Proteins 0.000 description 1
• 101000955254 Homo sapiens Multiple epidermal growth factor-like domains protein 9 Proteins 0.000 description 1
• 101000968663 Homo sapiens MutS protein homolog 5 Proteins 0.000 description 1
• 101000593398 Homo sapiens Myb-related protein A Proteins 0.000 description 1
• 101000593405 Homo sapiens Myb-related protein B Proteins 0.000 description 1
• 101000970561 Homo sapiens Myc box-dependent-interacting protein 1 Proteins 0.000 description 1
• 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 description 1
• 101001030197 Homo sapiens Myelin transcription factor 1 Proteins 0.000 description 1
• 101001015220 Homo sapiens Myelin-associated oligodendrocyte basic protein Proteins 0.000 description 1
• 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 1
• 101001013158 Homo sapiens Myeloid leukemia factor 1 Proteins 0.000 description 1
• 101000635895 Homo sapiens Myosin light chain 4 Proteins 0.000 description 1
• 101001022780 Homo sapiens Myosin light chain kinase, smooth muscle Proteins 0.000 description 1
• 101001000109 Homo sapiens Myosin-10 Proteins 0.000 description 1
• 101001030228 Homo sapiens Myosin-8 Proteins 0.000 description 1
• 101001030232 Homo sapiens Myosin-9 Proteins 0.000 description 1
• 101001132874 Homo sapiens Myotubularin Proteins 0.000 description 1
• 101000829958 Homo sapiens N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase Proteins 0.000 description 1
• 101000906927 Homo sapiens N-chimaerin Proteins 0.000 description 1
• 101000983292 Homo sapiens N-fatty-acyl-amino acid synthase/hydrolase PM20D1 Proteins 0.000 description 1
• 101000973778 Homo sapiens NAD(P)H dehydrogenase [quinone] 1 Proteins 0.000 description 1
• 101001111244 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Proteins 0.000 description 1
• 101001111238 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Proteins 0.000 description 1
• 101000573220 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Proteins 0.000 description 1
• 101000573234 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Proteins 0.000 description 1
• 101001023513 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Proteins 0.000 description 1
• 101001128634 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Proteins 0.000 description 1
• 101001128623 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Proteins 0.000 description 1
• 101001128608 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Proteins 0.000 description 1
• 101000601568 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Proteins 0.000 description 1
• 101000601579 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Proteins 0.000 description 1
• 101000979735 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Proteins 0.000 description 1
• 101000979731 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Proteins 0.000 description 1
• 101001023553 Homo sapiens NADH dehydrogenase [ubiquinone] 1 subunit C2 Proteins 0.000 description 1
• 101001111187 Homo sapiens NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Proteins 0.000 description 1
• 101001023640 Homo sapiens NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Proteins 0.000 description 1
• 101000573300 Homo sapiens NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Proteins 0.000 description 1
• 101001128687 Homo sapiens NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Proteins 0.000 description 1
• 101000601517 Homo sapiens NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Proteins 0.000 description 1
• 101000979243 Homo sapiens NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Proteins 0.000 description 1
• 101000636705 Homo sapiens NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Proteins 0.000 description 1
• 101000998623 Homo sapiens NADH-cytochrome b5 reductase 3 Proteins 0.000 description 1
• 101000928259 Homo sapiens NADPH:adrenodoxin oxidoreductase, mitochondrial Proteins 0.000 description 1
• 101000961071 Homo sapiens NF-kappa-B inhibitor alpha Proteins 0.000 description 1
• 101000583053 Homo sapiens NGFI-A-binding protein 1 Proteins 0.000 description 1
• 101001128163 Homo sapiens Nanos homolog 1 Proteins 0.000 description 1
• 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 description 1
• 101001024704 Homo sapiens Nck-associated protein 1-like Proteins 0.000 description 1
• 101000577555 Homo sapiens Neuritin Proteins 0.000 description 1
• 101000638044 Homo sapiens Neurogenic differentiation factor 1 Proteins 0.000 description 1
• 101000745175 Homo sapiens Neuronal acetylcholine receptor subunit alpha-5 Proteins 0.000 description 1
• 101001024605 Homo sapiens Next to BRCA1 gene 1 protein Proteins 0.000 description 1
• 101000958671 Homo sapiens Novel acetylcholine receptor chaperone Proteins 0.000 description 1
• 101001111328 Homo sapiens Nuclear factor 1 A-type Proteins 0.000 description 1
• 101000973211 Homo sapiens Nuclear factor 1 B-type Proteins 0.000 description 1
• 101000973200 Homo sapiens Nuclear factor 1 C-type Proteins 0.000 description 1
• 101000979347 Homo sapiens Nuclear factor 1 X-type Proteins 0.000 description 1
• 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 description 1
• 101000973177 Homo sapiens Nuclear factor interleukin-3-regulated protein Proteins 0.000 description 1
• 101001121654 Homo sapiens Nuclear pore complex protein Nup50 Proteins 0.000 description 1
• 101000633516 Homo sapiens Nuclear receptor subfamily 2 group F member 6 Proteins 0.000 description 1
• 101001109682 Homo sapiens Nuclear receptor subfamily 6 group A member 1 Proteins 0.000 description 1
• 101000851976 Homo sapiens Nucleoside diphosphate phosphatase ENTPD5 Proteins 0.000 description 1
• 101000974015 Homo sapiens Nucleosome assembly protein 1-like 1 Proteins 0.000 description 1
• 101000974007 Homo sapiens Nucleosome assembly protein 1-like 3 Proteins 0.000 description 1
• 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 description 1
• 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 description 1
• 101000720966 Homo sapiens Opsin-3 Proteins 0.000 description 1
• 101001121326 Homo sapiens Oxidative stress-induced growth inhibitor 2 Proteins 0.000 description 1
• 101000744394 Homo sapiens Oxidized purine nucleoside triphosphate hydrolase Proteins 0.000 description 1
• 101001091191 Homo sapiens Peptidyl-prolyl cis-trans isomerase F, mitochondrial Proteins 0.000 description 1
• 101000914053 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 description 1
• 101000827313 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 description 1
• 101001096050 Homo sapiens Perilipin-2 Proteins 0.000 description 1
• 101001045218 Homo sapiens Peroxisomal multifunctional enzyme type 2 Proteins 0.000 description 1
• 101000938567 Homo sapiens Persulfide dioxygenase ETHE1, mitochondrial Proteins 0.000 description 1
• 101000730493 Homo sapiens Phosphatidylinositol-glycan-specific phospholipase D Proteins 0.000 description 1
• 101000829725 Homo sapiens Phospholipid hydroperoxide glutathione peroxidase Proteins 0.000 description 1
• 101000615965 Homo sapiens Phosphoserine phosphatase Proteins 0.000 description 1
• 101000691783 Homo sapiens Pirin Proteins 0.000 description 1
• 101000595669 Homo sapiens Pituitary homeobox 2 Proteins 0.000 description 1
• 101000893745 Homo sapiens Plasma alpha-L-fucosidase Proteins 0.000 description 1
• 101000728095 Homo sapiens Plasma membrane calcium-transporting ATPase 1 Proteins 0.000 description 1
• 101000583692 Homo sapiens Pleckstrin homology-like domain family A member 1 Proteins 0.000 description 1
• 101000583702 Homo sapiens Pleckstrin homology-like domain family A member 2 Proteins 0.000 description 1
• 101000872170 Homo sapiens Polycomb complex protein BMI-1 Proteins 0.000 description 1
• 101000613350 Homo sapiens Polycomb group RING finger protein 5 Proteins 0.000 description 1
• 101001071145 Homo sapiens Polyhomeotic-like protein 1 Proteins 0.000 description 1
• 101000583616 Homo sapiens Polyhomeotic-like protein 2 Proteins 0.000 description 1
• 101000829541 Homo sapiens Polypeptide N-acetylgalactosaminyltransferase 13 Proteins 0.000 description 1
• 101001002235 Homo sapiens Polypeptide N-acetylgalactosaminyltransferase 2 Proteins 0.000 description 1
• 101000578474 Homo sapiens Polyunsaturated fatty acid lipoxygenase ALOX15B Proteins 0.000 description 1
• 101000997292 Homo sapiens Potassium voltage-gated channel subfamily B member 1 Proteins 0.000 description 1
• 101001047102 Homo sapiens Potassium voltage-gated channel subfamily G member 1 Proteins 0.000 description 1
• 101001077441 Homo sapiens Potassium voltage-gated channel subfamily S member 3 Proteins 0.000 description 1
• 101000854887 Homo sapiens Pre-B lymphocyte protein 3 Proteins 0.000 description 1
• 101001003584 Homo sapiens Prelamin-A/C Proteins 0.000 description 1
• 101000952113 Homo sapiens Probable ATP-dependent RNA helicase DDX5 Proteins 0.000 description 1
• 101000829779 Homo sapiens Probable G-protein coupled receptor 19 Proteins 0.000 description 1
• 101000983583 Homo sapiens Procathepsin L Proteins 0.000 description 1
• 101000928339 Homo sapiens Progressive ankylosis protein homolog Proteins 0.000 description 1
• 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 description 1
• 101001135391 Homo sapiens Prostaglandin E synthase Proteins 0.000 description 1
• 101000959489 Homo sapiens Protein AF-9 Proteins 0.000 description 1
• 101000892338 Homo sapiens Protein AF1q Proteins 0.000 description 1
• 101000933601 Homo sapiens Protein BTG1 Proteins 0.000 description 1
• 101000876829 Homo sapiens Protein C-ets-1 Proteins 0.000 description 1
• 101000817237 Homo sapiens Protein ECT2 Proteins 0.000 description 1
• 101001038300 Homo sapiens Protein ERGIC-53 Proteins 0.000 description 1
• 101001057166 Homo sapiens Protein EVI2A Proteins 0.000 description 1
• 101001057168 Homo sapiens Protein EVI2B Proteins 0.000 description 1
• 101001061041 Homo sapiens Protein FRG1 Proteins 0.000 description 1
• 101000693054 Homo sapiens Protein S100-A13 Proteins 0.000 description 1
• 101000693050 Homo sapiens Protein S100-A16 Proteins 0.000 description 1
• 101000707284 Homo sapiens Protein Shroom2 Proteins 0.000 description 1
• 101000652172 Homo sapiens Protein Smaug homolog 1 Proteins 0.000 description 1
• 101000873612 Homo sapiens Protein bicaudal D homolog 1 Proteins 0.000 description 1
• 101000928791 Homo sapiens Protein diaphanous homolog 1 Proteins 0.000 description 1
• 101000928408 Homo sapiens Protein diaphanous homolog 2 Proteins 0.000 description 1
• 101001098802 Homo sapiens Protein disulfide-isomerase A3 Proteins 0.000 description 1
• 101000861587 Homo sapiens Protein farnesyltransferase subunit beta Proteins 0.000 description 1
• 101000893493 Homo sapiens Protein flightless-1 homolog Proteins 0.000 description 1
• 101000981742 Homo sapiens Protein lifeguard 1 Proteins 0.000 description 1
• 101000735463 Homo sapiens Protein mono-ADP-ribosyltransferase PARP4 Proteins 0.000 description 1
• 101001014035 Homo sapiens Protein p13 MTCP-1 Proteins 0.000 description 1
• 101001000061 Homo sapiens Protein phosphatase 1 regulatory subunit 12A Proteins 0.000 description 1
• 101000629617 Homo sapiens Protein sprouty homolog 4 Proteins 0.000 description 1
• 101000878540 Homo sapiens Protein-tyrosine kinase 2-beta Proteins 0.000 description 1
• 101001098529 Homo sapiens Proteinase-activated receptor 1 Proteins 0.000 description 1
• 101000651439 Homo sapiens Prothrombin Proteins 0.000 description 1
• 101001072237 Homo sapiens Protocadherin-16 Proteins 0.000 description 1
• 101000936510 Homo sapiens Putative annexin A2-like protein Proteins 0.000 description 1
• 101000575036 Homo sapiens Putative homeobox protein Meis3-like 1 Proteins 0.000 description 1
• 101000957337 Homo sapiens Putative nucleotidyltransferase MAB21L1 Proteins 0.000 description 1
• 101000845206 Homo sapiens Putative peripheral benzodiazepine receptor-related protein Proteins 0.000 description 1
• 101001131748 Homo sapiens Quinone oxidoreductase Proteins 0.000 description 1
• 101000798015 Homo sapiens RAC-beta serine/threonine-protein kinase Proteins 0.000 description 1
• 101000717459 Homo sapiens RCC1 and BTB domain-containing protein 2 Proteins 0.000 description 1
• 101000668168 Homo sapiens RNA-binding motif, single-stranded-interacting protein 3 Proteins 0.000 description 1
• 101000926083 Homo sapiens Rab GDP dissociation inhibitor beta Proteins 0.000 description 1
• 101000620777 Homo sapiens Rab proteins geranylgeranyltransferase component A 1 Proteins 0.000 description 1
• 101000620788 Homo sapiens Rab proteins geranylgeranyltransferase component A 2 Proteins 0.000 description 1
• 101000994788 Homo sapiens Ras GTPase-activating-like protein IQGAP3 Proteins 0.000 description 1
• 101000712571 Homo sapiens Ras-related protein Rab-8A Proteins 0.000 description 1
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
• 101000695844 Homo sapiens Receptor-type tyrosine-protein phosphatase zeta Proteins 0.000 description 1
• 101000584743 Homo sapiens Recombining binding protein suppressor of hairless Proteins 0.000 description 1
• 101001106511 Homo sapiens Regulator of G-protein signaling 22 Proteins 0.000 description 1
• 101001096529 Homo sapiens Regulator of G-protein signaling 4 Proteins 0.000 description 1
• 101000890554 Homo sapiens Retinal dehydrogenase 2 Proteins 0.000 description 1
• 101001100101 Homo sapiens Retinoic acid-induced protein 3 Proteins 0.000 description 1
• 101000856728 Homo sapiens Rho GDP-dissociation inhibitor 1 Proteins 0.000 description 1
• 101000856696 Homo sapiens Rho GDP-dissociation inhibitor 2 Proteins 0.000 description 1
• 101001106395 Homo sapiens Rho GTPase-activating protein 5 Proteins 0.000 description 1
• 101001106325 Homo sapiens Rho GTPase-activating protein 6 Proteins 0.000 description 1
• 101000670585 Homo sapiens Ribonuclease H2 subunit C Proteins 0.000 description 1
• 101000873502 Homo sapiens S-adenosylmethionine decarboxylase proenzyme Proteins 0.000 description 1
• 101001055594 Homo sapiens S-adenosylmethionine synthase isoform type-1 Proteins 0.000 description 1
• 101000947881 Homo sapiens S-adenosylmethionine synthase isoform type-2 Proteins 0.000 description 1
• 101001010890 Homo sapiens S-formylglutathione hydrolase Proteins 0.000 description 1
• 101000697544 Homo sapiens SCL-interrupting locus protein Proteins 0.000 description 1
• 101000633792 Homo sapiens SLAM family member 9 Proteins 0.000 description 1
• 101000936922 Homo sapiens Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Proteins 0.000 description 1
• 101000936917 Homo sapiens Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Proteins 0.000 description 1
• 101000740659 Homo sapiens Scavenger receptor class B member 1 Proteins 0.000 description 1
• 101000867413 Homo sapiens Segment polarity protein dishevelled homolog DVL-1 Proteins 0.000 description 1
• 101000867466 Homo sapiens Segment polarity protein dishevelled homolog DVL-2 Proteins 0.000 description 1
• 101000867469 Homo sapiens Segment polarity protein dishevelled homolog DVL-3 Proteins 0.000 description 1
• 101000704221 Homo sapiens Serine palmitoyltransferase small subunit A Proteins 0.000 description 1
• 101001077723 Homo sapiens Serine protease inhibitor Kazal-type 6 Proteins 0.000 description 1
• 101000661819 Homo sapiens Serine/threonine-protein kinase 17B Proteins 0.000 description 1
• 101000880431 Homo sapiens Serine/threonine-protein kinase 4 Proteins 0.000 description 1
• 101000771237 Homo sapiens Serine/threonine-protein kinase A-Raf Proteins 0.000 description 1
• 101000904787 Homo sapiens Serine/threonine-protein kinase ATR Proteins 0.000 description 1
• 101000913761 Homo sapiens Serine/threonine-protein kinase ICK Proteins 0.000 description 1
• 101001123846 Homo sapiens Serine/threonine-protein kinase Nek1 Proteins 0.000 description 1
• 101000601441 Homo sapiens Serine/threonine-protein kinase Nek2 Proteins 0.000 description 1
• 101000601456 Homo sapiens Serine/threonine-protein kinase Nek3 Proteins 0.000 description 1
• 101000601460 Homo sapiens Serine/threonine-protein kinase Nek4 Proteins 0.000 description 1
• 101000691614 Homo sapiens Serine/threonine-protein kinase PLK3 Proteins 0.000 description 1
• 101000770770 Homo sapiens Serine/threonine-protein kinase WNK1 Proteins 0.000 description 1
• 101000799194 Homo sapiens Serine/threonine-protein kinase receptor R3 Proteins 0.000 description 1
• 101000929936 Homo sapiens Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Proteins 0.000 description 1
• 101001123859 Homo sapiens Sialidase-1 Proteins 0.000 description 1
• 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 description 1
• 101001026232 Homo sapiens Small conductance calcium-activated potassium channel protein 3 Proteins 0.000 description 1
• 101000684826 Homo sapiens Sodium channel protein type 2 subunit alpha Proteins 0.000 description 1
• 101001023149 Homo sapiens Sodium/calcium exchanger 1 Proteins 0.000 description 1
• 101000701334 Homo sapiens Sodium/potassium-transporting ATPase subunit alpha-1 Proteins 0.000 description 1
• 101000789523 Homo sapiens Sodium/potassium-transporting ATPase subunit beta-1 Proteins 0.000 description 1
• 101000974834 Homo sapiens Sodium/potassium-transporting ATPase subunit beta-3 Proteins 0.000 description 1
• 101000637919 Homo sapiens Sodium/potassium/calcium exchanger 3 Proteins 0.000 description 1
• 101000701625 Homo sapiens Sp110 nuclear body protein Proteins 0.000 description 1
• 101000693269 Homo sapiens Sphingosine 1-phosphate receptor 3 Proteins 0.000 description 1
• 101000878981 Homo sapiens Squalene synthase Proteins 0.000 description 1
• 101000829367 Homo sapiens Src substrate cortactin Proteins 0.000 description 1
• 101000831940 Homo sapiens Stathmin Proteins 0.000 description 1
• 101000861263 Homo sapiens Steroid 21-hydroxylase Proteins 0.000 description 1
• 101000875401 Homo sapiens Sterol 26-hydroxylase, mitochondrial Proteins 0.000 description 1
• 101000661600 Homo sapiens Steryl-sulfatase Proteins 0.000 description 1
• 101000820460 Homo sapiens Stomatin Proteins 0.000 description 1
• 101000903318 Homo sapiens Stress-70 protein, mitochondrial Proteins 0.000 description 1
• 101000880098 Homo sapiens Sushi repeat-containing protein SRPX Proteins 0.000 description 1
• 101000828537 Homo sapiens Synaptic functional regulator FMR1 Proteins 0.000 description 1
• 101000652315 Homo sapiens Synaptosomal-associated protein 25 Proteins 0.000 description 1
• 101000642676 Homo sapiens Syntaxin-2 Proteins 0.000 description 1
• 101000837401 Homo sapiens T-cell leukemia/lymphoma protein 1A Proteins 0.000 description 1
• 101000716149 Homo sapiens T-cell surface glycoprotein CD1b Proteins 0.000 description 1
• 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 description 1
• 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 description 1
• 101000653469 Homo sapiens T-complex protein 1 subunit zeta Proteins 0.000 description 1
• 101000679548 Homo sapiens TOX high mobility group box family member 3 Proteins 0.000 description 1
• 101000620880 Homo sapiens Tartrate-resistant acid phosphatase type 5 Proteins 0.000 description 1
• 101000626142 Homo sapiens Tensin-1 Proteins 0.000 description 1
• 101000662686 Homo sapiens Torsin-1A Proteins 0.000 description 1
• 101000881764 Homo sapiens Transcription elongation factor 1 homolog Proteins 0.000 description 1
• 101000891297 Homo sapiens Transcription elongation factor A protein-like 2 Proteins 0.000 description 1
• 101000904150 Homo sapiens Transcription factor E2F3 Proteins 0.000 description 1
• 101000866298 Homo sapiens Transcription factor E2F8 Proteins 0.000 description 1
• 101000813738 Homo sapiens Transcription factor ETV6 Proteins 0.000 description 1
• 101000819074 Homo sapiens Transcription factor GATA-4 Proteins 0.000 description 1
• 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 description 1
• 101001028730 Homo sapiens Transcription factor JunB Proteins 0.000 description 1
• 101001050297 Homo sapiens Transcription factor JunD Proteins 0.000 description 1
• 101000962473 Homo sapiens Transcription factor MafG Proteins 0.000 description 1
• 101000642528 Homo sapiens Transcription factor SOX-8 Proteins 0.000 description 1
• 101000635741 Homo sapiens Transcription initiation factor IIA subunit 1 Proteins 0.000 description 1
• 101000838169 Homo sapiens Transcription initiation factor IIA subunit 2 Proteins 0.000 description 1
• 101000800860 Homo sapiens Transcription initiation factor IIB Proteins 0.000 description 1
• 101000658563 Homo sapiens Transcription initiation factor IIE subunit beta Proteins 0.000 description 1
• 101000894871 Homo sapiens Transcription regulator protein BACH1 Proteins 0.000 description 1
• 101000904868 Homo sapiens Transcriptional regulator ATRX Proteins 0.000 description 1
• 101000840378 Homo sapiens Translation initiation factor IF-2, mitochondrial Proteins 0.000 description 1
• 101000845233 Homo sapiens Translocator protein Proteins 0.000 description 1
• 101000895030 Homo sapiens Transmembrane ascorbate-dependent reductase CYB561 Proteins 0.000 description 1
• 101000787862 Homo sapiens Transmembrane protein 255A Proteins 0.000 description 1
• 101000597903 Homo sapiens Transmembrane protein 258 Proteins 0.000 description 1
• 101000648531 Homo sapiens Transmembrane protein 50B Proteins 0.000 description 1
• 101000648491 Homo sapiens Transportin-1 Proteins 0.000 description 1
• 101000634975 Homo sapiens Tripartite motif-containing protein 29 Proteins 0.000 description 1
• 101000851892 Homo sapiens Tropomyosin beta chain Proteins 0.000 description 1
• 101000830570 Homo sapiens Tumor necrosis factor alpha-induced protein 3 Proteins 0.000 description 1
• 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 description 1
• 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 description 1
• 101000610794 Homo sapiens Tumor protein D53 Proteins 0.000 description 1
• 101000962366 Homo sapiens Type II inositol 1,4,5-trisphosphate 5-phosphatase Proteins 0.000 description 1
• 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 description 1
• 101001026790 Homo sapiens Tyrosine-protein kinase Fes/Fps Proteins 0.000 description 1
• 101001022129 Homo sapiens Tyrosine-protein kinase Fyn Proteins 0.000 description 1
• 101000644689 Homo sapiens Ubiquitin-conjugating enzyme E2 K Proteins 0.000 description 1
• 101000982054 Homo sapiens Unconventional myosin-Ib Proteins 0.000 description 1
• 101000982023 Homo sapiens Unconventional myosin-Ic Proteins 0.000 description 1
• 101001000095 Homo sapiens Unconventional myosin-Id Proteins 0.000 description 1
• 101001000122 Homo sapiens Unconventional myosin-Ie Proteins 0.000 description 1
• 101000585623 Homo sapiens Unconventional myosin-X Proteins 0.000 description 1
• 101000805729 Homo sapiens V-type proton ATPase 116 kDa subunit a 1 Proteins 0.000 description 1
• 101000775709 Homo sapiens V-type proton ATPase subunit C 1 Proteins 0.000 description 1
• 101000670960 Homo sapiens V-type proton ATPase subunit E 1 Proteins 0.000 description 1
• 101000617919 Homo sapiens VPS10 domain-containing receptor SorCS1 Proteins 0.000 description 1
• 101000805613 Homo sapiens Vacuole membrane protein 1 Proteins 0.000 description 1
• 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 description 1
• 101000860430 Homo sapiens Versican core protein Proteins 0.000 description 1
• 101000904228 Homo sapiens Vesicle transport protein GOT1A Proteins 0.000 description 1
• 101000904204 Homo sapiens Vesicle transport protein GOT1B Proteins 0.000 description 1
• 101000805481 Homo sapiens Vigilin Proteins 0.000 description 1
• 101000983956 Homo sapiens Voltage-dependent L-type calcium channel subunit beta-2 Proteins 0.000 description 1
• 101000804928 Homo sapiens X-ray repair cross-complementing protein 6 Proteins 0.000 description 1
• 101000744900 Homo sapiens Zinc finger homeobox protein 3 Proteins 0.000 description 1
• 101001117146 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Proteins 0.000 description 1
• 101000919269 Homo sapiens cAMP-responsive element modulator Proteins 0.000 description 1
• 101000856240 Homo sapiens cTAGE family member 2 Proteins 0.000 description 1
• 101000802094 Homo sapiens mRNA decay activator protein ZFP36L1 Proteins 0.000 description 1
• 101001039228 Homo sapiens mRNA export factor GLE1 Proteins 0.000 description 1
• 101000582267 Homo sapiens tRNA N(3)-methylcytidine methyltransferase METTL2B Proteins 0.000 description 1
• 101000641227 Homo sapiens von Willebrand factor A domain-containing protein 5A Proteins 0.000 description 1
• 108090000320 Hyaluronan Synthases Proteins 0.000 description 1
• 102000003918 Hyaluronan Synthases Human genes 0.000 description 1
• 102000004157 Hydrolases Human genes 0.000 description 1
• 108090000604 Hydrolases Proteins 0.000 description 1
• 102100030358 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Human genes 0.000 description 1
• 102100040544 Hydroxyacylglutathione hydrolase, mitochondrial Human genes 0.000 description 1
• 108010038663 Hydroxyprostaglandin Dehydrogenases Proteins 0.000 description 1
• 102000010817 Hydroxyprostaglandin Dehydrogenases Human genes 0.000 description 1
• 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 1
• 102000018251 Hypoxanthine Phosphoribosyltransferase Human genes 0.000 description 1
• 108010031792 IGF Type 2 Receptor Proteins 0.000 description 1
• 101150057269 IKBKB gene Proteins 0.000 description 1
• 101710096421 Iduronate 2-sulfatase Proteins 0.000 description 1
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 108060003951 Immunoglobulin Proteins 0.000 description 1
• 102100026211 Immunoglobulin heavy constant delta Human genes 0.000 description 1
• 102100029572 Immunoglobulin kappa constant Human genes 0.000 description 1
• 102100023538 Immunoglobulin superfamily containing leucine-rich repeat protein Human genes 0.000 description 1
• 102100022519 Immunoglobulin superfamily member 3 Human genes 0.000 description 1
• 102100036188 Importin subunit alpha-3 Human genes 0.000 description 1
• 102100036187 Importin subunit alpha-4 Human genes 0.000 description 1
• 102100036186 Importin subunit alpha-5 Human genes 0.000 description 1
• 102100036340 Importin-5 Human genes 0.000 description 1
• 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 description 1
• 102000003781 Inhibitor of growth protein 1 Human genes 0.000 description 1
• 108090000191 Inhibitor of growth protein 1 Proteins 0.000 description 1
• 102100024067 Inhibitor of growth protein 2 Human genes 0.000 description 1
• 102100025891 Inosine-5'-monophosphate dehydrogenase 2 Human genes 0.000 description 1
• 102100024039 Inositol 1,4,5-trisphosphate receptor type 1 Human genes 0.000 description 1
• 102100024035 Inositol 1,4,5-trisphosphate receptor type 3 Human genes 0.000 description 1
• 102100035679 Inositol monophosphatase 1 Human genes 0.000 description 1
• 101710133957 Inositol polyphosphate 1-phosphatase Proteins 0.000 description 1
• 102100022296 Inositol-tetrakisphosphate 1-kinase Human genes 0.000 description 1
• 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 description 1
• 102100029224 Insulin-like growth factor-binding protein 4 Human genes 0.000 description 1
• 102100029228 Insulin-like growth factor-binding protein 7 Human genes 0.000 description 1
• 102000000507 Integrin alpha2 Human genes 0.000 description 1
• 108010041012 Integrin alpha4 Proteins 0.000 description 1
• 108010041014 Integrin alpha5 Proteins 0.000 description 1
• 108010042918 Integrin alpha5beta1 Proteins 0.000 description 1
• 102100033010 Integrin beta-5 Human genes 0.000 description 1
• 108010022222 Integrin beta1 Proteins 0.000 description 1
• 102000012355 Integrin beta1 Human genes 0.000 description 1
• 108010020950 Integrin beta3 Proteins 0.000 description 1
• 102000008607 Integrin beta3 Human genes 0.000 description 1
• 102100039440 Inter-alpha-trypsin inhibitor heavy chain H2 Human genes 0.000 description 1
• 102100039460 Inter-alpha-trypsin inhibitor heavy chain H3 Human genes 0.000 description 1
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
• 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 description 1
• 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 description 1
• 101710169201 Interferon alpha-inducible protein 6 Proteins 0.000 description 1
• 102100035678 Interferon gamma receptor 1 Human genes 0.000 description 1
• 101710174028 Interferon gamma receptor 1 Proteins 0.000 description 1
• 102100036981 Interferon regulatory factor 1 Human genes 0.000 description 1
• 102100029838 Interferon regulatory factor 2 Human genes 0.000 description 1
• 102100030126 Interferon regulatory factor 4 Human genes 0.000 description 1
• 102100030131 Interferon regulatory factor 5 Human genes 0.000 description 1
• 102100033273 Interferon-induced 35 kDa protein Human genes 0.000 description 1
• 102100027303 Interferon-induced protein with tetratricopeptide repeats 2 Human genes 0.000 description 1
• 102100036527 Interferon-related developmental regulator 1 Human genes 0.000 description 1
• 101710107661 Interleukin enhancer-binding factor 2 Proteins 0.000 description 1
• 102000044594 Interleukin-1 Receptor Accessory Human genes 0.000 description 1
• 108700002862 Interleukin-1 Receptor Accessory Proteins 0.000 description 1
• 102100020788 Interleukin-10 receptor subunit beta Human genes 0.000 description 1
• 102000003815 Interleukin-11 Human genes 0.000 description 1
• 108090000177 Interleukin-11 Proteins 0.000 description 1
• 102100020791 Interleukin-13 receptor subunit alpha-1 Human genes 0.000 description 1
• 102100020789 Interleukin-15 receptor subunit alpha Human genes 0.000 description 1
• 102100039064 Interleukin-3 Human genes 0.000 description 1
• 108010002386 Interleukin-3 Proteins 0.000 description 1
• 108091092195 Intron Proteins 0.000 description 1
• 102100022774 Inward rectifier potassium channel 16 Human genes 0.000 description 1
• 108010008812 Ionotropic Glutamate Receptors Proteins 0.000 description 1
• 102000006541 Ionotropic Glutamate Receptors Human genes 0.000 description 1
• 102000004901 Iron regulatory protein 1 Human genes 0.000 description 1
• 108090001025 Iron regulatory protein 1 Proteins 0.000 description 1
• 102000004902 Iron regulatory protein 2 Human genes 0.000 description 1
• 108090001028 Iron regulatory protein 2 Proteins 0.000 description 1
• 102100024374 Iroquois-class homeodomain protein IRX-3 Human genes 0.000 description 1
• 102100027640 Islet cell autoantigen 1 Human genes 0.000 description 1
• 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 1
• 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 1
• 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 description 1
• 102100039906 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Human genes 0.000 description 1
• 108010044467 Isoenzymes Proteins 0.000 description 1
• 102100025392 Isovaleryl-CoA dehydrogenase, mitochondrial Human genes 0.000 description 1
• 102100026153 Junction plakoglobin Human genes 0.000 description 1
• 102100040504 Junctophilin-1 Human genes 0.000 description 1
• 102100033511 Keratin, type I cytoskeletal 17 Human genes 0.000 description 1
• 102100025656 Keratin, type II cytoskeletal 6A Human genes 0.000 description 1
• 102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 description 1
• 108010065038 Keratin-10 Proteins 0.000 description 1
• 102100034845 KiSS-1 receptor Human genes 0.000 description 1
• 102100020687 Kin of IRRE-like protein 1 Human genes 0.000 description 1
• 102100034751 Kinectin Human genes 0.000 description 1
• 102100020685 Kinesin heavy chain isoform 5A Human genes 0.000 description 1
• 102100027928 Kinesin heavy chain isoform 5C Human genes 0.000 description 1
• 102100027629 Kinesin-like protein KIF11 Human genes 0.000 description 1
• 102100034895 Kinesin-like protein KIF18A Human genes 0.000 description 1
• 102100038408 Kinesin-like protein KIF22 Human genes 0.000 description 1
• 102100020733 Kinesin-like protein KIF3C Human genes 0.000 description 1
• 102100027942 Kinesin-like protein KIFC1 Human genes 0.000 description 1
• 102100020880 Kit ligand Human genes 0.000 description 1
• 102100020680 Krueppel-like factor 5 Human genes 0.000 description 1
• 102100020679 Krueppel-like factor 6 Human genes 0.000 description 1
• 108010025026 Ku Autoantigen Proteins 0.000 description 1
• LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
• 125000000899 L-alpha-glutamyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(O[H])=O 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• ILRYLPWNYFXEMH-WHFBIAKZSA-N L-cystathionine Chemical compound [O-]C(=O)[C@@H]([NH3+])CCSC[C@H]([NH3+])C([O-])=O ILRYLPWNYFXEMH-WHFBIAKZSA-N 0.000 description 1
• 101710093778 L-dopachrome tautomerase Proteins 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• 102100034671 L-lactate dehydrogenase A chain Human genes 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• 239000005517 L01XE01 - Imatinib Substances 0.000 description 1
• 108010001831 LDL receptors Proteins 0.000 description 1
• 102000006259 LDL-Receptor Related Proteins Human genes 0.000 description 1
• 108010058141 LDL-Receptor Related Proteins Proteins 0.000 description 1
• 102100021754 LIM and senescent cell antigen-like-containing domain protein 1 Human genes 0.000 description 1
• 102100026023 LIM domain kinase 1 Human genes 0.000 description 1
• 102100022957 LLGL scribble cell polarity complex component 2 Human genes 0.000 description 1
• 101000879324 Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) Alanine-tRNA ligase 2 Proteins 0.000 description 1
• 102100039648 Lactadherin Human genes 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 102100026004 Lactoylglutathione lyase Human genes 0.000 description 1
• 102100027450 Laminin subunit alpha-5 Human genes 0.000 description 1
• 102100027454 Laminin subunit beta-2 Human genes 0.000 description 1
• 102100034710 Laminin subunit gamma-1 Human genes 0.000 description 1
• 102100021695 Lanosterol 14-alpha demethylase Human genes 0.000 description 1
• 108010059597 Lanosterol synthase Proteins 0.000 description 1
• 102100027919 Latexin Human genes 0.000 description 1
• 102100022956 Lethal(2) giant larvae protein homolog 1 Human genes 0.000 description 1
• 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
• 102100032680 Leucine-rich repeat and calponin homology domain-containing protein 4 Human genes 0.000 description 1
• 102100031035 Leucine-rich repeat-containing G-protein coupled receptor 4 Human genes 0.000 description 1
• 102100020872 Leucyl-cystinyl aminopeptidase Human genes 0.000 description 1
• 102100031586 Leukocyte antigen CD37 Human genes 0.000 description 1
• 102100024221 Leukocyte surface antigen CD53 Human genes 0.000 description 1
• 102100033374 Leukotriene B4 receptor 1 Human genes 0.000 description 1
• 241000239220 Limulus polyphemus Species 0.000 description 1
• 101710098556 Lipase A Proteins 0.000 description 1
• 102100027931 Lipid droplet-regulating VLDL assembly factor AUP1 Human genes 0.000 description 1
• 102100025357 Lipid-phosphate phosphatase Human genes 0.000 description 1
• 206010024612 Lipoma Diseases 0.000 description 1
• 102100026358 Lipoma-preferred partner Human genes 0.000 description 1
• 102100033353 Lipopolysaccharide-responsive and beige-like anchor protein Human genes 0.000 description 1
• 102100021644 Long-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 description 1
• 102100033995 Long-chain-fatty-acid-CoA ligase 1 Human genes 0.000 description 1
• 102100034319 Long-chain-fatty-acid-CoA ligase 4 Human genes 0.000 description 1
• 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 1
• 102100040323 Low molecular weight phosphotyrosine protein phosphatase Human genes 0.000 description 1
• 102100021917 Low-density lipoprotein receptor-related protein 3 Human genes 0.000 description 1
• 102000036243 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Human genes 0.000 description 1
• 108010002481 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Proteins 0.000 description 1
• 102100032131 Lymphocyte antigen 6E Human genes 0.000 description 1
• 101710195102 Lymphocyte cytosolic protein 2 Proteins 0.000 description 1
• 102000018247 Lymphocyte-specific proteins Human genes 0.000 description 1
• 108050007388 Lymphocyte-specific proteins Proteins 0.000 description 1
• 102100022539 Lymphoid-specific helicase Human genes 0.000 description 1
• 108010091221 Lymphotoxin beta Receptor Proteins 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 102100035529 Lysine-tRNA ligase Human genes 0.000 description 1
• 102000004137 Lysophosphatidic Acid Receptors Human genes 0.000 description 1
• 108090000642 Lysophosphatidic Acid Receptors Proteins 0.000 description 1
• 102100040607 Lysophosphatidic acid receptor 1 Human genes 0.000 description 1
• 102100026001 Lysosomal acid lipase/cholesteryl ester hydrolase Human genes 0.000 description 1
• 101710099648 Lysosomal acid lipase/cholesteryl ester hydrolase Proteins 0.000 description 1
• 102100035699 Lysosomal acid phosphatase Human genes 0.000 description 1
• 102100023231 Lysosomal alpha-mannosidase Human genes 0.000 description 1
• 108010009491 Lysosomal-Associated Membrane Protein 2 Proteins 0.000 description 1
• 102100033472 Lysosomal-trafficking regulator Human genes 0.000 description 1
• 102000014944 Lysosome-Associated Membrane Glycoproteins Human genes 0.000 description 1
• 108010064171 Lysosome-Associated Membrane Glycoproteins Proteins 0.000 description 1
• 102100038225 Lysosome-associated membrane glycoprotein 2 Human genes 0.000 description 1
• 102100021958 Lysyl oxidase homolog 1 Human genes 0.000 description 1
• 102100023326 M-phase inducer phosphatase 1 Human genes 0.000 description 1
• 102100023325 M-phase inducer phosphatase 2 Human genes 0.000 description 1
• 102100023330 M-phase inducer phosphatase 3 Human genes 0.000 description 1
• 102100033610 MAP kinase-interacting serine/threonine-protein kinase 2 Human genes 0.000 description 1
• 102100028920 MAP/microtubule affinity-regulating kinase 3 Human genes 0.000 description 1
• 101150040099 MAP2K2 gene Proteins 0.000 description 1
• 102000017274 MDM4 Human genes 0.000 description 1
• 108050005300 MDM4 Proteins 0.000 description 1
• 101150007128 MDM4 gene Proteins 0.000 description 1
• 101150083522 MECP2 gene Proteins 0.000 description 1
• 108010018650 MEF2 Transcription Factors Proteins 0.000 description 1
• 101150029107 MEIS1 gene Proteins 0.000 description 1
• 108060004872 MIF Proteins 0.000 description 1
• 102000034655 MIF Human genes 0.000 description 1
• 108700019589 MRE11 Homologue Proteins 0.000 description 1
• 229910015837 MSH2 Inorganic materials 0.000 description 1
• 108010048043 Macrophage Migration-Inhibitory Factors Proteins 0.000 description 1
• 101710125418 Major capsid protein Proteins 0.000 description 1
• 102100025833 Major centromere autoantigen B Human genes 0.000 description 1
• 102100025818 Major prion protein Human genes 0.000 description 1
• 102100026475 Malate dehydrogenase, cytoplasmic Human genes 0.000 description 1
• 102100025532 Male-enhanced antigen 1 Human genes 0.000 description 1
• 229920002774 Maltodextrin Polymers 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 102000019218 Mannose-6-phosphate receptors Human genes 0.000 description 1
• 101150024075 Mapk1 gene Proteins 0.000 description 1
• 108010076557 Matrix Metalloproteinase 14 Proteins 0.000 description 1
• 108090000560 Matrix metalloproteinase-15 Proteins 0.000 description 1
• 108090000561 Matrix metalloproteinase-16 Proteins 0.000 description 1
• 102100039185 Max dimerization protein 1 Human genes 0.000 description 1
• 102100025169 Max-binding protein MNT Human genes 0.000 description 1
• 102100035880 Max-interacting protein 1 Human genes 0.000 description 1
• 101710112905 Max-interacting protein 1 Proteins 0.000 description 1
• 101800001751 Melanocyte-stimulating hormone alpha Proteins 0.000 description 1
• 102100029778 Melanoma inhibitory activity protein 2 Human genes 0.000 description 1
• 108050008953 Melanoma-associated antigen Proteins 0.000 description 1
• 102100025084 Melanoma-associated antigen 12 Human genes 0.000 description 1
• 102100025081 Melanoma-associated antigen 2 Human genes 0.000 description 1
• 102100025082 Melanoma-associated antigen 3 Human genes 0.000 description 1
• 102100025077 Melanoma-associated antigen 4 Human genes 0.000 description 1
• 102000047724 Member 2 Solute Carrier Family 12 Human genes 0.000 description 1
• 101710146216 Membrane cofactor protein Proteins 0.000 description 1
• 102100037106 Merlin Human genes 0.000 description 1
• 102100021276 Metallophosphoesterase MPPED2 Human genes 0.000 description 1
• 102000005741 Metalloproteases Human genes 0.000 description 1
• 108010006035 Metalloproteases Proteins 0.000 description 1
• 102100037653 Metalloreductase STEAP3 Human genes 0.000 description 1
• 102100037514 Metallothionein-1F Human genes 0.000 description 1
• 102100037512 Metallothionein-1G Human genes 0.000 description 1
• 102100031742 Metallothionein-1H Human genes 0.000 description 1
• 101000859568 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) Carbamoyl-phosphate synthase Proteins 0.000 description 1
• 108010007784 Methionine adenosyltransferase Proteins 0.000 description 1
• 102000007357 Methionine adenosyltransferase Human genes 0.000 description 1
• 108010072388 Methyl-CpG-Binding Protein 2 Proteins 0.000 description 1
• 102100027383 Methyl-CpG-binding domain protein 1 Human genes 0.000 description 1
• 102100029676 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial Human genes 0.000 description 1
• 102100025600 Microfibril-associated glycoprotein 3 Human genes 0.000 description 1
• 102100036103 Microfibril-associated glycoprotein 4 Human genes 0.000 description 1
• 102100025602 Microfibrillar-associated protein 1 Human genes 0.000 description 1
• 102100025599 Microfibrillar-associated protein 2 Human genes 0.000 description 1
• 102100026108 Microfibrillar-associated protein 3-like Human genes 0.000 description 1
• 102000002151 Microfilament Proteins Human genes 0.000 description 1
• 108010040897 Microfilament Proteins Proteins 0.000 description 1
• 102100026722 Microsomal glutathione S-transferase 3 Human genes 0.000 description 1
• 102000029749 Microtubule Human genes 0.000 description 1
• 108091022875 Microtubule Proteins 0.000 description 1
• 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
• 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 1
• 108090001040 Microtubule-associated protein 1B Proteins 0.000 description 1
• 102000004866 Microtubule-associated protein 1B Human genes 0.000 description 1
• 102100021794 Microtubule-associated protein 4 Human genes 0.000 description 1
• 102100021791 Microtubule-associated protein 6 Human genes 0.000 description 1
• 108010092801 Midkine Proteins 0.000 description 1
• 108010079754 Minichromosome Maintenance Complex Component 6 Proteins 0.000 description 1
• 102000012942 Minichromosome Maintenance Complex Component 6 Human genes 0.000 description 1
• 101710118206 Mitochondrial carnitine/acylcarnitine carrier protein Proteins 0.000 description 1
• 102100026934 Mitochondrial intermediate peptidase Human genes 0.000 description 1
• 102100038243 Mitogen-activated protein kinase kinase kinase 10 Human genes 0.000 description 1
• 102100033060 Mitogen-activated protein kinase kinase kinase 4 Human genes 0.000 description 1
• 102100026909 Mitogen-activated protein kinase kinase kinase 9 Human genes 0.000 description 1
• 102100027869 Moesin Human genes 0.000 description 1
• 102100022492 Mucin-7 Human genes 0.000 description 1
• 208000001769 Multiple Acyl Coenzyme A Dehydrogenase Deficiency Diseases 0.000 description 1
• 102100038990 Multiple epidermal growth factor-like domains protein 8 Human genes 0.000 description 1
• 102100038989 Multiple epidermal growth factor-like domains protein 9 Human genes 0.000 description 1
• 208000034578 Multiple myelomas Diseases 0.000 description 1
• 101000715673 Mus musculus Cadherin EGF LAG seven-pass G-type receptor 2 Proteins 0.000 description 1
• 108700031745 MutS Homolog 2 Proteins 0.000 description 1
• 102100021156 MutS protein homolog 5 Human genes 0.000 description 1
• 102100034711 Myb-related protein A Human genes 0.000 description 1
• 102100034670 Myb-related protein B Human genes 0.000 description 1
• 102100021970 Myc box-dependent-interacting protein 1 Human genes 0.000 description 1
• 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
• 101001033610 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Inosine-5'-monophosphate dehydrogenase Proteins 0.000 description 1
• 102000006386 Myelin Proteins Human genes 0.000 description 1
• 108010083674 Myelin Proteins Proteins 0.000 description 1
• 102100030741 Myelin protein P0 Human genes 0.000 description 1
• 108050003852 Myelin protein P0 Proteins 0.000 description 1
• 102100038893 Myelin transcription factor 1 Human genes 0.000 description 1
• 102100032977 Myelin-associated oligodendrocyte basic protein Human genes 0.000 description 1
• 108700006140 Myeloid Cell Leukemia Sequence 1 Proteins 0.000 description 1
• 102000046234 Myeloid Cell Leukemia Sequence 1 Human genes 0.000 description 1
• 102000047831 Myeloid Ecotropic Viral Integration Site 1 Human genes 0.000 description 1
• 108700041619 Myeloid Ecotropic Viral Integration Site 1 Proteins 0.000 description 1
• 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 1
• 102100029691 Myeloid leukemia factor 1 Human genes 0.000 description 1
• 102100039229 Myocyte-specific enhancer factor 2C Human genes 0.000 description 1
• 102100030739 Myosin light chain 4 Human genes 0.000 description 1
• 102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 description 1
• 102100036640 Myosin-10 Human genes 0.000 description 1
• 102100038891 Myosin-8 Human genes 0.000 description 1
• 102100038938 Myosin-9 Human genes 0.000 description 1
• 102100030735 Myosin-binding protein C, slow-type Human genes 0.000 description 1
• 101710153664 Myosin-binding protein C, slow-type Proteins 0.000 description 1
• 206010068871 Myotonic dystrophy Diseases 0.000 description 1
• 102100033817 Myotubularin Human genes 0.000 description 1
• 102000015695 Myristoylated Alanine-Rich C Kinase Substrate Human genes 0.000 description 1
• 108010063737 Myristoylated Alanine-Rich C Kinase Substrate Proteins 0.000 description 1
• 102100021003 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Human genes 0.000 description 1
• KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
• HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
• 125000003047 N-acetyl group Chemical group 0.000 description 1
• 102100023315 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase Human genes 0.000 description 1
• 102100023648 N-chimaerin Human genes 0.000 description 1
• 108700025784 N-myc downstream-regulated gene 1 Proteins 0.000 description 1
• 102100022365 NAD(P)H dehydrogenase [quinone] 1 Human genes 0.000 description 1
• 102100032457 NAD-dependent malic enzyme, mitochondrial Human genes 0.000 description 1
• 101710108550 NAD-dependent malic enzyme, mitochondrial Proteins 0.000 description 1
• 102100023950 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Human genes 0.000 description 1
• 102100023948 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Human genes 0.000 description 1
• 102100026374 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Human genes 0.000 description 1
• 102100026377 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Human genes 0.000 description 1
• 102100035383 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Human genes 0.000 description 1
• 102100032194 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Human genes 0.000 description 1
• 102100032195 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Human genes 0.000 description 1
• 102100032205 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Human genes 0.000 description 1
• 102100037524 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Human genes 0.000 description 1
• 102100037520 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Human genes 0.000 description 1
• 102100024975 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Human genes 0.000 description 1
• 102100024978 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Human genes 0.000 description 1
• 102100035386 NADH dehydrogenase [ubiquinone] 1 subunit C2 Human genes 0.000 description 1
• XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 description 1
• 108010082739 NADPH Oxidase 2 Proteins 0.000 description 1
• 102100036777 NADPH:adrenodoxin oxidoreductase, mitochondrial Human genes 0.000 description 1
• 101150107958 NEDD8 gene Proteins 0.000 description 1
• 108010071380 NF-E2-Related Factor 1 Proteins 0.000 description 1
• 108010071382 NF-E2-Related Factor 2 Proteins 0.000 description 1
• 102100039337 NF-kappa-B inhibitor alpha Human genes 0.000 description 1
• 101710151580 NGFI-A-binding protein 1 Proteins 0.000 description 1
• 108010039435 NK Cell Lectin-Like Receptors Proteins 0.000 description 1
• 102000015223 NK Cell Lectin-Like Receptors Human genes 0.000 description 1
• 108020002076 NR2 subfamily Proteins 0.000 description 1
• 102000038100 NR2 subfamily Human genes 0.000 description 1
• 108020000002 NR3 subfamily Proteins 0.000 description 1
• 108020002397 NR6 subfamily Proteins 0.000 description 1
• 102100031887 Nanos homolog 1 Human genes 0.000 description 1
• 102100021462 Natural killer cells antigen CD94 Human genes 0.000 description 1
• 102100036942 Nck-associated protein 1-like Human genes 0.000 description 1
• 102100031900 Neogenin Human genes 0.000 description 1
• 102100028749 Neuritin Human genes 0.000 description 1
• 206010029260 Neuroblastoma Diseases 0.000 description 1
• 102000007517 Neurofibromin 2 Human genes 0.000 description 1
• 108010085839 Neurofibromin 2 Proteins 0.000 description 1
• 102100032063 Neurogenic differentiation factor 1 Human genes 0.000 description 1
• 208000005890 Neuroma Diseases 0.000 description 1
• 102100039907 Neuronal acetylcholine receptor subunit alpha-5 Human genes 0.000 description 1
• 102100023617 Neutrophil cytosol factor 4 Human genes 0.000 description 1
• 208000007256 Nevus Diseases 0.000 description 1
• 102100037001 Next to BRCA1 gene 1 protein Human genes 0.000 description 1
• 102100024403 Nibrin Human genes 0.000 description 1
• 208000025464 Norrie disease Diseases 0.000 description 1
• 238000000636 Northern blotting Methods 0.000 description 1
• 102100038157 Novel acetylcholine receptor chaperone Human genes 0.000 description 1
• 108010029782 Nuclear Cap-Binding Protein Complex Proteins 0.000 description 1
• 108700031302 Nuclear Factor 45 Proteins 0.000 description 1
• 101710169251 Nuclear cap-binding protein subunit 1 Proteins 0.000 description 1
• 102100024006 Nuclear factor 1 A-type Human genes 0.000 description 1
• 102100022165 Nuclear factor 1 B-type Human genes 0.000 description 1
• 102100022162 Nuclear factor 1 C-type Human genes 0.000 description 1
• 101710113455 Nuclear factor 1 C-type Proteins 0.000 description 1
• 102100023049 Nuclear factor 1 X-type Human genes 0.000 description 1
• 101710140810 Nuclear factor 1 X-type Proteins 0.000 description 1
• 101710082694 Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 description 1
• 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 1
• 102100022163 Nuclear factor interleukin-3-regulated protein Human genes 0.000 description 1
• 102100025447 Nuclear pore complex protein Nup50 Human genes 0.000 description 1
• 102100029528 Nuclear receptor subfamily 2 group F member 6 Human genes 0.000 description 1
• 102100022670 Nuclear receptor subfamily 6 group A member 1 Human genes 0.000 description 1
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
• 102100021010 Nucleolin Human genes 0.000 description 1
• 102100036518 Nucleoside diphosphate phosphatase ENTPD5 Human genes 0.000 description 1
• 102100022389 Nucleosome assembly protein 1-like 1 Human genes 0.000 description 1
• 102100022398 Nucleosome assembly protein 1-like 3 Human genes 0.000 description 1
• 102100022396 Nucleosome assembly protein 1-like 4 Human genes 0.000 description 1
• 102100025062 Nucleosome-remodeling factor subunit BPTF Human genes 0.000 description 1
• 102100037589 OX-2 membrane glycoprotein Human genes 0.000 description 1
• 102000015636 Oligopeptides Human genes 0.000 description 1
• 108010038807 Oligopeptides Proteins 0.000 description 1
• 102000043276 Oncogene Human genes 0.000 description 1
• 108010049358 Oncogene Protein p65(gag-jun) Proteins 0.000 description 1
• 108010053291 Oncogene Protein v-akt Proteins 0.000 description 1
• 101100532088 Oryza sativa subsp. japonica RUB2 gene Proteins 0.000 description 1
• 101100532090 Oryza sativa subsp. japonica RUB3 gene Proteins 0.000 description 1
• 101000855355 Ovis aries Cytochrome P450 1A1 Proteins 0.000 description 1
• 102100026317 Oxidative stress-induced growth inhibitor 2 Human genes 0.000 description 1
• 102100039792 Oxidized purine nucleoside triphosphate hydrolase Human genes 0.000 description 1
• 102100036201 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial Human genes 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 102100024894 PR domain zinc finger protein 1 Human genes 0.000 description 1
• 206010033554 Palmoplantar keratoderma Diseases 0.000 description 1
• 206010033701 Papillary thyroid cancer Diseases 0.000 description 1
• 201000011152 Pemphigus Diseases 0.000 description 1
• 102100034943 Peptidyl-prolyl cis-trans isomerase F, mitochondrial Human genes 0.000 description 1
• 102100026408 Peptidyl-prolyl cis-trans isomerase FKBP2 Human genes 0.000 description 1
• 102100023846 Peptidyl-prolyl cis-trans isomerase FKBP3 Human genes 0.000 description 1
• 102100020739 Peptidyl-prolyl cis-trans isomerase FKBP4 Human genes 0.000 description 1
• 102100037026 Peptidyl-prolyl cis-trans isomerase FKBP5 Human genes 0.000 description 1
• 102000017794 Perilipin-2 Human genes 0.000 description 1
• 108010067163 Perilipin-2 Proteins 0.000 description 1
• 102100037896 Perilipin-2 Human genes 0.000 description 1
• 102100022587 Peroxisomal multifunctional enzyme type 2 Human genes 0.000 description 1
• 102100030940 Persulfide dioxygenase ETHE1, mitochondrial Human genes 0.000 description 1
• 201000004014 Pfeiffer syndrome Diseases 0.000 description 1
• 101100219325 Phaseolus vulgaris BA13 gene Proteins 0.000 description 1
• 102100032538 Phosphatidylinositol-glycan-specific phospholipase D Human genes 0.000 description 1
• 102100032967 Phospholipase D1 Human genes 0.000 description 1
• 108010033024 Phospholipid Hydroperoxide Glutathione Peroxidase Proteins 0.000 description 1
• 101710139496 Phospholipid phosphatase-related protein type 1 Proteins 0.000 description 1
• 101710177166 Phosphoprotein Proteins 0.000 description 1
• 102000007982 Phosphoproteins Human genes 0.000 description 1
• 108010089430 Phosphoproteins Proteins 0.000 description 1
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
• 102100021762 Phosphoserine phosphatase Human genes 0.000 description 1
• 102100026123 Pirin Human genes 0.000 description 1
• 102100036090 Pituitary homeobox 2 Human genes 0.000 description 1
• 102100040523 Plasma alpha-L-fucosidase Human genes 0.000 description 1
• 206010035226 Plasma cell myeloma Diseases 0.000 description 1
• 102100029751 Plasma membrane calcium-transporting ATPase 1 Human genes 0.000 description 1
• 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 description 1
• 101000686491 Platymeris rhadamanthus Venom redulysin 1 Proteins 0.000 description 1
• 102100030887 Pleckstrin homology-like domain family A member 1 Human genes 0.000 description 1
• 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 description 1
• 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 description 1
• 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 1
• 102100033566 Polycomb complex protein BMI-1 Human genes 0.000 description 1
• 102100040916 Polycomb group RING finger protein 5 Human genes 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 102100033222 Polyhomeotic-like protein 1 Human genes 0.000 description 1
• 102100030903 Polyhomeotic-like protein 2 Human genes 0.000 description 1
• 102100023209 Polypeptide N-acetylgalactosaminyltransferase 13 Human genes 0.000 description 1
• 229920001213 Polysorbate 20 Polymers 0.000 description 1
• 239000004793 Polystyrene Substances 0.000 description 1
• 102100031949 Polyunsaturated fatty acid lipoxygenase ALOX12 Human genes 0.000 description 1
• 102100031950 Polyunsaturated fatty acid lipoxygenase ALOX15 Human genes 0.000 description 1
• 102100027921 Polyunsaturated fatty acid lipoxygenase ALOX15B Human genes 0.000 description 1
• 102100034391 Porphobilinogen deaminase Human genes 0.000 description 1
• 108010009975 Positive Regulatory Domain I-Binding Factor 1 Proteins 0.000 description 1
• 102100034310 Potassium voltage-gated channel subfamily B member 1 Human genes 0.000 description 1
• 102100022783 Potassium voltage-gated channel subfamily G member 1 Human genes 0.000 description 1
• 102100025068 Potassium voltage-gated channel subfamily S member 3 Human genes 0.000 description 1
• 201000010769 Prader-Willi syndrome Diseases 0.000 description 1
• 102100020742 Pre-B lymphocyte protein 3 Human genes 0.000 description 1
• 208000032236 Predisposition to disease Diseases 0.000 description 1
• 108010015078 Pregnancy-Associated alpha 2-Macroglobulins Proteins 0.000 description 1
• 102100026531 Prelamin-A/C Human genes 0.000 description 1
• 102100027467 Pro-opiomelanocortin Human genes 0.000 description 1
• 102100037434 Probable ATP-dependent RNA helicase DDX5 Human genes 0.000 description 1
• 102100023417 Probable G-protein coupled receptor 19 Human genes 0.000 description 1
• 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
• 102100026534 Procathepsin L Human genes 0.000 description 1
• 102100036812 Progressive ankylosis protein homolog Human genes 0.000 description 1
• 102100026126 Proline-tRNA ligase Human genes 0.000 description 1
• 102100023832 Prolyl endopeptidase FAP Human genes 0.000 description 1
• 101710098487 Prosaposin receptor GPR37 Proteins 0.000 description 1
• 102100032255 Prostaglandin reductase 3 Human genes 0.000 description 1
• 206010060862 Prostate cancer Diseases 0.000 description 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
• 102100039686 Protein AF-9 Human genes 0.000 description 1
• 102100040665 Protein AF1q Human genes 0.000 description 1
• 102100026036 Protein BTG1 Human genes 0.000 description 1
• 101710151089 Protein CLN8 Proteins 0.000 description 1
• 102000006010 Protein Disulfide-Isomerase Human genes 0.000 description 1
• 102100040437 Protein ECT2 Human genes 0.000 description 1
• 102100040252 Protein ERGIC-53 Human genes 0.000 description 1
• 102100027246 Protein EVI2A Human genes 0.000 description 1
• 102100027249 Protein EVI2B Human genes 0.000 description 1
• 102100028387 Protein FRG1 Human genes 0.000 description 1
• 108010059000 Protein Phosphatase 1 Proteins 0.000 description 1
• 102000005569 Protein Phosphatase 1 Human genes 0.000 description 1
• 101710150120 Protein Red Proteins 0.000 description 1
• 102100038276 Protein Red Human genes 0.000 description 1
• 102100025670 Protein S100-A13 Human genes 0.000 description 1
• 102100026296 Protein S100-A16 Human genes 0.000 description 1
• 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 description 1
• 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 description 1
• 102100031750 Protein Shroom2 Human genes 0.000 description 1
• 102100030591 Protein Smaug homolog 1 Human genes 0.000 description 1
• 102100035898 Protein bicaudal D homolog 1 Human genes 0.000 description 1
• 102100036490 Protein diaphanous homolog 1 Human genes 0.000 description 1
• 102100036469 Protein diaphanous homolog 2 Human genes 0.000 description 1
• 102100037097 Protein disulfide-isomerase A3 Human genes 0.000 description 1
• 102100027569 Protein farnesyltransferase subunit beta Human genes 0.000 description 1
• 102100040923 Protein flightless-1 homolog Human genes 0.000 description 1
• 102100024139 Protein lifeguard 1 Human genes 0.000 description 1
• 102100034931 Protein mono-ADP-ribosyltransferase PARP4 Human genes 0.000 description 1
• 102100031352 Protein p13 MTCP-1 Human genes 0.000 description 1
• 102100036547 Protein phosphatase 1 regulatory subunit 12A Human genes 0.000 description 1
• 102100026845 Protein sprouty homolog 4 Human genes 0.000 description 1
• 102100037787 Protein-tyrosine kinase 2-beta Human genes 0.000 description 1
• 102100037136 Proteinase-activated receptor 1 Human genes 0.000 description 1
• 102100027378 Prothrombin Human genes 0.000 description 1
• 102100036393 Protocadherin-16 Human genes 0.000 description 1
• 201000004681 Psoriasis Diseases 0.000 description 1
• 102100027469 Putative annexin A2-like protein Human genes 0.000 description 1
• 102100025551 Putative homeobox protein Meis3-like 1 Human genes 0.000 description 1
• 102100038753 Putative nucleotidyltransferase MAB21L1 Human genes 0.000 description 1
• 102100031269 Putative peripheral benzodiazepine receptor-related protein Human genes 0.000 description 1
• 102000009609 Pyrophosphatases Human genes 0.000 description 1
• 108010009413 Pyrophosphatases Proteins 0.000 description 1
• LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
• 108010090051 Pyruvate Dehydrogenase Complex Proteins 0.000 description 1
• 102000012751 Pyruvate Dehydrogenase Complex Human genes 0.000 description 1
• 102100034576 Quinone oxidoreductase Human genes 0.000 description 1
• 102100032315 RAC-beta serine/threonine-protein kinase Human genes 0.000 description 1
• 102100020834 RCC1 and BTB domain-containing protein 2 Human genes 0.000 description 1
• 102100039689 RNA-binding motif, single-stranded-interacting protein 3 Human genes 0.000 description 1
• 101710133282 RNA-binding protein 1 Proteins 0.000 description 1
• 102000004229 RNA-binding protein EWS Human genes 0.000 description 1
• 108090000740 RNA-binding protein EWS Proteins 0.000 description 1
• 102100034335 Rab GDP dissociation inhibitor alpha Human genes 0.000 description 1
• 102100034328 Rab GDP dissociation inhibitor beta Human genes 0.000 description 1
• 101710196445 Rab proteins geranylgeranyltransferase component A Proteins 0.000 description 1
• 102100022881 Rab proteins geranylgeranyltransferase component A 1 Human genes 0.000 description 1
• 102100022880 Rab proteins geranylgeranyltransferase component A 2 Human genes 0.000 description 1
• MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
• 101710156052 Rap guanine nucleotide exchange factor Proteins 0.000 description 1
• 102100034417 Ras GTPase-activating-like protein IQGAP3 Human genes 0.000 description 1
• 102100033480 Ras-related protein Rab-8A Human genes 0.000 description 1
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
• 102100028508 Receptor-type tyrosine-protein phosphatase zeta Human genes 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 102100030000 Recombining binding protein suppressor of hairless Human genes 0.000 description 1
• 102100021280 Regulator of G-protein signaling 22 Human genes 0.000 description 1
• 102100037420 Regulator of G-protein signaling 4 Human genes 0.000 description 1
• 102100040070 Retinal dehydrogenase 2 Human genes 0.000 description 1
• 108010022037 Retinoic Acid 4-Hydroxylase Proteins 0.000 description 1
• 102100038453 Retinoic acid-induced protein 3 Human genes 0.000 description 1
• 102100025642 Rho GDP-dissociation inhibitor 1 Human genes 0.000 description 1
• 102100025622 Rho GDP-dissociation inhibitor 2 Human genes 0.000 description 1
• 102100021428 Rho GTPase-activating protein 5 Human genes 0.000 description 1
• 102100021426 Rho GTPase-activating protein 6 Human genes 0.000 description 1
• 108010053823 Rho Guanine Nucleotide Exchange Factors Proteins 0.000 description 1
• 102100027611 Rho-related GTP-binding protein RhoB Human genes 0.000 description 1
• 102100039640 Rho-related GTP-binding protein RhoE Human genes 0.000 description 1
• 108050007494 Rho-related GTP-binding protein RhoE Proteins 0.000 description 1
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
• 102100039610 Ribonuclease H2 subunit C Human genes 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 102100025368 Runt-related transcription factor 2 Human genes 0.000 description 1
• 102100025369 Runt-related transcription factor 3 Human genes 0.000 description 1
• 230000018199 S phase Effects 0.000 description 1
• 102100035914 S-adenosylmethionine decarboxylase proenzyme Human genes 0.000 description 1
• 102100026115 S-adenosylmethionine synthase isoform type-1 Human genes 0.000 description 1
• 101710167557 S-adenosylmethionine synthase isoform type-2 Proteins 0.000 description 1
• 102100029991 S-formylglutathione hydrolase Human genes 0.000 description 1
• 102100034187 S-methyl-5'-thioadenosine phosphorylase Human genes 0.000 description 1
• 108091005488 SCARB2 Proteins 0.000 description 1
• 102100028029 SCL-interrupting locus protein Human genes 0.000 description 1
• 102000014400 SH2 domains Human genes 0.000 description 1
• 108050003452 SH2 domains Proteins 0.000 description 1
• 102100029196 SLAM family member 9 Human genes 0.000 description 1
• 108091006620 SLC12A2 Proteins 0.000 description 1
• 108091006788 SLC20A1 Proteins 0.000 description 1
• 108091006419 SLC25A12 Proteins 0.000 description 1
• 108091006422 SLC25A20 Proteins 0.000 description 1
• 108091006716 SLC25A4 Proteins 0.000 description 1
• 108091006715 SLC25A5 Proteins 0.000 description 1
• 108091006505 SLC26A2 Proteins 0.000 description 1
• 108091006551 SLC29A1 Proteins 0.000 description 1
• 108091006544 SLC29A2 Proteins 0.000 description 1
• 108091006565 SLC31A1 Proteins 0.000 description 1
• 108091006970 SLC35F1 Proteins 0.000 description 1
• 108091006268 SLC5A3 Proteins 0.000 description 1
• 102000005031 SLC6A15 Human genes 0.000 description 1
• 108060007754 SLC6A15 Proteins 0.000 description 1
• 101100379220 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) API2 gene Proteins 0.000 description 1
• 101100121445 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GCN20 gene Proteins 0.000 description 1
• 102100027732 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Human genes 0.000 description 1
• 102100027733 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Human genes 0.000 description 1
• 102100037118 Scavenger receptor class B member 1 Human genes 0.000 description 1
• 101100010298 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pol2 gene Proteins 0.000 description 1
• 101710152961 Segment polarity protein dishevelled homolog DVL-1 Proteins 0.000 description 1
• 101710152963 Segment polarity protein dishevelled homolog DVL-2 Proteins 0.000 description 1
• 101710152962 Segment polarity protein dishevelled homolog DVL-3 Proteins 0.000 description 1
• 102000017500 Septin 2 Human genes 0.000 description 1
• 108050005721 Septin 2 Proteins 0.000 description 1
• 102000017496 Septin 7 Human genes 0.000 description 1
• 108050005730 Septin 7 Proteins 0.000 description 1
• 102000012479 Serine Proteases Human genes 0.000 description 1
• 108010022999 Serine Proteases Proteins 0.000 description 1
• 102100031872 Serine palmitoyltransferase small subunit A Human genes 0.000 description 1
• 229940119135 Serine peptidase inhibitor Drugs 0.000 description 1
• 102100025421 Serine protease inhibitor Kazal-type 6 Human genes 0.000 description 1
• 102100037959 Serine/threonine-protein kinase 17B Human genes 0.000 description 1
• 102100037629 Serine/threonine-protein kinase 4 Human genes 0.000 description 1
• 102100029437 Serine/threonine-protein kinase A-Raf Human genes 0.000 description 1
• 102100023921 Serine/threonine-protein kinase ATR Human genes 0.000 description 1
• 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 1
• 102100026621 Serine/threonine-protein kinase ICK Human genes 0.000 description 1
• 102100028751 Serine/threonine-protein kinase Nek1 Human genes 0.000 description 1
• 102100037703 Serine/threonine-protein kinase Nek2 Human genes 0.000 description 1
• 102100037706 Serine/threonine-protein kinase Nek3 Human genes 0.000 description 1
• 102100037705 Serine/threonine-protein kinase Nek4 Human genes 0.000 description 1
• 102100026209 Serine/threonine-protein kinase PLK3 Human genes 0.000 description 1
• 102100029064 Serine/threonine-protein kinase WNK1 Human genes 0.000 description 1
• 102100034136 Serine/threonine-protein kinase receptor R3 Human genes 0.000 description 1
• 108010071390 Serum Albumin Proteins 0.000 description 1
• 102000007562 Serum Albumin Human genes 0.000 description 1
• 108010048287 Short Chain Dehydrogenase-Reductases Proteins 0.000 description 1
• 102000009105 Short Chain Dehydrogenase-Reductases Human genes 0.000 description 1
• 102100035766 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 description 1
• 102100028760 Sialidase-1 Human genes 0.000 description 1
• 102100038081 Signal transducer CD24 Human genes 0.000 description 1
• 102100037442 Small conductance calcium-activated potassium channel protein 3 Human genes 0.000 description 1
• 108020004459 Small interfering RNA Proteins 0.000 description 1
• 102100038439 Sodium-dependent phosphate transport protein 4 Human genes 0.000 description 1
• 102100030458 Sodium/potassium-transporting ATPase subunit alpha-1 Human genes 0.000 description 1
• 102100032070 Sodium/potassium/calcium exchanger 3 Human genes 0.000 description 1
• 238000002105 Southern blotting Methods 0.000 description 1
• 102100030435 Sp110 nuclear body protein Human genes 0.000 description 1
• 102100025747 Sphingosine 1-phosphate receptor 3 Human genes 0.000 description 1
• 102100037997 Squalene synthase Human genes 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 102100024237 Stathmin Human genes 0.000 description 1
• 102100036325 Sterol 26-hydroxylase, mitochondrial Human genes 0.000 description 1
• 102100021685 Stomatin Human genes 0.000 description 1
• 102100022760 Stress-70 protein, mitochondrial Human genes 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• 102100037352 Sushi repeat-containing protein SRPX Human genes 0.000 description 1
• 102100023532 Synaptic functional regulator FMR1 Human genes 0.000 description 1
• 102100030552 Synaptosomal-associated protein 25 Human genes 0.000 description 1
• 102100033920 Synemin Human genes 0.000 description 1
• 102100035936 Syntaxin-2 Human genes 0.000 description 1
• 230000033540 T cell apoptotic process Effects 0.000 description 1
• 102100033130 T-box transcription factor T Human genes 0.000 description 1
• 101710086566 T-box transcription factor T Proteins 0.000 description 1
• 208000000389 T-cell leukemia Diseases 0.000 description 1
• 102100028676 T-cell leukemia/lymphoma protein 1A Human genes 0.000 description 1
• 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 1
• 206010042971 T-cell lymphoma Diseases 0.000 description 1
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 102100035982 T-cell surface glycoprotein CD1b Human genes 0.000 description 1
• 102100036014 T-cell surface glycoprotein CD1c Human genes 0.000 description 1
• 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 1
• 102100030664 T-complex protein 1 subunit zeta Human genes 0.000 description 1
• 210000001744 T-lymphocyte Anatomy 0.000 description 1
• 102100033447 T-lymphocyte surface antigen Ly-9 Human genes 0.000 description 1
• 102000006467 TATA-Box Binding Protein Human genes 0.000 description 1
• 108010044281 TATA-Box Binding Protein Proteins 0.000 description 1
• 102100033766 TLE family member 5 Human genes 0.000 description 1
• 102000004398 TNF receptor-associated factor 1 Human genes 0.000 description 1
• 108090000920 TNF receptor-associated factor 1 Proteins 0.000 description 1
• 102100022608 TOX high mobility group box family member 3 Human genes 0.000 description 1
• 108010027179 Tacrolimus Binding Proteins Proteins 0.000 description 1
• 102000018679 Tacrolimus Binding Proteins Human genes 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 102100022919 Tartrate-resistant acid phosphatase type 5 Human genes 0.000 description 1
• 102000007000 Tenascin Human genes 0.000 description 1
• 108010008125 Tenascin Proteins 0.000 description 1
• 102100038126 Tenascin Human genes 0.000 description 1
• 102100024547 Tensin-1 Human genes 0.000 description 1
• 108010077690 Tetraspanin 28 Proteins 0.000 description 1
• 102100034769 Thioredoxin-dependent peroxide reductase, mitochondrial Human genes 0.000 description 1
• 101710150060 Thioredoxin-dependent peroxide reductase, mitochondrial Proteins 0.000 description 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
• 239000004473 Threonine Substances 0.000 description 1
• 102100037454 Torsin-1A Human genes 0.000 description 1
• 206010070863 Toxicity to various agents Diseases 0.000 description 1
• 108010037468 Transcription Factor HES-1 Proteins 0.000 description 1
• 102100040425 Transcription elongation factor A protein-like 2 Human genes 0.000 description 1
• 102100024207 Transcription factor COE1 Human genes 0.000 description 1
• 102100024024 Transcription factor E2F2 Human genes 0.000 description 1
• 102100024027 Transcription factor E2F3 Human genes 0.000 description 1
• 102100031555 Transcription factor E2F8 Human genes 0.000 description 1
• 102100039580 Transcription factor ETV6 Human genes 0.000 description 1
• 102100021380 Transcription factor GATA-4 Human genes 0.000 description 1
• 102100037168 Transcription factor JunB Human genes 0.000 description 1
• 102100023118 Transcription factor JunD Human genes 0.000 description 1
• 102100039189 Transcription factor Maf Human genes 0.000 description 1
• 102100039188 Transcription factor MafG Human genes 0.000 description 1
• 102100036731 Transcription factor SOX-8 Human genes 0.000 description 1
• 102100030879 Transcription initiation factor IIA subunit 1 Human genes 0.000 description 1
• 102100028604 Transcription initiation factor IIA subunit 2 Human genes 0.000 description 1
• 102100033662 Transcription initiation factor IIB Human genes 0.000 description 1
• 102100034904 Transcription initiation factor IIE subunit beta Human genes 0.000 description 1
• 102100021268 Transcription regulator protein BACH1 Human genes 0.000 description 1
• 108020004566 Transfer RNA Proteins 0.000 description 1
• 102100034030 Transient receptor potential cation channel subfamily M member 8 Human genes 0.000 description 1
• 102100026145 Transitional endoplasmic reticulum ATPase Human genes 0.000 description 1
• 101710132062 Transitional endoplasmic reticulum ATPase Proteins 0.000 description 1
• 102100029550 Translation initiation factor IF-2, mitochondrial Human genes 0.000 description 1
• 102100027059 Translation initiation factor eIF-2B subunit alpha Human genes 0.000 description 1
• 102100021338 Transmembrane ascorbate-dependent reductase CYB561 Human genes 0.000 description 1
• 108050008367 Transmembrane emp24 domain-containing protein 7 Proteins 0.000 description 1
• 102100025928 Transmembrane protein 255A Human genes 0.000 description 1
• 102100035328 Transmembrane protein 258 Human genes 0.000 description 1
• 102100028769 Transmembrane protein 50B Human genes 0.000 description 1
• 102100028842 Transmembrane protein 72 Human genes 0.000 description 1
• 102100028748 Transportin-1 Human genes 0.000 description 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
• 102100029519 Tripartite motif-containing protein 29 Human genes 0.000 description 1
• 108010039203 Tripeptidyl-Peptidase 1 Proteins 0.000 description 1
• 102100034197 Tripeptidyl-peptidase 1 Human genes 0.000 description 1
• 239000007983 Tris buffer Substances 0.000 description 1
• 108010065850 Tristetraprolin Proteins 0.000 description 1
• 102100036471 Tropomyosin beta chain Human genes 0.000 description 1
• 108010065729 Troponin I Proteins 0.000 description 1
• 102000013394 Troponin I Human genes 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102100040247 Tumor necrosis factor Human genes 0.000 description 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
• 102100040362 Tumor protein D53 Human genes 0.000 description 1
• 108010021428 Type 1 Melanocortin Receptor Proteins 0.000 description 1
• 108010021430 Type 2 Melanocortin Receptor Proteins 0.000 description 1
• 108010051765 Type I Bone Morphogenetic Protein Receptors Proteins 0.000 description 1
• 102000019044 Type I Bone Morphogenetic Protein Receptors Human genes 0.000 description 1
• 102100039257 Type II inositol 1,4,5-trisphosphate 5-phosphatase Human genes 0.000 description 1
• 102100037333 Tyrosine-protein kinase Fes/Fps Human genes 0.000 description 1
• 102100035221 Tyrosine-protein kinase Fyn Human genes 0.000 description 1
• 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 description 1
• HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-alpha-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-ABVWGUQPSA-N 0.000 description 1
• 102100021436 UDP-glucose 4-epimerase Human genes 0.000 description 1
• 108010075202 UDP-glucose 4-epimerase Proteins 0.000 description 1
• MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
• 102100037932 Ubiquitin D Human genes 0.000 description 1
• 102100020696 Ubiquitin-conjugating enzyme E2 K Human genes 0.000 description 1
• 102100026776 Unconventional myosin-Ib Human genes 0.000 description 1
• 102100026785 Unconventional myosin-Ic Human genes 0.000 description 1
• 102100036638 Unconventional myosin-Id Human genes 0.000 description 1
• 102100035820 Unconventional myosin-Ie Human genes 0.000 description 1
• 102100029827 Unconventional myosin-X Human genes 0.000 description 1
• 102100040076 Urea transporter 1 Human genes 0.000 description 1
• HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 description 1
• 102100037979 V-type proton ATPase 116 kDa subunit a 1 Human genes 0.000 description 1
• 102100032189 V-type proton ATPase subunit C 1 Human genes 0.000 description 1
• 102100039465 V-type proton ATPase subunit E 1 Human genes 0.000 description 1
• 102100021937 VPS10 domain-containing receptor SorCS1 Human genes 0.000 description 1
• 241000700618 Vaccinia virus Species 0.000 description 1
• 102100038001 Vacuole membrane protein 1 Human genes 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 description 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
• 102100039037 Vascular endothelial growth factor A Human genes 0.000 description 1
• 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 description 1
• 108010051583 Ventricular Myosins Proteins 0.000 description 1
• 101710200894 Versican core protein Proteins 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 101710101493 Viral myc transforming protein Proteins 0.000 description 1
• 206010047571 Visual impairment Diseases 0.000 description 1
• 108010026102 Vitamin D3 24-Hydroxylase Proteins 0.000 description 1
• 102100038182 Vitamin K-dependent gamma-carboxylase Human genes 0.000 description 1
• 108010048673 Vitronectin Receptors Proteins 0.000 description 1
• 102100025807 Voltage-dependent L-type calcium channel subunit beta-2 Human genes 0.000 description 1
• 208000018839 Wilson disease Diseases 0.000 description 1
• 208000026589 Wolman disease Diseases 0.000 description 1
• 108700042462 X-linked Nuclear Proteins 0.000 description 1
• 101000649206 Xanthomonas campestris pv. campestris (strain 8004) Uridine 5'-monophosphate transferase Proteins 0.000 description 1
• 241000269368 Xenopus laevis Species 0.000 description 1
• 206010048218 Xeroderma Diseases 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• 102100039966 Zinc finger homeobox protein 3 Human genes 0.000 description 1
• 102100026497 Zinc finger protein 654 Human genes 0.000 description 1
• 102100025093 Zinc fingers and homeoboxes protein 2 Human genes 0.000 description 1
• 102100024148 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Human genes 0.000 description 1
• ZUPXXZAVUHFCNV-UHFFFAOYSA-N [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [5-(3-carbamoyl-4h-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate;potassium Chemical compound [K].C1=CCC(C(=O)N)=CN1C1C(O)C(O)C(COP(O)(=O)OP(O)(=O)OCC2C(C(O)C(O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ZUPXXZAVUHFCNV-UHFFFAOYSA-N 0.000 description 1
• 230000001594 aberrant effect Effects 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• 102000034337 acetylcholine receptors Human genes 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 239000000488 activin Substances 0.000 description 1
• 108010023082 activin A Proteins 0.000 description 1
• 102000035181 adaptor proteins Human genes 0.000 description 1
• 108091005764 adaptor proteins Proteins 0.000 description 1
• 238000011374 additional therapy Methods 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
• LNQVTSROQXJCDD-UHFFFAOYSA-N adenosine monophosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)C(OP(O)(O)=O)C1O LNQVTSROQXJCDD-UHFFFAOYSA-N 0.000 description 1
• 210000001789 adipocyte Anatomy 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 230000004931 aggregating effect Effects 0.000 description 1
• 239000003513 alkali Substances 0.000 description 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
• WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
• 108010062688 alpha-N-acylamino acid hydrolase Proteins 0.000 description 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
• 150000001412 amines Chemical class 0.000 description 1
• 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 1
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 1
• 230000033115 angiogenesis Effects 0.000 description 1
• 230000002491 angiogenic effect Effects 0.000 description 1
• 238000000137 annealing Methods 0.000 description 1
• 230000001028 anti-proliverative effect Effects 0.000 description 1
• 230000001475 anti-trypsic effect Effects 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 239000002216 antistatic agent Substances 0.000 description 1
• 108010086766 apolipoprotein E5 Proteins 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 238000003491 array Methods 0.000 description 1
• 239000011668 ascorbic acid Chemical class 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
• 239000000605 aspartame Substances 0.000 description 1
• 235000010357 aspartame Nutrition 0.000 description 1
• 229960003438 aspartame Drugs 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 230000001746 atrial effect Effects 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• 108010032967 beta-Arrestin 2 Proteins 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
• 229960003237 betaine Drugs 0.000 description 1
• 230000002146 bilateral effect Effects 0.000 description 1
• 102000030904 bile acid binding Human genes 0.000 description 1
• 108091022863 bile acid binding Proteins 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 239000003114 blood coagulation factor Substances 0.000 description 1
• 108010047153 bovine corneal protein 54 Proteins 0.000 description 1
• 230000003139 buffering effect Effects 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical class O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• 102100029387 cAMP-responsive element modulator Human genes 0.000 description 1
• 238000010804 cDNA synthesis Methods 0.000 description 1
• 108010044208 calpastatin Proteins 0.000 description 1
• ZXJCOYBPXOBJMU-HSQGJUDPSA-N calpastatin peptide Ac 184-210 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C1=CC=C(O)C=C1 ZXJCOYBPXOBJMU-HSQGJUDPSA-N 0.000 description 1
• 102000006783 calponin Human genes 0.000 description 1
• 108010086826 calponin Proteins 0.000 description 1
• 230000036952 cancer formation Effects 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
• 231100000504 carcinogenesis Toxicity 0.000 description 1
• 230000000747 cardiac effect Effects 0.000 description 1
• 210000000845 cartilage Anatomy 0.000 description 1
• 239000005018 casein Substances 0.000 description 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
• 235000021240 caseins Nutrition 0.000 description 1
• 239000003054 catalyst Substances 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 150000001768 cations Chemical class 0.000 description 1
• 101150114475 cdc31 gene Proteins 0.000 description 1
• 102000013515 cdc42 GTP-Binding Protein Human genes 0.000 description 1
• 230000003915 cell function Effects 0.000 description 1
• 108010031373 centromere protein C Proteins 0.000 description 1
• 208000025434 cerebellar degeneration Diseases 0.000 description 1
• 239000002738 chelating agent Substances 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 210000000038 chest Anatomy 0.000 description 1
• 208000017568 chondrodysplasia Diseases 0.000 description 1
• 208000003571 choroideremia Diseases 0.000 description 1
• 235000015165 citric acid Nutrition 0.000 description 1
• 230000004186 co-expression Effects 0.000 description 1
• 229940105778 coagulation factor viii Drugs 0.000 description 1
• 208000029742 colonic neoplasm Diseases 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 210000001608 connective tissue cell Anatomy 0.000 description 1
• 108010014510 connexin 40 Proteins 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 230000036461 convulsion Effects 0.000 description 1
• 230000000875 corresponding effect Effects 0.000 description 1
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
• 229960000258 corticotropin Drugs 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 239000002875 cyclin dependent kinase inhibitor Substances 0.000 description 1
• 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 description 1
• 229940097362 cyclodextrins Drugs 0.000 description 1
• 108010018719 cytochrome P-450 CYP4B1 Proteins 0.000 description 1
• 108020001378 cytochrome b561 Proteins 0.000 description 1
• 229940104302 cytosine Drugs 0.000 description 1
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
• GYOZYWVXFNDGLU-XLPZGREQSA-N dTMP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 GYOZYWVXFNDGLU-XLPZGREQSA-N 0.000 description 1
• 101150047356 dec-1 gene Proteins 0.000 description 1
• 230000000911 decarboxylating effect Effects 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 230000002939 deleterious effect Effects 0.000 description 1
• 108700041286 delta Proteins 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000010511 deprotection reaction Methods 0.000 description 1
• 230000002074 deregulated effect Effects 0.000 description 1
• 230000003831 deregulation Effects 0.000 description 1
• 230000001627 detrimental effect Effects 0.000 description 1
• 229940096516 dextrates Drugs 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• VLYUGYAKYZETRF-UHFFFAOYSA-N dihydrolipoamide Chemical compound NC(=O)CCCCC(S)CCS VLYUGYAKYZETRF-UHFFFAOYSA-N 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 108010057167 dimethylaniline monooxygenase (N-oxide forming) Proteins 0.000 description 1
• 239000001177 diphosphate Substances 0.000 description 1
• 235000011180 diphosphates Nutrition 0.000 description 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
• 150000002016 disaccharides Chemical class 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 108010043113 dolichyl-phosphate alpha-N-acetylglucosaminyltransferase Proteins 0.000 description 1
• 108010051081 dopachrome isomerase Proteins 0.000 description 1
• 239000000890 drug combination Substances 0.000 description 1
• 238000009509 drug development Methods 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 239000002158 endotoxin Substances 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 230000002255 enzymatic effect Effects 0.000 description 1
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
• 208000033286 epidermolytic ichthyosis Diseases 0.000 description 1
• 206010015037 epilepsy Diseases 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• 108010041998 erythrocyte membrane protein band 4.1-like 1 Proteins 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 230000006846 excision repair Effects 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 108010062689 fatty acid-binding protein 6 Proteins 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 238000013467 fragmentation Methods 0.000 description 1
• 238000006062 fragmentation reaction Methods 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 229930182830 galactose Natural products 0.000 description 1
• 108010079306 galactoside 2-alpha-L-fucosyltransferase Proteins 0.000 description 1
• 108010062699 gamma-Glutamyl Hydrolase Proteins 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 238000012215 gene cloning Methods 0.000 description 1
• 229940080856 gleevec Drugs 0.000 description 1
• 208000005017 glioblastoma Diseases 0.000 description 1
• 239000000174 gluconic acid Chemical class 0.000 description 1
• 235000012208 gluconic acid Nutrition 0.000 description 1
• 125000002566 glucosaminyl group Chemical group 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 230000004153 glucose metabolism Effects 0.000 description 1
• 229930195712 glutamate Natural products 0.000 description 1
• 108010024847 glutamate decarboxylase 1 Proteins 0.000 description 1
• 108010024780 glutamate decarboxylase 2 Proteins 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
• 108010086596 glutathione peroxidase GPX1 Proteins 0.000 description 1
• 108010051015 glutathione-independent formaldehyde dehydrogenase Proteins 0.000 description 1
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
• 108010014977 glycine cleavage system Proteins 0.000 description 1
• 201000004502 glycogen storage disease II Diseases 0.000 description 1
• 229930004094 glycosylphosphatidylinositol Natural products 0.000 description 1
• 101150098203 grb2 gene Proteins 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 230000010005 growth-factor like effect Effects 0.000 description 1
• 102000009543 guanyl-nucleotide exchange factor activity proteins Human genes 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 108091008634 hepatocyte nuclear factors 4 Proteins 0.000 description 1
• 108010092427 high density lipoprotein binding protein Proteins 0.000 description 1
• 238000012188 high-throughput screening assay Methods 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 229940099552 hyaluronan Drugs 0.000 description 1
• 229920002674 hyaluronan Polymers 0.000 description 1
• KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
• 101150095658 ilf2 gene Proteins 0.000 description 1
• 238000003384 imaging method Methods 0.000 description 1
• 229960003685 imatinib mesylate Drugs 0.000 description 1
• 239000012642 immune effector Substances 0.000 description 1
• 108010008429 immunoglobulin-binding factors Proteins 0.000 description 1
• 230000002055 immunohistochemical effect Effects 0.000 description 1
• 229940121354 immunomodulator Drugs 0.000 description 1
• 238000000099 in vitro assay Methods 0.000 description 1
• 238000005462 in vivo assay Methods 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 108010019691 inhibin beta A subunit Proteins 0.000 description 1
• 108010029405 inosine triphosphatase Proteins 0.000 description 1
• 102000030582 inositol polyphosphate 5-phosphatase Human genes 0.000 description 1
• 108060004006 inositol polyphosphate 5-phosphatase Proteins 0.000 description 1
• 102000006495 integrins Human genes 0.000 description 1
• 108010044426 integrins Proteins 0.000 description 1
• 229940076264 interleukin-3 Drugs 0.000 description 1
• 208000030776 invasive breast carcinoma Diseases 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• 230000000366 juvenile effect Effects 0.000 description 1
• 238000000021 kinase assay Methods 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 239000000832 lactitol Substances 0.000 description 1
• 235000010448 lactitol Nutrition 0.000 description 1
• VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
• 229960003451 lactitol Drugs 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 108010019813 leptin receptors Proteins 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 229920006008 lipopolysaccharide Polymers 0.000 description 1
• 206010024627 liposarcoma Diseases 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 102100031622 mRNA decay activator protein ZFP36 Human genes 0.000 description 1
• 102100034702 mRNA decay activator protein ZFP36L1 Human genes 0.000 description 1
• 102100040700 mRNA export factor GLE1 Human genes 0.000 description 1
• 108090000286 malate dehydrogenase (decarboxylating) Proteins 0.000 description 1
• 108010035293 maleylacetoacetate isomerase Proteins 0.000 description 1
• 230000036210 malignancy Effects 0.000 description 1
• 230000003211 malignant effect Effects 0.000 description 1
• 239000000845 maltitol Substances 0.000 description 1
• 235000010449 maltitol Nutrition 0.000 description 1
• VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
• 229940035436 maltitol Drugs 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 229960001855 mannitol Drugs 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 description 1
• 230000003340 mental effect Effects 0.000 description 1
• 230000037353 metabolic pathway Effects 0.000 description 1
• 229930182817 methionine Natural products 0.000 description 1
• 238000002493 microarray Methods 0.000 description 1
• 210000003632 microfilament Anatomy 0.000 description 1
• 210000004688 microtubule Anatomy 0.000 description 1
• 230000001617 migratory effect Effects 0.000 description 1
• 230000025205 mitochondrial translational initiation Effects 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• 230000009456 molecular mechanism Effects 0.000 description 1
• 101150071637 mre11 gene Proteins 0.000 description 1
• 201000002273 mucopolysaccharidosis II Diseases 0.000 description 1
• 208000022018 mucopolysaccharidosis type 2 Diseases 0.000 description 1
• 201000006938 muscular dystrophy Diseases 0.000 description 1
• 210000005012 myelin Anatomy 0.000 description 1
• 208000025113 myeloid leukemia Diseases 0.000 description 1
• 210000000107 myocyte Anatomy 0.000 description 1
• 201000009340 myotonic dystrophy type 1 Diseases 0.000 description 1
• 229940085864 myoxin Drugs 0.000 description 1
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
• 108010037351 nascent-polypeptide-associated complex Proteins 0.000 description 1
• 108010076969 neogenin Proteins 0.000 description 1
• 208000007538 neurilemmoma Diseases 0.000 description 1
• 210000002241 neurite Anatomy 0.000 description 1
• 201000008051 neuronal ceroid lipofuscinosis Diseases 0.000 description 1
• 201000001119 neuropathy Diseases 0.000 description 1
• 230000007823 neuropathy Effects 0.000 description 1
• BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
• 108091027963 non-coding RNA Proteins 0.000 description 1
• 102000042567 non-coding RNA Human genes 0.000 description 1
• 239000002853 nucleic acid probe Substances 0.000 description 1
• 108010044762 nucleolin Proteins 0.000 description 1
• 210000004248 oligodendroglia Anatomy 0.000 description 1
• 229920001542 oligosaccharide Polymers 0.000 description 1
• 150000002482 oligosaccharides Chemical class 0.000 description 1
• 108010057248 oncogene proteins v-ets Proteins 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 230000006548 oncogenic transformation Effects 0.000 description 1
• 238000011275 oncology therapy Methods 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 150000007530 organic bases Chemical class 0.000 description 1
• 210000000963 osteoblast Anatomy 0.000 description 1
• 230000002611 ovarian Effects 0.000 description 1
• 230000002018 overexpression Effects 0.000 description 1
• 239000003002 pH adjusting agent Substances 0.000 description 1
• 230000000849 parathyroid Effects 0.000 description 1
• 201000001976 pemphigus vulgaris Diseases 0.000 description 1
• 238000010647 peptide synthesis reaction Methods 0.000 description 1
• 230000009984 peri-natal effect Effects 0.000 description 1
• 208000033808 peripheral neuropathy Diseases 0.000 description 1
• 230000000858 peroxisomal effect Effects 0.000 description 1
• 229940124531 pharmaceutical excipient Drugs 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 239000008363 phosphate buffer Substances 0.000 description 1
• 239000002953 phosphate buffered saline Substances 0.000 description 1
• 108010002266 phospholipase D1 Proteins 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 238000006303 photolysis reaction Methods 0.000 description 1
• 230000015843 photosynthesis, light reaction Effects 0.000 description 1
• 230000035790 physiological processes and functions Effects 0.000 description 1
• 235000002949 phytic acid Nutrition 0.000 description 1
• 230000003169 placental effect Effects 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 239000002985 plastic film Substances 0.000 description 1
• 229920006255 plastic film Polymers 0.000 description 1
• 108010017843 platelet-derived growth factor A Proteins 0.000 description 1
• 229920006122 polyamide resin Polymers 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 108010005636 polypeptide C Proteins 0.000 description 1
• 229920000136 polysorbate Polymers 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 229940068965 polysorbates Drugs 0.000 description 1
• 229920002223 polystyrene Polymers 0.000 description 1
• 229920005990 polystyrene resin Polymers 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 238000010837 poor prognosis Methods 0.000 description 1
• 238000002600 positron emission tomography Methods 0.000 description 1
• 210000001586 pre-b-lymphocyte Anatomy 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 210000001948 pro-b lymphocyte Anatomy 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 239000003805 procoagulant Substances 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 108020003519 protein disulfide isomerase Proteins 0.000 description 1
• 229940075993 receptor modulator Drugs 0.000 description 1
• 230000006798 recombination Effects 0.000 description 1
• 238000005215 recombination Methods 0.000 description 1
• 239000012925 reference material Substances 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 230000010076 replication Effects 0.000 description 1
• 230000004043 responsiveness Effects 0.000 description 1
• 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 108020004418 ribosomal RNA Proteins 0.000 description 1
• 101150024074 rub1 gene Proteins 0.000 description 1
• 235000002020 sage Nutrition 0.000 description 1
• 206010039667 schwannoma Diseases 0.000 description 1
• 208000004548 serous cystadenocarcinoma Diseases 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 210000002027 skeletal muscle Anatomy 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• XGRLSUFHELJJAB-JGSYTFBMSA-M sodium;[(2r)-2-hydroxy-3-[(z)-octadec-9-enoyl]oxypropyl] hydrogen phosphate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)([O-])=O XGRLSUFHELJJAB-JGSYTFBMSA-M 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 230000037439 somatic mutation Effects 0.000 description 1
• 150000003408 sphingolipids Chemical class 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 239000004094 surface-active agent Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 102000000580 synaptojanin Human genes 0.000 description 1
• 108010016910 synaptojanin Proteins 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 102100025028 tRNA (guanine-N(7)-)-methyltransferase Human genes 0.000 description 1
• 101710112043 tRNA (guanine-N(7)-)-methyltransferase Proteins 0.000 description 1
• 102100030609 tRNA N(3)-methylcytidine methyltransferase METTL2B Human genes 0.000 description 1
• 239000011975 tartaric acid Chemical class 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 150000004044 tetrasaccharides Chemical class 0.000 description 1
• 230000004797 therapeutic response Effects 0.000 description 1
• 229940113082 thymine Drugs 0.000 description 1
• 208000008732 thymoma Diseases 0.000 description 1
• 230000008791 toxic response Effects 0.000 description 1
• 108010014677 transcription factor TFIIE Proteins 0.000 description 1
• 230000007704 transition Effects 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• 150000004043 trisaccharides Chemical class 0.000 description 1
• 229940073585 tromethamine hydrochloride Drugs 0.000 description 1
• 210000002993 trophoblast Anatomy 0.000 description 1
• 239000002753 trypsin inhibitor Substances 0.000 description 1
• 241000701161 unidentified adenovirus Species 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• 229940035893 uracil Drugs 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 208000024126 vascular type Ehlers-Danlos syndrome Diseases 0.000 description 1
• 230000028973 vesicle-mediated transport Effects 0.000 description 1
• 230000004393 visual impairment Effects 0.000 description 1
• 102100034332 von Willebrand factor A domain-containing protein 5A Human genes 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 239000002676 xenobiotic agent Substances 0.000 description 1
• 230000002034 xenobiotic effect Effects 0.000 description 1
• 229910052725 zinc Inorganic materials 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1
• WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 description 1