MX2009002936A - Biomarcadores de la modulacion de objetivo, eficacia, diagnostico, y/o pronostico para los inhibidores de raf. - Google Patents

Biomarcadores de la modulacion de objetivo, eficacia, diagnostico, y/o pronostico para los inhibidores de raf.

Info

Publication number
MX2009002936A
MX2009002936A MX2009002936A MX2009002936A MX2009002936A MX 2009002936 A MX2009002936 A MX 2009002936A MX 2009002936 A MX2009002936 A MX 2009002936A MX 2009002936 A MX2009002936 A MX 2009002936A MX 2009002936 A MX2009002936 A MX 2009002936A
Authority
MX
Mexico
Prior art keywords
biomarkers
prognosis
efficacy
diagnosis
target modulation
Prior art date
Application number
MX2009002936A
Other languages
English (en)
Inventor
Darrin Stuart
Carla Heise
Edward Moler
Natasha Aziz
Kim Aardalen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009002936A publication Critical patent/MX2009002936A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En la presente se enseñan métodos para utilizar biomarcadores con el fin de identificar a los pacientes para el tratamiento o para monitorear su respuesta al tratamiento. Se miden las alteraciones en los niveles de la expresión genética de los biomarcadores, en particular en respuesta a la inhibición de la cinasa RAF, y de conformidad con lo mismo, se pueden hacer identificaciones o ajustes.
MX2009002936A 2006-09-19 2007-09-19 Biomarcadores de la modulacion de objetivo, eficacia, diagnostico, y/o pronostico para los inhibidores de raf. MX2009002936A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84560106P 2006-09-19 2006-09-19
PCT/US2007/078946 WO2008082730A2 (en) 2006-09-19 2007-09-19 Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors

Publications (1)

Publication Number Publication Date
MX2009002936A true MX2009002936A (es) 2009-04-01

Family

ID=39445772

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002936A MX2009002936A (es) 2006-09-19 2007-09-19 Biomarcadores de la modulacion de objetivo, eficacia, diagnostico, y/o pronostico para los inhibidores de raf.

Country Status (13)

Country Link
US (1) US20100004253A1 (es)
EP (1) EP2074226A2 (es)
JP (2) JP2010504530A (es)
KR (1) KR20090071603A (es)
CN (1) CN101541977A (es)
AU (1) AU2007340265B2 (es)
BR (1) BRPI0716944A2 (es)
CA (1) CA2662508A1 (es)
IL (1) IL197450A0 (es)
MX (1) MX2009002936A (es)
RU (1) RU2009114745A (es)
SG (1) SG174826A1 (es)
WO (1) WO2008082730A2 (es)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
DE102004024617A1 (de) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
CN103424541B (zh) 2006-05-18 2018-01-30 分子压型学会股份有限公司 确定针对病状的个性化医疗介入的系统和方法
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
AU2009262022A1 (en) * 2008-06-26 2009-12-30 Dana-Farber Cancer Institute, Inc. Signatures and determinants associated with metastasis and methods of use thereof
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
WO2010037041A2 (en) 2008-09-26 2010-04-01 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
CN102301002A (zh) 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
SG10201407718WA (en) 2009-11-18 2015-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
US8709419B2 (en) * 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US20120045433A1 (en) * 2010-08-17 2012-02-23 Kapil Dhingra Combination therapy
EP2619329B1 (en) 2010-09-24 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
EP2444503B1 (en) * 2010-10-20 2016-03-02 Université Joseph Fourier Use of specific genes for the prognosis of lung cancer and the corresponding progonosis method
EP2630237A4 (en) * 2010-10-21 2014-04-09 Oncotherapy Science Inc C18ORF54 PEPTIDES AND VACCINES CONTAINING THEM
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
SG195208A1 (en) 2011-06-02 2013-12-30 Almac Diagnostics Ltd Molecular diagnostic test for cancer
SG194800A1 (en) * 2011-06-02 2013-12-30 Novartis Ag Biomarkers for hedgehog inhibitor therapy
US20140302042A1 (en) * 2011-07-01 2014-10-09 Dana-Farber Cancer Institute, Inc. Methods of predicting prognosis in cancer
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
EP2788378A4 (en) * 2011-12-09 2015-09-09 Oncomed Pharm Inc ASSOCIATION THERAPY FOR THE TREATMENT OF CANCER
US20150160221A1 (en) * 2012-01-09 2015-06-11 Suzhou Microdiag Biomedicine Co., Ltd Biomarkers for breast cancer predictions and diagnoses
US9428813B2 (en) 2012-03-26 2016-08-30 The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services DNA methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
BR112015003418A2 (pt) 2012-08-17 2017-07-04 Hoffmann La Roche produto farmacêutico, conjunto, métodos para estender a duração da resposta ao tratamento, de retardar ou prevenir o desenvolvimento de resistência ao tratamento, para a seleção de uma terapia e para otimizar a eficácia terapêutica.
TWI601725B (zh) * 2012-08-27 2017-10-11 加拓科學公司 取代的氮雜吲哚化合物及其鹽、組合物和用途
CA2887058C (en) * 2012-10-03 2022-02-22 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
AU2013353839A1 (en) * 2012-12-03 2015-06-18 Almac Diagnostics Limited Molecular diagnostic test for cancer
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
RU2664180C2 (ru) * 2013-04-15 2018-08-15 Регенерон Фармасьютикалз, Инк. Маркеры ответа опухолевых клеток на противораковую терапию
CN103941016B (zh) * 2013-05-07 2016-04-27 上海良润生物医药科技有限公司 半胱氨酸蛋白酶抑制剂sn与癌胚抗原的联合应用
WO2014184211A1 (en) * 2013-05-13 2014-11-20 Institut Gustave Roussy Prognosis and predictive biomarkers and biological applications thereof
EP3039424B1 (en) * 2013-08-28 2020-07-29 Crown Bioscience, Inc. (Taicang) Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same
WO2015077781A1 (en) * 2013-11-25 2015-05-28 Children's Hospital Medical Center Temporal pediatric sepsis biomarker risk model
EA201691144A1 (ru) * 2013-12-06 2016-11-30 Селджин Корпорейшн Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка
AU2014361856A1 (en) * 2013-12-12 2016-06-30 Abbvie Stemcentrx Llc Novel anti-DPEP3 antibodies and methods of use
JP2017503169A (ja) 2013-12-31 2017-01-26 イエダ・リサーチ・アンド・デベロツプメント・カンパニー・リミテツド オリゴヌクレオチド抗原を使用する全身性エリテマトーデスの診断
GB201409479D0 (en) 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
CN106536753B (zh) * 2014-04-04 2020-07-21 中美冠科生物技术（太仓）有限公司 用于确定对mek/erk抑制剂的应答性的方法
GB201408100D0 (en) * 2014-05-07 2014-06-18 Sec Dep For Health The Detection method
WO2016011065A1 (en) * 2014-07-15 2016-01-21 Salk Institute For Biolofical Studies Detecting dixdc1 (dix domain-containing protein 1) expression to determine if a tumor will respond to fak and src kinase inhibitors
WO2016060702A1 (en) * 2014-10-13 2016-04-21 Celgene Corporaton Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
CN104502603B (zh) * 2014-12-03 2016-04-06 上海交通大学医学院附属上海儿童医学中心 Myo1d作为诊断动脉导管闭合或开放的标志物
WO2016131420A1 (zh) 2015-02-17 2016-08-25 上海交通大学医学院附属上海儿童医学中心 急性淋巴细胞白血病耐药复发相关突变基因及其应用
CN105986023B (zh) * 2015-02-17 2021-01-05 上海交通大学医学院附属上海儿童医学中心 急性淋巴细胞白血病耐药复发相关突变基因及其应用
WO2016139659A1 (en) 2015-03-01 2016-09-09 Immunarray Ltd. Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
CN105063183A (zh) * 2015-07-22 2015-11-18 浙江理工大学 泛素化途径相关基因在作为用于预测乳腺癌新辅助化疗疗效的生物标记物的应用
WO2017025954A1 (en) * 2015-08-09 2017-02-16 Immunarray Ltd Methods for determining the risk of a systemic lupus erythematosus (sle) patient to develop neuropsychiatric syndromes
EP3334844A4 (en) * 2015-08-12 2019-11-06 Celgene Corporation METHOD FOR THE TREATMENT OF SOLID TUMORS AND USE OF BIOMARKERS AS PREDICTORS OF CLINICAL SENSITIVITY TO IMMUNOMODULATORY THERAPIES
CN105126080A (zh) * 2015-09-29 2015-12-09 武汉大学 锌指蛋白436（znf436）在治疗心肌肥厚中的应用
CN105671158B (zh) * 2016-02-29 2019-01-18 北京泱深生物信息技术有限公司 Fam63b基因在制备诊治子宫肌瘤的产品中的用途
AU2017249229A1 (en) * 2016-04-15 2018-10-04 Genentech, Inc. Diagnostic and therapeutic methods for cancer
CN105695617A (zh) * 2016-04-22 2016-06-22 王冬国 乳头状癌的肿瘤标志物及其应用
MA45496A (fr) * 2016-06-17 2019-04-24 Hoffmann La Roche Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
CA3034332A1 (en) * 2016-08-17 2018-02-22 Ichan School Of Medicine At Mount Sinai Kinase inhibitor compounds, compositions, and methods of treating cancer
CN108300783A (zh) * 2017-01-11 2018-07-20 上海易毕恩基因科技有限公司 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
CA3056389A1 (en) * 2017-03-15 2018-09-20 Eisai R&D Management Co., Ltd. Spliceosome mutations and uses thereof
CN109081866B (zh) * 2017-06-13 2021-07-16 北京大学 癌症中的t细胞亚群及其特征基因
CN109111522B (zh) * 2017-06-22 2022-02-01 北海康成（北京）医药科技有限公司 预测食管癌对抗erbb3抗体治疗的应答的方法和试剂盒
US10953034B2 (en) 2017-10-16 2021-03-23 Hoffmann-La Roche Inc. Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection
CN109825508A (zh) * 2017-11-23 2019-05-31 深圳市第三人民医院 一种用来评估艾滋病合并结核感染的生物标记物
CN109870576B (zh) * 2017-12-05 2021-08-10 中国科学院大连化学物理研究所 Usp10蛋白的定量检测在原发性肝癌预后判断试剂盒中的应用
CN112153983A (zh) * 2018-05-23 2020-12-29 杰克逊实验室 抗ngly-1抗体及使用方法
CN108707628B (zh) * 2018-05-28 2021-11-23 上海海洋大学 斑马鱼notch2基因突变体的制备方法
CN108753834B (zh) * 2018-05-28 2021-11-23 上海海洋大学 ddx27基因缺失斑马鱼突变体的制备方法
CN108676867B (zh) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 诊治子痫前期的vwce基因及其应用
CN108624678B (zh) * 2018-06-26 2020-07-17 青岛泱深生物医药有限公司 一种用于子痫前期诊治的生物标志物
CN108841960B (zh) * 2018-07-12 2022-02-01 吉林大学 一种结肠腺癌易感性预测试剂盒及系统
CN109468320A (zh) * 2018-11-13 2019-03-15 复旦大学附属中山医院 一种环状rna及其在肝癌诊断中的应用
CN111467493A (zh) * 2019-01-23 2020-07-31 首都师范大学 人rev3l蛋白切割抑制剂及其应用
CN111896740A (zh) * 2019-05-06 2020-11-06 山东大学 诊断或预测生育缺陷的方法和试剂盒
WO2021032068A1 (zh) * 2019-08-16 2021-02-25 中国科学院脑科学与智能技术卓越创新中心 Ptbp1抑制剂在预防和/或治疗功能性神经元死亡相关的神经系统疾病中的应用
CN110551819B (zh) * 2019-08-23 2023-05-16 伯克利南京医学研究有限责任公司 一组卵巢癌预后相关基因的应用
CN110408706B (zh) * 2019-08-30 2023-04-11 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种评估鼻咽癌复发的生物标志物及其应用
CN110643571B (zh) * 2019-10-22 2021-07-27 康妍葆(北京)干细胞科技有限公司 人角蛋白6a在干细胞培养中的应用及产品
CN110819714B (zh) * 2019-11-22 2023-01-10 南方医科大学深圳医院 一种抑癌基因及其应用
TW202134239A (zh) * 2019-11-27 2021-09-16 大陸商蘇州亞盛藥業有限公司 用於預測靶向細胞凋亡途徑的化合物的抗癌功效的方法和組合物
CN111781358A (zh) * 2020-07-13 2020-10-16 张瑜 Xab2蛋白作为卵巢癌预后和/或预测铂类耐药标志物
CN113943798B (zh) * 2020-07-16 2023-10-27 中国农业大学 一种circ RNA作为肝细胞癌诊断标志物及治疗靶点的应用
CN112691195B (zh) * 2021-02-02 2023-03-14 黑龙江省科学院高技术研究院 Prpf8表达抑制剂在制备治疗肺癌的药物中的应用
CN112816708B (zh) * 2021-02-02 2022-05-31 中南大学湘雅二医院 一种预测食管鳞癌患者对化疗药物敏感性的蛋白指标及应用
CN112816711B (zh) * 2021-03-17 2024-04-19 中国医科大学附属盛京医院 用于神经管畸形、先天性心脏病和唇腭裂胎儿产前无创诊断的分子标志物及其应用
CN113373220A (zh) * 2021-05-08 2021-09-10 首都医科大学 与非小细胞肺癌预后相关的标志分子
CN113416739B (zh) * 2021-06-24 2022-04-19 黑龙江八一农垦大学 鲁氏酵母菌基因在提高微生物产hdmf的产量中的应用
CN113667749A (zh) * 2021-08-03 2021-11-19 广东省人民医院 四个关键基因组合评估乳腺癌风险的诊断试剂盒
CN113866424A (zh) * 2021-09-14 2021-12-31 哈尔滨医科大学 碳酸酐酶1和酸性鞘磷脂酶样磷酸二酯酶3a作为分子标志物在结直肠癌诊断中的应用
CN113897437B (zh) * 2021-11-30 2024-06-04 深圳市人民医院 检测样本中标志物表达水平的试剂在制备用于诊断乳腺癌的试剂盒中的应用
CN114592059A (zh) * 2022-01-11 2022-06-07 南方医科大学南方医院 一种评估5-fu治疗敏感性/耐药性的试剂盒
CN117529480A (zh) * 2022-03-16 2024-02-06 南京施江医药科技有限公司 一种含氮杂环类化合物
CN114672551B (zh) * 2022-05-17 2023-03-31 中国医科大学附属第一医院 Mat2a和mat2b作为检测或治疗良性前列腺增生的药物靶点的应用
CN115948529A (zh) * 2022-08-01 2023-04-11 湖南家辉生物技术有限公司 一种Cornelia de Lange综合征1型的致病基因、引物对及其应用
CN115948537B (zh) * 2022-12-19 2024-04-09 湖南家辉生物技术有限公司 一种基因chst3复合杂合突变的应用及检测试剂和应用
CN118045083B (zh) * 2024-04-15 2024-06-18 哈尔滨医科大学 L-脯氨酸在制备防治非酒精性脂肪肝病药物中的新用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604260A (en) * 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
US6358932B1 (en) * 1994-05-31 2002-03-19 Isis Pharmaceticals, Inc. Antisense oligonucleotide inhibition of raf gene expression
US6391636B1 (en) * 1994-05-31 2002-05-21 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
US20030119769A1 (en) * 1994-05-31 2003-06-26 Monia Brett P Antisense oligonucleotide modulation of raf gene expression
EP0910401A1 (en) * 1996-05-23 1999-04-28 Applied Research Systems ARS Holdings N.V. Compounds that inhibit the binding of raf-1 or 14-3-3 proteins to the beta chain of il-2 receptor, and pharmaceutical compositions containing same
AR012634A1 (es) * 1997-05-02 2000-11-08 Sugen Inc Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
US6187799B1 (en) * 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
ME00275B (me) * 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
US6610484B1 (en) * 1999-01-26 2003-08-26 Cytyc Health Corporation Identifying material from a breast duct
US20040018570A1 (en) * 1999-09-01 2004-01-29 Brown University Kinase inhibitors and methods of use in screening assays and modulation of cell proliferation and growth
CA2475206A1 (en) * 2002-02-15 2003-08-15 The General Hospital Corporation Map-kinase inhibitors as regulators of tumor-associated antigen expression
US20040224302A1 (en) * 2002-07-16 2004-11-11 Thomas Jessel Systems and methods for screening for modulators of neural differentiation
US20040121375A1 (en) * 2002-09-30 2004-06-24 Bayer Pharmaceuticals Corporation Methods for prediction and prognosis of cancer, and monitoring cancer therapy
EP2295602B1 (en) * 2005-07-27 2012-07-11 Oncotherapy Science, Inc. Method of prognosing cancers
PE20070335A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion

Also Published As

Publication number Publication date
AU2007340265A1 (en) 2008-07-10
KR20090071603A (ko) 2009-07-01
JP2010504530A (ja) 2010-02-12
CA2662508A1 (en) 2008-07-10
EP2074226A2 (en) 2009-07-01
RU2009114745A (ru) 2010-10-27
CN101541977A (zh) 2009-09-23
AU2007340265B2 (en) 2012-07-26
WO2008082730A3 (en) 2009-01-08
SG174826A1 (en) 2011-10-28
IL197450A0 (en) 2009-12-24
US20100004253A1 (en) 2010-01-07
JP2013128487A (ja) 2013-07-04
WO2008082730A2 (en) 2008-07-10
BRPI0716944A2 (pt) 2013-09-17

Similar Documents

Publication Publication Date Title
MX2009002936A (es) Biomarcadores de la modulacion de objetivo, eficacia, diagnostico, y/o pronostico para los inhibidores de raf.
WO2007067968A3 (en) Effects of inhibitors of fgfr3 on gene transcription
WO2008027428A3 (en) Gene expression profiling for identification, monitoring and treatment of transplant rejection
WO2008073919A3 (en) Mir-20 regulated genes and pathways as targets for therapeutic intervention
WO2006084015A3 (en) Raf inhibitor compounds and methods
WO2011090738A3 (en) Type ii raf kinase inhibitors
WO2007081740A3 (en) Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers
MX2012009030A (es) Identificacion de mutacion lkb1 como biomarcador predictivo para sensibilidad a inhibidores de tor cinasa.
UA101478C2 (ru) Соединения, полезные как ингибиторы raf-киназы
MY172372A (en) Compositions and methods for lowering triglycerides
WO2012045905A3 (es) Método para el diagnóstico, pronóstico y tratamiento de la metástasis de cáncer de mama
WO2010031056A3 (en) Methods and compositions for modulating ire1, src, and abl activity
WO2009126310A3 (en) Methods for identification and use of agents targeting cancer stem cells
WO2013182912A3 (en) Method for the diagnosis, prognosis and treatment of lung cancer metastasis
MX2009012625A (es) Metodos para el tratamiento, diagnostico y deteccion de trastornos asociados con el fgf21.
EA201200793A1 (ru) Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
WO2008036741A3 (en) Mir-200 regulated genes and pathways as targets for therapeutic intervention
WO2011088137A3 (en) Bad pathway gene signature
WO2014057357A3 (en) Method for the diagnosis, prognosis and treatment of prostate cancer metastasis using c-maf
MX2018008169A (es) Tratamiento de tumores que incorpora isocitrato deshidrogenasa mutante.
WO2009092108A3 (en) Biomarkers for the diagnosis and treatment of pancreatic cancer
MX2010005768A (es) Composiciones y métodos para inhibir la activación del arnbc-dependiente de la proteina de la kinasa y la inhibición del crecimiento tumoral.
ATE534738T1 (de) Mir-126-regulierte gene und pfade als ziele für therapeutische interventionen
WO2009017670A3 (en) Ras-mediated epigenetic silencing effectors and uses thereof
WO2011127202A3 (en) Methods for identifying and using inhibitors of casein kinase 1 epsilon isoform for inhibiting the growth and/or proliferation of myc-driven tumor cells

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration