AU2007340265B2 - Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for Raf inhibitors - Google Patents

Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for Raf inhibitors Download PDF

Info

Publication number
AU2007340265B2
AU2007340265B2 AU2007340265A AU2007340265A AU2007340265B2 AU 2007340265 B2 AU2007340265 B2 AU 2007340265B2 AU 2007340265 A AU2007340265 A AU 2007340265A AU 2007340265 A AU2007340265 A AU 2007340265A AU 2007340265 B2 AU2007340265 B2 AU 2007340265B2
Authority
AU
Australia
Prior art keywords
protein
factor
alpha
kinase
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007340265A
Other languages
English (en)
Other versions
AU2007340265A1 (en
Inventor
Kim Aardalen
Natasha Aziz
Carla Heise
Edward Moler
Darrin Stuart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2007340265A1 publication Critical patent/AU2007340265A1/en
Application granted granted Critical
Publication of AU2007340265B2 publication Critical patent/AU2007340265B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2007340265A 2006-09-19 2007-09-19 Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for Raf inhibitors Ceased AU2007340265B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84560106P 2006-09-19 2006-09-19
US60/845,601 2006-09-19
PCT/US2007/078946 WO2008082730A2 (en) 2006-09-19 2007-09-19 Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors

Publications (2)

Publication Number Publication Date
AU2007340265A1 AU2007340265A1 (en) 2008-07-10
AU2007340265B2 true AU2007340265B2 (en) 2012-07-26

Family

ID=39445772

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007340265A Ceased AU2007340265B2 (en) 2006-09-19 2007-09-19 Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for Raf inhibitors

Country Status (13)

Country Link
US (1) US20100004253A1 (enExample)
EP (1) EP2074226A2 (enExample)
JP (2) JP2010504530A (enExample)
KR (1) KR20090071603A (enExample)
CN (1) CN101541977A (enExample)
AU (1) AU2007340265B2 (enExample)
BR (1) BRPI0716944A2 (enExample)
CA (1) CA2662508A1 (enExample)
IL (1) IL197450A0 (enExample)
MX (1) MX2009002936A (enExample)
RU (1) RU2009114745A (enExample)
SG (1) SG174826A1 (enExample)
WO (1) WO2008082730A2 (enExample)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
DE102004024617A1 (de) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
BRPI0711011A2 (pt) 2006-05-18 2011-08-23 Molecular Profiling Inst Inc método para a determinação da intervenção médica para um estado de doença, método para a identificação de uma terapia de droga com capacidade de interação com um alvo molecular e sistema para a determinação da intervenção médica individualizada para um estado de doença
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
RU2011102743A (ru) * 2008-06-26 2012-08-10 Дана-Фарбер Кэнсер Инститьют, Инк. (Us) Характерные признаки и детерминанты, связанные с метастазированием, и способы их применения
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
MX2011003183A (es) 2008-09-26 2011-04-21 Oncomed Pharm Inc Agentes que se unen a receptor encrespado y usos de los mismos.
EP3181705A1 (en) 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
US20120041274A1 (en) * 2010-01-07 2012-02-16 Myriad Genetics, Incorporated Cancer biomarkers
EP2501236B1 (en) 2009-11-18 2017-03-29 Plexxikon Inc. N-[2-fluoro-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-benzenesulfonamide derivatives as Raf protein kinase modulators for the treatment of cancer
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
US20120045433A1 (en) * 2010-08-17 2012-02-23 Kapil Dhingra Combination therapy
US8709419B2 (en) * 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
EP2444503B1 (en) * 2010-10-20 2016-03-02 Université Joseph Fourier Use of specific genes for the prognosis of lung cancer and the corresponding progonosis method
JP2014500001A (ja) * 2010-10-21 2014-01-09 オンコセラピー・サイエンス株式会社 Ｃ１８ｏｒｆ５４ペプチドおよびそれを含むワクチン
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
SG194800A1 (en) * 2011-06-02 2013-12-30 Novartis Ag Biomarkers for hedgehog inhibitor therapy
BR112013031019A2 (pt) 2011-06-02 2017-03-21 Almac Diagnostics Ltd teste diagnóstico molecular para câncer
US20140302042A1 (en) * 2011-07-01 2014-10-09 Dana-Farber Cancer Institute, Inc. Methods of predicting prognosis in cancer
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
JP2015502958A (ja) * 2011-12-09 2015-01-29 オンコメッド ファーマシューティカルズ インコーポレイテッド がんの処置のための併用療法
GB2513771B (en) * 2012-01-09 2020-05-27 Suzhou Microdiag Biomedicine Co Ltd Biomarkers for breast cancer predictions and diagnoses
WO2013148147A1 (en) 2012-03-26 2013-10-03 The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
KR20240146112A (ko) 2012-08-17 2024-10-07 에프. 호프만-라 로슈 아게 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
TWI601725B (zh) * 2012-08-27 2017-10-11 加拓科學公司 取代的氮雜吲哚化合物及其鹽、組合物和用途
CN105025878A (zh) * 2012-10-03 2015-11-04 外来体诊断公司 微泡在医学疾病和病况的诊断、预后和治疗中的用途
US11091809B2 (en) 2012-12-03 2021-08-17 Almac Diagnostic Services Limited Molecular diagnostic test for cancer
HK1211887A1 (en) 2013-02-04 2016-06-03 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a wnt pathway inhibitor
US10023916B2 (en) * 2013-04-15 2018-07-17 Regeneron Pharmaceuticals, Inc. Markers of tumor cell response to anti-cancer therapy
CN103941016B (zh) * 2013-05-07 2016-04-27 上海良润生物医药科技有限公司 半胱氨酸蛋白酶抑制剂sn与癌胚抗原的联合应用
DK2997376T3 (da) * 2013-05-13 2020-09-21 Roussy Inst Gustave Prognose og prædiktive biomarkører og biologiske anvendelser deraf
US11136625B2 (en) 2013-08-28 2021-10-05 Crown Bioscience, Inc. (Taicang) Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same
EP3074536B1 (en) * 2013-11-25 2019-06-19 Children's Hospital Medical Center Temporal pediatric sepsis biomarker risk model
EA201691144A1 (ru) * 2013-12-06 2016-11-30 Селджин Корпорейшн Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка
JP2017500028A (ja) * 2013-12-12 2017-01-05 アッヴィ・ステムセントルクス・エル・エル・シー 新規の抗ｄｐｅｐ３抗体および使用方法
EP3090064B1 (en) 2013-12-31 2019-11-13 Yeda Research and Development Co. Ltd. Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
GB201409479D0 (en) 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
PT3126521T (pt) 2014-04-04 2019-06-27 Crown Bioscience Inc Taicang Gene de fusão hnf4g-rspo2
GB201408100D0 (en) * 2014-05-07 2014-06-18 Sec Dep For Health The Detection method
WO2016011065A1 (en) * 2014-07-15 2016-01-21 Salk Institute For Biolofical Studies Detecting dixdc1 (dix domain-containing protein 1) expression to determine if a tumor will respond to fak and src kinase inhibitors
US20170242014A1 (en) * 2014-10-13 2017-08-24 Celgene Corporaton Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
CN104502603B (zh) * 2014-12-03 2016-04-06 上海交通大学医学院附属上海儿童医学中心 Myo1d作为诊断动脉导管闭合或开放的标志物
WO2016131420A1 (zh) 2015-02-17 2016-08-25 上海交通大学医学院附属上海儿童医学中心 急性淋巴细胞白血病耐药复发相关突变基因及其应用
CN105986023B (zh) * 2015-02-17 2021-01-05 上海交通大学医学院附属上海儿童医学中心 急性淋巴细胞白血病耐药复发相关突变基因及其应用
WO2016139659A1 (en) 2015-03-01 2016-09-09 Immunarray Ltd. Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
CN105063183A (zh) * 2015-07-22 2015-11-18 浙江理工大学 泛素化途径相关基因在作为用于预测乳腺癌新辅助化疗疗效的生物标记物的应用
US20180231565A1 (en) * 2015-08-09 2018-08-16 Immunarray Ltd Methods for determining the risk of a systemic lupus erythematosus (sle) patient to develop neuropsychiatric syndromes
EP3334844A4 (en) * 2015-08-12 2019-11-06 Celgene Corporation METHOD FOR THE TREATMENT OF SOLID TUMORS AND USE OF BIOMARKERS AS PREDICTORS OF CLINICAL SENSITIVITY TO IMMUNOMODULATORY THERAPIES
CN105126080A (zh) * 2015-09-29 2015-12-09 武汉大学 锌指蛋白436（znf436）在治疗心肌肥厚中的应用
CN105671158B (zh) * 2016-02-29 2019-01-18 北京泱深生物信息技术有限公司 Fam63b基因在制备诊治子宫肌瘤的产品中的用途
MX2018012471A (es) * 2016-04-15 2019-02-21 Genentech Inc Metodos de diagnostico y terapeuticos para el cancer.
CN105695617A (zh) * 2016-04-22 2016-06-22 王冬国 乳头状癌的肿瘤标志物及其应用
MA45496A (fr) 2016-06-17 2019-04-24 Hoffmann La Roche Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
CN110072526A (zh) * 2016-08-17 2019-07-30 西奈山伊坎医学院 治疗癌症的激酶抑制剂化合物、组合物和方法
CN108300783A (zh) * 2017-01-11 2018-07-20 上海易毕恩基因科技有限公司 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途
WO2018134254A1 (en) 2017-01-17 2018-07-26 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
SG11201907887SA (en) * 2017-03-15 2019-09-27 Eisai Co Ltd Spliceosome mutations and uses thereof
CN109081866B (zh) * 2017-06-13 2021-07-16 北京大学 癌症中的t细胞亚群及其特征基因
CN113683698B (zh) * 2017-06-22 2023-03-31 北海康成（北京）医药科技有限公司 预测食管癌对抗erbb3抗体治疗的应答的方法和试剂盒
AU2018350693B2 (en) 2017-10-16 2021-03-04 F. Hoffmann-La Roche Ag Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection
CN109825508A (zh) * 2017-11-23 2019-05-31 深圳市第三人民医院 一种用来评估艾滋病合并结核感染的生物标记物
CN109870576B (zh) * 2017-12-05 2021-08-10 中国科学院大连化学物理研究所 Usp10蛋白的定量检测在原发性肝癌预后判断试剂盒中的应用
US12054558B2 (en) * 2018-05-23 2024-08-06 The Jackson Laboratory Anti-NGly-1 antibodies and methods of use
CN108753834B (zh) * 2018-05-28 2021-11-23 上海海洋大学 ddx27基因缺失斑马鱼突变体的制备方法
CN108707628B (zh) * 2018-05-28 2021-11-23 上海海洋大学 斑马鱼notch2基因突变体的制备方法
CN108676867B (zh) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 诊治子痫前期的vwce基因及其应用
CN108624678B (zh) * 2018-06-26 2020-07-17 青岛泱深生物医药有限公司 一种用于子痫前期诊治的生物标志物
CN108841960B (zh) * 2018-07-12 2022-02-01 吉林大学 一种结肠腺癌易感性预测试剂盒及系统
CN109468320A (zh) * 2018-11-13 2019-03-15 复旦大学附属中山医院 一种环状rna及其在肝癌诊断中的应用
JP7558167B2 (ja) 2018-12-03 2024-09-30 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム オリゴベンズアミド類似体およびがん処置におけるそれらの使用
CN111467493A (zh) * 2019-01-23 2020-07-31 首都师范大学 人rev3l蛋白切割抑制剂及其应用
CN111896740B (zh) * 2019-05-06 2025-02-11 山东大学 诊断或预测生育缺陷的试剂盒
EP4039801A4 (en) * 2019-08-16 2023-10-18 Center For Excellence In Brain Science And Intelligence Technology, Chinese Academy Of Sciences USE OF PTBP1 INHIBITORS TO PREVENT AND/OR TREAT NERVOUS SYSTEM DISEASES ASSOCIATED WITH FUNCTIONAL NEURONAL DEATH
CN110551819B (zh) * 2019-08-23 2023-05-16 伯克利南京医学研究有限责任公司 一组卵巢癌预后相关基因的应用
CN110408706B (zh) * 2019-08-30 2023-04-11 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种评估鼻咽癌复发的生物标志物及其应用
CN110643571B (zh) * 2019-10-22 2021-07-27 康妍葆(北京)干细胞科技有限公司 人角蛋白6a在干细胞培养中的应用及产品
KR102261606B1 (ko) * 2019-11-07 2021-06-07 (주)지노믹트리 대장암 검출 방법
CN110819714B (zh) * 2019-11-22 2023-01-10 南方医科大学深圳医院 一种抑癌基因及其应用
TWI885019B (zh) 2019-11-27 2025-06-01 大陸商蘇州亞盛藥業有限公司 用於預測靶向細胞凋亡途徑的化合物的抗癌功效的方法和組合物
CN116194121A (zh) * 2020-06-09 2023-05-30 吉尼松公司 用于治疗扩张型心肌病的cilp-1抑制剂
CN111781358A (zh) * 2020-07-13 2020-10-16 张瑜 Xab2蛋白作为卵巢癌预后和/或预测铂类耐药标志物
CN113943798B (zh) * 2020-07-16 2023-10-27 中国农业大学 一种circ RNA作为肝细胞癌诊断标志物及治疗靶点的应用
CN112816708B (zh) * 2021-02-02 2022-05-31 中南大学湘雅二医院 一种预测食管鳞癌患者对化疗药物敏感性的蛋白指标及应用
CN112691195B (zh) * 2021-02-02 2023-03-14 黑龙江省科学院高技术研究院 Prpf8表达抑制剂在制备治疗肺癌的药物中的应用
CN112816711B (zh) * 2021-03-17 2024-04-19 中国医科大学附属盛京医院 用于神经管畸形、先天性心脏病和唇腭裂胎儿产前无创诊断的分子标志物及其应用
CN113373220A (zh) * 2021-05-08 2021-09-10 首都医科大学 与非小细胞肺癌预后相关的标志分子
CN113416739B (zh) * 2021-06-24 2022-04-19 黑龙江八一农垦大学 鲁氏酵母菌基因在提高微生物产hdmf的产量中的应用
CN113667749A (zh) * 2021-08-03 2021-11-19 广东省人民医院 四个关键基因组合评估乳腺癌风险的诊断试剂盒
CN113866424A (zh) * 2021-09-14 2021-12-31 哈尔滨医科大学 碳酸酐酶1和酸性鞘磷脂酶样磷酸二酯酶3a作为分子标志物在结直肠癌诊断中的应用
CN113897437B (zh) * 2021-11-30 2024-06-04 深圳市人民医院 检测样本中标志物表达水平的试剂在制备用于诊断乳腺癌的试剂盒中的应用
CN114592059A (zh) * 2022-01-11 2022-06-07 南方医科大学南方医院 一种评估5-fu治疗敏感性/耐药性的试剂盒
CN114525342B (zh) * 2022-03-03 2025-02-14 温州医科大学附属第一医院 Linc02806在肝细胞癌诊断和治疗中的应用
CA3246050A1 (en) * 2022-03-16 2025-02-04 Shanghai Shijiang Biotechnology Co Ltd Nitrogen-containing heterocyclic compound and use thereof
CN114672551B (zh) * 2022-05-17 2023-03-31 中国医科大学附属第一医院 Mat2a和mat2b作为检测或治疗良性前列腺增生的药物靶点的应用
CN115389764A (zh) * 2022-07-28 2022-11-25 宁波大学 蛋白质fbxo7在制备子宫内膜癌诊断标志物中的应用
CN115948529A (zh) * 2022-08-01 2023-04-11 湖南家辉生物技术有限公司 一种Cornelia de Lange综合征1型的致病基因、引物对及其应用
CN116179691A (zh) * 2022-09-07 2023-05-30 苏州大学附属第一医院 一种胃癌组合标志物及标志物模型的建立方法
WO2024107924A2 (en) * 2022-11-17 2024-05-23 Board Of Regents, The University Of Texas System A blood-based lipid biomarker panel for personalized risk assessment of breast cancer
CN115948537B (zh) * 2022-12-19 2024-04-09 湖南家辉生物技术有限公司 一种基因chst3复合杂合突变的应用及检测试剂和应用
CN116287253B (zh) * 2023-02-22 2024-06-28 武汉科技大学 一种肺癌分子标志物及其应用
CN116430048B (zh) * 2023-03-07 2025-06-20 南通大学附属医院 BTF3L4基因及其RNAi干扰系统的应用
CN116500266B (zh) * 2023-03-07 2025-06-17 南通大学附属医院 MRPS21基因及其RNAi干扰系统的应用
CN117100866B (zh) * 2023-03-31 2025-10-28 兰州大学第二医院 一种抗肿瘤血管生成药物增效剂、抗肿瘤药物组合物及应用
CN116769916B (zh) * 2023-06-27 2025-03-07 南通大学附属医院 Tmed8基因在制备胰腺癌药物及其诊断试剂盒中的应用
CN116747215A (zh) * 2023-07-14 2023-09-15 新疆医科大学第三附属医院 V-9302在抑制肝癌和增强索拉菲尼抑癌作用中的应用
CN117257919B (zh) * 2023-11-10 2024-10-01 南通大学附属医院 Tbc1d15在筛选或制备保护肝脏的药物中的应用
CN117821469B (zh) * 2023-11-22 2024-08-02 扬州大学 一种鸡trim45截短体重组蛋白或其多克隆抗体的应用
CN118045083B (zh) * 2024-04-15 2024-06-18 哈尔滨医科大学 L-脯氨酸在制备防治非酒精性脂肪肝病药物中的新用途
CN118879858B (zh) * 2024-06-27 2025-09-30 中国科学院合肥物质科学研究院 一组用于预测非小细胞肺癌放疗预后的基因标签及应用
CN120442707B (zh) * 2025-07-14 2025-09-09 三亚中国农业科学院国家南繁研究院 棉花耐旱性和耐低温性相关蛋白GhCOX11及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604260A (en) * 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
US20030119769A1 (en) * 1994-05-31 2003-06-26 Monia Brett P Antisense oligonucleotide modulation of raf gene expression
US6358932B1 (en) * 1994-05-31 2002-03-19 Isis Pharmaceticals, Inc. Antisense oligonucleotide inhibition of raf gene expression
US6391636B1 (en) * 1994-05-31 2002-05-21 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
CA2256109A1 (en) * 1996-05-23 1997-11-27 Applied Research Systems Ars Holding N.V. Compounds that inhibit the binding of raf-1 or 14-3-3 proteins to the beta chain of il-2 receptor, and pharmaceutical compositions containing same
AR012634A1 (es) * 1997-05-02 2000-11-08 Sugen Inc Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
US6187799B1 (en) * 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
US7351834B1 (en) * 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US6610484B1 (en) * 1999-01-26 2003-08-26 Cytyc Health Corporation Identifying material from a breast duct
US20040018570A1 (en) * 1999-09-01 2004-01-29 Brown University Kinase inhibitors and methods of use in screening assays and modulation of cell proliferation and growth
AU2003222221A1 (en) * 2002-02-15 2004-10-25 The General Hospital Corporation Map-kinase inhibitors as regulators of tumour-associated antigen expression
US20040224302A1 (en) * 2002-07-16 2004-11-11 Thomas Jessel Systems and methods for screening for modulators of neural differentiation
CA2499852A1 (en) * 2002-09-30 2004-04-08 Bayer Pharmaceuticals Corporation Methods for prediction and prognosis of cancer, and monitoring cancer therapy
US8053183B2 (en) * 2005-07-27 2011-11-08 Oncotherapy Science, Inc. Method of diagnosing esophageal cancer
PE20070427A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EDAKUNI, G. et al., Pathology International, 2001, Vol. 51, pages 172-178 *
HASHEM, M.D. et al, Journal of the Egyptian Naat. Cancer Inst., 2005, Vol. 17, pages 114-120 *
NAMBIAR, S., et al, ', Archives of Dermatology, 2005. Vol. 141, No. 2, pages 165-173 *
TOI, M. et al., Clinical Cancer Research, 1998. Vol. 4, pages 659-664 *

Also Published As

Publication number Publication date
MX2009002936A (es) 2009-04-01
BRPI0716944A2 (pt) 2013-09-17
SG174826A1 (en) 2011-10-28
RU2009114745A (ru) 2010-10-27
AU2007340265A1 (en) 2008-07-10
CN101541977A (zh) 2009-09-23
KR20090071603A (ko) 2009-07-01
CA2662508A1 (en) 2008-07-10
US20100004253A1 (en) 2010-01-07
WO2008082730A2 (en) 2008-07-10
WO2008082730A3 (en) 2009-01-08
JP2010504530A (ja) 2010-02-12
IL197450A0 (en) 2009-12-24
JP2013128487A (ja) 2013-07-04
EP2074226A2 (en) 2009-07-01

Similar Documents

Publication Publication Date Title
AU2007340265B2 (en) Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for Raf inhibitors
US20240363249A1 (en) Machine Learning Disease Prediction and Treatment Prioritization
US11644466B2 (en) Methods for treating, preventing and predicting risk of developing breast cancer
US20220244263A1 (en) Methods for treating small cell neuroendocrine and related cancers
US8492328B2 (en) Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
US10870888B2 (en) Methods and systems for analysis of organ transplantation
US20250145636A1 (en) Protein degraders and uses thereof
US20200399714A1 (en) Cancer-related biological materials in microvesicles
US20220401460A1 (en) Modulating resistance to bcl-2 inhibitors
US10262103B2 (en) Individualized cancer treatment
US20230115184A1 (en) Protein degraders and uses thereof
US20060199204A1 (en) Genetic testing for male factor infertility
WO2021011634A1 (en) Protein degraders and uses thereof
US20090010908A1 (en) Materials and Methods for Diagnosis and Treatment of Chronic Fatigue Syndrome
WO2022187690A1 (en) Covalent binding compounds for the treatment of disease
US20110236903A1 (en) Materials and methods for determining diagnosis and prognosis of prostate cancer
WO2019079647A2 (en) IA STATISTICS FOR DEEP LEARNING AND PROBABILISTIC PROGRAMMING, ADVANCED, IN BIOSCIENCES
US20230220470A1 (en) Methods and systems for analyzing targetable pathologic processes in covid-19 via gene expression analysis
KR20090078365A (ko) 혈액 백혈구 마이크로어레이 분석을 통한 전이성 흑색종의 진단 및 면역억제 지표의 모니터링
WO2019008412A1 (en) USE OF BLOOD GENE EXPRESSION ANALYSIS FOR CANCER CARE
WO2019008415A1 (en) EXOSOMED AND PBMC GENE EXPRESSION ANALYSIS FOR CANCER CARE
WO2019008414A1 (en) GENE EXPRESSION ANALYSIS BASED ON EXOSOMES FOR THE CARE OF CANCER
US20250011886A1 (en) Systems and Methods for Targeting COVID-19 Therapies
US20210238698A1 (en) Methods of diagnosing and treating cancer patients expressing high levels of tgf-b response signature
WO2012135397A2 (en) Lactate-and ketones-induced gene signatures and use the same for diagnosing disease and predicting clinical outcome

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired