JP2010504088A5 - - Google Patents

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Publication number
JP2010504088A5
JP2010504088A5 JP2009528732A JP2009528732A JP2010504088A5 JP 2010504088 A5 JP2010504088 A5 JP 2010504088A5 JP 2009528732 A JP2009528732 A JP 2009528732A JP 2009528732 A JP2009528732 A JP 2009528732A JP 2010504088 A5 JP2010504088 A5 JP 2010504088A5
Authority
JP
Japan
Prior art keywords
seq
mature protein
nucleic acid
disease
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009528732A
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English (en)
Japanese (ja)
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JP2010504088A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/060013 external-priority patent/WO2008034891A2/en
Publication of JP2010504088A publication Critical patent/JP2010504088A/ja
Publication of JP2010504088A5 publication Critical patent/JP2010504088A5/ja
Pending legal-status Critical Current

Links

JP2009528732A 2006-09-21 2007-09-21 グルタミニルシクラーゼに関連した新規遺伝子 Pending JP2010504088A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84624406P 2006-09-21 2006-09-21
US94778007P 2007-07-03 2007-07-03
PCT/EP2007/060013 WO2008034891A2 (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

Publications (2)

Publication Number Publication Date
JP2010504088A JP2010504088A (ja) 2010-02-12
JP2010504088A5 true JP2010504088A5 (enExample) 2010-11-11

Family

ID=38779576

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009528732A Pending JP2010504088A (ja) 2006-09-21 2007-09-21 グルタミニルシクラーゼに関連した新規遺伝子

Country Status (12)

Country Link
US (3) US20080249083A1 (enExample)
EP (2) EP2082041B1 (enExample)
JP (1) JP2010504088A (enExample)
KR (1) KR101432848B1 (enExample)
AU (1) AU2007298929B2 (enExample)
BR (1) BRPI0718507A2 (enExample)
CA (1) CA2663635A1 (enExample)
EA (1) EA016584B1 (enExample)
IL (2) IL197090A (enExample)
MX (1) MX2009003090A (enExample)
NZ (2) NZ575727A (enExample)
WO (1) WO2008034891A2 (enExample)

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MX2009003090A (es) 2006-09-21 2009-04-02 Probiodrug Ag Genes novedosos relacionados con ciclasa de glutaminilo.
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
ES2481442T3 (es) * 2006-11-09 2014-07-30 Probiodrug Ag Inhibidores novedosos de glutaminil ciclasa
US8278345B2 (en) * 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
SI2091948T1 (sl) * 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
AU2008206936B2 (en) * 2007-01-19 2013-03-14 Probiodrug Ag In vivo screening models for treatment of Alzheimer's disease and other Qpct-related disorders
JP5612860B2 (ja) * 2007-03-09 2014-10-22 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体
JP5675341B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体
WO2008128983A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Cyano-guanidine derivatives as glutaminyl cyclase inhibitors
DK2142514T3 (da) * 2007-04-18 2015-03-23 Probiodrug Ag Thioureaderivater som glutaminylcyclase-inhibitorer
JP5675340B2 (ja) * 2007-04-18 2015-02-25 プロビオドルグ エージー 新規阻害剤
ES2473621T3 (es) * 2007-04-18 2014-07-07 Probiodrug Ag Derivados de nitrovinil-diamina como inhibidores de glutaminil ciclasa
WO2008128986A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Urea derivatives as glutaminyl cyclase inhibitors
WO2008128984A1 (en) * 2007-04-20 2008-10-30 Probiodrug Ag Aminopyrimidine derivatives as glutaminyl cyclase inhibitors
NZ583799A (en) * 2007-09-12 2011-12-22 Probiodrug Ag Transgenic mice comprising a DNA transgene encoding ABeta peptide
WO2009090190A1 (en) * 2008-01-14 2009-07-23 Probiodrug Ag Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene
EA025107B1 (ru) * 2008-07-31 2016-11-30 Пробиодруг Аг Способ диагностирования болезни альцгеймера, нейродегенерации при синдроме дауна или легкого когнитивного нарушения у субъекта (варианты) и набор для осуществления способа
CN102186475B (zh) * 2008-09-04 2016-08-03 前体生物药物股份公司 新抑制剂
WO2010026209A1 (en) * 2008-09-04 2010-03-11 Probiodrug Ag Use of isoQC inhibitors
CN102947705A (zh) * 2010-02-18 2013-02-27 前体生物药物股份公司 通过确定焦谷氨酸修饰的mcp-1诊断炎性疾病的方法和谷氨酰胺酰基环化酶抑制剂的筛选方法
ES2540467T3 (es) 2010-08-19 2015-07-09 Probiodrug Ag Estructura cristalina de glutaminil ciclasa
JP2013541938A (ja) 2010-09-02 2013-11-21 プロビオドルグ エージー アイソｑｃ関連障害の治療のためのインビボスクリーニングモデル
EP2635675B1 (en) 2010-11-02 2016-01-06 Probiodrug AG Crystal structure of isoglutaminyl cyclase
US9388126B2 (en) 2012-07-19 2016-07-12 Drexel University Sigma receptor ligands and methods of modulating cellular protein homeostasis using same
US20180318260A1 (en) * 2015-11-04 2018-11-08 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
WO2019022600A1 (en) * 2017-07-24 2019-01-31 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis TREATMENT OF PATHOLOGICAL CONDITIONS BY DIRECT AND INDIRECT TARGETING OF SIRPA INTERACTION - CD47
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases
GB201918108D0 (en) * 2019-12-10 2020-01-22 Vib Vzw Improved aminopeptiadases for single molecule peptide sequencing
WO2025224179A1 (en) 2024-04-23 2025-10-30 Vivoryon Therapeutics N.V. Glutaminyl cyclase inhbitors for use in the treatment of kidney disease
WO2025224169A1 (en) 2024-04-23 2025-10-30 Vivoryon Therapeutics N.V. Dose regimens for the glutaminyl cyclase inhibitor varoglutamstat

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DK2206496T3 (da) * 2003-05-05 2014-12-15 Probiodrug Ag Screening af inhibitorer af pyroglutaminsyredannelse i amyloid beta-peptid
US8338120B2 (en) * 2003-05-05 2012-12-25 Probiodrug Ag Method of treating inflammation with glutaminyl cyclase inhibitors
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MX2009003090A (es) * 2006-09-21 2009-04-02 Probiodrug Ag Genes novedosos relacionados con ciclasa de glutaminilo.
WO2008055947A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
WO2008128984A1 (en) 2007-04-20 2008-10-30 Probiodrug Ag Aminopyrimidine derivatives as glutaminyl cyclase inhibitors

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