JP2010504088A5 - - Google Patents

Download PDF

Info

Publication number
JP2010504088A5
JP2010504088A5 JP2009528732A JP2009528732A JP2010504088A5 JP 2010504088 A5 JP2010504088 A5 JP 2010504088A5 JP 2009528732 A JP2009528732 A JP 2009528732A JP 2009528732 A JP2009528732 A JP 2009528732A JP 2010504088 A5 JP2010504088 A5 JP 2010504088A5
Authority
JP
Japan
Prior art keywords
seq
mature protein
nucleic acid
disease
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009528732A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010504088A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/060013 external-priority patent/WO2008034891A2/en
Publication of JP2010504088A publication Critical patent/JP2010504088A/ja
Publication of JP2010504088A5 publication Critical patent/JP2010504088A5/ja
Pending legal-status Critical Current

Links

JP2009528732A 2006-09-21 2007-09-21 グルタミニルシクラーゼに関連した新規遺伝子 Pending JP2010504088A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84624406P 2006-09-21 2006-09-21
US94778007P 2007-07-03 2007-07-03
PCT/EP2007/060013 WO2008034891A2 (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

Publications (2)

Publication Number Publication Date
JP2010504088A JP2010504088A (ja) 2010-02-12
JP2010504088A5 true JP2010504088A5 (enExample) 2010-11-11

Family

ID=38779576

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009528732A Pending JP2010504088A (ja) 2006-09-21 2007-09-21 グルタミニルシクラーゼに関連した新規遺伝子

Country Status (12)

Country Link
US (3) US20080249083A1 (enExample)
EP (2) EP2082041B1 (enExample)
JP (1) JP2010504088A (enExample)
KR (1) KR101432848B1 (enExample)
AU (1) AU2007298929B2 (enExample)
BR (1) BRPI0718507A2 (enExample)
CA (1) CA2663635A1 (enExample)
EA (1) EA016584B1 (enExample)
IL (2) IL197090A (enExample)
MX (1) MX2009003090A (enExample)
NZ (2) NZ575727A (enExample)
WO (1) WO2008034891A2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1961416B1 (en) * 2003-05-05 2013-01-23 Probiodrug AG Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis.
US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
NZ575727A (en) * 2006-09-21 2011-12-22 Probiodrug Ag Novel genes related to glutaminyl cyclase
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5379692B2 (ja) * 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2086960B1 (en) * 2006-11-09 2014-03-05 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP2091948B1 (en) * 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP2121944B1 (en) * 2007-01-19 2011-08-24 Probiodrug AG In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders
JP5612860B2 (ja) * 2007-03-09 2014-10-22 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体
WO2008128987A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Novel inhibitors
US9656991B2 (en) * 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8227498B2 (en) * 2007-04-18 2012-07-24 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9034907B2 (en) * 2007-04-18 2015-05-19 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8772508B2 (en) * 2007-04-18 2014-07-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2008128986A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Urea derivatives as glutaminyl cyclase inhibitors
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
AU2008297070A1 (en) * 2007-09-12 2009-03-19 Probiodrug Ag Transgenic mice
NZ586665A (en) * 2008-01-14 2011-12-22 Probiodrug Ag MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct)
KR101682728B1 (ko) * 2008-07-31 2016-12-05 프로비오드룩 아게 신경변성 질환에 대한 진단적/예후적 지표로서 글루타미닐 사이클라제
JP5788320B2 (ja) * 2008-09-04 2015-09-30 プロビオドルグ エージー イソｑｃ阻害剤の使用
EP2344157B1 (en) * 2008-09-04 2016-05-25 Probiodrug AG Novel inhibitors
AU2010251176A1 (en) * 2009-05-19 2011-12-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
CA2789091A1 (en) * 2010-02-18 2011-08-25 Probiodrug Ag Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
WO2012022804A1 (en) 2010-08-19 2012-02-23 Probiodrug Ag Crystal structure of glutaminyl cyclase
WO2012028706A1 (en) 2010-09-02 2012-03-08 Probiodrug Ag IN VIVO SCREENING MODELS FOR TREATMENT OF isoQC-RELATED DISORDERS
US8741614B2 (en) 2010-11-02 2014-06-03 Probiodrug Ag Crystal structure of isoglutaminyl cyclase
US9388126B2 (en) 2012-07-19 2016-07-12 Drexel University Sigma receptor ligands and methods of modulating cellular protein homeostasis using same
WO2017079547A2 (en) * 2015-11-04 2017-05-11 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
DK3658141T3 (da) * 2017-07-24 2023-02-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Behandling af patologiske tilstande ved direkte og indirekte målretning af Sirpalpha-CD47-interaktion
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases
GB201918108D0 (en) * 2019-12-10 2020-01-22 Vib Vzw Improved aminopeptiadases for single molecule peptide sequencing
WO2025224169A1 (en) 2024-04-23 2025-10-30 Vivoryon Therapeutics N.V. Dose regimens for the glutaminyl cyclase inhibitor varoglutamstat
WO2025224179A1 (en) 2024-04-23 2025-10-30 Vivoryon Therapeutics N.V. Glutaminyl cyclase inhbitors for use in the treatment of kidney disease

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
IT1183575B (it) 1985-05-08 1987-10-22 Eurand Spa Formulazione deodorando ad effetto modulante sulla trfaspirazione
DD293584A5 (de) 1990-03-23 1991-09-05 Adw,Zi Fuer Organische Chemie,De Verfahren zur herstellung von neuen 3,5,5-trisubstituierten 1-(benzimidazol-2-yl)-imidazolidin-2,4-dionen bzw. -4-on-2-thionen
US20020168761A1 (en) 2000-01-24 2002-11-14 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US20040006011A1 (en) * 1996-07-12 2004-01-08 Gour Barbara J. Peptidomimetic modulators of cell adhesion
US6247293B1 (en) * 1998-11-03 2001-06-19 Klockner Bartelt, Inc. Modular packaging machine with web tension control
FR2796945B1 (fr) 1999-07-30 2002-06-28 Sod Conseils Rech Applic Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments
FR2808711B1 (fr) * 2000-05-10 2002-08-09 Poudres & Explosifs Ste Nale Procede de fabrication d'elements composites etain-tungstene de faible epaisseur
WO2002093436A1 (en) * 2001-05-11 2002-11-21 Swisscom Mobile Ag Method for transmitting an anonymous request from a consumer to a content or service provider through a telecommunication network
US6948038B2 (en) * 2001-07-24 2005-09-20 Microsoft Corporation System and method for backing up and restoring data
KR100474689B1 (ko) * 2001-08-30 2005-03-08 삼성전자주식회사 이동통신 시스템에서 소프트 핸드오프 도중의 전력제어 방법
WO2003045321A2 (en) * 2001-11-26 2003-06-05 Exelixis, Inc. MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE
US7677859B2 (en) 2002-07-22 2010-03-16 Brooks Automation, Inc. Substrate loading and uploading station with buffer
GB0220501D0 (en) * 2002-09-04 2002-10-09 Hall Geoffrey W Push 22
US20040098591A1 (en) * 2002-11-15 2004-05-20 Fahrny James W. Secure hardware device authentication method
US6851324B2 (en) * 2002-12-16 2005-02-08 Delphi Technologies, Inc. Non-contacting compliant torque sensor
EP1961416B1 (en) * 2003-05-05 2013-01-23 Probiodrug AG Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis.
ATE462432T1 (de) * 2003-05-05 2010-04-15 Probiodrug Ag Glutaminylcyclase-hemmer
NZ543146A (en) * 2003-05-05 2008-09-26 Probiodrug Ag Use of effectors of glutaminyl cyclase (QC) activity in combination with inhibitors of DP IV or DP IV-like enzymes for the treatment of conditions that can be treated by modulation of QC-and/or DPIV-activity
US7732162B2 (en) * 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8338120B2 (en) * 2003-05-05 2012-12-25 Probiodrug Ag Method of treating inflammation with glutaminyl cyclase inhibitors
US7192995B2 (en) * 2003-10-03 2007-03-20 Virginia Commonwealth University Homogenous compositions of polymers and crystalline solids or cross-linking agents and methods of making the same
KR20120007079A (ko) * 2003-10-15 2012-01-19 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도
JP2007509898A (ja) * 2003-11-03 2007-04-19 プロビオドルグ エージー 神経障害治療に有用な組合せ
US7667044B2 (en) * 2003-11-03 2010-02-23 Probiodrug Ag Compounds for the treatment of neurological disorders
US20050171112A1 (en) * 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
CN1882341A (zh) * 2003-11-19 2006-12-20 艾克若克斯Dds有限公司 用于治疗皮肤损伤的方法和组合物
KR101099206B1 (ko) * 2004-02-05 2011-12-27 프로비오드룩 아게 신규한 글루타미닐 시클라제 저해제
US20080299042A1 (en) * 2004-04-30 2008-12-04 Biogen Idec Ma Inc. Membrane Associated Molecules
KR101031834B1 (ko) * 2004-07-01 2011-05-02 마이크로 모우션, 인코포레이티드 유동 상의 밀도 효과를 제거하기 위한 분리된 균형추
US7663268B2 (en) * 2006-08-30 2010-02-16 The Regents of the University of Cailfornia Converters for high power applications
NZ575727A (en) * 2006-09-21 2011-12-22 Probiodrug Ag Novel genes related to glutaminyl cyclase
JP5456479B2 (ja) 2006-11-09 2014-03-26 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体

Similar Documents

Publication Publication Date Title
JP2010504088A5 (enExample)
CN102171365B (zh) 用于溃疡性结肠炎和相关疾病的抗tnf治疗的生物标记物
JP2012115275A5 (enExample)
CA2734519C (en) Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel
WO2016077366A1 (en) Therapeutic and diagnostic methods for il-33-mediated disorders
KR20090087494A (ko) 심장성 부정맥의 위험 관리를 위한 유전적 마커
US8597877B2 (en) Polymorphic loci that differentiate Escherichia coli O157:H7 from other strains
JP2009039107A5 (enExample)
US7645582B2 (en) Aptamers that bind to listeria surface proteins
RU2009135270A (ru) Способы выявления воспалительного заболевания кишечника
JP2003524415A5 (enExample)
US20100092468A1 (en) Method for predicting therapeutic responsiveness to tnf-alpha blocking agents
WO2001012664A2 (en) Notch receptor ligands and uses thereof
JP2004500117A5 (enExample)
KR100976005B1 (ko) 만성 류마티스관절염 질환 감수성 유전자, 이의 단백질,이들을 이용한 만성 류마티스관절염의 발증가능성의 판정방법 및 판정 키트, 및 만성 류마티스관절염의 치료 방법및 치료 약제
JP2009523004A5 (enExample)
CN104372009A (zh) 梅尔克松-罗森塔尔综合征新的致病基因及其编码蛋白质和应用
CN101294201A (zh) 冠心病检测方法和试剂盒
EP1558737A1 (en) Gene families associated with cancers
CN120866510A (zh) 巨噬细胞刺激1受体(mst1r)变体及其用途
WO2002100432A1 (en) Methods for the modulation of il-13
CN101294197A (zh) 冠心病检测方法和试剂盒
CN101525658A (zh) 强直性脊柱炎易感性检测方法和试剂盒
WO2004042052A1 (en) Modulating tnf (alpha) secretion
WO2001098456A2 (en) IDENTIFICATION OF cDNAs ASSOCIATED WITH BENIGN PROSTATIC HYPERPLASIA