|
WO2008058126A2
(en)
*
|
2006-11-06 |
2008-05-15 |
Supergen, Inc. |
Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
|
|
AR067326A1
(es)
*
|
2007-05-11 |
2009-10-07 |
Novartis Ag |
Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido
|
|
US8431608B2
(en)
|
2007-08-17 |
2013-04-30 |
Icagen Inc. |
Heterocycles as potassium channel modulators
|
|
ES2400604T3
(es)
*
|
2007-08-17 |
2013-04-11 |
Icagen, Inc. |
Heterociclos como moduladores del canal de potasio
|
|
UY31676A1
(es)
|
2008-02-28 |
2009-09-30 |
|
"derivados de 3-metil-imidiazo-[1,2-b]-piridazina"
|
|
EP2277881A4
(en)
*
|
2008-04-18 |
2011-09-07 |
Shionogi & Co |
HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K
|
|
WO2009130320A2
(en)
*
|
2008-04-25 |
2009-10-29 |
Pamgene Bv |
Measurement of protein kinase activity in cerebrospinal fluid for diagnosis of neurological and psychiatric disorders
|
|
KR101324804B1
(ko)
*
|
2008-05-13 |
2013-11-01 |
아이알엠 엘엘씨 |
키나제 억제제로서의 질소 함유 융합 헤테로사이클 및 그의 조성물
|
|
UY32049A
(es)
|
2008-08-14 |
2010-03-26 |
Takeda Pharmaceutical |
Inhibidores de cmet
|
|
WO2010033941A1
(en)
|
2008-09-22 |
2010-03-25 |
Array Biopharma Inc. |
Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
|
|
TWI491610B
(zh)
|
2008-10-09 |
2015-07-11 |
必治妥美雅史谷比公司 |
作為激酶抑制劑之咪唑并嗒腈
|
|
MY169791A
(en)
|
2008-10-22 |
2019-05-15 |
Array Biopharma Inc |
Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors
|
|
WO2010062829A1
(en)
*
|
2008-11-28 |
2010-06-03 |
Lexicon Pharmaceuticals, Inc. |
Tryptophan hydroxylase inhibitors for treating osteoporosis
|
|
PA8851101A1
(es)
|
2008-12-16 |
2010-07-27 |
Lilly Co Eli |
Compuesto amino pirazol
|
|
NZ595674A
(en)
|
2009-04-02 |
2012-12-21 |
Ct Nac Investigaciones Oncologicas Cnio |
Imidazo[2,1-b][1,3,4]thiadiazole derivatives
|
|
EP2243481A1
(en)
|
2009-04-24 |
2010-10-27 |
PamGene B.V. |
Irak kinase family as novel drug target for Alzheimer
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
KR101774035B1
(ko)
|
2009-10-30 |
2017-09-01 |
얀센 파마슈티카 엔.브이. |
이미다조[1,2―b]피리다진 유도체 및 PDE10 저해제로서의 그의 용도
|
|
AR080754A1
(es)
|
2010-03-09 |
2012-05-09 |
Janssen Pharmaceutica Nv |
Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
|
|
EP2563792B1
(en)
|
2010-04-28 |
2014-08-27 |
Bristol-Myers Squibb Company |
Imidazopyridazinyl compounds and their uses for cancer
|
|
ME03376B
(me)
|
2010-05-20 |
2020-01-20 |
Array Biopharma Inc |
Makrociklička jedinjenja kао inhibiтori trk kinaze
|
|
WO2012064815A1
(en)
|
2010-11-12 |
2012-05-18 |
Bristol-Myers Squibb Company |
Substituted azaindazole compounds
|
|
RU2632900C2
(ru)
*
|
2010-11-19 |
2017-10-11 |
Лиганд Фармасьютикалс Инкорпорейтед |
Гетероциклические амины и их применение
|
|
EP2463289A1
(en)
*
|
2010-11-26 |
2012-06-13 |
Almirall, S.A. |
Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
|
|
US20140288069A1
(en)
*
|
2011-05-17 |
2014-09-25 |
Bayer Intellectual Property Gmbh |
Amino-substituted imidazopyridazines as mknk1 kinase inhibitors
|
|
WO2012163942A1
(en)
|
2011-06-01 |
2012-12-06 |
Bayer Intellectual Property Gmbh |
Substituted aminoimidazopyridazines
|
|
WO2012175591A1
(en)
|
2011-06-22 |
2012-12-27 |
Bayer Intellectual Property Gmbh |
Heterocyclyl aminoimidazopyridazines
|
|
WO2013000924A1
(en)
|
2011-06-27 |
2013-01-03 |
Janssen Pharmaceutica Nv |
1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
|
|
EP3812387A1
(en)
|
2011-07-21 |
2021-04-28 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Heterocyclic protein kinase inhibitors
|
|
UA117092C2
(uk)
*
|
2011-09-06 |
2018-06-25 |
Байєр Інтеллектуал Проперті Гмбх |
Амінозаміщені імідазопіридазини
|
|
CA2849345A1
(en)
*
|
2011-09-23 |
2013-03-28 |
Bayer Intellectual Property Gmbh |
Substituted imidazopyridazines
|
|
US8969586B2
(en)
|
2011-09-27 |
2015-03-03 |
Bristol-Myers Squibb Company |
Substituted bicyclic heteroaryl compounds
|
|
US9221809B2
(en)
|
2011-10-31 |
2015-12-29 |
Merck Sharp & Dohme Corp. |
Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
|
|
CN104114559B
(zh)
*
|
2011-12-12 |
2016-08-24 |
拜耳知识产权有限责任公司 |
氨基取代的咪唑并哒嗪
|
|
EP2802576B1
(en)
*
|
2012-01-13 |
2018-06-27 |
Bristol-Myers Squibb Company |
Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors
|
|
WO2013134219A1
(en)
*
|
2012-03-09 |
2013-09-12 |
Lexicon Pharmaceuticals, Inc. |
Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
|
|
ES2663609T3
(es)
|
2012-03-29 |
2018-04-16 |
Bayer Intellectual Property Gmbh |
Imidazopiridazinas amino-sustituidas
|
|
EP2834245B1
(en)
*
|
2012-04-04 |
2017-12-13 |
Bayer Pharma Aktiengesellschaft |
Amino-substituted imidazopyridazines
|
|
WO2014001314A1
(en)
|
2012-06-26 |
2014-01-03 |
Janssen Pharmaceutica Nv |
Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
|
|
AU2013289284B2
(en)
|
2012-07-09 |
2017-03-30 |
Janssen Pharmaceutica Nv |
Inhibitors of phosphodiesterase 10 enzyme
|
|
PL400213A1
(pl)
|
2012-08-01 |
2014-02-03 |
Celon Pharma Spólka Z Ograniczona Odpowiedzialnoscia |
Pochodne imidazo[1,2-b]pirydazyno-6-aminy jako inhibitory kinazy JAK-2
|
|
AU2013337717B2
(en)
|
2012-11-01 |
2018-10-25 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using PI3 kinase isoform modulators
|
|
LT2925757T
(lt)
|
2012-11-19 |
2017-12-27 |
Novartis Ag |
Junginiai ir kompozicijos, skirti parazitinių ligų gydymui
|
|
ES2646916T3
(es)
|
2012-11-19 |
2017-12-18 |
Bayer Pharma Aktiengesellschaft |
Aminoimidazopiridazinas como inhibidores de MKNK1 cinasa
|
|
WO2014118135A1
(en)
|
2013-01-30 |
2014-08-07 |
Bayer Pharma Aktiengesellschaft |
Amidoimidazopyridazines as mknk-1 kinase inhibitors
|
|
HK1212699A1
(zh)
|
2013-02-20 |
2016-06-17 |
拜耳医药股份公司 |
作为mknk1抑制剂的取代的咪唑并[1,2-b]哒嗪类化合物
|
|
JP2016510764A
(ja)
|
2013-03-07 |
2016-04-11 |
カリフィア バイオ, インク.Califia Bio, Inc. |
混合系キナーゼ阻害剤および治療法
|
|
WO2014151386A1
(en)
|
2013-03-15 |
2014-09-25 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
|
CA2914284A1
(en)
|
2013-05-30 |
2014-12-04 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
AR097543A1
(es)
*
|
2013-09-06 |
2016-03-23 |
Lexicon Pharmaceuticals Inc |
COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
|
|
ES2702126T3
(es)
*
|
2013-12-10 |
2019-02-27 |
Bristol Myers Squibb Co |
Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa
|
|
CN105899512A
(zh)
|
2014-01-09 |
2016-08-24 |
拜耳医药股份公司 |
可用于治疗过度增殖性和/或血管生成疾病的酰胺基团取代的咪唑并哒嗪
|
|
EP3092226B1
(en)
*
|
2014-01-10 |
2019-03-13 |
Aurigene Discovery Technologies Limited |
Indazole compounds as irak4 inhibitors
|
|
LT3466955T
(lt)
|
2014-01-13 |
2021-02-25 |
Aurigene Discovery Technologies Limited |
Oksazol[4,5-b]piridino ir tiazol[4,5-b]piridino darinių, kaip irak4 inhibitorių, skirtų vėžio gydymui, gamybos būdas
|
|
US9969749B2
(en)
|
2014-09-30 |
2018-05-15 |
Merck Sharp & Dohme Corp. |
Inhibitors of IRAK4 activity
|
|
EP3200790B1
(en)
*
|
2014-09-30 |
2020-08-26 |
Merck Sharp & Dohme Corp. |
Inhibitors of irak4 activity
|
|
EP3200788B1
(en)
|
2014-09-30 |
2019-09-18 |
Merck Sharp & Dohme Corp. |
Inhibitors of irak4 activity
|
|
US9932350B2
(en)
|
2014-09-30 |
2018-04-03 |
Merck Sharp & Dohme Corp. |
Inhibitors of IRAK4 activity
|
|
CN113354649B
(zh)
|
2014-11-16 |
2024-12-10 |
阵列生物制药公司 |
一种新的晶型
|
|
KR20170095239A
(ko)
|
2014-12-19 |
2017-08-22 |
얀센 파마슈티카 엔.브이. |
PI3Kβ 저해제로서의 이미다조피리다진 유도체
|
|
AU2015366202B2
(en)
|
2014-12-19 |
2020-01-02 |
Janssen Pharmaceutica Nv |
Heterocyclyl linked imidazopyridazine derivatives as PI3Kbeta inhibitors
|
|
CN104592121A
(zh)
*
|
2015-02-13 |
2015-05-06 |
佛山市赛维斯医药科技有限公司 |
含酰肼和硝基苯类结构的化合物、其制备方法及用途
|
|
US10807983B2
(en)
|
2015-03-16 |
2020-10-20 |
Ligand Pharmaceuticals, Inc. |
Imidazo-fused heterocycles and uses thereof
|
|
ES2822956T3
(es)
*
|
2015-06-24 |
2021-05-05 |
Bristol Myers Squibb Co |
Compuestos de aminopiridina sustituidos con heteroarilo
|
|
WO2017004134A1
(en)
*
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
EP3368039A1
(en)
|
2015-10-26 |
2018-09-05 |
The Regents of The University of Colorado, A Body Corporate |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
FI3439662T3
(fi)
|
2016-04-04 |
2024-09-04 |
Loxo Oncology Inc |
(s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
EP3458456B1
(en)
|
2016-05-18 |
2020-11-25 |
Loxo Oncology Inc. |
Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
|
|
US11254667B2
(en)
|
2016-08-17 |
2022-02-22 |
Children's Hospital Medical Center |
Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
|
|
US11542261B2
(en)
|
2016-08-17 |
2023-01-03 |
Children's Hospital Medical Center |
Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
|
|
CN109715631B
(zh)
|
2016-09-16 |
2022-02-18 |
德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) |
Traf 6抑制剂
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
WO2018081361A1
(en)
|
2016-10-28 |
2018-05-03 |
Children's Hospital Medical Center |
Methods and compositions for treatment of myelodyspastic syndromes and/or acute myleoid leukemias
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
EP3600270B1
(en)
|
2017-03-31 |
2023-06-14 |
Aurigene Oncology Limited |
Compounds and compositions for treating hematological disorders
|
|
EP3642201A1
(en)
*
|
2017-06-21 |
2020-04-29 |
H. Hoffnabb-La Roche Ag |
Isoindolinone derivatives as irak4 modulators
|
|
HUE067356T2
(hu)
|
2017-10-31 |
2024-10-28 |
Curis Inc |
IRAK4 inhibitor és BCL-2 inhibitor kombinációban, rák kezelésére való felhasználásra
|
|
JP7229257B2
(ja)
*
|
2018-01-29 |
2023-02-28 |
メルク パテント ゲーエムベーハー |
Gcn2阻害剤およびその使用
|
|
KR20260008165A
(ko)
|
2019-02-12 |
2026-01-15 |
스미토모 파마 아메리카, 인크. |
헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
|
|
CN111226956B
(zh)
*
|
2019-11-26 |
2021-10-26 |
贵州医科大学 |
3,6-二取代咪唑[1,2-b]哒嗪类衍生物在制备抑制植物病原真菌杀菌剂中的应用
|
|
WO2021168197A1
(en)
|
2020-02-19 |
2021-08-26 |
Nurix Therapeutics, Inc. |
Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof
|
|
CA3176337A1
(en)
|
2020-04-21 |
2021-10-28 |
Peter King |
Rna-binding protein multimerization inhibitors and methods of use thereof
|
|
WO2022019920A1
(en)
|
2020-07-24 |
2022-01-27 |
Verastem, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
EP4289847A4
(en)
*
|
2021-02-08 |
2025-01-01 |
Hangzhou Biosun Pharmaceutical Co., Ltd. |
PIM KINASE INHIBITOR
|
|
EP4319750A4
(en)
|
2021-04-08 |
2025-02-26 |
Curis, Inc. |
COMBINATION THERAPIES FOR THE TREATMENT OF CANCER
|
|
CN117813307A
(zh)
|
2021-08-18 |
2024-04-02 |
新锐思生物制药股份有限公司 |
白介素-1受体相关激酶的双官能降解物及其治疗用途
|
|
CN117624166A
(zh)
*
|
2022-08-09 |
2024-03-01 |
苏州朗睿生物医药有限公司 |
一种三氮唑衍生物及其制备方法和用途
|