JP2010500331A5 - - Google Patents
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- Publication number
- JP2010500331A5 JP2010500331A5 JP2009523312A JP2009523312A JP2010500331A5 JP 2010500331 A5 JP2010500331 A5 JP 2010500331A5 JP 2009523312 A JP2009523312 A JP 2009523312A JP 2009523312 A JP2009523312 A JP 2009523312A JP 2010500331 A5 JP2010500331 A5 JP 2010500331A5
- Authority
- JP
- Japan
- Prior art keywords
- octapeptins
- residues
- polymyxins
- acid
- natural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010040201 Polymyxins Proteins 0.000 description 3
- 229940041153 polymyxins Drugs 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000001924 fatty-acyl group Chemical group 0.000 description 1
- HEDADCOWECPKFY-UHFFFAOYSA-N octapeptin Chemical compound CCC(C)CCCCC(O)CC(=O)NC(CCN)C(=O)NC1CCNC(=O)C(CC(C)C)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O HEDADCOWECPKFY-UHFFFAOYSA-N 0.000 description 1
- 108010093294 octapeptin antibiotics Proteins 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83742606P | 2006-08-11 | 2006-08-11 | |
| US60/837,426 | 2006-08-11 | ||
| DKPA200601055 | 2006-08-11 | ||
| DKPA200601055 | 2006-08-11 | ||
| PCT/FI2007/050441 WO2008017734A1 (en) | 2006-08-11 | 2007-08-10 | Polymyxin derivatives and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500331A JP2010500331A (ja) | 2010-01-07 |
| JP2010500331A5 true JP2010500331A5 (enExample) | 2010-08-12 |
| JP5226685B2 JP5226685B2 (ja) | 2013-07-03 |
Family
ID=39032653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523312A Expired - Fee Related JP5226685B2 (ja) | 2006-08-11 | 2007-08-10 | ポリミキシン誘導体およびその使用 |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP3078672A1 (enExample) |
| JP (1) | JP5226685B2 (enExample) |
| KR (2) | KR101502453B1 (enExample) |
| CN (2) | CN101501063B (enExample) |
| AU (1) | AU2007283514B2 (enExample) |
| BR (1) | BRPI0715095B8 (enExample) |
| CA (1) | CA2694289C (enExample) |
| CY (1) | CY1117848T1 (enExample) |
| DK (1) | DK2057185T3 (enExample) |
| ES (1) | ES2575521T3 (enExample) |
| HR (1) | HRP20160552T1 (enExample) |
| HU (1) | HUE028271T2 (enExample) |
| IL (2) | IL196693B (enExample) |
| MX (1) | MX2009001398A (enExample) |
| NO (1) | NO341982B1 (enExample) |
| NZ (1) | NZ575421A (enExample) |
| PL (1) | PL2057185T3 (enExample) |
| PT (1) | PT2057185E (enExample) |
| RU (1) | RU2455311C2 (enExample) |
| SI (1) | SI2057185T1 (enExample) |
| WO (1) | WO2008017734A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| AR074874A1 (es) | 2008-12-23 | 2011-02-16 | Biosource Pharm Inc | Composiciones antibioticas para el tratamiento de infecciones gram negativas. metodo. uso. compuesto. |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) * | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| EP2780357A1 (en) * | 2011-11-18 | 2014-09-24 | Novacta Biosystems Limited | Polymyxin derivatives |
| HUE059544T2 (hu) * | 2013-05-22 | 2022-11-28 | Spero Therapeutics Inc | Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal |
| HRP20220387T1 (hr) * | 2014-03-11 | 2022-05-27 | Spero Therapeutics, Inc. | Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima |
| KR101664106B1 (ko) | 2014-09-11 | 2016-10-10 | 한국화학연구원 | 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물 |
| AU2015352440B2 (en) | 2014-11-26 | 2020-02-06 | Spero Therapeutics, Inc. | Compounds |
| CA2970546A1 (en) | 2014-12-16 | 2016-06-23 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
| HRP20201828T1 (hr) * | 2014-12-18 | 2021-01-08 | Helperby Therapeutics Limited | Nova kombinacija i uporaba |
| FI126143B (en) * | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| CN104672307B (zh) * | 2015-03-23 | 2017-09-29 | 吉林大学 | 一种提高阳离子短肽抗菌性和稳定性的方法 |
| EP3072956A1 (en) * | 2015-03-25 | 2016-09-28 | Université de Fribourg | Selective culture medium for polymyxin-resistant, gram-negative bacteria |
| FR3036406B1 (fr) | 2015-05-20 | 2019-07-19 | Biomerieux | Identification des bacteries resistantes aux carbapenemes par impermeabilite membranaire |
| JP2018534303A (ja) * | 2015-11-12 | 2018-11-22 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計 |
| WO2017189866A1 (en) * | 2016-04-27 | 2017-11-02 | Spero Opco | Polymyxin analogs useful as antibiotic potentiators |
| WO2017189868A1 (en) * | 2016-04-27 | 2017-11-02 | Spero Opco | Serine replacement polymyxin analogues useful as antibiotic potentiators |
| GB201703898D0 (en) | 2017-03-10 | 2017-04-26 | Helperby Therapeautics Ltd | Method |
| GB201704620D0 (en) | 2017-03-23 | 2017-05-10 | Helperby Therapeautics Ltd | Combinations |
| WO2019084628A1 (en) * | 2017-11-02 | 2019-05-09 | The University Of Queensland | Peptide antibiotics |
| EP3560489A1 (en) * | 2018-04-27 | 2019-10-30 | European Molecular Biology Laboratory | Pharmaceutical compositions for prevention and/or treatment of infections and antibacterial-induced dysfunctions |
| EA202092819A1 (ru) | 2018-06-25 | 2021-05-21 | Сперо Терапьютикс, Инк. | Соединения |
| EP3823454A4 (en) * | 2018-07-19 | 2022-06-08 | Northeastern University | Compounds with antimicrobial properties |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| IT201900025414A1 (it) | 2019-12-23 | 2021-06-23 | Univ Bologna Alma Mater Studiorum | Composto per il trattamento della sindrome emolitico uremica |
| US20230141981A1 (en) | 2020-01-21 | 2023-05-11 | Shanghai Micurx Pharmaceuticals Co., Ltd | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| CN116497039B (zh) * | 2022-08-30 | 2024-04-09 | 四川大学华西医院 | 一类phoQ基因突变体、应用及其验证方法 |
| WO2024123712A1 (en) * | 2022-12-04 | 2024-06-13 | Genentech, Inc. | Analysis of candidate cytotoxic compositions |
| CN120399010B (zh) * | 2025-07-01 | 2025-09-12 | 杭州肽佳生物科技有限公司 | 抗生素多粘菌素的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450687A (en) | 1966-02-24 | 1969-06-17 | Pfizer & Co C | Lower alkanoyl esters of polymyxin antibiotics |
| JPS4915537B1 (enExample) | 1970-03-25 | 1974-04-16 | ||
| BE754411A (fr) | 1969-08-05 | 1971-02-04 | Rhone Poulenc Sa | Cyclopeptides derives des polymyxines et leur |
| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| US20040063754A1 (en) * | 2000-11-20 | 2004-04-01 | Hisashi Takahashi | Dehalogeno compounds |
| US7435716B2 (en) | 2001-01-16 | 2008-10-14 | Ramot At Tel Aviv University Ltd. | Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia |
| EP1752161A3 (en) * | 2002-03-01 | 2010-09-01 | CHIESI FARMACEUTICI S.p.A. | Pulmonary surfactans comprising a polymyxin for improving the surface properties |
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
-
2007
- 2007-08-10 EP EP16168287.7A patent/EP3078672A1/en not_active Withdrawn
- 2007-08-10 SI SI200731783A patent/SI2057185T1/sl unknown
- 2007-08-10 MX MX2009001398A patent/MX2009001398A/es active IP Right Grant
- 2007-08-10 KR KR1020097004841A patent/KR101502453B1/ko not_active Expired - Fee Related
- 2007-08-10 NZ NZ575421A patent/NZ575421A/en not_active IP Right Cessation
- 2007-08-10 ES ES07803704.1T patent/ES2575521T3/es active Active
- 2007-08-10 EP EP07803704.1A patent/EP2057185B1/en active Active
- 2007-08-10 PT PT07803704T patent/PT2057185E/pt unknown
- 2007-08-10 JP JP2009523312A patent/JP5226685B2/ja not_active Expired - Fee Related
- 2007-08-10 WO PCT/FI2007/050441 patent/WO2008017734A1/en not_active Ceased
- 2007-08-10 BR BRPI0715095A patent/BRPI0715095B8/pt not_active IP Right Cessation
- 2007-08-10 HR HRP20160552TT patent/HRP20160552T1/hr unknown
- 2007-08-10 KR KR1020147036680A patent/KR20150008198A/ko not_active Ceased
- 2007-08-10 DK DK07803704.1T patent/DK2057185T3/en active
- 2007-08-10 HU HUE07803704A patent/HUE028271T2/en unknown
- 2007-08-10 RU RU2009107857/04A patent/RU2455311C2/ru active
- 2007-08-10 CN CN200780029855.5A patent/CN101501063B/zh not_active Expired - Fee Related
- 2007-08-10 PL PL07803704.1T patent/PL2057185T3/pl unknown
- 2007-08-10 AU AU2007283514A patent/AU2007283514B2/en not_active Ceased
- 2007-08-10 CN CN201310011979.8A patent/CN103059106B/zh not_active Expired - Fee Related
- 2007-08-10 CA CA 2694289 patent/CA2694289C/en active Active
-
2009
- 2009-01-22 IL IL196693A patent/IL196693B/en active IP Right Grant
- 2009-02-12 NO NO20090674A patent/NO341982B1/no unknown
-
2012
- 2012-06-07 IL IL220270A patent/IL220270A0/en unknown
-
2016
- 2016-06-09 CY CY20161100502T patent/CY1117848T1/el unknown
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