JP2010500029A5 - - Google Patents
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- JP2010500029A5 JP2010500029A5 JP2009523850A JP2009523850A JP2010500029A5 JP 2010500029 A5 JP2010500029 A5 JP 2010500029A5 JP 2009523850 A JP2009523850 A JP 2009523850A JP 2009523850 A JP2009523850 A JP 2009523850A JP 2010500029 A5 JP2010500029 A5 JP 2010500029A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- dna
- genome
- sequences
- plant cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 7
- 108020004414 DNA Proteins 0.000 claims 4
- 101710163270 Nuclease Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000013611 chromosomal DNA Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 230000006801 homologous recombination Effects 0.000 claims 2
- 238000002744 homologous recombination Methods 0.000 claims 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
Claims (3)
- 植物細胞のゲノム中に外来配列を導入するための方法であって、
（ａ）細胞を第１、第２および第５ＤＮＡ配列を含むドナーＤＮＡベクターと接触させるステップであって、
ここで、第１配列はその植物細胞のゲノム中の第３配列に相同であり、第２配列はその植物細胞のゲノム中の第４配列に相同であり、そして、第５配列は、外来配列を含み、かつ第１配列と第２配列の間に挿入されている、ステップ、および
（ｂ）１またはそれ以上のヌクレアーゼを細胞内で発現させ、その１またはそれ以上のヌクレアーゼが第３配列と第４配列の間の１またはそれ以上の対応するターゲット配列において染色体ＤＮＡを切断するステップ
を含み、
ステップ（ｂ）における染色体ＤＮＡの切断が相同組換えによるゲノムへの第５ＤＮＡ配列の組み込みを刺激するようになっている方法。 - 植物細胞のゲノムにおける分子内相同組換えの方法であって、
（ａ）植物細胞のゲノム内のＤＮＡセグメントであって、第１配列、その第１配列に相同な第２配列、および第１配列と第２配列の間に挿入された第３配列を含むＤＮＡセグメントをジンクフィンガーヌクレアーゼと接触させ、そのヌクレアーゼがＤＮＡセグメントを第３配列内で切断するステップ
を含む方法であって、第１配列と第２配列の間にあるＤＮＡが染色体から削除される方法。 - １またはそれ以上のヌクレアーゼが第１または第２染色体配列のどちらか一方の０.１〜３キロ塩基対以内で染色体ＤＮＡを切断する、請求項１に記載の方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83714706P | 2006-08-11 | 2006-08-11 | |
| PCT/US2007/017748 WO2008021207A2 (en) | 2006-08-11 | 2007-08-09 | Zinc finger nuclease-mediated homologous recombination |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014114714A Division JP5964884B2 (ja) | 2006-08-11 | 2014-06-03 | ジンクフィンガーヌクレアーゼ媒介相同組換え |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010500029A JP2010500029A (ja) | 2010-01-07 |
| JP2010500029A5 true JP2010500029A5 (ja) | 2010-09-24 |
Family
ID=38624400
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523850A Withdrawn JP2010500029A (ja) | 2006-08-11 | 2007-08-09 | ジンクフィンガーヌクレアーゼ媒介相同組換え |
| JP2014114714A Active JP5964884B2 (ja) | 2006-08-11 | 2014-06-03 | ジンクフィンガーヌクレアーゼ媒介相同組換え |
| JP2016129574A Active JP6442442B2 (ja) | 2006-08-11 | 2016-06-30 | ジンクフィンガーヌクレアーゼ媒介相同組換え |
| JP2017188293A Active JP6652952B2 (ja) | 2006-08-11 | 2017-09-28 | ジンクフィンガーヌクレアーゼ媒介相同組換え |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014114714A Active JP5964884B2 (ja) | 2006-08-11 | 2014-06-03 | ジンクフィンガーヌクレアーゼ媒介相同組換え |
| JP2016129574A Active JP6442442B2 (ja) | 2006-08-11 | 2016-06-30 | ジンクフィンガーヌクレアーゼ媒介相同組換え |
| JP2017188293A Active JP6652952B2 (ja) | 2006-08-11 | 2017-09-28 | ジンクフィンガーヌクレアーゼ媒介相同組換え |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9428756B2 (ja) |
| EP (2) | EP2049663B1 (ja) |
| JP (4) | JP2010500029A (ja) |
| KR (1) | KR101439568B1 (ja) |
| CN (2) | CN105296527B (ja) |
| AR (3) | AR062336A1 (ja) |
| AU (1) | AU2007284748B2 (ja) |
| BR (1) | BRPI0716427A2 (ja) |
| CA (1) | CA2660485C (ja) |
| DK (1) | DK2049663T3 (ja) |
| ES (1) | ES2532002T3 (ja) |
| HK (2) | HK1221251A1 (ja) |
| IL (1) | IL196942A (ja) |
| PL (1) | PL2049663T3 (ja) |
| SI (1) | SI2049663T1 (ja) |
| TW (1) | TWI424061B (ja) |
| UA (1) | UA106193C2 (ja) |
| WO (1) | WO2008021207A2 (ja) |
| ZA (1) | ZA200900787B (ja) |
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