JP2010100624A5 - - Google Patents

Info

Publication number

JP2010100624A5

JP2010100624A5 JP2009259497A JP2009259497A JP2010100624A5 JP 2010100624 A5 JP2010100624 A5 JP 2010100624A5 JP 2009259497 A JP2009259497 A JP 2009259497A JP 2009259497 A JP2009259497 A JP 2009259497A JP 2010100624 A5 JP2010100624 A5 JP 2010100624A5

Authority

JP

Japan

Prior art keywords

angptl3

antibody

medicament

medicament according

seq

Prior art date

2009-11-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 claims 16
• 101100001705 Mus musculus Angptl3 gene Proteins 0.000 claims 11
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• 230000002757 inflammatory effect Effects 0.000 claims 6
• 208000019423 liver disease Diseases 0.000 claims 6
• 102000006495 integrins Human genes 0.000 claims 5
• 108010044426 integrins Proteins 0.000 claims 5
• 239000005557 antagonist Substances 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 230000027455 binding Effects 0.000 claims 3
• 208000019425 cirrhosis of liver Diseases 0.000 claims 3
• 208000006454 hepatitis Diseases 0.000 claims 3
• 206010016654 Fibrosis Diseases 0.000 claims 2
• 108060003951 Immunoglobulin Proteins 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 230000007882 cirrhosis Effects 0.000 claims 2
• 231100000283 hepatitis Toxicity 0.000 claims 2
• 102000018358 immunoglobulin Human genes 0.000 claims 2
• 210000004185 liver Anatomy 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
• 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
• 206010008909 Chronic Hepatitis Diseases 0.000 claims 1
• 206010009208 Cirrhosis alcoholic Diseases 0.000 claims 1
• 208000004930 Fatty Liver Diseases 0.000 claims 1
• 102000008946 Fibrinogen Human genes 0.000 claims 1
• 108010049003 Fibrinogen Proteins 0.000 claims 1
• 206010019708 Hepatic steatosis Diseases 0.000 claims 1
• 208000005176 Hepatitis C Diseases 0.000 claims 1
• 208000005331 Hepatitis D Diseases 0.000 claims 1
• 206010019773 Hepatitis G Diseases 0.000 claims 1
• 206010019799 Hepatitis viral Diseases 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 206010067125 Liver injury Diseases 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
• 206010063837 Reperfusion injury Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 208000002353 alcoholic hepatitis Diseases 0.000 claims 1
• 208000010002 alcoholic liver cirrhosis Diseases 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 230000036755 cellular response Effects 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 210000002889 endothelial cell Anatomy 0.000 claims 1
• 208000010706 fatty liver disease Diseases 0.000 claims 1
• 229940012952 fibrinogen Drugs 0.000 claims 1
• 208000002672 hepatitis B Diseases 0.000 claims 1
• 201000010284 hepatitis E Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000000302 ischemic effect Effects 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000005012 migration Effects 0.000 claims 1
• 238000013508 migration Methods 0.000 claims 1
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
• 150000007523 nucleic acids Chemical group 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 230000009870 specific binding Effects 0.000 claims 1
• 231100000240 steatosis hepatitis Toxicity 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 231100000331 toxic Toxicity 0.000 claims 1
• 230000002588 toxic effect Effects 0.000 claims 1
• 201000001862 viral hepatitis Diseases 0.000 claims 1