CN101905024A - 含有血管生成素-样蛋白质3angptl3的组合物及其使用方法 - Google Patents

含有血管生成素-样蛋白质3angptl3的组合物及其使用方法 Download PDF

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Publication number
CN101905024A
CN101905024A CN2010102426068A CN201010242606A CN101905024A CN 101905024 A CN101905024 A CN 101905024A CN 2010102426068 A CN2010102426068 A CN 2010102426068A CN 201010242606 A CN201010242606 A CN 201010242606A CN 101905024 A CN101905024 A CN 101905024A
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angptl3
tissue
liver
seq
antibody
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Chinese (zh)
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纳波莱昂内·费拉拉
汉斯-彼得·格伯
乔·科沃尔斯基
玛丽亚·T·皮萨巴罗
丹尼尔·E·舍曼
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Genentech Inc
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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CN2010102426068A 2001-11-16 2002-11-13 含有血管生成素-样蛋白质3angptl3的组合物及其使用方法 Pending CN101905024A (zh)

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US33242901P 2001-11-16 2001-11-16
US60/332,429 2001-11-16

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CN (2) CN101905024A (enExample)
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CA (1) CA2464542C (enExample)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103732624A (zh) * 2011-06-17 2014-04-16 瑞泽恩制药公司 抗angptl3抗体及其用途
CN104062432A (zh) * 2013-03-22 2014-09-24 中山大学 ang2在制备ECTC血管类型肝癌诊断试剂及治疗药物中的应用
CN108779159A (zh) * 2016-02-04 2018-11-09 瑞泽恩制药公司 具有经改造的angptl8基因的非人动物
CN114934021A (zh) * 2022-04-21 2022-08-23 复旦大学附属儿科医院 一种Angptl3敲除的鼠永生化足细胞系及其应用
US12281173B2 (en) 2016-03-03 2025-04-22 Regeneron Pharmaceuticals, Inc. Methods for treating patients with hyperlipidemia by administering a PCSK9 inhibitor in combination with an ANGPTL3 inhibitor
CN120254294A (zh) * 2025-06-05 2025-07-04 南昌大学第一附属医院 Angptl3在乙肝相关慢加急性肝衰竭预后中的应用

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US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
NZ532852A (en) 2001-11-16 2006-08-31 Genentech Inc Composition comprising and method of using angiopoietin-like protein 3 Angptl3
US20050112211A1 (en) * 2003-08-21 2005-05-26 Eric Gervais Micronutrient supplement
RU2380411C2 (ru) * 2004-07-20 2010-01-27 Дженентек, Инк. Способ ингибирования пролиферации гепатоцитов, способ ингибирования клеточной адгезии гепатоцитов и способ ингибирования биологической активности angptl4 в гепатоцитах или предшественниках гепатоцитов
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
KR101254815B1 (ko) 2004-07-20 2013-09-03 제넨테크, 인크. 안지오포이에틴-유사 4 단백질의 저해제, 배합물, 그의용도
US7807645B2 (en) 2005-09-23 2010-10-05 The Regents Of The University Of California Method of treating degenerative disorders of the nervous system by administration of fibrinogen fragment
CN101855241B (zh) * 2006-12-08 2013-11-06 莱克康制药公司 针对angptl3的单克隆抗体
US8354111B2 (en) 2008-04-14 2013-01-15 Hadasit Medical Research Services And Development Ltd. Stable cell binding chimeric peptides
CN101852805B (zh) * 2009-03-31 2015-04-01 浙江大学 Angptl3作为卵巢癌的诊断标记物的用途
US9139633B2 (en) * 2009-07-14 2015-09-22 Novartis Ag Mesenchymal stem cell differentiation
AU2015200969A1 (en) * 2010-01-08 2015-03-19 Ionis Pharmaceuticals, Inc. Modulation of angiopoietin-like 3 expression
AU2011203986C1 (en) * 2010-01-08 2015-03-05 Ionis Pharmaceuticals, Inc. Modulation of angiopoietin-like 3 expression
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US20130330752A1 (en) * 2011-01-29 2013-12-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104271590B (zh) 2012-01-24 2018-06-05 Inter-K私人有限公司 用于癌治疗的肽剂
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JO3564B1 (ar) 2013-03-08 2020-07-05 Novartis Ag ببتيدات وتركيبات لعلاج ضرر المفاصل
BR112015027319A8 (pt) 2013-05-01 2018-01-02 Isis Pharmaceuticals Inc Métodos e composições para modular a expressão de apolipoproteína (a)
MX383753B (es) 2013-12-24 2025-03-14 Ionis Pharmaceuticals Inc Modulación de la expresión similar a la angiopoyetina tipo 3.
KR102356388B1 (ko) 2014-05-01 2022-01-26 아이오니스 파마수티컬즈, 인코포레이티드 안지오포이에틴-유사 3 발현을 조절하기 위한 조성물 및 방법
CN105021827B (zh) * 2015-07-17 2016-09-28 北京大学第一医院 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用
CN108348478A (zh) 2015-11-06 2018-07-31 Ionis 制药公司 调节载脂蛋白(a)表达
PE20201287A1 (es) * 2017-09-14 2020-11-24 Arrowhead Pharmaceuticals Inc Agentes de iarn y composiciones para inhibir la expresion de la angiopoyetina tipo 3 (angptl3) y metodos de uso
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
WO2020099482A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Angptl 3 oligonucleotides influencing the regulation of the fatty acid metabolism
TWI747098B (zh) * 2018-12-21 2021-11-21 美商美國禮來大藥廠 抗angptl3/8複合物抗體及其使用方法
US20220380425A1 (en) * 2019-07-04 2022-12-01 Cadila Healthcare Limited Angptl3 based vaccine for the treatment of liver disease
CN111122872B (zh) * 2019-11-20 2023-01-20 中山大学附属第一医院 血管生成素样蛋白7在心力衰竭预后评估中的应用
CN110938144B (zh) * 2019-11-27 2022-07-26 复旦大学附属儿科医院 一种抗angptl3单克隆抗体及其在制备治疗肾病综合征药物中的用途
US20240141029A1 (en) * 2021-03-05 2024-05-02 Anji Pharmaceuticals Inc. Methods and compositions for treating sepsis

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WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences
KR100553300B1 (ko) * 1999-03-08 2006-02-20 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
NZ532852A (en) 2001-11-16 2006-08-31 Genentech Inc Composition comprising and method of using angiopoietin-like protein 3 Angptl3

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103732624A (zh) * 2011-06-17 2014-04-16 瑞泽恩制药公司 抗angptl3抗体及其用途
CN103732624B (zh) * 2011-06-17 2016-08-17 瑞泽恩制药公司 抗angptl3抗体及其用途
US9951127B2 (en) 2011-06-17 2018-04-24 Regeneron Pharmaceuticals, Inc. Anti-ANGPTL3 antibodies and uses thereof
US10358487B2 (en) 2011-06-17 2019-07-23 Regeneron Pharmaceuticals, Inc. Anti-ANGPTL3 antibodies and uses thereof
CN104062432A (zh) * 2013-03-22 2014-09-24 中山大学 ang2在制备ECTC血管类型肝癌诊断试剂及治疗药物中的应用
CN104062432B (zh) * 2013-03-22 2016-01-20 中山大学 ang2在制备ECTC血管类型肝癌诊断试剂及治疗药物中的应用
CN108779159A (zh) * 2016-02-04 2018-11-09 瑞泽恩制药公司 具有经改造的angptl8基因的非人动物
CN108779159B (zh) * 2016-02-04 2022-12-30 瑞泽恩制药公司 具有经改造的angptl8基因的非人动物
US12281173B2 (en) 2016-03-03 2025-04-22 Regeneron Pharmaceuticals, Inc. Methods for treating patients with hyperlipidemia by administering a PCSK9 inhibitor in combination with an ANGPTL3 inhibitor
CN114934021A (zh) * 2022-04-21 2022-08-23 复旦大学附属儿科医院 一种Angptl3敲除的鼠永生化足细胞系及其应用
CN114934021B (zh) * 2022-04-21 2023-08-08 复旦大学附属儿科医院 一种Angptl3敲除的鼠永生化足细胞系及其应用
CN120254294A (zh) * 2025-06-05 2025-07-04 南昌大学第一附属医院 Angptl3在乙肝相关慢加急性肝衰竭预后中的应用

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WO2003044172A2 (en) 2003-05-30
US8541376B2 (en) 2013-09-24
KR20100029861A (ko) 2010-03-17
ES2429034T3 (es) 2013-11-12
US20070134250A1 (en) 2007-06-14
ZA200403070B (en) 2005-06-29
US20090098117A1 (en) 2009-04-16
NZ532852A (en) 2006-08-31
CN1615440A (zh) 2005-05-11
CA2464542C (en) 2015-01-20
US7267819B2 (en) 2007-09-11
KR101012904B1 (ko) 2011-02-08
AU2002348286A1 (en) 2003-06-10
IL161542A0 (en) 2004-09-27
JP5105696B2 (ja) 2012-12-26
IL203894A (en) 2013-09-30
WO2003044172B1 (en) 2004-03-18
JP2010100624A (ja) 2010-05-06
JP2005521643A (ja) 2005-07-21
EP1451578B1 (en) 2013-08-21
WO2003044172A3 (en) 2003-11-20
EP1451578A4 (en) 2006-02-01
NO20042410L (no) 2004-06-09
CA2464542A1 (en) 2003-05-30
EP1451578A2 (en) 2004-09-01
MXPA04004609A (es) 2004-08-12
NO336021B1 (no) 2015-04-20
KR20050044485A (ko) 2005-05-12
AU2002348286B2 (en) 2008-04-03
US20030215451A1 (en) 2003-11-20

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Application publication date: 20101208