JP2010083886A5 - - Google Patents
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- Publication number
- JP2010083886A5 JP2010083886A5 JP2009222020A JP2009222020A JP2010083886A5 JP 2010083886 A5 JP2010083886 A5 JP 2010083886A5 JP 2009222020 A JP2009222020 A JP 2009222020A JP 2009222020 A JP2009222020 A JP 2009222020A JP 2010083886 A5 JP2010083886 A5 JP 2010083886A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- oral administration
- water
- administration according
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 23
- 239000000126 substance Substances 0.000 claims description 16
- 229920001577 copolymer Polymers 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 9
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 8
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 7
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 239000000454 talc Substances 0.000 claims description 6
- 229910052623 talc Inorganic materials 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920000578 graft copolymer Polymers 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 18
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 9
- 239000011248 coating agent Substances 0.000 claims 9
- 238000000576 coating method Methods 0.000 claims 9
- 229920003169 water-soluble polymer Polymers 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 239000000463 material Substances 0.000 claims 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 235000012239 silicon dioxide Nutrition 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 4
- -1 copolyvidone Polymers 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 4
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 3
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 3
- 229960005370 atorvastatin Drugs 0.000 claims 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 3
- 235000010981 methylcellulose Nutrition 0.000 claims 3
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 3
- 239000000377 silicon dioxide Substances 0.000 claims 3
- 239000005995 Aluminium silicate Substances 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- 235000012211 aluminium silicate Nutrition 0.000 claims 2
- 239000000378 calcium silicate Substances 0.000 claims 2
- 229910052918 calcium silicate Inorganic materials 0.000 claims 2
- 235000012241 calcium silicate Nutrition 0.000 claims 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims 2
- 239000011247 coating layer Substances 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 229940075507 glyceryl monostearate Drugs 0.000 claims 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 2
- 229960003511 macrogol Drugs 0.000 claims 2
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims 2
- 239000000391 magnesium silicate Substances 0.000 claims 2
- 229910052919 magnesium silicate Inorganic materials 0.000 claims 2
- 235000019792 magnesium silicate Nutrition 0.000 claims 2
- 235000019359 magnesium stearate Nutrition 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 229910000000 metal hydroxide Inorganic materials 0.000 claims 2
- 150000004692 metal hydroxides Chemical class 0.000 claims 2
- 229910044991 metal oxide Inorganic materials 0.000 claims 2
- 150000004706 metal oxides Chemical class 0.000 claims 2
- 229910052914 metal silicate Inorganic materials 0.000 claims 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 2
- 229940069328 povidone Drugs 0.000 claims 2
- 235000012222 talc Nutrition 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- 229920002261 Corn starch Polymers 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000000748 compression moulding Methods 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 1
- 229920001002 functional polymer Polymers 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000010440 gypsum Substances 0.000 claims 1
- 229910052602 gypsum Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 235000013980 iron oxide Nutrition 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 1
- 239000001095 magnesium carbonate Substances 0.000 claims 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000006191 orally-disintegrating tablet Substances 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 239000007788 liquid Substances 0.000 description 6
- 238000005507 spraying Methods 0.000 description 6
- 239000008213 purified water Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 229920003148 Eudragit® E polymer Polymers 0.000 description 4
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 229920003115 HPC-SL Polymers 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10137908P | 2008-09-30 | 2008-09-30 | |
| US10139408P | 2008-09-30 | 2008-09-30 | |
| US61/101,394 | 2008-09-30 | ||
| US61/101,379 | 2008-09-30 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010188328A Division JP5282772B2 (ja) | 2008-09-30 | 2010-08-25 | 経口投与用粒子状医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010083886A JP2010083886A (ja) | 2010-04-15 |
| JP2010083886A5 true JP2010083886A5 (enExample) | 2010-10-07 |
| JP4706785B2 JP4706785B2 (ja) | 2011-06-22 |
Family
ID=42073455
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009222020A Expired - Fee Related JP4706785B2 (ja) | 2008-09-30 | 2009-09-28 | 経口投与用粒子状医薬組成物 |
| JP2010188328A Expired - Fee Related JP5282772B2 (ja) | 2008-09-30 | 2010-08-25 | 経口投与用粒子状医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010188328A Expired - Fee Related JP5282772B2 (ja) | 2008-09-30 | 2010-08-25 | 経口投与用粒子状医薬組成物 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20100136110A1 (enExample) |
| JP (2) | JP4706785B2 (enExample) |
| WO (1) | WO2010038691A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5506415B2 (ja) * | 2010-01-13 | 2014-05-28 | 東和薬品株式会社 | ＨＭＧ−ＣｏＡレダクターゼ阻害剤含有経口固形製剤 |
| JP5614445B2 (ja) * | 2010-03-29 | 2014-10-29 | アステラス製薬株式会社 | 経口投与用粒子状医薬組成物 |
| JP5534004B2 (ja) * | 2010-03-29 | 2014-06-25 | アステラス製薬株式会社 | 口腔内崩壊錠 |
| JP6073543B2 (ja) * | 2010-07-08 | 2017-02-01 | 沢井製薬株式会社 | ロラタジン含有口腔内崩壊錠の製造方法 |
| WO2012056509A1 (ja) * | 2010-10-25 | 2012-05-03 | 興和株式会社 | 医薬組成物 |
| EP2500013B1 (en) * | 2011-03-15 | 2019-10-02 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical composition comprising solifenacin |
| US20140178484A1 (en) * | 2011-05-16 | 2014-06-26 | Sun Pharma Advanced Research Company Ltd. | Multi-particulate pharmaceutical composition |
| FI126168B (en) | 2012-09-18 | 2016-07-29 | Novaldmedical Ltd Oy | A method for coating pharmaceutical substrates |
| RU2018141241A (ru) * | 2012-11-30 | 2019-01-24 | Экьюра Фармасьютикалз, Инк. | Саморегулируемое высвобождение фармацевтического ингредиента |
| CN104042628B (zh) * | 2013-03-15 | 2017-04-12 | 复旦大学 | 氢氧化铝在制备治疗肝癌药物中的应用 |
| EP2979697A4 (en) * | 2013-03-26 | 2016-11-30 | Kissei Pharmaceutical | PREPARATION FOR ORAL ADMINISTRATION WITH MASKED BITTERNITY OF SILODOSINE |
| SI3033076T1 (sl) * | 2013-08-14 | 2021-01-29 | Evonik Operations Gmbh | Sestavek za oplaščenje |
| JP6344678B2 (ja) * | 2013-09-27 | 2018-06-20 | キョーリンリメディオ株式会社 | テルミサルタン含有製剤及びその製造方法 |
| KR20180098282A (ko) * | 2015-12-28 | 2018-09-03 | 니뽄 신야쿠 가부시키가이샤 | 압축 성형 제제 |
| BR112018017173A2 (pt) | 2016-02-23 | 2019-01-02 | Univ Colorado Regents | composições e métodos para a produção e uso de formulações imunogênicas termoestáveis com compatibilidade aumentada de uso como vacinas contra um ou mais patógenos |
| EP3421032A4 (en) * | 2016-02-23 | 2019-10-23 | Nipro Corporation | PARTICULARS OF A PHARMACEUTICAL COMPOSITION, ORAL DECOMPOSITION PREPARATION THEREOF AND METHOD FOR PRODUCING PARTICLES OF A PHARMACEUTICAL COMPOSITION |
| KR102865751B1 (ko) * | 2016-03-15 | 2025-09-29 | 에이서 테라퓨틱스 인크. | 소듐 페닐부티레이트를 포함하는 맛우수한 조성물 및 그의 용도 |
| JP6957610B2 (ja) * | 2016-10-06 | 2021-11-02 | スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ | 医薬品用途のための多層ビーズ |
| JP7293131B2 (ja) * | 2017-12-28 | 2023-06-19 | 住友ファーマ株式会社 | 新規微粒子コーティング（薬物含有中空粒子及びその製法） |
| WO2019143744A1 (en) | 2018-01-16 | 2019-07-25 | Applied Materials, Inc. | Metal oxide encapsulated drug compositions and methods of preparing the same |
| EP4021421A4 (en) * | 2019-08-27 | 2023-05-10 | Applied Materials, Inc. | VAPOR PHASE COATINGS FOR PHARMACEUTICAL SOLUTION CONTROL |
| TWI870622B (zh) | 2020-10-02 | 2025-01-21 | 美商應用材料股份有限公司 | 製備氧化矽塗佈藥品的低溫處理 |
| CN118215470A (zh) | 2021-09-30 | 2024-06-18 | 应用材料公司 | 用于制药应用的低温氧化硅涂层 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE59287B1 (en) * | 1984-02-10 | 1994-02-09 | Benzon Pharma As | Diffusion coated multiple-units dosage form |
| DK62184D0 (da) * | 1984-02-10 | 1984-02-10 | Benzon As Alfred | Diffusionsovertrukket polydepotpraeparat |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
| US5576014A (en) * | 1994-01-31 | 1996-11-19 | Yamanouchi Pharmaceutical Co., Ltd | Intrabuccally dissolving compressed moldings and production process thereof |
| JPH08333242A (ja) * | 1995-06-09 | 1996-12-17 | Tanabe Seiyaku Co Ltd | 圧縮成型製剤 |
| CA2277017C (en) * | 1997-01-06 | 2002-11-26 | Pfizer Inc. | Rapidly releasing and taste-masking pharmaceutical dosage form |
| JP2000273037A (ja) * | 1999-03-19 | 2000-10-03 | Kyoto Pharmaceutical Industries Ltd | 解熱・鎮痛チュアブル錠およびその製造法 |
| US6872405B2 (en) * | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
| CA2579767A1 (en) * | 2004-04-30 | 2005-11-10 | Astellas Pharma Inc. | Oral pharmaceutical composition in timed-release particle form and fast-disintegrating tablets containing this composition |
| JP2007211006A (ja) * | 2006-01-16 | 2007-08-23 | Ono Pharmaceut Co Ltd | 溶出安定性を有するコーティング固形製剤 |
| CN101410109A (zh) * | 2006-03-24 | 2009-04-15 | 万能药生物有限公司 | 抗生素的调节释放组合物及其制备方法 |
| AR060662A1 (es) * | 2006-04-27 | 2008-07-02 | Takeda Pharmaceutical | Preparacion solida |
| CN101516403B (zh) * | 2006-09-14 | 2013-10-02 | 安斯泰来制药株式会社 | 口腔崩解片及其制备方法 |
-
2009
- 2009-09-28 JP JP2009222020A patent/JP4706785B2/ja not_active Expired - Fee Related
- 2009-09-28 US US12/568,257 patent/US20100136110A1/en not_active Abandoned
- 2009-09-28 WO PCT/JP2009/066743 patent/WO2010038691A1/ja not_active Ceased
-
2010
- 2010-08-25 JP JP2010188328A patent/JP5282772B2/ja not_active Expired - Fee Related
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