JP2009543858A5 - - Google Patents
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- Publication number
- JP2009543858A5 JP2009543858A5 JP2009520129A JP2009520129A JP2009543858A5 JP 2009543858 A5 JP2009543858 A5 JP 2009543858A5 JP 2009520129 A JP2009520129 A JP 2009520129A JP 2009520129 A JP2009520129 A JP 2009520129A JP 2009543858 A5 JP2009543858 A5 JP 2009543858A5
- Authority
- JP
- Japan
- Prior art keywords
- gaba
- product
- chemical component
- chemical
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 claims 27
- 239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 claims 11
- 229940001470 psychoactive drug Drugs 0.000 claims 9
- 239000004089 psychotropic agent Substances 0.000 claims 9
- 208000002193 Pain Diseases 0.000 claims 6
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 6
- 239000005022 packaging material Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 150000007524 organic acids Chemical group 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000001430 anti-depressive effect Effects 0.000 claims 2
- 239000001961 anticonvulsive agent Substances 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 229960003965 antiepileptics Drugs 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- PHVGLTMQBUFIQQ-UHFFFAOYSA-N Nortryptiline Chemical compound C1CC2=CC=CC=C2C(=CCCNC)C2=CC=CC=C21 PHVGLTMQBUFIQQ-UHFFFAOYSA-N 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940124277 aminobutyric acid Drugs 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229960002464 fluoxetine Drugs 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 229960001158 nortriptyline Drugs 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims 1
- 229940102566 valproate Drugs 0.000 claims 1
- 229960000604 valproic acid Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83119206P | 2006-07-17 | 2006-07-17 | |
| US83119506P | 2006-07-17 | 2006-07-17 | |
| US60/831,192 | 2006-07-17 | ||
| US60/831,195 | 2006-07-17 | ||
| PCT/IL2007/000903 WO2008010223A2 (en) | 2006-07-17 | 2007-07-17 | Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use in treating pain and other cns disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009543858A JP2009543858A (ja) | 2009-12-10 |
| JP2009543858A5 true JP2009543858A5 (enExample) | 2010-09-02 |
| JP5192485B2 JP5192485B2 (ja) | 2013-05-08 |
Family
ID=38621178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009520129A Expired - Fee Related JP5192485B2 (ja) | 2006-07-17 | 2007-07-17 | 向精神性薬物またはgabaアゴニストと有機酸とを含むコンジュゲート、ならびに疼痛および他のcns障害を治療するためのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8222296B2 (enExample) |
| EP (1) | EP2051735B1 (enExample) |
| JP (1) | JP5192485B2 (enExample) |
| KR (1) | KR20090048462A (enExample) |
| CN (1) | CN101511388B (enExample) |
| AU (1) | AU2007274583B2 (enExample) |
| CA (1) | CA2659521A1 (enExample) |
| ES (1) | ES2393933T3 (enExample) |
| IL (1) | IL196538A0 (enExample) |
| MX (1) | MX2009000641A (enExample) |
| WO (2) | WO2008010222A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7544681B2 (en) | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| US20090298814A1 (en) * | 2005-06-07 | 2009-12-03 | Ramot At Tel Aviv Univeristy Ltd | Novel salts of conjugated psychotropic drugs and processes of preparing same |
| CA2659521A1 (en) * | 2006-07-17 | 2008-01-24 | Ramot At Tel Aviv University Ltd. | Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use in treating pain and other cns disorders |
| US20090074677A1 (en) * | 2007-01-08 | 2009-03-19 | Duke University | Neuroactive steroid compositions and methods of use therefor |
| EP2252578B1 (en) * | 2008-02-11 | 2012-08-01 | Ramot at Tel Aviv University Ltd. | Conjugates for treating neurodegenerative diseases and disorders |
| WO2010027266A1 (en) * | 2008-09-05 | 2010-03-11 | Van De Langenberg, Hendrikus Theodorus Ardina Hubertus | Means and methods for counteracting neurological disorders |
| WO2010042759A2 (en) | 2008-10-08 | 2010-04-15 | Kyphia Pharmaceuticals Inc | Gaba conjugates and methods of use thereof |
| WO2010110916A2 (en) * | 2009-03-26 | 2010-09-30 | Seventh Sense Biosystems, Inc. | Determination of tracers within subjects |
| US8141697B2 (en) * | 2009-04-03 | 2012-03-27 | Ackley Machine Corporation | Method and apparatus for transporting caplets |
| EP2480536B1 (en) * | 2009-09-23 | 2014-08-13 | The Regents of the University of Colorado, A Body Corporate | Toll-like receptor modulators and uses thereof |
| EP2509603A1 (en) | 2009-12-09 | 2012-10-17 | Biolinerx Ltd. | Methods of improving cognitive functions |
| US8916610B2 (en) * | 2010-09-22 | 2014-12-23 | Ramot At Tel-Aviv University Ltd. | Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same |
| US9526718B2 (en) * | 2011-06-28 | 2016-12-27 | Vivozon, Inc. | Combination of effective substances causing synergistic effects of multiple targeting and use thereof |
| WO2014022807A2 (en) * | 2012-08-03 | 2014-02-06 | Alumend, Llc | Compositions and methods of using the compositions for plaque softening |
| CA2999367C (en) | 2015-09-23 | 2023-09-26 | Xw Laboratories Inc. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| KR102510784B1 (ko) | 2017-03-30 | 2023-03-15 | 엑스더블유파마 리미티드 | 이환형 헤테로아릴 유도체 및 이의 제조 및 용도 |
| WO2018199174A1 (ja) * | 2017-04-25 | 2018-11-01 | 生化学工業株式会社 | 第3級アミン化合物又はイミン化合物-ポリマーコンジュゲートとその製造方法 |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| JP7441181B2 (ja) * | 2018-05-14 | 2024-02-29 | エックスジーン ファーマシューティカル インク. | ナプロキセンとプレガバリンの1-(アシルオキシ)-アルキルカルバメート薬品複合体の結晶形態 |
| WO2020062251A1 (en) | 2018-09-30 | 2020-04-02 | Xw Laboratories, Inc. | Compounds as neuronal histamine receptor-3 antagonists and uses thereof |
| JP2022529353A (ja) | 2019-04-17 | 2022-06-21 | コンパス パスファインダー リミテッド | 神経認知障害、慢性疼痛を治療し、炎症を低減させる方法 |
| WO2021127461A1 (en) | 2019-12-20 | 2021-06-24 | Xw Laboratories Limited | Methods of synthesizing 4-valyloxybutyric acid |
| WO2021257886A1 (en) | 2020-06-18 | 2021-12-23 | XWPharma Ltd. | Controlled release granulations of water-soluble active pharmaceutical ingredients |
| WO2021257832A1 (en) | 2020-06-18 | 2021-12-23 | XWPharma Ltd. | Pharmaceutical granulations of water-soluble active pharmaceutical ingredients |
| CN116261451A (zh) | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
| CN119970650A (zh) | 2020-10-05 | 2025-05-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的修饰释放组合物 |
| EP4308086B1 (en) | 2021-03-19 | 2025-10-15 | XWPharma Ltd. | Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative |
| CN114452256A (zh) * | 2021-12-31 | 2022-05-10 | 浙江大学 | 脊髓损伤靶向药物、聚合物-疏水化合物胶束及其制备方法 |
| CN115057865B (zh) * | 2022-05-10 | 2023-03-31 | 国药集团工业有限公司 | 一种磷酸可待因半水合物的制备方法 |
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| US7872046B2 (en) | 2008-01-25 | 2011-01-18 | Xenoport, Inc. | Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
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-
2007
- 2007-07-17 CA CA002659521A patent/CA2659521A1/en not_active Abandoned
- 2007-07-17 US US12/373,542 patent/US8222296B2/en not_active Expired - Fee Related
- 2007-07-17 WO PCT/IL2007/000902 patent/WO2008010222A2/en not_active Ceased
- 2007-07-17 AU AU2007274583A patent/AU2007274583B2/en not_active Ceased
- 2007-07-17 MX MX2009000641A patent/MX2009000641A/es active IP Right Grant
- 2007-07-17 KR KR1020097003169A patent/KR20090048462A/ko not_active Ceased
- 2007-07-17 ES ES07789958T patent/ES2393933T3/es active Active
- 2007-07-17 JP JP2009520129A patent/JP5192485B2/ja not_active Expired - Fee Related
- 2007-07-17 US US12/309,361 patent/US8377990B2/en not_active Expired - Fee Related
- 2007-07-17 WO PCT/IL2007/000903 patent/WO2008010223A2/en not_active Ceased
- 2007-07-17 CN CN2007800332946A patent/CN101511388B/zh not_active Expired - Fee Related
- 2007-07-17 EP EP07789958A patent/EP2051735B1/en not_active Not-in-force
-
2009
- 2009-01-15 IL IL196538A patent/IL196538A0/en unknown
-
2012
- 2012-09-06 US US13/604,718 patent/US20130059910A1/en not_active Abandoned
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