JP2007536279A5 - - Google Patents
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- Publication number
- JP2007536279A5 JP2007536279A5 JP2007511722A JP2007511722A JP2007536279A5 JP 2007536279 A5 JP2007536279 A5 JP 2007536279A5 JP 2007511722 A JP2007511722 A JP 2007511722A JP 2007511722 A JP2007511722 A JP 2007511722A JP 2007536279 A5 JP2007536279 A5 JP 2007536279A5
- Authority
- JP
- Japan
- Prior art keywords
- random copolymer
- dose
- yfak
- phenylalanine
- pharmaceuticals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920005604 random copolymer Polymers 0.000 claims 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- 235000019766 L-Lysine Nutrition 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000000034 method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56929204P | 2004-05-07 | 2004-05-07 | |
| US60/569,292 | 2004-05-07 | ||
| US66333305P | 2005-03-18 | 2005-03-18 | |
| US60/663,333 | 2005-03-18 | ||
| PCT/US2005/016344 WO2005112972A1 (en) | 2004-05-07 | 2005-05-09 | Methods of treating disease with random copolymers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012044246A Division JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007536279A JP2007536279A (ja) | 2007-12-13 |
| JP2007536279A5 true JP2007536279A5 (enExample) | 2012-06-14 |
| JP5495490B2 JP5495490B2 (ja) | 2014-05-21 |
Family
ID=35159680
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511722A Expired - Fee Related JP5495490B2 (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2007511720A Pending JP2007536278A (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012044246A Expired - Fee Related JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012216951A Withdrawn JP2012255034A (ja) | 2004-05-07 | 2012-09-28 | ランダム共重合体を用いる疾患の治療方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511720A Pending JP2007536278A (ja) | 2004-05-07 | 2005-05-09 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012044246A Expired - Fee Related JP5892815B2 (ja) | 2004-05-07 | 2012-02-29 | ランダム共重合体を用いる疾患の治療方法 |
| JP2012216951A Withdrawn JP2012255034A (ja) | 2004-05-07 | 2012-09-28 | ランダム共重合体を用いる疾患の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (3) | EP1750741B1 (enExample) |
| JP (4) | JP5495490B2 (enExample) |
| KR (1) | KR20070036062A (enExample) |
| AU (2) | AU2005251686B2 (enExample) |
| BR (1) | BRPI0510738A (enExample) |
| CA (2) | CA2565703A1 (enExample) |
| ES (1) | ES2560448T3 (enExample) |
| IL (2) | IL179074A0 (enExample) |
| MX (1) | MXPA06012864A (enExample) |
| NZ (1) | NZ551236A (enExample) |
| RU (1) | RU2410115C2 (enExample) |
| WO (2) | WO2005120542A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ549731A (en) * | 2004-03-01 | 2009-11-27 | Peptimmune Inc | Methods and compositions for treatment of autoimmune diseases |
| US7655221B2 (en) * | 2004-05-07 | 2010-02-02 | Peptimmune, Inc. | Methods of treating disease with random copolymers |
| US20060194725A1 (en) * | 2004-05-07 | 2006-08-31 | James Rasmussen | Methods of treating disease with random copolymers |
| CA2649296A1 (en) * | 2006-04-13 | 2007-10-25 | Peptimmune, Inc. | Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability |
| AU2008311897B2 (en) | 2007-10-16 | 2015-03-26 | Declion Holdings Llc | Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes |
| EP2278998A1 (en) | 2008-04-17 | 2011-02-02 | Declion Pharmaceuticals, Inc. | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| WO2011011706A2 (en) * | 2009-07-24 | 2011-01-27 | The Johns Hopkins University | Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents |
| SG178495A1 (en) | 2009-08-20 | 2012-03-29 | Yeda Res & Dev | Low frequency glatiramer acetate therapy |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| AU2017290907A1 (en) * | 2016-07-01 | 2019-02-14 | Declion Holdings Llc | Amino acid copolymer compositions and uses thereof |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| LT3506921T (lt) | 2016-08-31 | 2023-08-10 | Mapi Pharma Ltd | Ilgesnio atpalaidavimo sistemos, kuriose yra glatiramero acetato |
| AU2018242998B2 (en) | 2017-03-26 | 2023-11-02 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
| WO2022103673A2 (en) | 2020-11-10 | 2022-05-19 | Fridkis Hareli Masha | Compositions of embedded epitope random peptides (eerp) for treatment of immune-mediated conditions, and methods of use |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| US5800808A (en) | 1994-05-24 | 1998-09-01 | Veda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
| US5858964A (en) | 1995-04-14 | 1999-01-12 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD |
| US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| JPH11330431A (ja) | 1998-05-18 | 1999-11-30 | Nec Corp | 不揮発性半導体記憶装置の製造方法 |
| IL140592A0 (en) | 1998-07-23 | 2002-02-10 | Harvard College | Synthetic peptides and methods of use for autoimmune disease therapies |
| EP1098902A4 (en) | 1998-07-23 | 2002-07-24 | Yeda Res & Dev | TREATMENT OF AUTOIMMUNE DISEASES WITH COPOLYMER 1 AND RELATED COPOLYMERS AND PEPTIDES |
| NZ509901A (en) * | 1998-07-23 | 2003-10-31 | Yeda Res & Dev | Treatment of autoimmune conditions terpolymers consisting of three amino acids selected from glu, ala, lys or tyr |
| US6514938B1 (en) | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| EP1128839A4 (en) * | 1998-11-12 | 2002-10-09 | Yeda Res & Dev | PHARMACEUTICAL COMPOSITIONS CONTAINING COPOLYMERS OF SYNTHETIC PEPTIDES AND METHODS FOR PREVENTING AND TREATING GVHD AND HVGD |
| HK1054507B (zh) * | 2000-01-20 | 2008-10-31 | 耶达研究及发展有限公司 | 共聚物1和相关肽和多肽及其处理过的t细胞在神经保护性治疗中的用途 |
| IL150801A0 (en) | 2000-06-07 | 2003-02-12 | Yeda Res & Dev | The use of copolymer 1 and related peptides and polypeptides for protecting central nervous system cells from glutamate toxicity |
| US20040003888A1 (en) | 2000-07-11 | 2004-01-08 | Laurence Mott | Process for the manufacture of an improved floor element |
| WO2002059143A2 (en) | 2001-01-24 | 2002-08-01 | President And Fellows Of Harvard College | Therapeutic peptides for demyelinating conditions |
| JP2005500520A (ja) * | 2001-06-28 | 2005-01-06 | ケンブレックス バイオ サイエンス ウォカーズビル インコーポレーティッド | エンドトキシンを検出するための方法および試薬 |
| CA2614171C (en) * | 2001-10-03 | 2012-04-24 | President And Fellows Of Harvard College | Copolymers for suppression of autoimmune diseases, and methods of use |
| EP1438061B1 (en) * | 2001-10-03 | 2016-05-11 | President and Fellows of Harvard College | Copolymers for suppression of autoimmune diseases, and methods of use |
| RU2303996C2 (ru) * | 2001-12-06 | 2007-08-10 | Йеда Рисерч Энд Дивелопмент Ко.Лтд. | Вакцина и способ лечения болезней двигательных нейронов |
| AU2004206120B2 (en) * | 2003-01-21 | 2009-09-24 | Yeda Research And Development Co. Ltd. | COP 1 for treatment of inflammatory bowel diseases |
-
2005
- 2005-05-09 MX MXPA06012864A patent/MXPA06012864A/es active IP Right Grant
- 2005-05-09 AU AU2005251686A patent/AU2005251686B2/en not_active Ceased
- 2005-05-09 ES ES05779362.2T patent/ES2560448T3/es not_active Expired - Lifetime
- 2005-05-09 NZ NZ551236A patent/NZ551236A/en not_active IP Right Cessation
- 2005-05-09 WO PCT/US2005/016340 patent/WO2005120542A2/en not_active Ceased
- 2005-05-09 JP JP2007511722A patent/JP5495490B2/ja not_active Expired - Fee Related
- 2005-05-09 JP JP2007511720A patent/JP2007536278A/ja active Pending
- 2005-05-09 AU AU2005244814A patent/AU2005244814B2/en not_active Ceased
- 2005-05-09 EP EP05779362.2A patent/EP1750741B1/en not_active Expired - Lifetime
- 2005-05-09 BR BRPI0510738-5A patent/BRPI0510738A/pt not_active IP Right Cessation
- 2005-05-09 WO PCT/US2005/016344 patent/WO2005112972A1/en not_active Ceased
- 2005-05-09 RU RU2006143334/15A patent/RU2410115C2/ru not_active IP Right Cessation
- 2005-05-09 EP EP12174215A patent/EP2508194A1/en not_active Withdrawn
- 2005-05-09 CA CA002565703A patent/CA2565703A1/en not_active Abandoned
- 2005-05-09 CA CA002565819A patent/CA2565819A1/en not_active Abandoned
- 2005-05-09 KR KR1020067025802A patent/KR20070036062A/ko not_active Ceased
- 2005-05-09 EP EP05783041A patent/EP1750742A2/en not_active Withdrawn
-
2006
- 2006-11-06 IL IL179074A patent/IL179074A0/en unknown
- 2006-11-06 IL IL179075A patent/IL179075A/en not_active IP Right Cessation
-
2012
- 2012-02-29 JP JP2012044246A patent/JP5892815B2/ja not_active Expired - Fee Related
- 2012-09-28 JP JP2012216951A patent/JP2012255034A/ja not_active Withdrawn
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