IL179074A0 - Methods of treating disease with random copolymers - Google Patents
Methods of treating disease with random copolymersInfo
- Publication number
- IL179074A0 IL179074A0 IL179074A IL17907406A IL179074A0 IL 179074 A0 IL179074 A0 IL 179074A0 IL 179074 A IL179074 A IL 179074A IL 17907406 A IL17907406 A IL 17907406A IL 179074 A0 IL179074 A0 IL 179074A0
- Authority
- IL
- Israel
- Prior art keywords
- methods
- random copolymers
- treating disease
- disease
- treating
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229920005604 random copolymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56929204P | 2004-05-07 | 2004-05-07 | |
| US66333305P | 2005-03-18 | 2005-03-18 | |
| PCT/US2005/016340 WO2005120542A2 (en) | 2004-05-07 | 2005-05-09 | Methods of treating disease with random copolymers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL179074A0 true IL179074A0 (en) | 2007-03-08 |
Family
ID=35159680
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL179074A IL179074A0 (en) | 2004-05-07 | 2006-11-06 | Methods of treating disease with random copolymers |
| IL179075A IL179075A (en) | 2004-05-07 | 2006-11-06 | Use of random copolymer preparations in the preparation of drugs for the treatment of diseases, the reduction of undesirable immune reactions and the treatment of multiple sclerosis and pharmaceutical preparations containing random copolymer preparations |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL179075A IL179075A (en) | 2004-05-07 | 2006-11-06 | Use of random copolymer preparations in the preparation of drugs for the treatment of diseases, the reduction of undesirable immune reactions and the treatment of multiple sclerosis and pharmaceutical preparations containing random copolymer preparations |
Country Status (12)
| Country | Link |
|---|---|
| EP (3) | EP2508194A1 (enExample) |
| JP (4) | JP5495490B2 (enExample) |
| KR (1) | KR20070036062A (enExample) |
| AU (2) | AU2005251686B2 (enExample) |
| BR (1) | BRPI0510738A (enExample) |
| CA (2) | CA2565819A1 (enExample) |
| ES (1) | ES2560448T3 (enExample) |
| IL (2) | IL179074A0 (enExample) |
| MX (1) | MXPA06012864A (enExample) |
| NZ (1) | NZ551236A (enExample) |
| RU (1) | RU2410115C2 (enExample) |
| WO (2) | WO2005120542A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2006134701A (ru) * | 2004-03-01 | 2008-04-10 | Пептиммьюн | Способы и композиции для лечения аутоиммунных заболеваний |
| US7655221B2 (en) | 2004-05-07 | 2010-02-02 | Peptimmune, Inc. | Methods of treating disease with random copolymers |
| US20060194725A1 (en) * | 2004-05-07 | 2006-08-31 | James Rasmussen | Methods of treating disease with random copolymers |
| EP2016095A2 (en) * | 2006-04-13 | 2009-01-21 | Peptimmune, Inc. | Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability |
| BRPI0817682A2 (pt) | 2007-10-16 | 2015-04-07 | Peptimmune Inc | Métodos para projetar e preparar vacinas compreendendo composições de polímero de sequência direcionada via a expansão direta de epítopos |
| AU2009236583B2 (en) | 2008-04-17 | 2015-07-16 | Declion Holdings Llc | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| US20120237472A1 (en) * | 2009-07-24 | 2012-09-20 | The Johns Hopkins University | Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents |
| KR20160038057A (ko) | 2009-08-20 | 2016-04-06 | 에다 리서치 앤드 디벨럽먼트 컴퍼니 리미티드 | 글라티라머 아세테이트를 포함하는 약제 |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| AU2017290907A1 (en) * | 2016-07-01 | 2019-02-14 | Declion Holdings Llc | Amino acid copolymer compositions and uses thereof |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| SMT202500136T1 (it) | 2016-08-31 | 2025-05-12 | Mapi Pharma Ltd | Sistemi a deposito comprendenti glatiramer acetato |
| US11167003B2 (en) | 2017-03-26 | 2021-11-09 | Mapi Pharma Ltd. | Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems |
| US20230414732A1 (en) | 2020-11-10 | 2023-12-28 | Palena Therapeutics, Inc. | Compositions of embedded epitope random peptides (eerp) for treatment of immune-mediated conditions, and methods of use |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| US5800808A (en) | 1994-05-24 | 1998-09-01 | Veda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
| US5858964A (en) | 1995-04-14 | 1999-01-12 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD |
| US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| JPH11330431A (ja) | 1998-05-18 | 1999-11-30 | Nec Corp | 不揮発性半導体記憶装置の製造方法 |
| NZ509901A (en) * | 1998-07-23 | 2003-10-31 | Yeda Res & Dev | Treatment of autoimmune conditions terpolymers consisting of three amino acids selected from glu, ala, lys or tyr |
| WO2000005249A2 (en) | 1998-07-23 | 2000-02-03 | The President And Fellows Of Harvard College | Synthetic peptides and methods of use for autoimmune disease therapies |
| WO2000005250A1 (en) | 1998-07-23 | 2000-02-03 | Yeda Research And Development Co., Ltd | Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides |
| US6514938B1 (en) | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| WO2000027417A1 (en) * | 1998-11-12 | 2000-05-18 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd |
| EP1248643B1 (en) * | 2000-01-20 | 2005-08-17 | YEDA RESEARCH AND DEVELOPMENT Co. LTD. | The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy |
| EP1294390B1 (en) | 2000-06-07 | 2006-01-04 | YEDA RESEARCH AND DEVELOPMENT CO., Ltd. | The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotection from glutamate toxicity |
| US20040003888A1 (en) | 2000-07-11 | 2004-01-08 | Laurence Mott | Process for the manufacture of an improved floor element |
| US6930168B2 (en) | 2001-01-24 | 2005-08-16 | The President And Fellows Of Harvard College | Synthetic peptides for demyelinating conditions |
| PT1409984E (pt) * | 2001-06-28 | 2009-10-29 | Lonza Walkersville Inc | Processos e reagentes para a detecção de endotoxinas |
| CA2614171C (en) * | 2001-10-03 | 2012-04-24 | President And Fellows Of Harvard College | Copolymers for suppression of autoimmune diseases, and methods of use |
| HUP0401863A3 (en) * | 2001-10-03 | 2012-09-28 | Harvard College | Amino acid-copolymers for suppression of autoimmune diseases, and methods of use |
| EP1429800B1 (en) * | 2001-12-06 | 2009-02-11 | Yeda Research And Development Co., Ltd. | Vaccine and use thereof for treatment of amyotrophic lateral sclerosis |
| ES2397836T3 (es) * | 2003-01-21 | 2013-03-11 | Yeda Research And Development Co., Ltd. | Copolímero 1 para el tratamiento de enfermedades inflamatorias del intestino |
-
2005
- 2005-05-09 EP EP12174215A patent/EP2508194A1/en not_active Withdrawn
- 2005-05-09 JP JP2007511722A patent/JP5495490B2/ja not_active Expired - Fee Related
- 2005-05-09 NZ NZ551236A patent/NZ551236A/en not_active IP Right Cessation
- 2005-05-09 AU AU2005251686A patent/AU2005251686B2/en not_active Ceased
- 2005-05-09 WO PCT/US2005/016340 patent/WO2005120542A2/en not_active Ceased
- 2005-05-09 KR KR1020067025802A patent/KR20070036062A/ko not_active Ceased
- 2005-05-09 CA CA002565819A patent/CA2565819A1/en not_active Abandoned
- 2005-05-09 WO PCT/US2005/016344 patent/WO2005112972A1/en not_active Ceased
- 2005-05-09 MX MXPA06012864A patent/MXPA06012864A/es active IP Right Grant
- 2005-05-09 EP EP05783041A patent/EP1750742A2/en not_active Withdrawn
- 2005-05-09 BR BRPI0510738-5A patent/BRPI0510738A/pt not_active IP Right Cessation
- 2005-05-09 EP EP05779362.2A patent/EP1750741B1/en not_active Expired - Lifetime
- 2005-05-09 AU AU2005244814A patent/AU2005244814B2/en not_active Ceased
- 2005-05-09 RU RU2006143334/15A patent/RU2410115C2/ru not_active IP Right Cessation
- 2005-05-09 CA CA002565703A patent/CA2565703A1/en not_active Abandoned
- 2005-05-09 ES ES05779362.2T patent/ES2560448T3/es not_active Expired - Lifetime
- 2005-05-09 JP JP2007511720A patent/JP2007536278A/ja active Pending
-
2006
- 2006-11-06 IL IL179074A patent/IL179074A0/en unknown
- 2006-11-06 IL IL179075A patent/IL179075A/en not_active IP Right Cessation
-
2012
- 2012-02-29 JP JP2012044246A patent/JP5892815B2/ja not_active Expired - Fee Related
- 2012-09-28 JP JP2012216951A patent/JP2012255034A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012255034A (ja) | 2012-12-27 |
| WO2005120542A2 (en) | 2005-12-22 |
| NZ551236A (en) | 2010-11-26 |
| BRPI0510738A (pt) | 2007-11-20 |
| IL179075A (en) | 2016-03-31 |
| KR20070036062A (ko) | 2007-04-02 |
| JP5892815B2 (ja) | 2016-03-23 |
| WO2005120542A3 (en) | 2006-05-26 |
| MXPA06012864A (es) | 2007-07-18 |
| JP2007536279A (ja) | 2007-12-13 |
| AU2005244814B2 (en) | 2011-09-15 |
| JP2007536278A (ja) | 2007-12-13 |
| ES2560448T3 (es) | 2016-02-19 |
| AU2005251686A1 (en) | 2005-12-22 |
| EP1750741A1 (en) | 2007-02-14 |
| WO2005112972A1 (en) | 2005-12-01 |
| AU2005244814A1 (en) | 2005-12-01 |
| CA2565819A1 (en) | 2005-12-01 |
| CA2565703A1 (en) | 2005-12-22 |
| EP2508194A1 (en) | 2012-10-10 |
| IL179075A0 (en) | 2007-03-08 |
| RU2410115C2 (ru) | 2011-01-27 |
| RU2006143334A (ru) | 2008-06-20 |
| EP1750742A2 (en) | 2007-02-14 |
| AU2005251686B2 (en) | 2011-09-08 |
| EP1750741B1 (en) | 2015-12-02 |
| JP5495490B2 (ja) | 2014-05-21 |
| JP2012116866A (ja) | 2012-06-21 |
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