NZ551236A - Methods of treating disease with random copolymers - Google Patents

Info

Publication number

NZ551236A

NZ551236A NZ551236A NZ55123605A NZ551236A NZ 551236 A NZ551236 A NZ 551236A NZ 551236 A NZ551236 A NZ 551236A NZ 55123605 A NZ55123605 A NZ 55123605A NZ 551236 A NZ551236 A NZ 551236A

Authority

NZ

New Zealand

Prior art keywords

disease

copolymer

random copolymer

autoimmune

administration

Prior art date

2004-05-07

Links

• Espacenet
• Global Dossier
• Discuss

• 229920005604 random copolymer Polymers 0.000 title claims abstract description 226
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 183
• 201000010099 disease Diseases 0.000 title claims abstract description 158
• 238000000034 method Methods 0.000 title description 109
• 229920001577 copolymer Polymers 0.000 claims abstract description 200
• 239000000203 mixture Substances 0.000 claims abstract description 135
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract description 83
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims abstract description 78
• 229960003767 alanine Drugs 0.000 claims abstract description 68
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims abstract description 61
• 229960004441 tyrosine Drugs 0.000 claims abstract description 53
• 239000004472 Lysine Substances 0.000 claims abstract description 50
• 239000003814 drug Substances 0.000 claims abstract description 38
• QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims abstract description 29
• 125000000539 amino acid group Chemical group 0.000 claims abstract description 29
• QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims abstract description 27
• 235000019766 L-Lysine Nutrition 0.000 claims abstract description 26
• QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims abstract description 24
• 229960003646 lysine Drugs 0.000 claims abstract description 24
• 238000004519 manufacturing process Methods 0.000 claims abstract description 21
• 235000001014 amino acid Nutrition 0.000 claims description 137
• 229940024606 amino acid Drugs 0.000 claims description 129
• 150000001413 amino acids Chemical class 0.000 claims description 121
• 208000023275 Autoimmune disease Diseases 0.000 claims description 55
• 201000006417 multiple sclerosis Diseases 0.000 claims description 54
• 238000011282 treatment Methods 0.000 claims description 53
• 230000003442 weekly effect Effects 0.000 claims description 39
• 235000004279 alanine Nutrition 0.000 claims description 34
• 238000009472 formulation Methods 0.000 claims description 32
• 230000001363 autoimmune Effects 0.000 claims description 29
• 239000007790 solid phase Substances 0.000 claims description 27
• 239000012730 sustained-release form Substances 0.000 claims description 25
• 238000013268 sustained release Methods 0.000 claims description 24
• 210000004027 cell Anatomy 0.000 claims description 23
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 22
• 241000282414 Homo sapiens Species 0.000 claims description 21
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 19
• 239000008194 pharmaceutical composition Substances 0.000 claims description 17
• 208000009329 Graft vs Host Disease Diseases 0.000 claims description 16
• 208000024908 graft versus host disease Diseases 0.000 claims description 16
• 230000001404 mediated effect Effects 0.000 claims description 16
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 14
• -1 L-pbenylalanine Chemical compound 0.000 claims description 12
• 208000000659 Autoimmune lymphoproliferative syndrome Diseases 0.000 claims description 11
• 239000003921 oil Substances 0.000 claims description 10
• 238000012384 transportation and delivery Methods 0.000 claims description 10
• 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 claims description 9
• 230000028993 immune response Effects 0.000 claims description 9
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 8
• 201000004681 Psoriasis Diseases 0.000 claims description 8
• 239000002253 acid Substances 0.000 claims description 8
• 239000003995 emulsifying agent Substances 0.000 claims description 8
• 208000011231 Crohn disease Diseases 0.000 claims description 7
• 206010018364 Glomerulonephritis Diseases 0.000 claims description 7
• 208000003807 Graves Disease Diseases 0.000 claims description 7
• 208000015023 Graves' disease Diseases 0.000 claims description 7
• 208000035895 Guillain-Barré syndrome Diseases 0.000 claims description 7
• 208000030836 Hashimoto thyroiditis Diseases 0.000 claims description 7
• 241000124008 Mammalia Species 0.000 claims description 7
• 206010049567 Miller Fisher syndrome Diseases 0.000 claims description 7
• 206010028665 Myxoedema Diseases 0.000 claims description 7
• 206010039710 Scleroderma Diseases 0.000 claims description 7
• 208000021386 Sjogren Syndrome Diseases 0.000 claims description 7
• 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims description 7
• 206010009887 colitis Diseases 0.000 claims description 7
• 206010028417 myasthenia gravis Diseases 0.000 claims description 7
• 208000003786 myxedema Diseases 0.000 claims description 7
• 208000026872 Addison Disease Diseases 0.000 claims description 6
• 206010003827 Autoimmune hepatitis Diseases 0.000 claims description 6
• 208000007882 Gastritis Diseases 0.000 claims description 6
• 208000024869 Goodpasture syndrome Diseases 0.000 claims description 6
• 208000031220 Hemophilia Diseases 0.000 claims description 6
• 208000009292 Hemophilia A Diseases 0.000 claims description 6
• 208000003250 Mixed connective tissue disease Diseases 0.000 claims description 6
• 206010034277 Pemphigoid Diseases 0.000 claims description 6
• 208000031845 Pernicious anaemia Diseases 0.000 claims description 6
• 230000003367 anti-collagen effect Effects 0.000 claims description 6
• 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims description 6
• 208000000594 bullous pemphigoid Diseases 0.000 claims description 6
• 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims description 6
• 239000000839 emulsion Substances 0.000 claims description 6
• 201000002491 encephalomyelitis Diseases 0.000 claims description 6
• 208000007475 hemolytic anemia Diseases 0.000 claims description 6
• 208000000509 infertility Diseases 0.000 claims description 6
• 230000036512 infertility Effects 0.000 claims description 6
• 231100000535 infertility Toxicity 0.000 claims description 6
• 238000001990 intravenous administration Methods 0.000 claims description 6
• 206010057056 paraneoplastic pemphigus Diseases 0.000 claims description 6
• 229960005190 phenylalanine Drugs 0.000 claims description 6
• 208000005987 polymyositis Diseases 0.000 claims description 6
• 238000007920 subcutaneous administration Methods 0.000 claims description 6
• 208000011580 syndromic disease Diseases 0.000 claims description 6
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 5
• 238000007912 intraperitoneal administration Methods 0.000 claims description 4
• 230000037396 body weight Effects 0.000 claims description 3
• 238000007918 intramuscular administration Methods 0.000 claims description 3
• 239000011859 microparticle Substances 0.000 claims description 3
• 239000002480 mineral oil Substances 0.000 claims description 3
• 235000010446 mineral oil Nutrition 0.000 claims description 3
• 229940037003 alum Drugs 0.000 claims description 2
• 239000000600 sorbitol Substances 0.000 claims description 2
• 239000007762 w/o emulsion Substances 0.000 claims description 2
• 239000008346 aqueous phase Substances 0.000 claims 2
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
• 210000000447 Th1 cell Anatomy 0.000 claims 1
• 239000002260 anti-inflammatory agent Substances 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 230000000052 comparative effect Effects 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 description 89
• 102000004196 processed proteins & peptides Human genes 0.000 description 53
• 229920001184 polypeptide Polymers 0.000 description 39
• 210000001744 T-lymphocyte Anatomy 0.000 description 36
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 29
• 230000027455 binding Effects 0.000 description 28
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 27
• 239000004220 glutamic acid Substances 0.000 description 27
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 26
• 208000035475 disorder Diseases 0.000 description 25
• 235000013922 glutamic acid Nutrition 0.000 description 25
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 24
• 235000002374 tyrosine Nutrition 0.000 description 24
• 102000004127 Cytokines Human genes 0.000 description 23
• 108090000695 Cytokines Proteins 0.000 description 23
• 235000018977 lysine Nutrition 0.000 description 23
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 20
• 208000024891 symptom Diseases 0.000 description 20
• 108700028369 Alleles Proteins 0.000 description 19
• 239000000427 antigen Substances 0.000 description 19
• 108091007433 antigens Proteins 0.000 description 19
• 102000036639 antigens Human genes 0.000 description 19
• 239000003795 chemical substances by application Substances 0.000 description 18
• 150000001875 compounds Chemical class 0.000 description 17
• 230000000694 effects Effects 0.000 description 17
• 101100284398 Bos taurus BoLA-DQB gene Proteins 0.000 description 16
• 229920001897 terpolymer Polymers 0.000 description 16
• 102100029966 HLA class II histocompatibility antigen, DP alpha 1 chain Human genes 0.000 description 15
• 101000864089 Homo sapiens HLA class II histocompatibility antigen, DP alpha 1 chain Proteins 0.000 description 15
• 101000930802 Homo sapiens HLA class II histocompatibility antigen, DQ alpha 1 chain Proteins 0.000 description 15
• 101000968032 Homo sapiens HLA class II histocompatibility antigen, DR beta 3 chain Proteins 0.000 description 15
• 241000699670 Mus sp. Species 0.000 description 15
• 108010058597 HLA-DR Antigens Proteins 0.000 description 14
• 102000006354 HLA-DR Antigens Human genes 0.000 description 14
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 14
• 230000015572 biosynthetic process Effects 0.000 description 14
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 14
• 230000001225 therapeutic effect Effects 0.000 description 14
• 125000003275 alpha amino acid group Chemical group 0.000 description 13
• 229920000642 polymer Polymers 0.000 description 13
• 235000018102 proteins Nutrition 0.000 description 13
• 102000004169 proteins and genes Human genes 0.000 description 13
• 108090000623 proteins and genes Proteins 0.000 description 13
• 235000003704 aspartic acid Nutrition 0.000 description 12
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 12
• 108091054438 MHC class II family Proteins 0.000 description 11
• 230000002757 inflammatory effect Effects 0.000 description 11
• 238000003786 synthesis reaction Methods 0.000 description 11
• 108010062347 HLA-DQ Antigens Proteins 0.000 description 10
• 102000043131 MHC class II family Human genes 0.000 description 10
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 10
• 238000002347 injection Methods 0.000 description 10
• 239000007924 injection Substances 0.000 description 10
• 238000002054 transplantation Methods 0.000 description 10
• 239000004471 Glycine Substances 0.000 description 9
• 108010064578 myelin proteolipid protein (139-151) Proteins 0.000 description 9
• 230000008569 process Effects 0.000 description 9
• 230000004044 response Effects 0.000 description 9
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 9
• 208000015943 Coeliac disease Diseases 0.000 description 8
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 8
• 241001465754 Metazoa Species 0.000 description 8
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 8
• 235000009697 arginine Nutrition 0.000 description 8
• 206010012601 diabetes mellitus Diseases 0.000 description 8
• 230000002093 peripheral effect Effects 0.000 description 8
• 238000012360 testing method Methods 0.000 description 8
• 238000011269 treatment regimen Methods 0.000 description 8
• 239000004475 Arginine Substances 0.000 description 7
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 7
• 102000004877 Insulin Human genes 0.000 description 7
• 108090001061 Insulin Proteins 0.000 description 7
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 7
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 7
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 7
• 239000013543 active substance Substances 0.000 description 7
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 7
• 230000002917 arthritic effect Effects 0.000 description 7
• 210000004369 blood Anatomy 0.000 description 7
• 239000008280 blood Substances 0.000 description 7
• 238000006243 chemical reaction Methods 0.000 description 7
• 230000008878 coupling Effects 0.000 description 7
• 238000010168 coupling process Methods 0.000 description 7
• 238000005859 coupling reaction Methods 0.000 description 7
• 208000033068 episodic angioedema with eosinophilia Diseases 0.000 description 7
• 230000002209 hydrophobic effect Effects 0.000 description 7
• 229940125396 insulin Drugs 0.000 description 7
• 235000019198 oils Nutrition 0.000 description 7
• 230000001717 pathogenic effect Effects 0.000 description 7
• 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 7
• 208000033222 Biliary cirrhosis primary Diseases 0.000 description 6
• 102000000503 Collagen Type II Human genes 0.000 description 6
• 108010041390 Collagen Type II Proteins 0.000 description 6
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
• 208000012654 Primary biliary cholangitis Diseases 0.000 description 6
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 6
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 6
• 230000001594 aberrant effect Effects 0.000 description 6
• 125000001931 aliphatic group Chemical group 0.000 description 6
• 201000004982 autoimmune uveitis Diseases 0.000 description 6
• 210000003719 b-lymphocyte Anatomy 0.000 description 6
• 239000008103 glucose Substances 0.000 description 6
• 230000016784 immunoglobulin production Effects 0.000 description 6
• 230000004054 inflammatory process Effects 0.000 description 6
• 230000004048 modification Effects 0.000 description 6
• 238000012986 modification Methods 0.000 description 6
• 239000000816 peptidomimetic Substances 0.000 description 6
• 239000000243 solution Substances 0.000 description 6
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 5
• KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 5
• 241000282412 Homo Species 0.000 description 5
• 206010020751 Hypersensitivity Diseases 0.000 description 5
• 206010061218 Inflammation Diseases 0.000 description 5
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 5
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 5
• 102000006386 Myelin Proteins Human genes 0.000 description 5
• 108010083674 Myelin Proteins Proteins 0.000 description 5
• 208000026935 allergic disease Diseases 0.000 description 5
• 208000003455 anaphylaxis Diseases 0.000 description 5
• 210000000612 antigen-presenting cell Anatomy 0.000 description 5
• 230000008901 benefit Effects 0.000 description 5
• 239000002775 capsule Substances 0.000 description 5
• 230000001684 chronic effect Effects 0.000 description 5
• 230000006378 damage Effects 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• 230000009610 hypersensitivity Effects 0.000 description 5
• 210000001503 joint Anatomy 0.000 description 5
• 210000002540 macrophage Anatomy 0.000 description 5
• 229930182817 methionine Natural products 0.000 description 5
• 210000000056 organ Anatomy 0.000 description 5
• 238000002360 preparation method Methods 0.000 description 5
• 239000000126 substance Substances 0.000 description 5
• 230000009885 systemic effect Effects 0.000 description 5
• 238000002255 vaccination Methods 0.000 description 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 4
• 208000016192 Demyelinating disease Diseases 0.000 description 4
• 101001100327 Homo sapiens RNA-binding protein 45 Proteins 0.000 description 4
• 102000003816 Interleukin-13 Human genes 0.000 description 4
• 108090000176 Interleukin-13 Proteins 0.000 description 4
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 4
• 241000699666 Mus <mouse, genus> Species 0.000 description 4
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 4
• 102100038823 RNA-binding protein 45 Human genes 0.000 description 4
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 4
• 206010003246 arthritis Diseases 0.000 description 4
• 239000003153 chemical reaction reagent Substances 0.000 description 4
• 238000012217 deletion Methods 0.000 description 4
• 230000037430 deletion Effects 0.000 description 4
• 238000011161 development Methods 0.000 description 4
• 230000018109 developmental process Effects 0.000 description 4
• 239000003937 drug carrier Substances 0.000 description 4
• 229960002989 glutamic acid Drugs 0.000 description 4
• 238000001802 infusion Methods 0.000 description 4
• 239000004615 ingredient Substances 0.000 description 4
• 230000002401 inhibitory effect Effects 0.000 description 4
• 210000004153 islets of langerhan Anatomy 0.000 description 4
• 229960000310 isoleucine Drugs 0.000 description 4
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 4
• 239000000178 monomer Substances 0.000 description 4
• 210000005012 myelin Anatomy 0.000 description 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
• 239000002904 solvent Substances 0.000 description 4
• 239000003826 tablet Substances 0.000 description 4
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
• 229940124597 therapeutic agent Drugs 0.000 description 4
• 210000001541 thymus gland Anatomy 0.000 description 4
• 102000003390 tumor necrosis factor Human genes 0.000 description 4
• 239000004474 valine Substances 0.000 description 4
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 206010002199 Anaphylactic shock Diseases 0.000 description 3
• 206010003591 Ataxia Diseases 0.000 description 3
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 3
• 108010036949 Cyclosporine Proteins 0.000 description 3
• 150000008574 D-amino acids Chemical class 0.000 description 3
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
• 108010061711 Gliadin Proteins 0.000 description 3
• 108091022930 Glutamate decarboxylase Proteins 0.000 description 3
• 102000004388 Interleukin-4 Human genes 0.000 description 3
• 108090000978 Interleukin-4 Proteins 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 3
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 3
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 3
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
• 102000018697 Membrane Proteins Human genes 0.000 description 3
• 108010052285 Membrane Proteins Proteins 0.000 description 3
• 108091005804 Peptidases Proteins 0.000 description 3
• 108010081690 Pertussis Toxin Proteins 0.000 description 3
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 3
• 239000004365 Protease Substances 0.000 description 3
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 3
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
• 239000004473 Threonine Substances 0.000 description 3
• 230000002378 acidificating effect Effects 0.000 description 3
• 230000001154 acute effect Effects 0.000 description 3
• 230000003110 anti-inflammatory effect Effects 0.000 description 3
• 125000004429 atom Chemical group 0.000 description 3
• 208000010928 autoimmune thyroid disease Diseases 0.000 description 3
• 210000001185 bone marrow Anatomy 0.000 description 3
• 238000010322 bone marrow transplantation Methods 0.000 description 3
• 229960001265 ciclosporin Drugs 0.000 description 3
• 238000013270 controlled release Methods 0.000 description 3
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
• 235000018417 cysteine Nutrition 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 230000003210 demyelinating effect Effects 0.000 description 3
• 230000001419 dependent effect Effects 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• 230000008030 elimination Effects 0.000 description 3
• 238000003379 elimination reaction Methods 0.000 description 3
• 239000002532 enzyme inhibitor Substances 0.000 description 3
• 229940125532 enzyme inhibitor Drugs 0.000 description 3
• 239000012634 fragment Substances 0.000 description 3
• 239000003862 glucocorticoid Substances 0.000 description 3
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
• 210000002216 heart Anatomy 0.000 description 3
• 210000002443 helper t lymphocyte Anatomy 0.000 description 3
• 230000001939 inductive effect Effects 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 229960000485 methotrexate Drugs 0.000 description 3
• 210000000496 pancreas Anatomy 0.000 description 3
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 3
• 230000001766 physiological effect Effects 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 230000002265 prevention Effects 0.000 description 3
• 230000000750 progressive effect Effects 0.000 description 3
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 3
• 230000000069 prophylactic effect Effects 0.000 description 3
• 230000001681 protective effect Effects 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 230000001105 regulatory effect Effects 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 238000010254 subcutaneous injection Methods 0.000 description 3
• 239000007929 subcutaneous injection Substances 0.000 description 3
• 239000000375 suspending agent Substances 0.000 description 3
• 239000000725 suspension Substances 0.000 description 3
• 230000000699 topical effect Effects 0.000 description 3
• 239000003981 vehicle Substances 0.000 description 3
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
• QWXZOFZKSQXPDC-NSHDSACASA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)propanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](C)C(O)=O)C3=CC=CC=C3C2=C1 QWXZOFZKSQXPDC-NSHDSACASA-N 0.000 description 2
• YRKFMPDOFHQWPI-IBGZPJMESA-N (2s)-6-azaniumyl-2-(9h-fluoren-9-ylmethoxycarbonylamino)hexanoate Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCCCN)C(O)=O)C3=CC=CC=C3C2=C1 YRKFMPDOFHQWPI-IBGZPJMESA-N 0.000 description 2
• 239000005541 ACE inhibitor Substances 0.000 description 2
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
• 208000024827 Alzheimer disease Diseases 0.000 description 2
• 206010002198 Anaphylactic reaction Diseases 0.000 description 2
• 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 2
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 2
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 2
• 206010010099 Combined immunodeficiency Diseases 0.000 description 2
• 229940122204 Cyclooxygenase inhibitor Drugs 0.000 description 2
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
• 229930105110 Cyclosporin A Natural products 0.000 description 2
• 206010012305 Demyelination Diseases 0.000 description 2
• ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 2
• 102000004190 Enzymes Human genes 0.000 description 2
• 108090000790 Enzymes Proteins 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
• 229920003136 Eudragit® L polymer Polymers 0.000 description 2
• 229920003137 Eudragit® S polymer Polymers 0.000 description 2
• 101150064015 FAS gene Proteins 0.000 description 2
• 108010072051 Glatiramer Acetate Proteins 0.000 description 2
• 208000010412 Glaucoma Diseases 0.000 description 2
• 108010046732 HLA-DR4 Antigen Proteins 0.000 description 2
• 206010019280 Heart failures Diseases 0.000 description 2
• 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 2
• 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 2
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
• 208000001718 Immediate Hypersensitivity Diseases 0.000 description 2
• 102000003814 Interleukin-10 Human genes 0.000 description 2
• 108090000174 Interleukin-10 Proteins 0.000 description 2
• 150000008575 L-amino acids Chemical class 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 208000004155 Malabsorption Syndromes Diseases 0.000 description 2
• 101000909851 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) cAMP/cGMP dual specificity phosphodiesterase Rv0805 Proteins 0.000 description 2
• 102000047918 Myelin Basic Human genes 0.000 description 2
• 101710107068 Myelin basic protein Proteins 0.000 description 2
• 102000017099 Myelin-Associated Glycoprotein Human genes 0.000 description 2
• 108010013731 Myelin-Associated Glycoprotein Proteins 0.000 description 2
• 102000002233 Myelin-Oligodendrocyte Glycoprotein Human genes 0.000 description 2
• 108010000123 Myelin-Oligodendrocyte Glycoprotein Proteins 0.000 description 2
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 2
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
• 206010030113 Oedema Diseases 0.000 description 2
• 208000003435 Optic Neuritis Diseases 0.000 description 2
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
• 206010040070 Septic Shock Diseases 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 230000005867 T cell response Effects 0.000 description 2
• 210000004241 Th2 cell Anatomy 0.000 description 2
• 206010045240 Type I hypersensitivity Diseases 0.000 description 2
• 239000003875 Wang resin Substances 0.000 description 2
• LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 2
• NERFNHBZJXXFGY-UHFFFAOYSA-N [4-[(4-methylphenyl)methoxy]phenyl]methanol Chemical compound C1=CC(C)=CC=C1COC1=CC=C(CO)C=C1 NERFNHBZJXXFGY-UHFFFAOYSA-N 0.000 description 2
• FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 230000009471 action Effects 0.000 description 2
• 230000006786 activation induced cell death Effects 0.000 description 2
• 239000002671 adjuvant Substances 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• 150000003862 amino acid derivatives Chemical class 0.000 description 2
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 2
• 230000036783 anaphylactic response Effects 0.000 description 2
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 239000000883 anti-obesity agent Substances 0.000 description 2
• 230000030741 antigen processing and presentation Effects 0.000 description 2
• 239000003443 antiviral agent Substances 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 125000003118 aryl group Chemical group 0.000 description 2
• 208000010216 atopic IgE responsiveness Diseases 0.000 description 2
• 230000006470 autoimmune attack Effects 0.000 description 2
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 238000009833 condensation Methods 0.000 description 2
• 230000005494 condensation Effects 0.000 description 2
• 239000000470 constituent Substances 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• 229960004397 cyclophosphamide Drugs 0.000 description 2
• 229930182912 cyclosporin Natural products 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• 230000007850 degeneration Effects 0.000 description 2
• 235000005911 diet Nutrition 0.000 description 2
• 235000014113 dietary fatty acids Nutrition 0.000 description 2
• 239000000539 dimer Substances 0.000 description 2
• 230000006806 disease prevention Effects 0.000 description 2
• 239000002552 dosage form Substances 0.000 description 2
• 239000002702 enteric coating Substances 0.000 description 2
• 238000009505 enteric coating Methods 0.000 description 2
• 239000000194 fatty acid Substances 0.000 description 2
• 229930195729 fatty acid Natural products 0.000 description 2
• 150000004665 fatty acids Chemical class 0.000 description 2
• 239000000945 filler Substances 0.000 description 2
• 230000002068 genetic effect Effects 0.000 description 2
• 102000054766 genetic haplotypes Human genes 0.000 description 2
• 229960003776 glatiramer acetate Drugs 0.000 description 2
• 108010050792 glutenin Proteins 0.000 description 2
• 208000003532 hypothyroidism Diseases 0.000 description 2
• 230000002989 hypothyroidism Effects 0.000 description 2
• 230000002163 immunogen Effects 0.000 description 2
• 239000003018 immunosuppressive agent Substances 0.000 description 2
• 239000007943 implant Substances 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 208000027866 inflammatory disease Diseases 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• 208000014674 injury Diseases 0.000 description 2
• 230000003993 interaction Effects 0.000 description 2
• 230000018711 interleukin-13 production Effects 0.000 description 2
• 238000010253 intravenous injection Methods 0.000 description 2
• 208000028867 ischemia Diseases 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 239000002502 liposome Substances 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 230000014759 maintenance of location Effects 0.000 description 2
• 239000000463 material Substances 0.000 description 2
• 230000000116 mitigating effect Effects 0.000 description 2
• 238000012544 monitoring process Methods 0.000 description 2
• 210000003205 muscle Anatomy 0.000 description 2
• 208000010125 myocardial infarction Diseases 0.000 description 2
• 201000001119 neuropathy Diseases 0.000 description 2
• 230000007823 neuropathy Effects 0.000 description 2
• AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 2
• 238000004806 packaging method and process Methods 0.000 description 2
• 230000001575 pathological effect Effects 0.000 description 2
• 229940124531 pharmaceutical excipient Drugs 0.000 description 2
• 239000000825 pharmaceutical preparation Substances 0.000 description 2
• 230000026731 phosphorylation Effects 0.000 description 2
• 238000006366 phosphorylation reaction Methods 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2
• 238000011321 prophylaxis Methods 0.000 description 2
• 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 2
• 125000006239 protecting group Chemical group 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 239000011347 resin Substances 0.000 description 2
• 229920005989 resin Polymers 0.000 description 2
• 210000002966 serum Anatomy 0.000 description 2
• 208000002491 severe combined immunodeficiency Diseases 0.000 description 2
• 230000011664 signaling Effects 0.000 description 2
• 210000003491 skin Anatomy 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 238000010532 solid phase synthesis reaction Methods 0.000 description 2
• 235000011067 sorbitan monolaureate Nutrition 0.000 description 2
• 210000000952 spleen Anatomy 0.000 description 2
• 210000004988 splenocyte Anatomy 0.000 description 2
• 230000003637 steroidlike Effects 0.000 description 2
• 150000003431 steroids Chemical class 0.000 description 2
• 238000003860 storage Methods 0.000 description 2
• 238000001356 surgical procedure Methods 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• 230000002194 synthesizing effect Effects 0.000 description 2
• 229940037128 systemic glucocorticoids Drugs 0.000 description 2
• 238000002560 therapeutic procedure Methods 0.000 description 2
• 210000001519 tissue Anatomy 0.000 description 2
• 230000008733 trauma Effects 0.000 description 2
• 230000005951 type IV hypersensitivity Effects 0.000 description 2
• 208000027930 type IV hypersensitivity disease Diseases 0.000 description 2
• 229960005486 vaccine Drugs 0.000 description 2
• 239000001993 wax Substances 0.000 description 2
• 208000016261 weight loss Diseases 0.000 description 2
• 230000004580 weight loss Effects 0.000 description 2
• FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 description 1
• QEPWHIXHJNNGLU-KRWDZBQOSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCC(=O)O)C(O)=O)C3=CC=CC=C3C2=C1 QEPWHIXHJNNGLU-KRWDZBQOSA-N 0.000 description 1
• BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 description 1
• HFZKKJHBHCZXTQ-SNVBAGLBSA-N (4r)-4-azaniumyl-5-oxo-5-phenylmethoxypentanoate Chemical compound OC(=O)CC[C@@H](N)C(=O)OCC1=CC=CC=C1 HFZKKJHBHCZXTQ-SNVBAGLBSA-N 0.000 description 1
• METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 1
• 108010019911 (T,G)-A-L Proteins 0.000 description 1
• DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
• IQFYYKKMVGJFEH-OFKYTIFKSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO[3H])O[C@H]1N1C(=O)NC(=O)C(C)=C1 IQFYYKKMVGJFEH-OFKYTIFKSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• SGUAFYQXFOLMHL-UHFFFAOYSA-N 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide Chemical compound C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 SGUAFYQXFOLMHL-UHFFFAOYSA-N 0.000 description 1
• ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 description 1
• XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
• 208000023761 AL amyloidosis Diseases 0.000 description 1
• 206010000599 Acromegaly Diseases 0.000 description 1
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
• 201000011452 Adrenoleukodystrophy Diseases 0.000 description 1
• 208000018126 Adrenomyeloneuropathy Diseases 0.000 description 1
• 235000019489 Almond oil Nutrition 0.000 description 1
• 208000000044 Amnesia Diseases 0.000 description 1
• 208000031091 Amnestic disease Diseases 0.000 description 1
• 208000003808 Amyloid Neuropathies Diseases 0.000 description 1
• 206010002329 Aneurysm Diseases 0.000 description 1
• 208000019901 Anxiety disease Diseases 0.000 description 1
• 208000032467 Aplastic anaemia Diseases 0.000 description 1
• 108010039627 Aprotinin Proteins 0.000 description 1
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
• 206010003694 Atrophy Diseases 0.000 description 1
• 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
• 235000007319 Avena orientalis Nutrition 0.000 description 1
• 244000075850 Avena orientalis Species 0.000 description 1
• 208000000412 Avitaminosis Diseases 0.000 description 1
• 208000037157 Azotemia Diseases 0.000 description 1
• 208000009137 Behcet syndrome Diseases 0.000 description 1
• XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 description 1
• 206010004659 Biliary cirrhosis Diseases 0.000 description 1
• 201000006474 Brain Ischemia Diseases 0.000 description 1
• 229940124802 CB1 antagonist Drugs 0.000 description 1
• 108010041397 CD4 Antigens Proteins 0.000 description 1
• 201000002829 CREST Syndrome Diseases 0.000 description 1
• 206010006895 Cachexia Diseases 0.000 description 1
• 206010007509 Cardiac amyloidosis Diseases 0.000 description 1
• 206010007559 Cardiac failure congestive Diseases 0.000 description 1
• 206010048610 Cardiotoxicity Diseases 0.000 description 1
• 229940122805 Cathepsin S inhibitor Drugs 0.000 description 1
• 206010008120 Cerebral ischaemia Diseases 0.000 description 1
• 102000019034 Chemokines Human genes 0.000 description 1
• 108010012236 Chemokines Proteins 0.000 description 1
• 108010009685 Cholinergic Receptors Proteins 0.000 description 1
• 208000018652 Closed Head injury Diseases 0.000 description 1
• 206010010356 Congenital anomaly Diseases 0.000 description 1
• 206010010904 Convulsion Diseases 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
• 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
• 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• FDKWRPBBCBCIGA-UWTATZPHSA-N D-Selenocysteine Natural products [Se]C[C@@H](N)C(O)=O FDKWRPBBCBCIGA-UWTATZPHSA-N 0.000 description 1
• OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 description 1
• 206010011968 Decreased immune responsiveness Diseases 0.000 description 1
• 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
• 201000004624 Dermatitis Diseases 0.000 description 1
• 206010012438 Dermatitis atopic Diseases 0.000 description 1
• 206010012468 Dermatitis herpetiformis Diseases 0.000 description 1
• 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 1
• 108010016626 Dipeptides Proteins 0.000 description 1
• 208000003164 Diplopia Diseases 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• 206010013887 Dysarthria Diseases 0.000 description 1
• 238000002965 ELISA Methods 0.000 description 1
• 239000004097 EU approved flavor enhancer Substances 0.000 description 1
• 108010061435 Enalapril Proteins 0.000 description 1
• 241000792859 Enema Species 0.000 description 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
• 229920003134 Eudragit® polymer Polymers 0.000 description 1
• 241000035300 Euphorbia polyacantha Species 0.000 description 1
• 208000024720 Fabry Disease Diseases 0.000 description 1
• 102000015212 Fas Ligand Protein Human genes 0.000 description 1
• 108010039471 Fas Ligand Protein Proteins 0.000 description 1
• 208000028387 Felty syndrome Diseases 0.000 description 1
• 206010016654 Fibrosis Diseases 0.000 description 1
• 208000024412 Friedreich ataxia Diseases 0.000 description 1
• 206010017711 Gangrene Diseases 0.000 description 1
• 208000018522 Gastrointestinal disease Diseases 0.000 description 1
• 208000015872 Gaucher disease Diseases 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
• 208000009119 Giant Axonal Neuropathy Diseases 0.000 description 1
• 208000003433 Gingival Pocket Diseases 0.000 description 1
• 102000008214 Glutamate decarboxylase Human genes 0.000 description 1
• 108010068370 Glutens Proteins 0.000 description 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
• 208000023329 Gun shot wound Diseases 0.000 description 1
• 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 description 1
• 108010010378 HLA-DP Antigens Proteins 0.000 description 1
• 102000015789 HLA-DP Antigens Human genes 0.000 description 1
• 108010065026 HLA-DQB1 antigen Proteins 0.000 description 1
• 108010051539 HLA-DR2 Antigen Proteins 0.000 description 1
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
• 208000010496 Heart Arrest Diseases 0.000 description 1
• 208000013875 Heart injury Diseases 0.000 description 1
• 208000032456 Hemorrhagic Shock Diseases 0.000 description 1
• 208000016988 Hemorrhagic Stroke Diseases 0.000 description 1
• 101000591210 Homo sapiens Receptor-type tyrosine-protein phosphatase-like N Proteins 0.000 description 1
• 240000005979 Hordeum vulgare Species 0.000 description 1
• 235000007340 Hordeum vulgare Nutrition 0.000 description 1
• 208000023105 Huntington disease Diseases 0.000 description 1
• 208000004454 Hyperalgesia Diseases 0.000 description 1
• 208000035154 Hyperesthesia Diseases 0.000 description 1
• 208000013016 Hypoglycemia Diseases 0.000 description 1
• 206010021135 Hypovitaminosis Diseases 0.000 description 1
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
• 208000010159 IgA glomerulonephritis Diseases 0.000 description 1
• 206010021263 IgA nephropathy Diseases 0.000 description 1
• 208000024781 Immune Complex disease Diseases 0.000 description 1
• 208000028622 Immune thrombocytopenia Diseases 0.000 description 1
• 108060003951 Immunoglobulin Proteins 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 208000005531 Immunoglobulin Light-chain Amyloidosis Diseases 0.000 description 1
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
• 108010005716 Interferon beta-1a Proteins 0.000 description 1
• 102000008070 Interferon-gamma Human genes 0.000 description 1
• 108010074328 Interferon-gamma Proteins 0.000 description 1
• 108010002350 Interleukin-2 Proteins 0.000 description 1
• 108010002616 Interleukin-5 Proteins 0.000 description 1
• 102000000743 Interleukin-5 Human genes 0.000 description 1
• 102000004889 Interleukin-6 Human genes 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 108090001007 Interleukin-8 Proteins 0.000 description 1
• 102000004890 Interleukin-8 Human genes 0.000 description 1
• 102000015696 Interleukins Human genes 0.000 description 1
• 108010063738 Interleukins Proteins 0.000 description 1
• 208000003618 Intervertebral Disc Displacement Diseases 0.000 description 1
• 206010050296 Intervertebral disc protrusion Diseases 0.000 description 1
• 208000032382 Ischaemic stroke Diseases 0.000 description 1
• UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
• 208000012659 Joint disease Diseases 0.000 description 1
• 208000003456 Juvenile Arthritis Diseases 0.000 description 1
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 1
• LOOZZTFGSTZNRX-VIFPVBQESA-N L-Homotyrosine Chemical group OC(=O)[C@@H](N)CCC1=CC=C(O)C=C1 LOOZZTFGSTZNRX-VIFPVBQESA-N 0.000 description 1
• RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
• 229930195714 L-glutamate Natural products 0.000 description 1
• 240000007472 Leucaena leucocephala Species 0.000 description 1
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
• 229940127470 Lipase Inhibitors Drugs 0.000 description 1
• 108010007859 Lisinopril Proteins 0.000 description 1
• 208000008771 Lymphadenopathy Diseases 0.000 description 1
• 235000019759 Maize starch Nutrition 0.000 description 1
• 206010025476 Malabsorption Diseases 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• UWWDHYUMIORJTA-HSQYWUDLSA-N Moexipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC(OC)=C(OC)C=C2C1)C(O)=O)CC1=CC=CC=C1 UWWDHYUMIORJTA-HSQYWUDLSA-N 0.000 description 1
• 208000008238 Muscle Spasticity Diseases 0.000 description 1
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 1
• RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
• 206010028851 Necrosis Diseases 0.000 description 1
• 206010028980 Neoplasm Diseases 0.000 description 1
• 208000001738 Nervous System Trauma Diseases 0.000 description 1
• 206010029240 Neuritis Diseases 0.000 description 1
• 208000011623 Obstructive Lung disease Diseases 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 206010061323 Optic neuropathy Diseases 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• 206010033799 Paralysis Diseases 0.000 description 1
• 208000030852 Parasitic disease Diseases 0.000 description 1
• 208000018737 Parkinson disease Diseases 0.000 description 1
• 208000037273 Pathologic Processes Diseases 0.000 description 1
• 201000011152 Pemphigus Diseases 0.000 description 1
• 241000721454 Pemphigus Species 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 206010034620 Peripheral sensory neuropathy Diseases 0.000 description 1
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
• 206010036030 Polyarthritis Diseases 0.000 description 1
• 206010065159 Polychondritis Diseases 0.000 description 1
• 206010036105 Polyneuropathy Diseases 0.000 description 1
• 241000097929 Porphyria Species 0.000 description 1
• 208000010642 Porphyrias Diseases 0.000 description 1
• 208000034943 Primary Sjögren syndrome Diseases 0.000 description 1
• 206010036673 Primary amyloidosis Diseases 0.000 description 1
• 208000024777 Prion disease Diseases 0.000 description 1
• 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
• KNAHARQHSZJURB-UHFFFAOYSA-N Propylthiouracile Chemical compound CCCC1=CC(=O)NC(=S)N1 KNAHARQHSZJURB-UHFFFAOYSA-N 0.000 description 1
• 108010029485 Protein Isoforms Proteins 0.000 description 1
• 102000001708 Protein Isoforms Human genes 0.000 description 1
• 108010010974 Proteolipids Proteins 0.000 description 1
• 102000016202 Proteolipids Human genes 0.000 description 1
• 208000028017 Psychotic disease Diseases 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 208000005587 Refsum Disease Diseases 0.000 description 1
• 206010063837 Reperfusion injury Diseases 0.000 description 1
• 235000019485 Safflower oil Nutrition 0.000 description 1
• 206010039966 Senile dementia Diseases 0.000 description 1
• 206010040030 Sensory loss Diseases 0.000 description 1
• 201000001880 Sexual dysfunction Diseases 0.000 description 1
• 206010049771 Shock haemorrhagic Diseases 0.000 description 1
• 208000032023 Signs and Symptoms Diseases 0.000 description 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
• 206010041660 Splenomegaly Diseases 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 206010041969 Steatorrhoea Diseases 0.000 description 1
• 208000004732 Systemic Vasculitis Diseases 0.000 description 1
• 230000006044 T cell activation Effects 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 208000001871 Tachycardia Diseases 0.000 description 1
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 1
• 208000002903 Thalassemia Diseases 0.000 description 1
• 244000299461 Theobroma cacao Species 0.000 description 1
• 235000009470 Theobroma cacao Nutrition 0.000 description 1
• 201000008982 Thoracic Aortic Aneurysm Diseases 0.000 description 1
• 208000010641 Tooth disease Diseases 0.000 description 1
• 206010044248 Toxic shock syndrome Diseases 0.000 description 1
• 231100000650 Toxic shock syndrome Toxicity 0.000 description 1
• VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 description 1
• 206010052779 Transplant rejections Diseases 0.000 description 1
• 206010044565 Tremor Diseases 0.000 description 1
• 235000021307 Triticum Nutrition 0.000 description 1
• 244000098338 Triticum aestivum Species 0.000 description 1
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
• 206010054094 Tumour necrosis Diseases 0.000 description 1
• 206010054000 Type II hypersensitivity Diseases 0.000 description 1
• 206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 1
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
• 206010046851 Uveitis Diseases 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 208000036142 Viral infection Diseases 0.000 description 1
• 102000007624 ZAP-70 Protein-Tyrosine Kinase Human genes 0.000 description 1
• 108010046882 ZAP-70 Protein-Tyrosine Kinase Proteins 0.000 description 1
• UWAOJIWUVCMBAZ-UHFFFAOYSA-N [1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-dimethylazanium;chloride Chemical compound Cl.C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UWAOJIWUVCMBAZ-UHFFFAOYSA-N 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• 229960002122 acebutolol Drugs 0.000 description 1
• GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 description 1
• 102000034337 acetylcholine receptors Human genes 0.000 description 1
• 229960001138 acetylsalicylic acid Drugs 0.000 description 1
• 229960004150 aciclovir Drugs 0.000 description 1
• MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
• 238000005903 acid hydrolysis reaction Methods 0.000 description 1
• 208000017733 acquired polycythemia vera Diseases 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 208000002552 acute disseminated encephalomyelitis Diseases 0.000 description 1
• 230000009798 acute exacerbation Effects 0.000 description 1
• 208000018254 acute transverse myelitis Diseases 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 108010013985 adhesion receptor Proteins 0.000 description 1
• 102000019997 adhesion receptor Human genes 0.000 description 1
• 208000030597 adult Refsum disease Diseases 0.000 description 1
• 239000000556 agonist Substances 0.000 description 1
• 230000000735 allogeneic effect Effects 0.000 description 1
• 239000008168 almond oil Substances 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 230000006986 amnesia Effects 0.000 description 1
• LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
• 229960003022 amoxicillin Drugs 0.000 description 1
• 239000003708 ampul Substances 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 208000007502 anemia Diseases 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• 230000001772 anti-angiogenic effect Effects 0.000 description 1
• 229940124599 anti-inflammatory drug Drugs 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 230000005875 antibody response Effects 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 239000002220 antihypertensive agent Substances 0.000 description 1
• 229940127088 antihypertensive drug Drugs 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 229940030999 antipsoriatics Drugs 0.000 description 1
• 230000036506 anxiety Effects 0.000 description 1
• 208000007474 aortic aneurysm Diseases 0.000 description 1
• 230000006907 apoptotic process Effects 0.000 description 1
• 239000002830 appetite depressant Substances 0.000 description 1
• 229960004405 aprotinin Drugs 0.000 description 1
• 239000012062 aqueous buffer Substances 0.000 description 1
• 239000008135 aqueous vehicle Substances 0.000 description 1
• 150000001484 arginines Chemical class 0.000 description 1
• 210000001188 articular cartilage Anatomy 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• 230000001977 ataxic effect Effects 0.000 description 1
• 229960002274 atenolol Drugs 0.000 description 1
• 201000008937 atopic dermatitis Diseases 0.000 description 1
• 230000037444 atrophy Effects 0.000 description 1
• 208000006424 autoimmune oophoritis Diseases 0.000 description 1
• 230000006472 autoimmune response Effects 0.000 description 1
• 230000002567 autonomic effect Effects 0.000 description 1
• 229940003504 avonex Drugs 0.000 description 1
• 229960002170 azathioprine Drugs 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 229960004530 benazepril Drugs 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 229940049706 benzodiazepine Drugs 0.000 description 1
• 150000001557 benzodiazepines Chemical class 0.000 description 1
• 210000000941 bile Anatomy 0.000 description 1
• 229920000080 bile acid sequestrant Polymers 0.000 description 1
• 229940096699 bile acid sequestrants Drugs 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 229960002685 biotin Drugs 0.000 description 1
• 235000020958 biotin Nutrition 0.000 description 1
• 239000011616 biotin Substances 0.000 description 1
• 229960002781 bisoprolol Drugs 0.000 description 1
• VHYCDWMUTMEGQY-UHFFFAOYSA-N bisoprolol Chemical compound CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1 VHYCDWMUTMEGQY-UHFFFAOYSA-N 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 230000036760 body temperature Effects 0.000 description 1
• 230000036471 bradycardia Effects 0.000 description 1
• 208000006218 bradycardia Diseases 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 208000029028 brain injury Diseases 0.000 description 1
• 244000309464 bull Species 0.000 description 1
• 235000014121 butter Nutrition 0.000 description 1
• FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
• 239000000828 canola oil Substances 0.000 description 1
• 235000019519 canola oil Nutrition 0.000 description 1
• 229960000830 captopril Drugs 0.000 description 1
• FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 229910002092 carbon dioxide Inorganic materials 0.000 description 1
• 229960004424 carbon dioxide Drugs 0.000 description 1
• 230000003683 cardiac damage Effects 0.000 description 1
• 206010007625 cardiogenic shock Diseases 0.000 description 1
• 231100000259 cardiotoxicity Toxicity 0.000 description 1
• NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 description 1
• 229960004195 carvedilol Drugs 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 230000021164 cell adhesion Effects 0.000 description 1
• 230000003915 cell function Effects 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 235000010980 cellulose Nutrition 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 239000004464 cereal grain Substances 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 206010008118 cerebral infarction Diseases 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 230000003399 chemotactic effect Effects 0.000 description 1
• FLASNYPZGWUPSU-SICDJOISSA-N chitosan Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)N)O[C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)N)O[C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)N)O[C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)N)O[C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)N)O[C@H]1[C@H](O)[C@H]([C@@H](O[C@@H]1CO)O[C@@H]1[C@H](O[C@@H](O[C@@H]2[C@H](O[C@@H](O)[C@H](N)[C@H]2O)CO)[C@H](N)[C@H]1O)CO)NC(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1N FLASNYPZGWUPSU-SICDJOISSA-N 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 208000037976 chronic inflammation Diseases 0.000 description 1
• 230000006020 chronic inflammation Effects 0.000 description 1
• 230000012085 chronic inflammatory response Effects 0.000 description 1
• 230000007882 cirrhosis Effects 0.000 description 1
• 208000019425 cirrhosis of liver Diseases 0.000 description 1
• 235000013477 citrulline Nutrition 0.000 description 1
• 229960002173 citrulline Drugs 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 238000012875 competitive assay Methods 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 230000003750 conditioning effect Effects 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 235000005687 corn oil Nutrition 0.000 description 1
• 239000002285 corn oil Substances 0.000 description 1
• 229960000258 corticotropin Drugs 0.000 description 1
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
• 229940111134 coxibs Drugs 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 108010057085 cytokine receptors Proteins 0.000 description 1
• 102000003675 cytokine receptors Human genes 0.000 description 1
• 231100000433 cytotoxic Toxicity 0.000 description 1
• 230000001472 cytotoxic effect Effects 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 230000006735 deficit Effects 0.000 description 1
• 230000003412 degenerative effect Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000006866 deterioration Effects 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 235000019700 dicalcium phosphate Nutrition 0.000 description 1
• 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• 230000000378 dietary effect Effects 0.000 description 1
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 239000007884 disintegrant Substances 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 239000002612 dispersion medium Substances 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• 208000002173 dizziness Diseases 0.000 description 1
• ZITKDVFRMRXIJQ-UHFFFAOYSA-N dodecane-1,2-diol Chemical compound CCCCCCCCCCC(O)CO ZITKDVFRMRXIJQ-UHFFFAOYSA-N 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 229940126534 drug product Drugs 0.000 description 1
• 239000008157 edible vegetable oil Substances 0.000 description 1
• 230000004406 elevated intraocular pressure Effects 0.000 description 1
• 229960000873 enalapril Drugs 0.000 description 1
• GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 1
• 239000007920 enema Substances 0.000 description 1
• 229940079360 enema for constipation Drugs 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 230000007071 enzymatic hydrolysis Effects 0.000 description 1
• 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
• 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 1
• 206010015037 epilepsy Diseases 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• 229960003276 erythromycin Drugs 0.000 description 1
• 229960003745 esmolol Drugs 0.000 description 1
• AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 201000005884 exanthem Diseases 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
• 239000003889 eye drop Substances 0.000 description 1
• 229940012356 eye drops Drugs 0.000 description 1
• 208000027993 eye symptom Diseases 0.000 description 1
• 210000000256 facial nerve Anatomy 0.000 description 1
• 208000003457 familial thoracic 1 aortic aneurysm Diseases 0.000 description 1
• 239000003925 fat Substances 0.000 description 1
• 235000019197 fats Nutrition 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 229940125753 fibrate Drugs 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 235000019264 food flavour enhancer Nutrition 0.000 description 1
• 229960002490 fosinopril Drugs 0.000 description 1
• 125000000524 functional group Chemical group 0.000 description 1
• 125000001965 gamma-lactamyl group Chemical group 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 230000030279 gene silencing Effects 0.000 description 1
• 235000021312 gluten Nutrition 0.000 description 1
• 125000005456 glyceride group Chemical group 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 230000003394 haemopoietic effect Effects 0.000 description 1
• 150000004820 halides Chemical group 0.000 description 1
• 229920000140 heteropolymer Polymers 0.000 description 1
• 239000013628 high molecular weight specie Substances 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
• 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
• 230000002218 hypoglycaemic effect Effects 0.000 description 1
• 229960001680 ibuprofen Drugs 0.000 description 1
• 230000002519 immonomodulatory effect Effects 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 102000018358 immunoglobulin Human genes 0.000 description 1
• 229940125721 immunosuppressive agent Drugs 0.000 description 1
• 229940124589 immunosuppressive drug Drugs 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 230000008595 infiltration Effects 0.000 description 1
• 238000001764 infiltration Methods 0.000 description 1
• 230000010365 information processing Effects 0.000 description 1
• ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
• 239000003999 initiator Substances 0.000 description 1
• 229960003130 interferon gamma Drugs 0.000 description 1
• 229940076144 interleukin-10 Drugs 0.000 description 1
• 229940028885 interleukin-4 Drugs 0.000 description 1
• 229940100601 interleukin-6 Drugs 0.000 description 1
• 229940096397 interleukin-8 Drugs 0.000 description 1
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 1
• 229940047122 interleukins Drugs 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 208000020658 intracerebral hemorrhage Diseases 0.000 description 1
• 210000003228 intrahepatic bile duct Anatomy 0.000 description 1
• 238000010255 intramuscular injection Methods 0.000 description 1
• 239000007927 intramuscular injection Substances 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 208000037906 ischaemic injury Diseases 0.000 description 1
• 208000012947 ischemia reperfusion injury Diseases 0.000 description 1
• 208000018937 joint inflammation Diseases 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• 210000003127 knee Anatomy 0.000 description 1
• 229960001632 labetalol Drugs 0.000 description 1
• 230000002045 lasting effect Effects 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 229960004194 lidocaine Drugs 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 229920005684 linear copolymer Polymers 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 229960002394 lisinopril Drugs 0.000 description 1
• RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 239000003589 local anesthetic agent Substances 0.000 description 1
• 230000005923 long-lasting effect Effects 0.000 description 1
• 231100000053 low toxicity Toxicity 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 210000004072 lung Anatomy 0.000 description 1
• 206010025135 lupus erythematosus Diseases 0.000 description 1
• 208000018555 lymphatic system disease Diseases 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 230000036630 mental development Effects 0.000 description 1
• 229940045623 meridia Drugs 0.000 description 1
• 230000006371 metabolic abnormality Effects 0.000 description 1
• PMRYVIKBURPHAH-UHFFFAOYSA-N methimazole Chemical compound CN1C=CNC1=S PMRYVIKBURPHAH-UHFFFAOYSA-N 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
• 229960002237 metoprolol Drugs 0.000 description 1
• IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
• 229960000282 metronidazole Drugs 0.000 description 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
• 239000004530 micro-emulsion Substances 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 230000002025 microglial effect Effects 0.000 description 1
• 229960005170 moexipril Drugs 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 description 1
• 229960004866 mycophenolate mofetil Drugs 0.000 description 1
• 210000003007 myelin sheath Anatomy 0.000 description 1
• 201000003631 narcolepsy Diseases 0.000 description 1
• 229940100662 nasal drops Drugs 0.000 description 1
• 239000006199 nebulizer Substances 0.000 description 1
• 230000017074 necrotic cell death Effects 0.000 description 1
• 208000019045 nephrotic syndrome of childhood - steroid sensitive Diseases 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 208000028412 nervous system injury Diseases 0.000 description 1
• 210000005157 neural retina Anatomy 0.000 description 1
• 230000000926 neurological effect Effects 0.000 description 1
• 210000000715 neuromuscular junction Anatomy 0.000 description 1
• 210000002569 neuron Anatomy 0.000 description 1
• 238000010855 neuropsychological testing Methods 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• 230000003472 neutralizing effect Effects 0.000 description 1
• 208000004235 neutropenia Diseases 0.000 description 1
• 229960003512 nicotinic acid Drugs 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
• 239000002687 nonaqueous vehicle Substances 0.000 description 1
• 231100000252 nontoxic Toxicity 0.000 description 1
• 230000003000 nontoxic effect Effects 0.000 description 1
• 230000031787 nutrient reservoir activity Effects 0.000 description 1
• 210000004248 oligodendroglia Anatomy 0.000 description 1
• 229940127240 opiate Drugs 0.000 description 1
• 208000020911 optic nerve disease Diseases 0.000 description 1
• 229960001243 orlistat Drugs 0.000 description 1
• 201000008482 osteoarthritis Diseases 0.000 description 1
• 208000002865 osteopetrosis Diseases 0.000 description 1
• 230000036542 oxidative stress Effects 0.000 description 1
• LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
• 208000021090 palsy Diseases 0.000 description 1
• 229960005489 paracetamol Drugs 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 208000035824 paresthesia Diseases 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000009054 pathological process Effects 0.000 description 1
• 201000001976 pemphigus vulgaris Diseases 0.000 description 1
• 230000000149 penetrating effect Effects 0.000 description 1
• 238000010647 peptide synthesis reaction Methods 0.000 description 1
• 229960002582 perindopril Drugs 0.000 description 1
• IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 description 1
• 210000005259 peripheral blood Anatomy 0.000 description 1
• 239000011886 peripheral blood Substances 0.000 description 1
• 208000033808 peripheral neuropathy Diseases 0.000 description 1
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 description 1
• 230000036470 plasma concentration Effects 0.000 description 1
• 210000004180 plasmocyte Anatomy 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920001987 poloxamine Polymers 0.000 description 1
• 208000030428 polyarticular arthritis Diseases 0.000 description 1
• 208000037244 polycythemia vera Diseases 0.000 description 1
• 238000006116 polymerization reaction Methods 0.000 description 1
• 208000019629 polyneuritis Diseases 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 229960004618 prednisone Drugs 0.000 description 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 208000026526 progressive weakness Diseases 0.000 description 1
• 239000003380 propellant Substances 0.000 description 1
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
• QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical class CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
• 229960002662 propylthiouracil Drugs 0.000 description 1
• 239000011253 protective coating Substances 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 230000002797 proteolythic effect Effects 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 239000002510 pyrogen Substances 0.000 description 1
• 230000001698 pyrogenic effect Effects 0.000 description 1
• 229960001455 quinapril Drugs 0.000 description 1
• JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 1
• 229960003401 ramipril Drugs 0.000 description 1
• HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 1
• 206010037844 rash Diseases 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 230000008929 regeneration Effects 0.000 description 1
• 238000011069 regeneration method Methods 0.000 description 1
• 230000012121 regulation of immune response Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 208000023504 respiratory system disease Diseases 0.000 description 1
• JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
• 229960001225 rifampicin Drugs 0.000 description 1
• 239000003813 safflower oil Substances 0.000 description 1
• 235000005713 safflower oil Nutrition 0.000 description 1
• 235000002020 sage Nutrition 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 238000010187 selection method Methods 0.000 description 1
• 235000016491 selenocysteine Nutrition 0.000 description 1
• ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 description 1
• 229940055619 selenocysteine Drugs 0.000 description 1
• 201000005572 sensory peripheral neuropathy Diseases 0.000 description 1
• 230000036303 septic shock Effects 0.000 description 1
• 231100000872 sexual dysfunction Toxicity 0.000 description 1
• UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 description 1
• 229960004425 sibutramine Drugs 0.000 description 1
• 238000007086 side reaction Methods 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 238000004513 sizing Methods 0.000 description 1
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
• 229940079832 sodium starch glycolate Drugs 0.000 description 1
• 239000008109 sodium starch glycolate Substances 0.000 description 1
• 229920003109 sodium starch glycolate Polymers 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 229940035044 sorbitan monolaurate Drugs 0.000 description 1
• 235000010356 sorbitol Nutrition 0.000 description 1
• 239000003549 soybean oil Substances 0.000 description 1
• 235000012424 soybean oil Nutrition 0.000 description 1
• 208000018198 spasticity Diseases 0.000 description 1
• 210000000278 spinal cord Anatomy 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 229940032147 starch Drugs 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 208000005809 status epilepticus Diseases 0.000 description 1
• 208000001162 steatorrhea Diseases 0.000 description 1
• 239000008223 sterile water Substances 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
• NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
• 229960001940 sulfasalazine Drugs 0.000 description 1
• NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 239000002511 suppository base Substances 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 230000008961 swelling Effects 0.000 description 1
• 238000001308 synthesis method Methods 0.000 description 1
• 238000010189 synthetic method Methods 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 230000006794 tachycardia Effects 0.000 description 1
• 229960001967 tacrolimus Drugs 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 231100001274 therapeutic index Toxicity 0.000 description 1
• 229960002178 thiamazole Drugs 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 229960002051 trandolapril Drugs 0.000 description 1
• 230000009261 transgenic effect Effects 0.000 description 1
• 230000001052 transient effect Effects 0.000 description 1
• 108091005703 transmembrane proteins Proteins 0.000 description 1
• 102000035160 transmembrane proteins Human genes 0.000 description 1
• 208000009174 transverse myelitis Diseases 0.000 description 1
• 230000000472 traumatic effect Effects 0.000 description 1
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
• 229940029284 trichlorofluoromethane Drugs 0.000 description 1
• 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
• 206010044652 trigeminal neuralgia Diseases 0.000 description 1
• 230000001960 triggered effect Effects 0.000 description 1
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
• 230000009959 type I hypersensitivity Effects 0.000 description 1
• 230000008026 type II hypersensitivity Effects 0.000 description 1
• 230000028063 type III hypersensitivity Effects 0.000 description 1
• 208000025883 type III hypersensitivity disease Diseases 0.000 description 1
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 208000009852 uremia Diseases 0.000 description 1
• 210000001745 uvea Anatomy 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 208000030401 vitamin deficiency disease Diseases 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 210000004885 white matter Anatomy 0.000 description 1
• 229940002552 xenical Drugs 0.000 description 1