RU2410115C2 - Способы лечения заболеваний с помощью статистических сополимеров - Google Patents

Способы лечения заболеваний с помощью статистических сополимеров Download PDF

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RU2410115C2
RU2410115C2 RU2006143334/15A RU2006143334A RU2410115C2 RU 2410115 C2 RU2410115 C2 RU 2410115C2 RU 2006143334/15 A RU2006143334/15 A RU 2006143334/15A RU 2006143334 A RU2006143334 A RU 2006143334A RU 2410115 C2 RU2410115 C2 RU 2410115C2
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copolymer
disease
residues
present
hours
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RU2006143334/15A
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RU2006143334A (ru
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Джеймс РАСМУССЕН (US)
Джеймс Расмуссен
Джианксин ЖАНГ (US)
Джианксин ЖАНГ
Сэм БОЛДВИН (US)
Сэм БОЛДВИН
Эрик ЗАНЕЛЛИ (US)
Эрик Занелли
Беи Ю (US)
Беи Ю
Дастен БОННИН (US)
Дастен БОННИН
Кейт ДЖОНСОН (US)
Кейт ДЖОНСОН
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Пептиммьюн, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00Drugs for disorders of the endocrine system
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
RU2006143334/15A 2004-05-07 2005-05-09 Способы лечения заболеваний с помощью статистических сополимеров RU2410115C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56929204P 2004-05-07 2004-05-07
US60/569,292 2004-05-07
US66333305P 2005-03-18 2005-03-18
US60/663,333 2005-03-18

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RU2006143334A RU2006143334A (ru) 2008-06-20
RU2410115C2 true RU2410115C2 (ru) 2011-01-27

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EP (3) EP2508194A1 (enExample)
JP (4) JP5495490B2 (enExample)
KR (1) KR20070036062A (enExample)
AU (2) AU2005251686B2 (enExample)
BR (1) BRPI0510738A (enExample)
CA (2) CA2565819A1 (enExample)
ES (1) ES2560448T3 (enExample)
IL (2) IL179074A0 (enExample)
MX (1) MXPA06012864A (enExample)
NZ (1) NZ551236A (enExample)
RU (1) RU2410115C2 (enExample)
WO (2) WO2005120542A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2841463C2 (ru) * 2018-10-22 2025-06-06 Ра Фармасьютикалз, Инк. Лечение неврологических заболеваний зилукопланом

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2006134701A (ru) * 2004-03-01 2008-04-10 Пептиммьюн Способы и композиции для лечения аутоиммунных заболеваний
US7655221B2 (en) 2004-05-07 2010-02-02 Peptimmune, Inc. Methods of treating disease with random copolymers
US20060194725A1 (en) * 2004-05-07 2006-08-31 James Rasmussen Methods of treating disease with random copolymers
EP2016095A2 (en) * 2006-04-13 2009-01-21 Peptimmune, Inc. Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
BRPI0817682A2 (pt) 2007-10-16 2015-04-07 Peptimmune Inc Métodos para projetar e preparar vacinas compreendendo composições de polímero de sequência direcionada via a expansão direta de epítopos
AU2009236583B2 (en) 2008-04-17 2015-07-16 Declion Holdings Llc Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
US20120237472A1 (en) * 2009-07-24 2012-09-20 The Johns Hopkins University Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents
KR20160038057A (ko) 2009-08-20 2016-04-06 에다 리서치 앤드 디벨럽먼트 컴퍼니 리미티드 글라티라머 아세테이트를 포함하는 약제
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
AU2017290907A1 (en) * 2016-07-01 2019-02-14 Declion Holdings Llc Amino acid copolymer compositions and uses thereof
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
SMT202500136T1 (it) 2016-08-31 2025-05-12 Mapi Pharma Ltd Sistemi a deposito comprendenti glatiramer acetato
US11167003B2 (en) 2017-03-26 2021-11-09 Mapi Pharma Ltd. Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems
US20230414732A1 (en) 2020-11-10 2023-12-28 Palena Therapeutics, Inc. Compositions of embedded epitope random peptides (eerp) for treatment of immune-mediated conditions, and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU99114020A (ru) * 1996-12-02 2001-05-27 Энджиотек Фармасьютикалз, Инк. Композиции и способы лечения или предупреждения воспалительных заболеваний
CA2614171A1 (en) * 2001-10-03 2003-04-10 President And Fellows Of Harvard College Copolymers for suppression of autoimmune diseases, and methods of use
WO2003029276A2 (en) * 2001-10-03 2003-04-10 President And Fellows Of Harvard College Copolymers for suppression of autoimmune diseases, and methods of use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
US5800808A (en) 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
US5858964A (en) 1995-04-14 1999-01-12 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD
US6515016B2 (en) * 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
JPH11330431A (ja) 1998-05-18 1999-11-30 Nec Corp 不揮発性半導体記憶装置の製造方法
NZ509901A (en) * 1998-07-23 2003-10-31 Yeda Res & Dev Treatment of autoimmune conditions terpolymers consisting of three amino acids selected from glu, ala, lys or tyr
WO2000005249A2 (en) 1998-07-23 2000-02-03 The President And Fellows Of Harvard College Synthetic peptides and methods of use for autoimmune disease therapies
WO2000005250A1 (en) 1998-07-23 2000-02-03 Yeda Research And Development Co., Ltd Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides
US6514938B1 (en) 1998-09-25 2003-02-04 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
WO2000027417A1 (en) * 1998-11-12 2000-05-18 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd
EP1248643B1 (en) * 2000-01-20 2005-08-17 YEDA RESEARCH AND DEVELOPMENT Co. LTD. The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy
EP1294390B1 (en) 2000-06-07 2006-01-04 YEDA RESEARCH AND DEVELOPMENT CO., Ltd. The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotection from glutamate toxicity
US20040003888A1 (en) 2000-07-11 2004-01-08 Laurence Mott Process for the manufacture of an improved floor element
US6930168B2 (en) 2001-01-24 2005-08-16 The President And Fellows Of Harvard College Synthetic peptides for demyelinating conditions
PT1409984E (pt) * 2001-06-28 2009-10-29 Lonza Walkersville Inc Processos e reagentes para a detecção de endotoxinas
EP1429800B1 (en) * 2001-12-06 2009-02-11 Yeda Research And Development Co., Ltd. Vaccine and use thereof for treatment of amyotrophic lateral sclerosis
ES2397836T3 (es) * 2003-01-21 2013-03-11 Yeda Research And Development Co., Ltd. Copolímero 1 para el tratamiento de enfermedades inflamatorias del intestino

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU99114020A (ru) * 1996-12-02 2001-05-27 Энджиотек Фармасьютикалз, Инк. Композиции и способы лечения или предупреждения воспалительных заболеваний
CA2614171A1 (en) * 2001-10-03 2003-04-10 President And Fellows Of Harvard College Copolymers for suppression of autoimmune diseases, and methods of use
WO2003029276A2 (en) * 2001-10-03 2003-04-10 President And Fellows Of Harvard College Copolymers for suppression of autoimmune diseases, and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
КИРЬЯКОВ В.А. Иммуносупрессивная терапия некоторых аутоиммунных заболеваний нервной системы. Обзор. Советская медицина, 1990, №12, с.31-35. ГЛАЗАНОВА Т.В. Иммунологические и иммуногенетические особенности органоспецифических и системных аутоиммунных заболеваний. Автореф. дис… д.м.н. 2002. FRIDKIS-HARELI M. Novel synthetic amino acid copolymers that inhibit autoantigen-specific Т cell responses and suppress experimental autoimmune encephalomyelitis. J. Clin. Invest. 2002 Jun; 109 (12), p.1635-1643. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2841463C2 (ru) * 2018-10-22 2025-06-06 Ра Фармасьютикалз, Инк. Лечение неврологических заболеваний зилукопланом

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Publication number Publication date
JP2012255034A (ja) 2012-12-27
WO2005120542A2 (en) 2005-12-22
NZ551236A (en) 2010-11-26
BRPI0510738A (pt) 2007-11-20
IL179075A (en) 2016-03-31
KR20070036062A (ko) 2007-04-02
JP5892815B2 (ja) 2016-03-23
WO2005120542A3 (en) 2006-05-26
MXPA06012864A (es) 2007-07-18
IL179074A0 (en) 2007-03-08
JP2007536279A (ja) 2007-12-13
AU2005244814B2 (en) 2011-09-15
JP2007536278A (ja) 2007-12-13
ES2560448T3 (es) 2016-02-19
AU2005251686A1 (en) 2005-12-22
EP1750741A1 (en) 2007-02-14
WO2005112972A1 (en) 2005-12-01
AU2005244814A1 (en) 2005-12-01
CA2565819A1 (en) 2005-12-01
CA2565703A1 (en) 2005-12-22
EP2508194A1 (en) 2012-10-10
IL179075A0 (en) 2007-03-08
RU2006143334A (ru) 2008-06-20
EP1750742A2 (en) 2007-02-14
AU2005251686B2 (en) 2011-09-08
EP1750741B1 (en) 2015-12-02
JP5495490B2 (ja) 2014-05-21
JP2012116866A (ja) 2012-06-21

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