ES2393933T3 - Conjugados que comprenden un fármaco psicotrópico o un agonista GABA y un ácido orgánico y su uso para el tratamiento del dolor y otros transtornos del SNC - Google Patents
Conjugados que comprenden un fármaco psicotrópico o un agonista GABA y un ácido orgánico y su uso para el tratamiento del dolor y otros transtornos del SNC Download PDFInfo
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- ES2393933T3 ES2393933T3 ES07789958T ES07789958T ES2393933T3 ES 2393933 T3 ES2393933 T3 ES 2393933T3 ES 07789958 T ES07789958 T ES 07789958T ES 07789958 T ES07789958 T ES 07789958T ES 2393933 T3 ES2393933 T3 ES 2393933T3
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- gaba
- pain
- nortriptyline
- treatment
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| CN101511388B (zh) | 2006-07-17 | 2012-10-24 | 特拉维夫大学拉莫特有限公司 | 含有精神药物或gaba激动剂和有机酸的缀合物以及它们在治疗疼痛和其它cns疾病中的用途 |
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| US20100272652A1 (en) * | 2009-03-26 | 2010-10-28 | Seventh Sense Biosystems, Inc. | Determination of tracers within subjects |
| US8141697B2 (en) * | 2009-04-03 | 2012-03-27 | Ackley Machine Corporation | Method and apparatus for transporting caplets |
| EP2480536B1 (en) * | 2009-09-23 | 2014-08-13 | The Regents of the University of Colorado, A Body Corporate | Toll-like receptor modulators and uses thereof |
| WO2011070579A1 (en) | 2009-12-09 | 2011-06-16 | Biolinerx Ltd. | Methods of improving cognitive functions |
| WO2012038963A1 (en) | 2010-09-22 | 2012-03-29 | Ramot At Tel-Aviv University Ltd. | An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same |
| EP2727473A4 (en) * | 2011-06-28 | 2015-05-06 | Vivozon Inc | COMBINATION OF EFFICIENT SUBSTANCES WITH SYNERGISTIC EFFECTS OF MULTIPLE TARGETING AND USE THEREOF |
| WO2014022807A2 (en) * | 2012-08-03 | 2014-02-06 | Alumend, Llc | Compositions and methods of using the compositions for plaque softening |
| EP4119539A1 (en) | 2015-09-23 | 2023-01-18 | XWPharma Ltd. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| CN115025086A (zh) | 2017-03-30 | 2022-09-09 | 凯瑞康宁生物工程（武汉）有限公司 | 双环杂芳基衍生物及其制备与用途 |
| US20200138964A1 (en) * | 2017-04-25 | 2020-05-07 | Seikagaku Corporation | Tertiary amine compound or imine compound-polymer conjugate and production method therefor |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| CN114621119A (zh) * | 2018-05-14 | 2022-06-14 | 昌郁医药公司 | 萘普生和普瑞巴林的1-(酰氧基)-烷基氨基甲酸酯药物缀合物的结晶形式 |
| JP6996029B2 (ja) | 2018-09-30 | 2022-01-17 | エックスダブリューファルマ リミテッド | ニューロンヒスタミン受容体－３アンタゴニストとしての化合物およびその使用 |
| KR20220009954A (ko) | 2019-04-17 | 2022-01-25 | 컴퍼스 패쓰파인더 리미티드 | 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법 |
| CN115244028A (zh) | 2019-12-20 | 2022-10-25 | 凯瑞康宁生物工程有限公司 | 4-缬氨酰氧基丁酸的合成方法 |
| JP7682215B2 (ja) | 2020-06-18 | 2025-05-23 | エックスダブリューファーマ リミテッド | 水溶性医薬品有効成分の制御放出造粒物 |
| KR20230008190A (ko) | 2020-06-18 | 2023-01-13 | 엑스더블유파마 리미티드 | 수용성 원료의약품의 약학적 과립화제 |
| US11896573B2 (en) | 2020-07-24 | 2024-02-13 | XWPharma Ltd. | Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative |
| TW202228665A (zh) | 2020-10-05 | 2022-08-01 | 凱瑞康寧生技股份有限公司 | γ－羥基丁酸衍生物之修飾釋放組合物 |
| EP4588471A3 (en) | 2021-03-19 | 2025-09-24 | XWPharma Ltd. | Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative |
| CN114452256A (zh) * | 2021-12-31 | 2022-05-10 | 浙江大学 | 脊髓损伤靶向药物、聚合物-疏水化合物胶束及其制备方法 |
| CN115057865B (zh) * | 2022-05-10 | 2023-03-31 | 国药集团工业有限公司 | 一种磷酸可待因半水合物的制备方法 |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2944053A (en) | 1960-07-05 | Uiiilcu | ||
| US3058979A (en) | 1957-05-13 | 1962-10-16 | Smith Kline French Lab | New perfluoroalkylphenothiazine derivatives |
| US2914528A (en) * | 1958-04-16 | 1959-11-24 | Smith Kline French Lab | Substituted phenothiazinyl trifluoro-methyl sulfones |
| NL105973C (enExample) * | 1957-09-11 | 1900-01-01 | ||
| US2969358A (en) * | 1958-12-08 | 1961-01-24 | Searle & Co | 2-chloro-10-phenothiazinecarbonylpiperazines |
| GB1460713A (en) | 1973-06-08 | 1977-01-06 | Kefalas As | 7-fluoro substituted phenothiazines method for preparation thereof and compositions bladed rotor for a gas turbine engine |
| US3978216A (en) | 1974-06-03 | 1976-08-31 | Nelson Research & Development Company | Method for treating schizophrenia and method and composition for potentiating neuroleptic drugs |
| US3947579A (en) | 1974-06-03 | 1976-03-30 | Nelson Research & Development Company | Method and composition for potentiating neuroleptic drugs |
| US3956493A (en) | 1974-10-21 | 1976-05-11 | E. R. Squibb & Sons, Inc. | Long acting tranquilizing agent |
| GB1540842A (en) * | 1976-08-25 | 1979-02-14 | Kefalas As | Phenothiazines |
| US5525727A (en) * | 1982-05-18 | 1996-06-11 | University Of Florida | Brain-specific drug delivery |
| JPS6072868A (ja) | 1982-10-04 | 1985-04-24 | Fujisawa Pharmaceut Co Ltd | 縮合複素環誘導体およびその製造法 |
| US4629691A (en) * | 1983-08-01 | 1986-12-16 | Syntex (U.S.A.) Inc. | Tricyclic antidepressant conjugates with antigens and enzymes |
| GB8413605D0 (en) | 1984-05-29 | 1984-07-04 | Gersan Ets | Examining unfinished gemstone |
| US5051448A (en) | 1984-07-24 | 1991-09-24 | The Mclean Hospital Corporation | GABA esters and GABA analog esters |
| US4818936A (en) | 1985-02-15 | 1989-04-04 | The Broken Hill Proprietary Company Limited | Method and apparatus for identifying and classifying steels |
| WO1986004991A1 (en) | 1985-02-15 | 1986-08-28 | The Broken Hill Proprietary Company Limited | Classification of steel |
| GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| ES8707175A1 (es) | 1986-06-13 | 1987-07-16 | Inke Sa | Procedimiento para la obtencion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina |
| US5994392A (en) | 1988-02-26 | 1999-11-30 | Neuromedica, Inc. | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid |
| US5104858A (en) | 1988-09-29 | 1992-04-14 | Yale University | Sensitizing multidrug resistant cells to antitumor agents |
| JPH02128564A (ja) | 1988-11-08 | 1990-05-16 | Nec Corp | 電話付きパーソナルコンピュータ |
| JP2801648B2 (ja) | 1989-06-14 | 1998-09-21 | 日本化薬株式会社 | ６―フルオロ―４―クロマノン―２―カルボン酸アミド又はエステルの製造法 |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| WO1993012496A1 (en) | 1991-12-09 | 1993-06-24 | Gem International Network, Inc. | Computer imaging system for gemstones |
| US5780590A (en) | 1993-10-15 | 1998-07-14 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
| JPH09505601A (ja) * | 1993-11-24 | 1997-06-03 | メルク エンド カンパニー インコーポレーテッド | インドリル基含有化合物類および成長ホルモン放出を促進するためのそれらの使用 |
| US5534522A (en) | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| AU6636996A (en) | 1995-07-13 | 1997-02-10 | Anormed Inc. | 2-{2-(dimethylamino)ethyl}-8,8-dipropyl-2-azaspiro{4.5}decan edimaleate |
| CA2162532C (en) * | 1995-11-09 | 2001-01-30 | Dana J. Vanier | Gemstone registration system |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| DE19622489A1 (de) | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| US5966673A (en) * | 1997-01-10 | 1999-10-12 | Diamond Technologies, Inc. | System and method for computerized evaluation of gemstones |
| US6130221A (en) | 1997-03-05 | 2000-10-10 | Nymox Corporation | Pharmaceutical agents that impede the initiation and progression of primary and secondary DMS disruptions |
| US6197764B1 (en) | 1997-11-26 | 2001-03-06 | Protarga, Inc. | Clozapine compositions and uses thereof |
| US6020954A (en) | 1997-12-18 | 2000-02-01 | Imagestatistics, Inc. | Method and associated apparatus for the standardized grading of gemstones |
| US5983238A (en) | 1997-12-26 | 1999-11-09 | Diamond Id | Gemstons identification tracking and recovery system |
| JP4002006B2 (ja) | 1998-06-29 | 2007-10-31 | 日本電信電話株式会社 | 色校正装置、色校正方法、および色校正プログラムを記録した記録媒体 |
| US20010024532A1 (en) * | 1998-09-21 | 2001-09-27 | Malnekoff Peter J. | Automated gemstone evaluation system |
| US6304853B1 (en) | 1998-09-21 | 2001-10-16 | Peter J. Malnekoff | Automated gemstone evaluation system |
| IL134664A0 (en) | 1999-10-29 | 2001-04-30 | Diamond And Jewelry 4 U Ltd | System for trade in precious gemstones |
| US6381510B1 (en) | 1999-11-19 | 2002-04-30 | Eruggallery.Com | Methods and apparatus for facilitating electronic commerce in area rugs |
| EP1600168A3 (en) * | 1999-12-01 | 2009-09-23 | Ucb, S.A. | A pyrrolidineacetamide derivative alone or in combination for treatment of CNS disorder |
| US20010036943A1 (en) * | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| US8706645B2 (en) | 2000-05-23 | 2014-04-22 | David W. Hendry, Jr. | System and method for appraising valuable items |
| US20020021439A1 (en) * | 2000-08-07 | 2002-02-21 | Derek Priestley | Colour matching system |
| US7251619B2 (en) * | 2000-09-01 | 2007-07-31 | Garry Ian Holloway | Computer implemented method, computer program product, and system for gem evaluation |
| JP2005097120A (ja) | 2000-10-06 | 2005-04-14 | Mochida Pharmaceut Co Ltd | ４−ヒドロキシピペリジン誘導体の非潮解性塩 |
| US6992076B2 (en) | 2000-10-06 | 2006-01-31 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| US6569853B1 (en) * | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| IL139975A0 (en) | 2000-11-29 | 2002-02-10 | Univ Ramot | Anti proliferative drugs |
| US20030065586A1 (en) | 2001-07-31 | 2003-04-03 | Shaftel Keith L. | Electronic commerce product pricing and selection system and method |
| US20030115079A1 (en) * | 2001-08-30 | 2003-06-19 | Rapaport Martin M. | Method of and system for ranking optimal values |
| EP2275143B1 (en) | 2001-09-27 | 2012-12-19 | Ramot at Tel Aviv University Ltd. | Conjugates of perphenazine or fluphenazine with carboxylic acids |
| US7544681B2 (en) | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| US7005138B2 (en) * | 2001-12-21 | 2006-02-28 | Duramed Pharmaceuticals, Inc. | Method of systematically delivering SSRIs |
| JP2005518411A (ja) | 2002-01-16 | 2005-06-23 | エンド ファーマシューティカルズ インコーポレーテッド | 中枢神経系の障害を治療する製薬組成物及び方法 |
| US8046274B2 (en) * | 2002-01-25 | 2011-10-25 | Menahem Sevdermish | Method for digital color grading of gems and communication thereof |
| JP4680507B2 (ja) | 2002-01-25 | 2011-05-11 | メナヘム セヴデルミシュ， | 宝石のデジタルカラーグレーディングおよびその伝達の方法 |
| US20040092504A1 (en) * | 2002-11-12 | 2004-05-13 | Anuthep Benja-Athon | Definitive medications for treating fibromyalgia |
| NZ546226A (en) | 2003-09-30 | 2009-03-31 | Shire Llc | Oxycodone conjugates for prevention of overdose or abuse |
| MX2007002210A (es) * | 2004-08-26 | 2007-05-07 | Nicholas Piramal India Ltd | Profarmacos que contienen enlazantes bioescindibles novedosos. |
| TW200616604A (en) * | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| US7151084B2 (en) * | 2004-12-27 | 2006-12-19 | Miller Landon C G | Compound and method of treating neurogenic conditions using non-steroidal anti-inflammatory drug complexes |
| US7074775B2 (en) * | 2004-09-14 | 2006-07-11 | Miller Landon C G | Aminobutyramide conjugate and a pharmaceutical composition for treatment of neuronal disorders |
| TW200715156A (en) | 2004-11-24 | 2007-04-16 | Interdigital Tech Corp | Intelligent information dissemination using a dynamic profile |
| ES2400772T3 (es) | 2005-06-07 | 2013-04-12 | Ramot At Tel Aviv University Ltd. | Sales novedosas de fármacos psicotrópicos conjugados y procedimientos para la preparación de las mismas |
| WO2007050318A2 (en) | 2005-10-24 | 2007-05-03 | Duke University | Lipidomics approaches for central nervous system disorders |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| WO2007139818A2 (en) | 2006-05-22 | 2007-12-06 | The Board Of Trustees Of The Leland Stanford Junior University | Pharmacological treatment of cognitive impairment |
| CN101511388B (zh) * | 2006-07-17 | 2012-10-24 | 特拉维夫大学拉莫特有限公司 | 含有精神药物或gaba激动剂和有机酸的缀合物以及它们在治疗疼痛和其它cns疾病中的用途 |
| WO2009094563A2 (en) * | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use |
| WO2009101616A1 (en) | 2008-02-11 | 2009-08-20 | Ramot At Tel Aviv University Ltd. | Novel conjugates for treating neurodegenerative diseases and disorders |
| CN102858345A (zh) | 2010-02-24 | 2013-01-02 | 雷蒙特亚特特拉维夫大学有限公司 | 奋乃静-gaba的三甲磺酸盐的晶型及其制备方法 |
-
2007
- 2007-07-17 CN CN2007800332946A patent/CN101511388B/zh not_active Expired - Fee Related
- 2007-07-17 US US12/309,361 patent/US8377990B2/en not_active Expired - Fee Related
- 2007-07-17 MX MX2009000641A patent/MX2009000641A/es active IP Right Grant
- 2007-07-17 US US12/373,542 patent/US8222296B2/en not_active Expired - Fee Related
- 2007-07-17 KR KR1020097003169A patent/KR20090048462A/ko not_active Ceased
- 2007-07-17 WO PCT/IL2007/000902 patent/WO2008010222A2/en not_active Ceased
- 2007-07-17 ES ES07789958T patent/ES2393933T3/es active Active
- 2007-07-17 CA CA002659521A patent/CA2659521A1/en not_active Abandoned
- 2007-07-17 EP EP07789958A patent/EP2051735B1/en not_active Not-in-force
- 2007-07-17 WO PCT/IL2007/000903 patent/WO2008010223A2/en not_active Ceased
- 2007-07-17 AU AU2007274583A patent/AU2007274583B2/en not_active Ceased
- 2007-07-17 JP JP2009520129A patent/JP5192485B2/ja not_active Expired - Fee Related
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2009
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2012
- 2012-09-06 US US13/604,718 patent/US20130059910A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090304584A1 (en) | 2009-12-10 |
| JP5192485B2 (ja) | 2013-05-08 |
| EP2051735A2 (en) | 2009-04-29 |
| CN101511388B (zh) | 2012-10-24 |
| US20130059910A1 (en) | 2013-03-07 |
| WO2008010222A3 (en) | 2008-04-10 |
| US20100144869A1 (en) | 2010-06-10 |
| US8222296B2 (en) | 2012-07-17 |
| US8377990B2 (en) | 2013-02-19 |
| AU2007274583B2 (en) | 2012-11-01 |
| JP2009543858A (ja) | 2009-12-10 |
| WO2008010222A2 (en) | 2008-01-24 |
| IL196538A0 (en) | 2009-11-18 |
| AU2007274583A1 (en) | 2008-01-24 |
| MX2009000641A (es) | 2009-02-12 |
| KR20090048462A (ko) | 2009-05-13 |
| WO2008010223A3 (en) | 2008-03-20 |
| CA2659521A1 (en) | 2008-01-24 |
| EP2051735B1 (en) | 2012-08-29 |
| WO2008010223A2 (en) | 2008-01-24 |
| CN101511388A (zh) | 2009-08-19 |
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