JP2009538276A5 - - Google Patents
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- Publication number
- JP2009538276A5 JP2009538276A5 JP2009507606A JP2009507606A JP2009538276A5 JP 2009538276 A5 JP2009538276 A5 JP 2009538276A5 JP 2009507606 A JP2009507606 A JP 2009507606A JP 2009507606 A JP2009507606 A JP 2009507606A JP 2009538276 A5 JP2009538276 A5 JP 2009538276A5
- Authority
- JP
- Japan
- Prior art keywords
- deoxynojirimycin
- pentane
- neopentyloxy
- methoxy
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 101000859679 Homo sapiens Non-lysosomal glucosylceramidase Proteins 0.000 claims 1
- 102100027814 Non-lysosomal glucosylceramidase Human genes 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79408806P | 2006-04-24 | 2006-04-24 | |
| PCT/NL2007/050177 WO2007123403A1 (en) | 2006-04-24 | 2007-04-24 | Improved treatment of cystic fibrosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009538276A JP2009538276A (ja) | 2009-11-05 |
| JP2009538276A5 true JP2009538276A5 (enExample) | 2010-04-08 |
Family
ID=38283020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507606A Ceased JP2009538276A (ja) | 2006-04-24 | 2007-04-24 | 嚢胞性線維症の改良型治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8410081B2 (enExample) |
| EP (1) | EP2010551B1 (enExample) |
| JP (1) | JP2009538276A (enExample) |
| CN (1) | CN101479288B (enExample) |
| AT (1) | ATE479696T1 (enExample) |
| AU (1) | AU2007241622A1 (enExample) |
| BR (1) | BRPI0710883A2 (enExample) |
| CA (1) | CA2650311A1 (enExample) |
| DE (1) | DE602007008870D1 (enExample) |
| WO (1) | WO2007123403A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0712494D0 (en) | 2007-06-27 | 2007-08-08 | Isis Innovation | Substrate reduction therapy |
| KR101755133B1 (ko) | 2009-02-23 | 2017-07-06 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 바이러스성 질환을 치료하는 방법 |
| CN102625660B (zh) * | 2009-02-24 | 2015-03-11 | 联合治疗公司 | 亚氨基糖以及治疗沙粒病毒感染的方法 |
| CA2765086C (en) | 2009-06-12 | 2015-12-15 | United Therapeutics Corporation | Iminosugars and methods of treating bunyaviral and togaviral diseases |
| CN105748476A (zh) * | 2009-09-04 | 2016-07-13 | 联合治疗公司 | 亚氨基糖以及治疗丝状病毒性疾病的方法 |
| WO2011028781A1 (en) * | 2009-09-04 | 2011-03-10 | United Therapeutics Corporation | Methods of treating poxviral infections |
| KR101497194B1 (ko) * | 2009-09-04 | 2015-02-27 | 유나이티드 세러퓨틱스 코오포레이션 | 오르토믹소바이러스 감염의 치료 방법 |
| GB201000499D0 (en) | 2010-01-13 | 2010-03-03 | Fleet George W J | Treatment of cystic fibrosis |
| WO2011095772A2 (en) | 2010-02-04 | 2011-08-11 | Summit Corporation Plc | Novel iminosugar therapeutics |
| GB201006434D0 (en) | 2010-04-19 | 2010-06-02 | Summit Corp Plc | Novel iminosugar combinations |
| DK2753346T3 (da) | 2011-09-07 | 2020-05-25 | Sinai School Medicine | Ceramidase og celledifferentiering |
| EP2854910B1 (en) * | 2012-06-01 | 2020-04-15 | Icahn School of Medicine at Mount Sinai | Ceramide levels in the treatment and prevention of infections |
| WO2014086934A1 (en) * | 2012-12-05 | 2014-06-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Diagnosis of cystic fibrosis |
| EP3659619A1 (en) | 2013-03-14 | 2020-06-03 | Icahn School of Medicine at Mount Sinai | Therapeutic acid ceramidase compositions and methods of making and using them |
| WO2017178499A1 (en) | 2016-04-11 | 2017-10-19 | Spedding Research Solutions | Inhibitors of glucosylceramide degradation in the treatment of diseases of the motor units |
| DK3630725T3 (da) | 2017-06-01 | 2026-02-09 | Idorsia Pharmaceuticals Ltd | Krystallinsk form af n-butyldeoxygalactonojirimycin |
| CA3211755A1 (en) * | 2021-03-12 | 2022-09-15 | Barbara MERTINS | Systems and methods for protein expression |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998002161A1 (en) | 1996-07-15 | 1998-01-22 | Universiteit Van Amsterdam | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| AU5799500A (en) | 1999-06-29 | 2001-01-22 | Mcgill University | Human alpha 1,2-mannosidase |
| EP1528056A1 (en) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| FR2861991B1 (fr) * | 2003-11-07 | 2008-01-18 | Centre Nat Rech Scient | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| US20090111812A1 (en) * | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| AU2006272497B2 (en) | 2005-07-27 | 2012-07-19 | University Of Florida Research Foundation, Inc. | Small compounds that correct protein misfolding and uses thereof |
-
2007
- 2007-04-24 AT AT07747401T patent/ATE479696T1/de not_active IP Right Cessation
- 2007-04-24 JP JP2009507606A patent/JP2009538276A/ja not_active Ceased
- 2007-04-24 DE DE602007008870T patent/DE602007008870D1/de active Active
- 2007-04-24 BR BRPI0710883-4A patent/BRPI0710883A2/pt not_active IP Right Cessation
- 2007-04-24 AU AU2007241622A patent/AU2007241622A1/en not_active Abandoned
- 2007-04-24 WO PCT/NL2007/050177 patent/WO2007123403A1/en not_active Ceased
- 2007-04-24 CN CN2007800237886A patent/CN101479288B/zh not_active Expired - Fee Related
- 2007-04-24 CA CA002650311A patent/CA2650311A1/en not_active Abandoned
- 2007-04-24 EP EP07747401A patent/EP2010551B1/en not_active Not-in-force
- 2007-04-24 US US12/298,506 patent/US8410081B2/en not_active Expired - Fee Related