CN101479288B - 囊性纤维化的改进的治疗 - Google Patents

囊性纤维化的改进的治疗 Download PDF

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Publication number
CN101479288B
CN101479288B CN2007800237886A CN200780023788A CN101479288B CN 101479288 B CN101479288 B CN 101479288B CN 2007800237886 A CN2007800237886 A CN 2007800237886A CN 200780023788 A CN200780023788 A CN 200780023788A CN 101479288 B CN101479288 B CN 101479288B
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CN
China
Prior art keywords
deoxynojirimycin
gba2
cftr
inhibitor
pentyl
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Expired - Fee Related
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CN2007800237886A
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English (en)
Chinese (zh)
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CN101479288A (zh
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J·M·F·G·阿尔特斯
R·G·布特
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Academisch Medisch Centrum
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Academic Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
CN2007800237886A 2006-04-24 2007-04-24 囊性纤维化的改进的治疗 Expired - Fee Related CN101479288B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79408806P 2006-04-24 2006-04-24
US60/794,088 2006-04-24
PCT/NL2007/050177 WO2007123403A1 (en) 2006-04-24 2007-04-24 Improved treatment of cystic fibrosis

Publications (2)

Publication Number Publication Date
CN101479288A CN101479288A (zh) 2009-07-08
CN101479288B true CN101479288B (zh) 2012-06-27

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ID=38283020

Family Applications (1)

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CN2007800237886A Expired - Fee Related CN101479288B (zh) 2006-04-24 2007-04-24 囊性纤维化的改进的治疗

Country Status (10)

Country Link
US (1) US8410081B2 (enExample)
EP (1) EP2010551B1 (enExample)
JP (1) JP2009538276A (enExample)
CN (1) CN101479288B (enExample)
AT (1) ATE479696T1 (enExample)
AU (1) AU2007241622A1 (enExample)
BR (1) BRPI0710883A2 (enExample)
CA (1) CA2650311A1 (enExample)
DE (1) DE602007008870D1 (enExample)
WO (1) WO2007123403A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0712494D0 (en) 2007-06-27 2007-08-08 Isis Innovation Substrate reduction therapy
EP2398321B1 (en) 2009-02-23 2015-11-25 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
CA2753194A1 (en) * 2009-02-24 2010-09-02 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
CN102639133B (zh) 2009-06-12 2015-03-11 联合治疗公司 亚氨基糖和治疗布尼亚病毒性疾病以及披膜病毒性疾病的方法
JP5752689B2 (ja) * 2009-09-04 2015-07-22 ユナイテッド セラピューティクス コーポレイション フィロウイルス疾患を治療するイミノ糖および方法
CA2772807A1 (en) * 2009-09-04 2011-03-10 The Chancellor, Masters And Scholars Of The University Of Oxford Methods of treating poxviral infections
US20110065752A1 (en) * 2009-09-04 2011-03-17 United Therapeutics Corporation Methods of treating orthomyxoviral infections
GB201000499D0 (en) 2010-01-13 2010-03-03 Fleet George W J Treatment of cystic fibrosis
WO2011095772A2 (en) 2010-02-04 2011-08-11 Summit Corporation Plc Novel iminosugar therapeutics
GB201006434D0 (en) 2010-04-19 2010-06-02 Summit Corp Plc Novel iminosugar combinations
ES2791760T3 (es) 2011-09-07 2020-11-05 Sinai School Medicine Ceramidasa y diferenciación celular
HUE051020T2 (hu) * 2012-06-01 2021-01-28 Icahn School Med Mount Sinai A ceramid szintjei a fertõzések kezelésében és megelõzésében
US20150346185A1 (en) * 2012-12-05 2015-12-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Diagnosis of cystic fibrosis
JP6832158B2 (ja) 2013-03-14 2021-02-24 アイカーン スクール オブ メディシン アット マウント サイナイ 治療用酸性セラミダーゼ組成物ならびにそれを作製および使用する方法
WO2017178499A1 (en) 2016-04-11 2017-10-19 Spedding Research Solutions Inhibitors of glucosylceramide degradation in the treatment of diseases of the motor units
MA48944A (fr) 2017-06-01 2020-04-08 Idorsia Pharmaceuticals Ltd Forme cristalline de n-butyldéoxygalactonojirimycine
CA3211755A1 (en) * 2021-03-12 2022-09-15 Barbara MERTINS Systems and methods for protein expression

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123055A2 (en) * 2004-06-14 2005-12-29 Musc Foundation For Research Development Methods for treating inflammatory disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002161A1 (en) 1996-07-15 1998-01-22 Universiteit Van Amsterdam Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors
WO2001002586A1 (en) 1999-06-29 2001-01-11 Mcgill University Human alpha 1,2-mannosidase
EP1528056A1 (en) * 2003-10-29 2005-05-04 Academisch Ziekenhuis bij de Universiteit van Amsterdam Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
FR2861991B1 (fr) 2003-11-07 2008-01-18 Centre Nat Rech Scient Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
US20100004156A1 (en) 2005-07-27 2010-01-07 Shalesh Kaushal Small Compounds That Correct Protein Misfolding and Uses Thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123055A2 (en) * 2004-06-14 2005-12-29 Musc Foundation For Research Development Methods for treating inflammatory disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Herman S Overkleeft等.Generation of Specific Deoxynojirimycin-type Inhibitors of the Non-lysosomal Glucosylceramidase.《Journal of Biological Chemistry》.1998,第273卷(第41期),第26524-26525页. *

Also Published As

Publication number Publication date
AU2007241622A8 (en) 2008-12-04
CA2650311A1 (en) 2007-11-01
US20090186862A1 (en) 2009-07-23
AU2007241622A1 (en) 2007-11-01
US8410081B2 (en) 2013-04-02
EP2010551B1 (en) 2010-09-01
WO2007123403A1 (en) 2007-11-01
CN101479288A (zh) 2009-07-08
JP2009538276A (ja) 2009-11-05
BRPI0710883A2 (pt) 2011-08-09
EP2010551A1 (en) 2009-01-07
ATE479696T1 (de) 2010-09-15
DE602007008870D1 (de) 2010-10-14

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Granted publication date: 20120627

Termination date: 20140424