ATE479696T1 - Verbessertes verfahren zur behandlung von cystischer fibrose - Google Patents
Verbessertes verfahren zur behandlung von cystischer fibroseInfo
- Publication number
- ATE479696T1 ATE479696T1 AT07747401T AT07747401T ATE479696T1 AT E479696 T1 ATE479696 T1 AT E479696T1 AT 07747401 T AT07747401 T AT 07747401T AT 07747401 T AT07747401 T AT 07747401T AT E479696 T1 ATE479696 T1 AT E479696T1
- Authority
- AT
- Austria
- Prior art keywords
- cystic fibrosis
- improved method
- found
- treating cystic
- membrane bilayer
- Prior art date
Links
- 201000003883 Cystic fibrosis Diseases 0.000 title abstract 2
- 102100027814 Non-lysosomal glucosylceramidase Human genes 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101000859679 Homo sapiens Non-lysosomal glucosylceramidase Proteins 0.000 abstract 1
- 101710083785 Non-lysosomal glucosylceramidase Proteins 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical class OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79408806P | 2006-04-24 | 2006-04-24 | |
| PCT/NL2007/050177 WO2007123403A1 (en) | 2006-04-24 | 2007-04-24 | Improved treatment of cystic fibrosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE479696T1 true ATE479696T1 (de) | 2010-09-15 |
Family
ID=38283020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07747401T ATE479696T1 (de) | 2006-04-24 | 2007-04-24 | Verbessertes verfahren zur behandlung von cystischer fibrose |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8410081B2 (enExample) |
| EP (1) | EP2010551B1 (enExample) |
| JP (1) | JP2009538276A (enExample) |
| CN (1) | CN101479288B (enExample) |
| AT (1) | ATE479696T1 (enExample) |
| AU (1) | AU2007241622A1 (enExample) |
| BR (1) | BRPI0710883A2 (enExample) |
| CA (1) | CA2650311A1 (enExample) |
| DE (1) | DE602007008870D1 (enExample) |
| WO (1) | WO2007123403A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0712494D0 (en) * | 2007-06-27 | 2007-08-08 | Isis Innovation | Substrate reduction therapy |
| ES2579628T3 (es) | 2009-02-23 | 2016-08-12 | Emergent Virology Llc | Iminoazúcares y métodos de tratamiento de enfermedades virales |
| EP2400843B1 (en) * | 2009-02-24 | 2015-11-11 | United Therapeutics Corporation | Iminosugars and methods of treating arenaviral infections |
| WO2010144759A1 (en) | 2009-06-12 | 2010-12-16 | United Therapeutics Corporation | Iminosugars and methods of treating bunyaviral and togaviral diseases |
| JP5575246B2 (ja) * | 2009-09-04 | 2014-08-20 | ユナイテッド セラピューティクス コーポレイション | ポックスウイルス感染の治療方法 |
| EP2473482B1 (en) * | 2009-09-04 | 2014-03-05 | United Therapeutics Corporation | Methods of treating orthomyxoviral infections |
| CN102595895A (zh) * | 2009-09-04 | 2012-07-18 | 联合治疗公司 | 亚氨基糖以及治疗丝状病毒性疾病的方法 |
| GB201000499D0 (en) | 2010-01-13 | 2010-03-03 | Fleet George W J | Treatment of cystic fibrosis |
| WO2011095772A2 (en) | 2010-02-04 | 2011-08-11 | Summit Corporation Plc | Novel iminosugar therapeutics |
| GB201006434D0 (en) | 2010-04-19 | 2010-06-02 | Summit Corp Plc | Novel iminosugar combinations |
| US10350277B2 (en) | 2011-09-07 | 2019-07-16 | Icahn School Of Medicine At Mount Sinai | Ceramidase and cell differentiation |
| ES2786128T3 (es) * | 2012-06-01 | 2020-10-08 | Icahn School Med Mount Sinai | Niveles de ceramida en el tratamiento y prevención de infecciones |
| WO2014086934A1 (en) * | 2012-12-05 | 2014-06-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Diagnosis of cystic fibrosis |
| JP6832158B2 (ja) | 2013-03-14 | 2021-02-24 | アイカーン スクール オブ メディシン アット マウント サイナイ | 治療用酸性セラミダーゼ組成物ならびにそれを作製および使用する方法 |
| US20190142782A1 (en) | 2016-04-11 | 2019-05-16 | Spedding Research Solutions | Inhibitors of glucosylceramide degradation in the treatment of diseases of the motor units |
| HRP20251697T1 (hr) | 2017-06-01 | 2026-02-27 | Idorsia Pharmaceuticals Ltd | Kristalni oblik n-butildeoksigalaktonojirimicina |
| MX2023010658A (es) * | 2021-03-12 | 2023-10-30 | Excepgen Inc | Sistemas y metodos para la expresion de proteinas. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177447B1 (en) * | 1996-07-15 | 2001-01-23 | Universiteit Van Amsterdam | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| AU5799500A (en) | 1999-06-29 | 2001-01-22 | Mcgill University | Human alpha 1,2-mannosidase |
| EP1528056A1 (en) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| FR2861991B1 (fr) * | 2003-11-07 | 2008-01-18 | Centre Nat Rech Scient | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| WO2005123055A2 (en) | 2004-06-14 | 2005-12-29 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| CN101267779A (zh) * | 2005-07-27 | 2008-09-17 | 福罗里达大学研究基金会有限公司 | 使用热休克治疗眼睛疾病 |
-
2007
- 2007-04-24 DE DE602007008870T patent/DE602007008870D1/de active Active
- 2007-04-24 BR BRPI0710883-4A patent/BRPI0710883A2/pt not_active IP Right Cessation
- 2007-04-24 CA CA002650311A patent/CA2650311A1/en not_active Abandoned
- 2007-04-24 US US12/298,506 patent/US8410081B2/en not_active Expired - Fee Related
- 2007-04-24 EP EP07747401A patent/EP2010551B1/en not_active Not-in-force
- 2007-04-24 CN CN2007800237886A patent/CN101479288B/zh not_active Expired - Fee Related
- 2007-04-24 WO PCT/NL2007/050177 patent/WO2007123403A1/en not_active Ceased
- 2007-04-24 AU AU2007241622A patent/AU2007241622A1/en not_active Abandoned
- 2007-04-24 AT AT07747401T patent/ATE479696T1/de not_active IP Right Cessation
- 2007-04-24 JP JP2009507606A patent/JP2009538276A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007241622A8 (en) | 2008-12-04 |
| CN101479288B (zh) | 2012-06-27 |
| DE602007008870D1 (de) | 2010-10-14 |
| EP2010551B1 (en) | 2010-09-01 |
| CA2650311A1 (en) | 2007-11-01 |
| EP2010551A1 (en) | 2009-01-07 |
| US20090186862A1 (en) | 2009-07-23 |
| WO2007123403A1 (en) | 2007-11-01 |
| CN101479288A (zh) | 2009-07-08 |
| BRPI0710883A2 (pt) | 2011-08-09 |
| AU2007241622A1 (en) | 2007-11-01 |
| US8410081B2 (en) | 2013-04-02 |
| JP2009538276A (ja) | 2009-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602007008870D1 (de) | Verbessertes verfahren zur behandlung von cystischer fibrose | |
| IL185428A0 (en) | 2-[isoquinolin-3- carbonyl) amino] - propionic acid derivatives as inhibitors of factors xi and ix for the treatment of thrombosis | |
| MXPA05003493A (es) | Metodos para generar y seleccionar proteasas con especificidad alterada. | |
| DE602004004665D1 (en) | Acetylenderivate als inhibitoren von histondeacetylase | |
| NO20065864L (no) | Femleddete heterosykler anvendelige som serinproteaseinhibitorer | |
| DE602005006938D1 (de) | Gebrauchslimitierendes elektronisches Schlüsselsystem für Plasmagerät zur Behandlung von Gewebeoberflächen | |
| WO2016111546A3 (ko) | 혈액 응고인자 viii 유전자를 타겟으로 하는 엔도뉴클레아제 및 이를 포함하는 혈우병 치료용 조성물 | |
| ATE455574T1 (de) | Prä-exzitations-pacing zur behandlung von hypertonie | |
| DK1611088T3 (da) | Hydroxymater som terapeutiske midler | |
| MX342128B (es) | Compuestos farmaceuticos. | |
| EP1572075A4 (en) | METHOD OF TREATING DISEASES ASSOCIATED WITH ABNORMAL KINASE ACTIVITY | |
| BR0007778A (pt) | Peptidila cetonas heterocìclicas úteis como inibidores de triptase | |
| DE602004020263D1 (de) | Amino-substituierte diaryläa,dücyclohepten- analoga als muscarinische agonisten und verfahren zur behandlung von neuropsychiatrischen erkrankungen | |
| NO20051107L (no) | Substituerte tienylhydroksaminsyrer og deres anvendelse til behandling av sykdommer forbundet med enzymatisk histondeacetylueaktivitet | |
| BRPI0510817A (pt) | protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de uma doença | |
| EA200700333A1 (ru) | Терапевтические применения ингибиторов rtp801 | |
| ATE423561T1 (de) | Verwendung von glucosidase-hemmern zur behandlung von mukoviszidose | |
| EP4320245A4 (en) | COMPOSITIONS, METHODS AND USES FOR TREATING CYSTIC FIBROSIS AND RELATED DISORDERS | |
| DE602004017283D1 (de) | Verfahren zur behandlung von schwerer herzinsuffizienz und medikament dafür | |
| SG164371A1 (en) | Inhibitors of microsomal triglyceride transfer protein and apo-b secretion | |
| DE112004000961D2 (de) | Verwendung von Wirksubstanzen zur Vorbeugung oder Behandlung von Viruserkrankungen sowie Testsystem zum Auffinden solcher Wirksubstanzen | |
| WO2003099202A3 (en) | Beta-secretase inhibitors | |
| NO20071466L (no) | 3-substituerte-5- og 6-aminoalkyl indol-2-karboksylsyreamider og relaterte analoger som inhibitorer av kaseinkinase IE | |
| ATE250936T1 (de) | Verfahren zur behandlung von erkrankungen oder störungen des innenohrs | |
| NO20044321L (no) | Piperazinyl- eller piperidinylamin-sulfaminsyreamider som inhibitorer av steroid sulfatase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |