ATE479696T1 - Verbessertes verfahren zur behandlung von cystischer fibrose - Google Patents
Verbessertes verfahren zur behandlung von cystischer fibroseInfo
- Publication number
- ATE479696T1 ATE479696T1 AT07747401T AT07747401T ATE479696T1 AT E479696 T1 ATE479696 T1 AT E479696T1 AT 07747401 T AT07747401 T AT 07747401T AT 07747401 T AT07747401 T AT 07747401T AT E479696 T1 ATE479696 T1 AT E479696T1
- Authority
- AT
- Austria
- Prior art keywords
- cystic fibrosis
- improved method
- found
- treating cystic
- membrane bilayer
- Prior art date
Links
- 201000003883 Cystic fibrosis Diseases 0.000 title abstract 2
- 102100027814 Non-lysosomal glucosylceramidase Human genes 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101000859679 Homo sapiens Non-lysosomal glucosylceramidase Proteins 0.000 abstract 1
- 101710083785 Non-lysosomal glucosylceramidase Proteins 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical class OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79408806P | 2006-04-24 | 2006-04-24 | |
| PCT/NL2007/050177 WO2007123403A1 (en) | 2006-04-24 | 2007-04-24 | Improved treatment of cystic fibrosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE479696T1 true ATE479696T1 (de) | 2010-09-15 |
Family
ID=38283020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07747401T ATE479696T1 (de) | 2006-04-24 | 2007-04-24 | Verbessertes verfahren zur behandlung von cystischer fibrose |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8410081B2 (de) |
| EP (1) | EP2010551B1 (de) |
| JP (1) | JP2009538276A (de) |
| CN (1) | CN101479288B (de) |
| AT (1) | ATE479696T1 (de) |
| AU (1) | AU2007241622A1 (de) |
| BR (1) | BRPI0710883A2 (de) |
| CA (1) | CA2650311A1 (de) |
| DE (1) | DE602007008870D1 (de) |
| WO (1) | WO2007123403A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0712494D0 (en) | 2007-06-27 | 2007-08-08 | Isis Innovation | Substrate reduction therapy |
| KR101755133B1 (ko) | 2009-02-23 | 2017-07-06 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 바이러스성 질환을 치료하는 방법 |
| CN102625660B (zh) * | 2009-02-24 | 2015-03-11 | 联合治疗公司 | 亚氨基糖以及治疗沙粒病毒感染的方法 |
| CA2765086C (en) | 2009-06-12 | 2015-12-15 | United Therapeutics Corporation | Iminosugars and methods of treating bunyaviral and togaviral diseases |
| CN105748476A (zh) * | 2009-09-04 | 2016-07-13 | 联合治疗公司 | 亚氨基糖以及治疗丝状病毒性疾病的方法 |
| WO2011028781A1 (en) * | 2009-09-04 | 2011-03-10 | United Therapeutics Corporation | Methods of treating poxviral infections |
| KR101497194B1 (ko) * | 2009-09-04 | 2015-02-27 | 유나이티드 세러퓨틱스 코오포레이션 | 오르토믹소바이러스 감염의 치료 방법 |
| GB201000499D0 (en) | 2010-01-13 | 2010-03-03 | Fleet George W J | Treatment of cystic fibrosis |
| WO2011095772A2 (en) | 2010-02-04 | 2011-08-11 | Summit Corporation Plc | Novel iminosugar therapeutics |
| GB201006434D0 (en) | 2010-04-19 | 2010-06-02 | Summit Corp Plc | Novel iminosugar combinations |
| DK2753346T3 (da) | 2011-09-07 | 2020-05-25 | Sinai School Medicine | Ceramidase og celledifferentiering |
| EP2854910B1 (de) * | 2012-06-01 | 2020-04-15 | Icahn School of Medicine at Mount Sinai | Ceramidspiegel bei der behandlung und vorbeugung von infektionen |
| WO2014086934A1 (en) * | 2012-12-05 | 2014-06-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Diagnosis of cystic fibrosis |
| EP3659619A1 (de) | 2013-03-14 | 2020-06-03 | Icahn School of Medicine at Mount Sinai | Therapeutische säure-ceramidase-zusammensetzungen und verfahren zur herstellung und verwendung davon |
| WO2017178499A1 (en) | 2016-04-11 | 2017-10-19 | Spedding Research Solutions | Inhibitors of glucosylceramide degradation in the treatment of diseases of the motor units |
| DK3630725T3 (da) | 2017-06-01 | 2026-02-09 | Idorsia Pharmaceuticals Ltd | Krystallinsk form af n-butyldeoxygalactonojirimycin |
| CA3211755A1 (en) * | 2021-03-12 | 2022-09-15 | Barbara MERTINS | Systems and methods for protein expression |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998002161A1 (en) | 1996-07-15 | 1998-01-22 | Universiteit Van Amsterdam | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| AU5799500A (en) | 1999-06-29 | 2001-01-22 | Mcgill University | Human alpha 1,2-mannosidase |
| EP1528056A1 (de) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin Derivate und ihre Verwendung als Glukosesylceramidase-Inhibitoren |
| FR2861991B1 (fr) * | 2003-11-07 | 2008-01-18 | Centre Nat Rech Scient | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| US20090111812A1 (en) * | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| AU2006272497B2 (en) | 2005-07-27 | 2012-07-19 | University Of Florida Research Foundation, Inc. | Small compounds that correct protein misfolding and uses thereof |
-
2007
- 2007-04-24 AT AT07747401T patent/ATE479696T1/de not_active IP Right Cessation
- 2007-04-24 JP JP2009507606A patent/JP2009538276A/ja not_active Ceased
- 2007-04-24 DE DE602007008870T patent/DE602007008870D1/de active Active
- 2007-04-24 BR BRPI0710883-4A patent/BRPI0710883A2/pt not_active IP Right Cessation
- 2007-04-24 AU AU2007241622A patent/AU2007241622A1/en not_active Abandoned
- 2007-04-24 WO PCT/NL2007/050177 patent/WO2007123403A1/en not_active Ceased
- 2007-04-24 CN CN2007800237886A patent/CN101479288B/zh not_active Expired - Fee Related
- 2007-04-24 CA CA002650311A patent/CA2650311A1/en not_active Abandoned
- 2007-04-24 EP EP07747401A patent/EP2010551B1/de not_active Not-in-force
- 2007-04-24 US US12/298,506 patent/US8410081B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2010551A1 (de) | 2009-01-07 |
| US20090186862A1 (en) | 2009-07-23 |
| AU2007241622A8 (en) | 2008-12-04 |
| EP2010551B1 (de) | 2010-09-01 |
| CN101479288B (zh) | 2012-06-27 |
| CA2650311A1 (en) | 2007-11-01 |
| JP2009538276A (ja) | 2009-11-05 |
| BRPI0710883A2 (pt) | 2011-08-09 |
| US8410081B2 (en) | 2013-04-02 |
| AU2007241622A1 (en) | 2007-11-01 |
| DE602007008870D1 (de) | 2010-10-14 |
| WO2007123403A1 (en) | 2007-11-01 |
| CN101479288A (zh) | 2009-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE479696T1 (de) | Verbessertes verfahren zur behandlung von cystischer fibrose | |
| IL185428A0 (en) | 2-[isoquinolin-3- carbonyl) amino] - propionic acid derivatives as inhibitors of factors xi and ix for the treatment of thrombosis | |
| MXPA05003493A (es) | Metodos para generar y seleccionar proteasas con especificidad alterada. | |
| EP1490677A4 (de) | Computerberechnungsverfahren zur konstruktion von enzymen zum einbau von aminosäureanalogen in proteine | |
| NO20065864L (no) | Femleddete heterosykler anvendelige som serinproteaseinhibitorer | |
| DE602004004665D1 (en) | Acetylenderivate als inhibitoren von histondeacetylase | |
| SG152262A1 (en) | Improved modulators of coagulation factors | |
| EA200401043A1 (ru) | Лечение доброкачественной гиперплазии простаты селективным модулятором рецептора андрогенов ( sarm ) | |
| NO20055216L (no) | Nye hydroksamater som terapeutiske midler | |
| MX342128B (es) | Compuestos farmaceuticos. | |
| DE602007004514D1 (de) | Prä-exzitations-pacing zur behandlung von hypertonie | |
| DK1590340T3 (da) | Histondeacetylase-inhibitorer | |
| NO20071240L (no) | Terapeutiske anvendelser av RTP801 inhibitorer | |
| DK1620082T3 (da) | Medicinsk anvendelse af inhibitorer af glutaminyl- og glutamatcyclaser til behandling af Alzheimers sygdom og Downs syndrom | |
| ATE423561T1 (de) | Verwendung von glucosidase-hemmern zur behandlung von mukoviszidose | |
| DE602004017283D1 (de) | Verfahren zur behandlung von schwerer herzinsuffizienz und medikament dafür | |
| DE112004000961D2 (de) | Verwendung von Wirksubstanzen zur Vorbeugung oder Behandlung von Viruserkrankungen sowie Testsystem zum Auffinden solcher Wirksubstanzen | |
| ATE250936T1 (de) | Verfahren zur behandlung von erkrankungen oder störungen des innenohrs | |
| ATE470453T1 (de) | Verfahren zur behandlung von atherosklerose | |
| NO20044321L (no) | Piperazinyl- eller piperidinylamin-sulfaminsyreamider som inhibitorer av steroid sulfatase | |
| NO20073610L (no) | Nye substituerte tiofenpyrimidinonderivater som inhibitorer for 17 β-hydroksysteroiddehydrogenase | |
| DE602004019779D1 (de) | Enalapril-nitroxy-derivate und verwandte verbindungen als ace-hemmer zur behandlung von kardiovaskulären erkrankungen | |
| JO2724B1 (en) | 3-Alternative-5 -6-Amino Alkyl Indole-2-Carboxyl Acid Amide and Related Isotopes as Casein Kinase Inhibitors | |
| ATE469168T1 (de) | Peptide zur transglutaminase-hemmung | |
| ATE395073T1 (de) | Behandlung von nicht-alkoholischer steatotischer hepatitis (nash) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |