JP2010533717A5 - - Google Patents
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- Publication number
- JP2010533717A5 JP2010533717A5 JP2010517021A JP2010517021A JP2010533717A5 JP 2010533717 A5 JP2010533717 A5 JP 2010533717A5 JP 2010517021 A JP2010517021 A JP 2010517021A JP 2010517021 A JP2010517021 A JP 2010517021A JP 2010533717 A5 JP2010533717 A5 JP 2010533717A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- pharmaceutical composition
- alkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 206010062519 Poor quality sleep Diseases 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 208000032140 Sleepiness Diseases 0.000 claims 1
- 230000001430 anti-depressive effect Effects 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229940005513 antidepressants Drugs 0.000 claims 1
- 230000037007 arousal Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 206010020765 hypersomnia Diseases 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 230000033764 rhythmic process Effects 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000037321 sleepiness Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96120707P | 2007-07-18 | 2007-07-18 | |
| PCT/US2008/008773 WO2009011901A2 (en) | 2007-07-18 | 2008-07-18 | Methods for promoting wakefulness |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533717A JP2010533717A (ja) | 2010-10-28 |
| JP2010533717A5 true JP2010533717A5 (enExample) | 2011-09-01 |
Family
ID=39832375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517021A Withdrawn JP2010533717A (ja) | 2007-07-18 | 2008-07-18 | 覚醒を促進する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090048229A1 (enExample) |
| EP (1) | EP2182938A2 (enExample) |
| JP (1) | JP2010533717A (enExample) |
| CN (1) | CN101795683A (enExample) |
| AU (1) | AU2008276459A1 (enExample) |
| CA (1) | CA2693110A1 (enExample) |
| WO (1) | WO2009011901A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2125709A2 (en) | 2007-02-02 | 2009-12-02 | Colucid Pharmaceuticals, Inc. | Compounds that inhibit cholinesterase |
| US20100256229A1 (en) * | 2009-04-02 | 2010-10-07 | Colucid Pharmaceuticals, Inc. | Compositions of cholinesterase inhibitors |
| PT3150575T (pt) * | 2010-09-27 | 2023-11-13 | Corteva Agriscience Llc | Método de preparação de 2-amino-n-(2,2,2- trifluoroetil)acetamida |
| CA3123900A1 (en) * | 2011-07-28 | 2013-01-31 | Kempharm Inc. | Methylphenidate-prodrugs, processes of making and using the same |
| ES2545836B1 (es) * | 2014-03-13 | 2016-07-07 | Elaborados Castellano, S.L. | Composición potenciadora de vigilia, y usos de la misma |
| JPWO2019112007A1 (ja) * | 2017-12-07 | 2020-12-24 | 国立大学法人 筑波大学 | 鎮痛薬による眠気の予防または治療薬 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3600427A (en) * | 1967-05-08 | 1971-08-17 | Anthony J Verbiscar | Phenyl carbamate latentiated phenethylamines |
| IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| HU201906B (en) * | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
| US5187165A (en) * | 1987-05-15 | 1993-02-16 | Hoechst-Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles |
| IT1251166B (it) * | 1991-08-09 | 1995-05-04 | Chiesi Farma Spa | Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono |
| US5302721A (en) * | 1992-07-21 | 1994-04-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of preparation of physostigmine carbamate derivatives from eseretholes |
| US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| SE9504537D0 (sv) * | 1995-12-19 | 1995-12-19 | Jan Hedner | Sätt att behandla och diagnosticera andningsstörningar under sömn och medel för utförande av sättet |
| US5665880A (en) * | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
| US5677457A (en) * | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
| AU749088C (en) * | 1997-07-09 | 2005-11-03 | Axonyx, Inc. | Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of Alzheimer's disease and dementias |
| SE9803760D0 (sv) * | 1998-11-04 | 1998-11-04 | Jan Hedner | Sätt att behandla och diagnostisera syndromet restless legs och motsvarande medel |
| WO2004034963A2 (en) * | 2002-05-17 | 2004-04-29 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| WO2005016327A2 (en) * | 2003-08-13 | 2005-02-24 | Janssen Pharmaceutica, N.V. | Treatment of sleep disorders with cholinesterase inhibitors |
| US7897639B2 (en) * | 2003-10-21 | 2011-03-01 | Colucid Pharmaceuticals, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
| EP2125709A2 (en) * | 2007-02-02 | 2009-12-02 | Colucid Pharmaceuticals, Inc. | Compounds that inhibit cholinesterase |
| AU2008248382B2 (en) * | 2007-05-07 | 2013-07-18 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders |
-
2008
- 2008-07-18 CA CA2693110A patent/CA2693110A1/en not_active Abandoned
- 2008-07-18 EP EP08780244A patent/EP2182938A2/en not_active Withdrawn
- 2008-07-18 JP JP2010517021A patent/JP2010533717A/ja not_active Withdrawn
- 2008-07-18 CN CN200880105586A patent/CN101795683A/zh active Pending
- 2008-07-18 AU AU2008276459A patent/AU2008276459A1/en not_active Abandoned
- 2008-07-18 WO PCT/US2008/008773 patent/WO2009011901A2/en not_active Ceased
- 2008-07-18 US US12/218,813 patent/US20090048229A1/en not_active Abandoned
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