JP2009543825A5 - - Google Patents
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- Publication number
- JP2009543825A5 JP2009543825A5 JP2009519861A JP2009519861A JP2009543825A5 JP 2009543825 A5 JP2009543825 A5 JP 2009543825A5 JP 2009519861 A JP2009519861 A JP 2009519861A JP 2009519861 A JP2009519861 A JP 2009519861A JP 2009543825 A5 JP2009543825 A5 JP 2009543825A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- drug
- abuse
- anxiety
- stress
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000011117 substance-related disease Diseases 0.000 claims description 7
- 208000007848 Alcoholism Diseases 0.000 claims description 4
- 208000024827 Alzheimer disease Diseases 0.000 claims description 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 4
- 206010013663 drug dependence Diseases 0.000 claims description 4
- 208000019901 Anxiety disease Diseases 0.000 claims description 3
- 206010013654 Drug abuse Diseases 0.000 claims description 3
- 230000036506 anxiety Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 206010006895 Cachexia Diseases 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 208000009132 Catalepsy Diseases 0.000 claims description 2
- 206010011878 Deafness Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 208000001953 Hypotension Diseases 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 208000004880 Polyuria Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 206010039966 Senile dementia Diseases 0.000 claims description 2
- 201000001880 Sexual dysfunction Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 206010046543 Urinary incontinence Diseases 0.000 claims description 2
- 206010047853 Waxy flexibility Diseases 0.000 claims description 2
- 206010001584 alcohol abuse Diseases 0.000 claims description 2
- 201000007930 alcohol dependence Diseases 0.000 claims description 2
- 208000025746 alcohol use disease Diseases 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 229940124575 antispasmodic agent Drugs 0.000 claims description 2
- 125000005334 azaindolyl group Chemical class N1N=C(C2=CC=CC=C12)* 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 230000035619 diuresis Effects 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 239000003193 general anesthetic agent Substances 0.000 claims description 2
- 230000010370 hearing loss Effects 0.000 claims description 2
- 231100000888 hearing loss Toxicity 0.000 claims description 2
- 208000016354 hearing loss disease Diseases 0.000 claims description 2
- 230000036543 hypotension Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 206010027175 memory impairment Diseases 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 239000003158 myorelaxant agent Substances 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 230000003957 neurotransmitter release Effects 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 239000000014 opioid analgesic Substances 0.000 claims description 2
- 229940005483 opioid analgesics Drugs 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 229940001470 psychoactive drug Drugs 0.000 claims description 2
- 239000004089 psychotropic agent Substances 0.000 claims description 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 206010002091 Anaesthesia Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000026251 Opioid-Related disease Diseases 0.000 claims 1
- 230000037005 anaesthesia Effects 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- 230000002921 anti-spasmodic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 230000037023 motor activity Effects 0.000 claims 1
- 229940035363 muscle relaxants Drugs 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000049 anti-anxiety effect Effects 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 229940052318 opioid anesthetics Drugs 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006033114.1 | 2006-07-18 | ||
| DE102006033114A DE102006033114A1 (de) | 2006-07-18 | 2006-07-18 | Spirocyclische Azaindol-Derivate |
| PCT/EP2007/006326 WO2008009416A1 (de) | 2006-07-18 | 2007-07-17 | Spirocyclische azaindol-derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009543825A JP2009543825A (ja) | 2009-12-10 |
| JP2009543825A5 true JP2009543825A5 (enExample) | 2013-04-11 |
| JP5269784B2 JP5269784B2 (ja) | 2013-08-21 |
Family
ID=38704887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519861A Expired - Fee Related JP5269784B2 (ja) | 2006-07-18 | 2007-07-17 | スピロ環状アザインドール誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8399503B2 (enExample) |
| EP (1) | EP2041142B1 (enExample) |
| JP (1) | JP5269784B2 (enExample) |
| KR (1) | KR101421034B1 (enExample) |
| CN (1) | CN101490055B (enExample) |
| AR (1) | AR062079A1 (enExample) |
| AU (1) | AU2007276414B2 (enExample) |
| BR (1) | BRPI0714650A2 (enExample) |
| CA (1) | CA2658379C (enExample) |
| CL (1) | CL2007001917A1 (enExample) |
| DE (1) | DE102006033114A1 (enExample) |
| ES (1) | ES2434114T3 (enExample) |
| IL (1) | IL196525A (enExample) |
| MX (1) | MX2009000670A (enExample) |
| NO (1) | NO342282B1 (enExample) |
| NZ (1) | NZ573688A (enExample) |
| PE (1) | PE20080277A1 (enExample) |
| PL (1) | PL2041142T3 (enExample) |
| RU (1) | RU2468028C2 (enExample) |
| WO (1) | WO2008009416A1 (enExample) |
| ZA (1) | ZA200901128B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
| AR071066A1 (es) * | 2008-03-27 | 2010-05-26 | Gruenenthal Chemie | Derivados de (hetero) aril-ciclohexano |
| CA2719743A1 (en) | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
| US8288430B2 (en) * | 2008-03-27 | 2012-10-16 | Grunenthal Gmbh | Spiro(5.5)undecane derivatives |
| RU2532545C2 (ru) | 2008-03-27 | 2014-11-10 | Грюненталь Гмбх | Замещенные производные 4-аминоциклогексана |
| TWI450899B (zh) * | 2008-03-27 | 2014-09-01 | 被取代之螺環環已烷衍生物 | |
| EP2575815A4 (en) | 2010-06-04 | 2013-12-25 | Albany Molecular Res Inc | GLYCIN TRANSPORTER 1 INHIBITORS, METHODS OF MAKING THE SAME, AND USES THEREOF |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| AR084209A1 (es) | 2010-12-08 | 2013-05-02 | Gruenenthal Gmbh | Metodo para la sintesis de derivados de aminociclohexanona sustituidos |
| CA2942522A1 (en) * | 2014-03-12 | 2015-09-17 | The Trustees Of Columbia University In The City Of New York | 5,5-dioxo-11h-benzo[c][2,1]benzothiazepine derivatives and their use as mu-opioid receptor agonists |
| PL3169666T3 (pl) | 2014-07-15 | 2019-03-29 | Grünenthal GmbH | Podstawione pochodne azaspiro(4,5)dekanu |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| WO2017049158A1 (en) | 2015-09-16 | 2017-03-23 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
| CN117447384B (zh) * | 2023-10-24 | 2024-12-27 | 四川大学 | 一种螺杂环芳基类化合物及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065573A (en) | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| JPH06502147A (ja) * | 1990-10-09 | 1994-03-10 | ニューロゲン コーポレイション | 或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド |
| WO2000038720A1 (en) * | 1998-12-24 | 2000-07-06 | Meiji Seika Kaisha, Ltd. | Remedies for pain |
| GB9918965D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| EA005409B1 (ru) * | 2000-04-10 | 2005-02-24 | Пфайзер Продактс Инк. | Производные бензамидопиперидина в качестве антагонистов рецепторов вещества p |
| DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| RU2216737C1 (ru) * | 2002-03-19 | 2003-11-20 | Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова | Способ оценки течения хронического воспалительного процесса в бронхолегочной системе больного муковисцидозом |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| EP1637521B1 (en) * | 2003-06-23 | 2013-06-19 | Ono Pharmaceutical Co., Ltd. | Novel tricyclic heterocycle compound |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004039382A1 (de) * | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| CN101072771B (zh) * | 2004-10-07 | 2010-09-29 | 默沙东公司 | Cgrp受体拮抗剂 |
| EP1829874B1 (en) * | 2004-12-22 | 2014-02-12 | Ono Pharmaceutical Co., Ltd. | Tricyclic compound and use thereof |
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006019597A1 (de) * | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102007009235A1 (de) * | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102007009319A1 (de) * | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| TWI450899B (zh) * | 2008-03-27 | 2014-09-01 | 被取代之螺環環已烷衍生物 |
-
2006
- 2006-07-18 DE DE102006033114A patent/DE102006033114A1/de not_active Withdrawn
-
2007
- 2007-06-29 CL CL200701917A patent/CL2007001917A1/es unknown
- 2007-07-16 PE PE2007000917A patent/PE20080277A1/es active IP Right Grant
- 2007-07-16 AR ARP070103151A patent/AR062079A1/es not_active Application Discontinuation
- 2007-07-17 CA CA2658379A patent/CA2658379C/en not_active Expired - Fee Related
- 2007-07-17 ES ES07786123T patent/ES2434114T3/es active Active
- 2007-07-17 EP EP07786123.5A patent/EP2041142B1/de active Active
- 2007-07-17 AU AU2007276414A patent/AU2007276414B2/en not_active Ceased
- 2007-07-17 BR BRPI0714650-7A patent/BRPI0714650A2/pt not_active Application Discontinuation
- 2007-07-17 CN CN2007800272998A patent/CN101490055B/zh not_active Expired - Fee Related
- 2007-07-17 KR KR1020097003277A patent/KR101421034B1/ko not_active Expired - Fee Related
- 2007-07-17 MX MX2009000670A patent/MX2009000670A/es active IP Right Grant
- 2007-07-17 JP JP2009519861A patent/JP5269784B2/ja not_active Expired - Fee Related
- 2007-07-17 WO PCT/EP2007/006326 patent/WO2008009416A1/de not_active Ceased
- 2007-07-17 PL PL07786123T patent/PL2041142T3/pl unknown
- 2007-07-17 NZ NZ573688A patent/NZ573688A/en not_active IP Right Cessation
- 2007-07-17 RU RU2009105399/04A patent/RU2468028C2/ru not_active IP Right Cessation
-
2009
- 2009-01-15 IL IL196525A patent/IL196525A/en active IP Right Grant
- 2009-01-15 US US12/354,001 patent/US8399503B2/en not_active Expired - Fee Related
- 2009-01-19 NO NO20090294A patent/NO342282B1/no not_active IP Right Cessation
- 2009-02-17 ZA ZA2009/01128A patent/ZA200901128B/en unknown
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