JP2011517669A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011517669A5 JP2011517669A5 JP2011501142A JP2011501142A JP2011517669A5 JP 2011517669 A5 JP2011517669 A5 JP 2011517669A5 JP 2011501142 A JP2011501142 A JP 2011501142A JP 2011501142 A JP2011501142 A JP 2011501142A JP 2011517669 A5 JP2011517669 A5 JP 2011517669A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- abuse
- anxiety
- stress
- withdrawal symptoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08005809 | 2008-03-27 | ||
| EP08005809.2 | 2008-03-27 | ||
| PCT/EP2009/002184 WO2009118171A1 (de) | 2008-03-27 | 2009-03-25 | Hydroxymethylcyclohexylamine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517669A JP2011517669A (ja) | 2011-06-16 |
| JP2011517669A5 true JP2011517669A5 (enExample) | 2014-04-03 |
| JP5599774B2 JP5599774B2 (ja) | 2014-10-01 |
Family
ID=39791743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501142A Expired - Fee Related JP5599774B2 (ja) | 2008-03-27 | 2009-03-25 | ヒドロキシメチルシクロヘキシルアミン類 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8288406B2 (enExample) |
| EP (1) | EP2271613B1 (enExample) |
| JP (1) | JP5599774B2 (enExample) |
| CN (1) | CN102046591B (enExample) |
| AR (1) | AR073841A1 (enExample) |
| AU (1) | AU2009228645B2 (enExample) |
| CA (1) | CA2719739A1 (enExample) |
| CL (1) | CL2009000732A1 (enExample) |
| CY (1) | CY1115437T1 (enExample) |
| DK (1) | DK2271613T3 (enExample) |
| ES (1) | ES2482108T3 (enExample) |
| HR (1) | HRP20140650T1 (enExample) |
| IL (1) | IL208280A (enExample) |
| MX (1) | MX2010010448A (enExample) |
| PE (1) | PE20091822A1 (enExample) |
| PL (1) | PL2271613T3 (enExample) |
| PT (1) | PT2271613E (enExample) |
| RU (1) | RU2514192C2 (enExample) |
| SI (1) | SI2271613T1 (enExample) |
| WO (1) | WO2009118171A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835689B2 (en) | 2008-03-27 | 2014-09-16 | Grünenthal GmbH | Substituted 4-aminocyclohexane derivatives |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI450899B (zh) | 2008-03-27 | 2014-09-01 | 被取代之螺環環已烷衍生物 | |
| AR071066A1 (es) | 2008-03-27 | 2010-05-26 | Gruenenthal Chemie | Derivados de (hetero) aril-ciclohexano |
| US8288430B2 (en) | 2008-03-27 | 2012-10-16 | Grunenthal Gmbh | Spiro(5.5)undecane derivatives |
| CA2719743A1 (en) | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
| SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
| US8818396B2 (en) | 2008-07-11 | 2014-08-26 | Qualcomm Incorporated | Apparatus and methods for associating a location fix having a quality of service with an event occuring on a wireless device |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| CN105924362B (zh) * | 2016-02-05 | 2018-08-17 | 上海龙翔生物医药开发有限公司 | 芳香环丙基胺类化合物、其药学上可接受的盐、其制备方法及其用途 |
| ES2896487T3 (es) | 2016-09-01 | 2022-02-24 | Mebias Discovery Llc | Derivados de urea sustituidos para el tratamiento del dolor |
| CN109535157B (zh) * | 2018-12-03 | 2021-10-15 | 江苏科技大学 | 一种半蜡梅碱类似物、其合成方法及其用途 |
| CA3165903A1 (en) | 2019-12-26 | 2021-07-01 | Gilgamesh Pharmaceuticals, Inc. | Arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders |
| LT4084791T (lt) | 2020-02-18 | 2025-02-25 | Gilgamesh Pharmaceuticals, Inc. | Specifiniai triptaminai, skirti nuotaikos sutrikimams gydyti |
| US12157722B1 (en) | 2023-08-03 | 2024-12-03 | Gilgamesh Pharmaceuticals, Inc. | Crystalline hydrochloride salts of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine |
| US12129234B1 (en) | 2023-08-03 | 2024-10-29 | Gilgamesh Pharmaceuticals, Inc. | Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1055203A (en) | 1964-09-16 | 1967-01-18 | Ici Ltd | -ß-carboline derivatives, a process for their manufacture, and compositions containing them |
| US4065573A (en) | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| US4115589A (en) | 1977-05-17 | 1978-09-19 | The Upjohn Company | Compounds, compositions and method of use |
| US4366172A (en) * | 1977-09-29 | 1982-12-28 | The Upjohn Company | 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use |
| US4291039A (en) | 1980-08-08 | 1981-09-22 | Miles Laboratories, Inc. | Tetrahydro β-carbolines having anti-hypertensive activity |
| DE3309596A1 (de) | 1982-08-05 | 1984-04-05 | Basf Ag, 6700 Ludwigshafen | 2-substituierte 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-ss-carboline, ihre herstellung und verwendung als arzneimittel |
| US5328905A (en) | 1987-07-20 | 1994-07-12 | Duphar International Research B.V. | 8,9-anellated-1,2,3,4-tetrahydro-β-carboline derivatives |
| EP0620222A3 (en) | 1993-04-14 | 1995-04-12 | Lilly Co Eli | Tetrahydro-beta-carbolines. |
| US5631265A (en) | 1994-03-11 | 1997-05-20 | Eli Lilly And Company | 8-substituted tetrahydro-beta-carbolines |
| US5861408A (en) | 1995-05-19 | 1999-01-19 | Eli Lilly And Company | Tetrahydro-Beta-Carbolines |
| EP2308833A3 (en) * | 1999-04-15 | 2011-09-28 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| GB0012240D0 (en) | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
| DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| DE10135636A1 (de) * | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
| DE10213051B4 (de) | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
| TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
| US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
| DE10252666A1 (de) | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10252650A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| DE10252665A1 (de) | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
| AU2003296564A1 (en) | 2002-11-12 | 2004-06-03 | Grunenthal Gmbh | 4-hydroxymethyl-1-aryl-cyclohexylamine derivatives |
| AU2003287995A1 (en) * | 2002-11-12 | 2004-06-03 | Grunenthal Gmbh | 4-alkyl/4-alkenyl/4-alkynyl methyl/-1-arylcyclohexylamine derivatives |
| US20060235012A1 (en) | 2003-06-16 | 2006-10-19 | Chroma Therapeutics Limited | Carboline and betacarboline derivatives for use as hdac enzyme inhibitors |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360793A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023501A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023507A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
| DE102004023632A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
| DE102004023506A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023522A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023508A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
| DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| CA2588607A1 (en) | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
| DE102005016460A1 (de) | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| EP1747779A1 (en) | 2005-07-28 | 2007-01-31 | Laboratorios Del Dr. Esteve, S.A. | Tetrahydro-b-carbolin-sulfonamide derivatives as 5-HT6 ligands |
| US20070149557A1 (en) | 2005-11-21 | 2007-06-28 | Amgen Inc. | CXCR3 antagonists |
| WO2007070796A1 (en) | 2005-12-15 | 2007-06-21 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
| DE102005061429A1 (de) | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxazol-Derivate |
| DE102005061428A1 (de) | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
| DE102005061427A1 (de) | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxadiazol-Derivate |
| DE102005061430A1 (de) | 2005-12-22 | 2007-07-05 | Grünenthal GmbH | Substituierte Imidazolin-Derivate |
| DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102007009235A1 (de) | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102007009319A1 (de) | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| AR071066A1 (es) | 2008-03-27 | 2010-05-26 | Gruenenthal Chemie | Derivados de (hetero) aril-ciclohexano |
| CA2719743A1 (en) | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
| SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
| US8288430B2 (en) | 2008-03-27 | 2012-10-16 | Grunenthal Gmbh | Spiro(5.5)undecane derivatives |
| RU2532545C2 (ru) | 2008-03-27 | 2014-11-10 | Грюненталь Гмбх | Замещенные производные 4-аминоциклогексана |
| TWI450899B (zh) | 2008-03-27 | 2014-09-01 | 被取代之螺環環已烷衍生物 |
-
2009
- 2009-03-25 SI SI200930978T patent/SI2271613T1/sl unknown
- 2009-03-25 AU AU2009228645A patent/AU2009228645B2/en not_active Ceased
- 2009-03-25 JP JP2011501142A patent/JP5599774B2/ja not_active Expired - Fee Related
- 2009-03-25 EP EP09725940.2A patent/EP2271613B1/de not_active Not-in-force
- 2009-03-25 PL PL09725940T patent/PL2271613T3/pl unknown
- 2009-03-25 CA CA2719739A patent/CA2719739A1/en not_active Abandoned
- 2009-03-25 DK DK09725940.2T patent/DK2271613T3/da active
- 2009-03-25 CL CL2009000732A patent/CL2009000732A1/es unknown
- 2009-03-25 HR HRP20140650AT patent/HRP20140650T1/hr unknown
- 2009-03-25 CN CN200980120245.5A patent/CN102046591B/zh not_active Expired - Fee Related
- 2009-03-25 RU RU2010143447/04A patent/RU2514192C2/ru not_active IP Right Cessation
- 2009-03-25 MX MX2010010448A patent/MX2010010448A/es active IP Right Grant
- 2009-03-25 PE PE2009000446A patent/PE20091822A1/es not_active Application Discontinuation
- 2009-03-25 ES ES09725940.2T patent/ES2482108T3/es active Active
- 2009-03-25 PT PT97259402T patent/PT2271613E/pt unknown
- 2009-03-25 WO PCT/EP2009/002184 patent/WO2009118171A1/de not_active Ceased
- 2009-03-25 AR ARP090101055A patent/AR073841A1/es unknown
-
2010
- 2010-09-21 IL IL208280A patent/IL208280A/en not_active IP Right Cessation
- 2010-09-22 US US12/887,997 patent/US8288406B2/en not_active Expired - Fee Related
-
2014
- 2014-08-06 CY CY20141100609T patent/CY1115437T1/el unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835689B2 (en) | 2008-03-27 | 2014-09-16 | Grünenthal GmbH | Substituted 4-aminocyclohexane derivatives |
| US9580386B2 (en) | 2008-03-27 | 2017-02-28 | Grünenthal | Substituted 4-aminocyclohexane derivatives |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011517669A5 (enExample) | ||
| US7790753B2 (en) | Derivatives of N-[phenyl(alkylpiperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics | |
| TWI298635B (en) | Benzimidazolone carboxylic acid derivatives | |
| ATE545413T1 (de) | Antagonisten des opioidrezeptors | |
| IL311953A (en) | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use | |
| RU2012141951A (ru) | Курс лечения с использованием агониста рецептора sip | |
| JP2009543825A5 (enExample) | ||
| JP2006515587A5 (enExample) | ||
| WO2009154780A1 (en) | S1p1 receptor agonists and use thereof | |
| WO2005037785A2 (fr) | Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide, et n-[azepan-2-yl) phenylmethyl]benzamide, leur preparation et leur application en therapeutique | |
| PT2203444E (pt) | Formas sólidas de 2-amino-3-(4-(2-amino-6-((r)-1-(4-cloro-2- (3-metil-1h-pirazol-1-il)fenil)-2,2,2-trifluoroetoxi)- pirimidin-4-il)fenil)propanoato de (s)-etilo | |
| JP2011515430A5 (enExample) | ||
| RU2162848C2 (ru) | Производные окса- или тиадиазола, способ их получения (варианты), фармацевтическая композиция | |
| HUP0500201A2 (hu) | Policiklusos vegyületek, mint potenciális alfa2-adrenoceptor antagonisták és ezeket tartalmazó gyógyszerkészítmények | |
| JP2008530050A5 (enExample) | ||
| ATE475640T1 (de) | Antagonisten des opioidrezeptors | |
| JP2009500425A5 (enExample) | ||
| TWI345467B (en) | 4-imidazolines as taar's ligands | |
| JP2011515429A5 (enExample) | ||
| JP2009502770A (ja) | ５ｈｔ４受容体アゴニストとしてのインダゾールカルボキサミド誘導体 | |
| US20150266864A1 (en) | Heteroaromatic compounds, method for preparing the compounds, pharmaceutical compositions, uses and method for treating acute and chronic pain | |
| CN1812987A (zh) | 取代的二酮哌嗪及其作为催产素拮抗剂的用途 | |
| ATE399164T1 (de) | Antagonisten des opioidrezeptors | |
| JP2009503048A (ja) | 尿路機能障害を治療するためのｍｃ４ｒ作動薬 | |
| JP2005511567A (ja) | 置換１ｈ−キノリン−２−オン化合物 |