AU2007276414B2 - Spirocyclic azaindole derivatives - Google Patents
Spirocyclic azaindole derivatives Download PDFInfo
- Publication number
- AU2007276414B2 AU2007276414B2 AU2007276414A AU2007276414A AU2007276414B2 AU 2007276414 B2 AU2007276414 B2 AU 2007276414B2 AU 2007276414 A AU2007276414 A AU 2007276414A AU 2007276414 A AU2007276414 A AU 2007276414A AU 2007276414 B2 AU2007276414 B2 AU 2007276414B2
- Authority
- AU
- Australia
- Prior art keywords
- azaindole
- alkyl
- polysubstituted
- monosubstituted
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 229920006395 saturated elastomer Polymers 0.000 claims description 58
- 125000003118 aryl group Chemical group 0.000 claims description 57
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 53
- -1 benzodioxanyl Chemical group 0.000 claims description 51
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 150000003385 sodium Chemical class 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- MNWBNISUBARLIT-UHFFFAOYSA-N sodium cyanide Chemical compound [Na+].N#[C-] MNWBNISUBARLIT-UHFFFAOYSA-N 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 150000003459 sulfonic acid esters Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 125000005425 toluyl group Chemical group 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BPLUKJNHPBNVQL-UHFFFAOYSA-N triphenylarsine Chemical compound C1=CC=CC=C1[As](C=1C=CC=CC=1)C1=CC=CC=C1 BPLUKJNHPBNVQL-UHFFFAOYSA-N 0.000 description 1
- BWHDROKFUHTORW-UHFFFAOYSA-N tritert-butylphosphane Chemical compound CC(C)(C)P(C(C)(C)C)C(C)(C)C BWHDROKFUHTORW-UHFFFAOYSA-N 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006033114.1 | 2006-07-18 | ||
| DE102006033114A DE102006033114A1 (de) | 2006-07-18 | 2006-07-18 | Spirocyclische Azaindol-Derivate |
| PCT/EP2007/006326 WO2008009416A1 (de) | 2006-07-18 | 2007-07-17 | Spirocyclische azaindol-derivate |
Publications (2)
| Publication Number | Publication Date |
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| AU2007276414A1 AU2007276414A1 (en) | 2008-01-24 |
| AU2007276414B2 true AU2007276414B2 (en) | 2012-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2007276414A Ceased AU2007276414B2 (en) | 2006-07-18 | 2007-07-17 | Spirocyclic azaindole derivatives |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8399503B2 (enExample) |
| EP (1) | EP2041142B1 (enExample) |
| JP (1) | JP5269784B2 (enExample) |
| KR (1) | KR101421034B1 (enExample) |
| CN (1) | CN101490055B (enExample) |
| AR (1) | AR062079A1 (enExample) |
| AU (1) | AU2007276414B2 (enExample) |
| BR (1) | BRPI0714650A2 (enExample) |
| CA (1) | CA2658379C (enExample) |
| CL (1) | CL2007001917A1 (enExample) |
| DE (1) | DE102006033114A1 (enExample) |
| ES (1) | ES2434114T3 (enExample) |
| IL (1) | IL196525A (enExample) |
| MX (1) | MX2009000670A (enExample) |
| NO (1) | NO342282B1 (enExample) |
| NZ (1) | NZ573688A (enExample) |
| PE (1) | PE20080277A1 (enExample) |
| PL (1) | PL2041142T3 (enExample) |
| RU (1) | RU2468028C2 (enExample) |
| WO (1) | WO2008009416A1 (enExample) |
| ZA (1) | ZA200901128B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
| AR071066A1 (es) * | 2008-03-27 | 2010-05-26 | Gruenenthal Chemie | Derivados de (hetero) aril-ciclohexano |
| CA2719743A1 (en) | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
| US8288430B2 (en) * | 2008-03-27 | 2012-10-16 | Grunenthal Gmbh | Spiro(5.5)undecane derivatives |
| RU2532545C2 (ru) | 2008-03-27 | 2014-11-10 | Грюненталь Гмбх | Замещенные производные 4-аминоциклогексана |
| TWI450899B (zh) * | 2008-03-27 | 2014-09-01 | 被取代之螺環環已烷衍生物 | |
| EP2575815A4 (en) | 2010-06-04 | 2013-12-25 | Albany Molecular Res Inc | GLYCIN TRANSPORTER 1 INHIBITORS, METHODS OF MAKING THE SAME, AND USES THEREOF |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| AR084209A1 (es) | 2010-12-08 | 2013-05-02 | Gruenenthal Gmbh | Metodo para la sintesis de derivados de aminociclohexanona sustituidos |
| CA2942522A1 (en) * | 2014-03-12 | 2015-09-17 | The Trustees Of Columbia University In The City Of New York | 5,5-dioxo-11h-benzo[c][2,1]benzothiazepine derivatives and their use as mu-opioid receptor agonists |
| PL3169666T3 (pl) | 2014-07-15 | 2019-03-29 | Grünenthal GmbH | Podstawione pochodne azaspiro(4,5)dekanu |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| WO2017049158A1 (en) | 2015-09-16 | 2017-03-23 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
| CN117447384B (zh) * | 2023-10-24 | 2024-12-27 | 四川大学 | 一种螺杂环芳基类化合物及其应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1142587A1 (en) * | 1998-12-24 | 2001-10-10 | Meiji Seika Kaisha Ltd. | Remedies for pain |
| WO2004043967A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate |
| WO2005063769A1 (de) * | 2003-12-23 | 2005-07-14 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate |
| WO2005066183A1 (de) * | 2003-12-23 | 2005-07-21 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor |
| WO2006108565A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065573A (en) | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| JPH06502147A (ja) * | 1990-10-09 | 1994-03-10 | ニューロゲン コーポレイション | 或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド |
| GB9918965D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| EA005409B1 (ru) * | 2000-04-10 | 2005-02-24 | Пфайзер Продактс Инк. | Производные бензамидопиперидина в качестве антагонистов рецепторов вещества p |
| DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| RU2216737C1 (ru) * | 2002-03-19 | 2003-11-20 | Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова | Способ оценки течения хронического воспалительного процесса в бронхолегочной системе больного муковисцидозом |
| EP1637521B1 (en) * | 2003-06-23 | 2013-06-19 | Ono Pharmaceutical Co., Ltd. | Novel tricyclic heterocycle compound |
| DE102004039382A1 (de) * | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| CN101072771B (zh) * | 2004-10-07 | 2010-09-29 | 默沙东公司 | Cgrp受体拮抗剂 |
| EP1829874B1 (en) * | 2004-12-22 | 2014-02-12 | Ono Pharmaceutical Co., Ltd. | Tricyclic compound and use thereof |
| DE102006019597A1 (de) * | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102007009235A1 (de) * | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102007009319A1 (de) * | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| TWI450899B (zh) * | 2008-03-27 | 2014-09-01 | 被取代之螺環環已烷衍生物 |
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- 2007-07-17 WO PCT/EP2007/006326 patent/WO2008009416A1/de not_active Ceased
- 2007-07-17 PL PL07786123T patent/PL2041142T3/pl unknown
- 2007-07-17 NZ NZ573688A patent/NZ573688A/en not_active IP Right Cessation
- 2007-07-17 RU RU2009105399/04A patent/RU2468028C2/ru not_active IP Right Cessation
-
2009
- 2009-01-15 IL IL196525A patent/IL196525A/en active IP Right Grant
- 2009-01-15 US US12/354,001 patent/US8399503B2/en not_active Expired - Fee Related
- 2009-01-19 NO NO20090294A patent/NO342282B1/no not_active IP Right Cessation
- 2009-02-17 ZA ZA2009/01128A patent/ZA200901128B/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1142587A1 (en) * | 1998-12-24 | 2001-10-10 | Meiji Seika Kaisha Ltd. | Remedies for pain |
| WO2004043967A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate |
| WO2005063769A1 (de) * | 2003-12-23 | 2005-07-14 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate |
| WO2005066183A1 (de) * | 2003-12-23 | 2005-07-21 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor |
| WO2006108565A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20090294L (no) | 2009-03-31 |
| EP2041142A1 (de) | 2009-04-01 |
| JP5269784B2 (ja) | 2013-08-21 |
| MX2009000670A (es) | 2009-01-30 |
| IL196525A0 (en) | 2009-11-18 |
| NZ573688A (en) | 2011-12-22 |
| KR20090035708A (ko) | 2009-04-10 |
| PL2041142T3 (pl) | 2014-01-31 |
| CN101490055A (zh) | 2009-07-22 |
| BRPI0714650A2 (pt) | 2013-04-02 |
| RU2009105399A (ru) | 2010-08-27 |
| US20090156593A1 (en) | 2009-06-18 |
| ES2434114T3 (es) | 2013-12-13 |
| HK1129676A1 (en) | 2009-12-04 |
| WO2008009416A1 (de) | 2008-01-24 |
| US8399503B2 (en) | 2013-03-19 |
| RU2468028C2 (ru) | 2012-11-27 |
| AU2007276414A1 (en) | 2008-01-24 |
| AR062079A1 (es) | 2008-10-15 |
| JP2009543825A (ja) | 2009-12-10 |
| CA2658379C (en) | 2014-05-06 |
| DE102006033114A1 (de) | 2008-01-24 |
| EP2041142B1 (de) | 2013-10-09 |
| IL196525A (en) | 2015-07-30 |
| NO342282B1 (no) | 2018-04-30 |
| KR101421034B1 (ko) | 2014-07-22 |
| ZA200901128B (en) | 2009-12-30 |
| PE20080277A1 (es) | 2008-04-11 |
| CN101490055B (zh) | 2013-10-16 |
| CL2007001917A1 (es) | 2008-03-14 |
| CA2658379A1 (en) | 2008-01-24 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |