DE102006033114A1 - Spirocyclische Azaindol-Derivate - Google Patents

Spirocyclische Azaindol-Derivate Download PDF

Info

Publication number
DE102006033114A1
DE102006033114A1 DE102006033114A DE102006033114A DE102006033114A1 DE 102006033114 A1 DE102006033114 A1 DE 102006033114A1 DE 102006033114 A DE102006033114 A DE 102006033114A DE 102006033114 A DE102006033114 A DE 102006033114A DE 102006033114 A1 DE102006033114 A1 DE 102006033114A1
Authority
DE
Germany
Prior art keywords
unsubstituted
polysubstituted
alkyl
monosubstituted
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102006033114A
Other languages
German (de)
English (en)
Inventor
Saskia Dr. Zemolka
Stefan Dr. Schunk
Ellen Bergrath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE102006033114A priority Critical patent/DE102006033114A1/de
Priority to CL200701917A priority patent/CL2007001917A1/es
Priority to PE2007000917A priority patent/PE20080277A1/es
Priority to ARP070103151A priority patent/AR062079A1/es
Priority to JP2009519861A priority patent/JP5269784B2/ja
Priority to ES07786123T priority patent/ES2434114T3/es
Priority to RU2009105399/04A priority patent/RU2468028C2/ru
Priority to CA2658379A priority patent/CA2658379C/en
Priority to PCT/EP2007/006326 priority patent/WO2008009416A1/de
Priority to PL07786123T priority patent/PL2041142T3/pl
Priority to KR1020097003277A priority patent/KR101421034B1/ko
Priority to CN2007800272998A priority patent/CN101490055B/zh
Priority to MX2009000670A priority patent/MX2009000670A/es
Priority to HK09108973.5A priority patent/HK1129676B/xx
Priority to BRPI0714650-7A priority patent/BRPI0714650A2/pt
Priority to AU2007276414A priority patent/AU2007276414B2/en
Priority to NZ573688A priority patent/NZ573688A/en
Priority to EP07786123.5A priority patent/EP2041142B1/de
Publication of DE102006033114A1 publication Critical patent/DE102006033114A1/de
Priority to US12/354,001 priority patent/US8399503B2/en
Priority to IL196525A priority patent/IL196525A/en
Priority to NO20090294A priority patent/NO342282B1/no
Priority to ZA2009/01128A priority patent/ZA200901128B/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
DE102006033114A 2006-07-18 2006-07-18 Spirocyclische Azaindol-Derivate Withdrawn DE102006033114A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE102006033114A DE102006033114A1 (de) 2006-07-18 2006-07-18 Spirocyclische Azaindol-Derivate
CL200701917A CL2007001917A1 (es) 2006-07-18 2007-06-29 Compuestos derivados de azaindol espirociclicos; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento del dolor, condiciones de panico, depresion, mal de alzheimer, migrana, entre otras.
PE2007000917A PE20080277A1 (es) 2006-07-18 2007-07-16 Derivados de azaindol espirociclicos y sustituidos
ARP070103151A AR062079A1 (es) 2006-07-18 2007-07-16 Derivados de azaindol sustituidos, procedimientos para su preparacion, composiciones farmaceuticas que contienen estos compuestos y el uso de derivados de azaindol sustituidos para la preparacion de composiciones farmaceuticas
CN2007800272998A CN101490055B (zh) 2006-07-18 2007-07-17 螺环氮杂吲哚衍生物
HK09108973.5A HK1129676B (en) 2006-07-18 2007-07-17 Spirocyclic azaindole derivatives
RU2009105399/04A RU2468028C2 (ru) 2006-07-18 2007-07-17 Спироциклические азаиндольные производные
CA2658379A CA2658379C (en) 2006-07-18 2007-07-17 Spirocyclic azaindole derivatives
PCT/EP2007/006326 WO2008009416A1 (de) 2006-07-18 2007-07-17 Spirocyclische azaindol-derivate
PL07786123T PL2041142T3 (pl) 2006-07-18 2007-07-17 Spirocykliczne pochodne azaindolu
KR1020097003277A KR101421034B1 (ko) 2006-07-18 2007-07-17 스피로사이클릭 아자인돌 유도체
JP2009519861A JP5269784B2 (ja) 2006-07-18 2007-07-17 スピロ環状アザインドール誘導体
MX2009000670A MX2009000670A (es) 2006-07-18 2007-07-17 Derivados espirociclicos de azaindol.
ES07786123T ES2434114T3 (es) 2006-07-18 2007-07-17 Derivados azaindol espirocíclicos
BRPI0714650-7A BRPI0714650A2 (pt) 2006-07-18 2007-07-17 derivados de azaindol espirocÍclicos
AU2007276414A AU2007276414B2 (en) 2006-07-18 2007-07-17 Spirocyclic azaindole derivatives
NZ573688A NZ573688A (en) 2006-07-18 2007-07-17 Spirocyclic azaindole derivatives
EP07786123.5A EP2041142B1 (de) 2006-07-18 2007-07-17 Spirocyclische azaindol-derivate
US12/354,001 US8399503B2 (en) 2006-07-18 2009-01-15 Spirocyclic azaindole derivatives
IL196525A IL196525A (en) 2006-07-18 2009-01-15 A history of spirocyclic azindole, a process for their preparation and medications containing them
NO20090294A NO342282B1 (no) 2006-07-18 2009-01-19 Spirocykliske azaindolderivater, fremgangsmåter for fremstilling av disse, forbindelser, legemidler og anvendelser
ZA2009/01128A ZA200901128B (en) 2006-07-18 2009-02-17 Spirocyclic azaindole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006033114A DE102006033114A1 (de) 2006-07-18 2006-07-18 Spirocyclische Azaindol-Derivate

Publications (1)

Publication Number Publication Date
DE102006033114A1 true DE102006033114A1 (de) 2008-01-24

Family

ID=38704887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102006033114A Withdrawn DE102006033114A1 (de) 2006-07-18 2006-07-18 Spirocyclische Azaindol-Derivate

Country Status (21)

Country Link
US (1) US8399503B2 (enExample)
EP (1) EP2041142B1 (enExample)
JP (1) JP5269784B2 (enExample)
KR (1) KR101421034B1 (enExample)
CN (1) CN101490055B (enExample)
AR (1) AR062079A1 (enExample)
AU (1) AU2007276414B2 (enExample)
BR (1) BRPI0714650A2 (enExample)
CA (1) CA2658379C (enExample)
CL (1) CL2007001917A1 (enExample)
DE (1) DE102006033114A1 (enExample)
ES (1) ES2434114T3 (enExample)
IL (1) IL196525A (enExample)
MX (1) MX2009000670A (enExample)
NO (1) NO342282B1 (enExample)
NZ (1) NZ573688A (enExample)
PE (1) PE20080277A1 (enExample)
PL (1) PL2041142T3 (enExample)
RU (1) RU2468028C2 (enExample)
WO (1) WO2008009416A1 (enExample)
ZA (1) ZA200901128B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
WO2009118163A1 (de) * 2008-03-27 2009-10-01 Grünenthal GmbH (hetero-)aryl-cyclohexan-derivate
EP2502907B1 (de) 2008-03-27 2018-08-29 Grünenthal GmbH Substituierte 4-Aminocyclohexan-Derivate
PL2271613T3 (pl) 2008-03-27 2014-09-30 Gruenenthal Gmbh Hydroksymetylocykloheksyloaminy
AR071067A1 (es) 2008-03-27 2010-05-26 Gruenenthal Chemie Ciclohexildiaminas sustituidas
PT2260042E (pt) * 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos
CA2719736C (en) * 2008-03-27 2016-02-09 Gruenenthal Gmbh Spiro(5.5)undecane derivatives
KR20130087002A (ko) 2010-06-04 2013-08-05 알바니 몰레큘라 리써치, 인크. 글리신 수송체-1 저해제, 그의 제조 방법 및 그의 용도
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
SI2649044T1 (en) 2010-12-08 2018-01-31 Gruenenthal Gmbh A process for the synthesis of substituted aminocyclohexanone derivatives
JP6557674B2 (ja) * 2014-03-12 2019-08-07 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 新規クラスのミュー−オピオイド受容体アゴニスト
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
ES2686326T3 (es) 2014-07-15 2018-10-17 Grünenthal GmbH Derivados de azaspiro(4,5)decano sustituidos
US10844027B2 (en) 2015-09-16 2020-11-24 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
CN117447384B (zh) * 2023-10-24 2024-12-27 四川大学 一种螺杂环芳基类化合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004043967A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische cyclohexan-derivate
WO2006041830A2 (en) * 2004-10-07 2006-04-20 Merck & Co., Inc. Cgrp receptor antagonists
DE60112064T2 (de) * 2000-04-10 2006-06-01 Pfizer Products Inc., Groton Benzoamid-piperidin verbindungen als substanz p-antagonisten

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065573A (en) 1976-06-03 1977-12-27 The Upjohn Company 4-Amino-4-phenylcyclohexanone ketal compositions and process of use
CA2091986C (en) 1990-10-09 1995-11-28 Andrew Thurkauf Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
WO2000038720A1 (en) * 1998-12-24 2000-07-06 Meiji Seika Kaisha, Ltd. Remedies for pain
GB9918965D0 (en) 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
DE10123163A1 (de) 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
RU2216737C1 (ru) * 2002-03-19 2003-11-20 Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова Способ оценки течения хронического воспалительного процесса в бронхолегочной системе больного муковисцидозом
EP1637521B1 (en) 2003-06-23 2013-06-19 Ono Pharmaceutical Co., Ltd. Novel tricyclic heterocycle compound
DE10360793A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
PL1829874T3 (pl) * 2004-12-22 2014-07-31 Ono Pharmaceutical Co Tricykliczny związek i jego zastosowanie
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006019597A1 (de) 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102007009319A1 (de) 2007-02-22 2008-08-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102007009235A1 (de) 2007-02-22 2008-09-18 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
PT2260042E (pt) 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60112064T2 (de) * 2000-04-10 2006-06-01 Pfizer Products Inc., Groton Benzoamid-piperidin verbindungen als substanz p-antagonisten
WO2004043967A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische cyclohexan-derivate
WO2006041830A2 (en) * 2004-10-07 2006-04-20 Merck & Co., Inc. Cgrp receptor antagonists

Also Published As

Publication number Publication date
AR062079A1 (es) 2008-10-15
US20090156593A1 (en) 2009-06-18
CA2658379C (en) 2014-05-06
MX2009000670A (es) 2009-01-30
EP2041142A1 (de) 2009-04-01
US8399503B2 (en) 2013-03-19
BRPI0714650A2 (pt) 2013-04-02
RU2468028C2 (ru) 2012-11-27
ZA200901128B (en) 2009-12-30
KR101421034B1 (ko) 2014-07-22
KR20090035708A (ko) 2009-04-10
RU2009105399A (ru) 2010-08-27
NO20090294L (no) 2009-03-31
ES2434114T3 (es) 2013-12-13
CN101490055A (zh) 2009-07-22
IL196525A0 (en) 2009-11-18
EP2041142B1 (de) 2013-10-09
IL196525A (en) 2015-07-30
PL2041142T3 (pl) 2014-01-31
WO2008009416A1 (de) 2008-01-24
JP5269784B2 (ja) 2013-08-21
HK1129676A1 (en) 2009-12-04
CL2007001917A1 (es) 2008-03-14
JP2009543825A (ja) 2009-12-10
CN101490055B (zh) 2013-10-16
CA2658379A1 (en) 2008-01-24
NZ573688A (en) 2011-12-22
AU2007276414A1 (en) 2008-01-24
PE20080277A1 (es) 2008-04-11
NO342282B1 (no) 2018-04-30
AU2007276414B2 (en) 2012-05-31

Similar Documents

Publication Publication Date Title
EP1725567B1 (de) Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor
EP2041142B1 (de) Spirocyclische azaindol-derivate
EP1697379B1 (de) Spirocyclische cyclohexan-derivate
DE102006033109A1 (de) Substituierte Heteroaryl-Derivate
EP2121689B1 (de) Spirocyclische cyclohexan-derivate
EP2121691B1 (de) Spirocyclische cyclohexan-derivate
EP1560835B1 (de) Spirocyclische cyclohexan-derivate
EP2260042A1 (de) Substituierte spirocyclische cyclohexan-derivate
WO2007124903A1 (de) Spirocycliche cyclohexanderivate mit analgesischer wirkung
EP1778680B1 (de) Spirocyclische cyclohexan-derivate
IL223515A (en) Triazaspiroodecanyl compounds and their uses
EP1745009B1 (de) Heteroarylsubstituierte cyclohexyl-1,4-diamin-derivate
EP2257526A1 (de) Spiro(5.5)undecan derivate
JP6509321B2 (ja) 置換アザスピロ（４．５）デカン誘導体
EP1751090B1 (de) Säurederivate substituierter cyclohexyl-1,4-diamine
EP1751088B1 (de) Oxosubstituierte cyclohexyl-1,4-diamin-derivate
EP2332529A1 (de) Substituierte aromatische Diamine als Liganden der vesikulären Glutamat-Transporter 1 und 2 (vGLUT1 und vGLUT2)
EP2332528A1 (de) Substituierte aromatische Dicarbonsäureamide als Arzneimittel
EP2338485A1 (de) Substituierte 1,3-Dioxoisoindoline als Arzneimittel
WO2009106307A1 (de) Substituierte 4-aminocyclohexan-derivate zur behandlung von schmerz

Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
R012 Request for examination validly filed

Effective date: 20130708

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee