JP2009543825A5 - - Google Patents
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- Publication number
- JP2009543825A5 JP2009543825A5 JP2009519861A JP2009519861A JP2009543825A5 JP 2009543825 A5 JP2009543825 A5 JP 2009543825A5 JP 2009519861 A JP2009519861 A JP 2009519861A JP 2009519861 A JP2009519861 A JP 2009519861A JP 2009543825 A5 JP2009543825 A5 JP 2009543825A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- drug
- abuse
- anxiety
- stress
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010001897 Alzheimer's disease Diseases 0.000 claims description 4
- 206010013663 Drug dependence Diseases 0.000 claims description 4
- 206010013754 Drug withdrawal syndrome Diseases 0.000 claims description 4
- 206010002855 Anxiety Diseases 0.000 claims description 3
- 206010057666 Anxiety disease Diseases 0.000 claims description 3
- 206010013654 Drug abuse Diseases 0.000 claims description 3
- 230000036506 anxiety Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 206010001584 Alcohol abuse Diseases 0.000 claims description 2
- 208000007848 Alcoholism Diseases 0.000 claims description 2
- 206010006895 Cachexia Diseases 0.000 claims description 2
- 208000008787 Cardiovascular Disease Diseases 0.000 claims description 2
- 208000009132 Catalepsy Diseases 0.000 claims description 2
- 206010057668 Cognitive disease Diseases 0.000 claims description 2
- 206010011878 Deafness Diseases 0.000 claims description 2
- 206010061428 Decreased appetite Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 206010015037 Epilepsy Diseases 0.000 claims description 2
- 208000004559 Hearing Loss Diseases 0.000 claims description 2
- 206010011879 Hearing loss Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 208000001953 Hypotension Diseases 0.000 claims description 2
- 206010027175 Memory impairment Diseases 0.000 claims description 2
- 206010027599 Migraine Diseases 0.000 claims description 2
- 208000008085 Migraine Disorders Diseases 0.000 claims description 2
- 206010053643 Neurodegenerative disease Diseases 0.000 claims description 2
- 229940005483 OPIOID ANALGESICS Drugs 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 208000004880 Polyuria Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 206010039966 Senile dementia Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 206010046543 Urinary incontinence Diseases 0.000 claims description 2
- 206010047853 Waxy flexibility Diseases 0.000 claims description 2
- 201000007930 alcohol dependence Diseases 0.000 claims description 2
- 201000003082 alcohol use disease Diseases 0.000 claims description 2
- 230000003444 anaesthetic Effects 0.000 claims description 2
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 claims description 2
- 201000008286 diarrhea Diseases 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 230000035619 diuresis Effects 0.000 claims description 2
- 201000006180 eating disease Diseases 0.000 claims description 2
- 231100000888 hearing loss Toxicity 0.000 claims description 2
- 230000036543 hypotension Effects 0.000 claims description 2
- 230000000968 intestinal Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003158 myorelaxant agent Substances 0.000 claims description 2
- 230000003957 neurotransmitter release Effects 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 239000000014 opioid analgesic Substances 0.000 claims description 2
- 210000000056 organs Anatomy 0.000 claims description 2
- 230000025627 positive regulation of urine volume Effects 0.000 claims description 2
- 239000004089 psychotropic agent Substances 0.000 claims description 2
- 201000001880 sexual dysfunction Diseases 0.000 claims description 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims description 2
- 201000010874 syndrome Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 230000001105 regulatory Effects 0.000 claims 2
- 229940035674 ANESTHETICS Drugs 0.000 claims 1
- 206010002091 Anaesthesia Diseases 0.000 claims 1
- 229940035363 MUSCLE RELAXANTS Drugs 0.000 claims 1
- 229940083876 Muscle relaxants FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 208000001908 Opioid-Related Disorders Diseases 0.000 claims 1
- 230000037005 anaesthesia Effects 0.000 claims 1
- 230000002921 anti-spasmodic Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 230000037023 motor activity Effects 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 description 2
- 229940052318 Opioid anesthetics Drugs 0.000 description 1
- 230000000049 anti-anxiety Effects 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000003364 opioid Effects 0.000 description 1
- 230000000607 poisoning Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
Description
本発明の他の対象は、不安状態、ストレス及びストレスと関連する症候群、鬱病、てんかん、アルツハイマー病、老人性痴呆、カタレプシー、全般的認知機能障害、学習及び記憶障害（向精神薬として）、禁断症状、アルコール乱用及び／又はドラッグ乱用及び／又は薬物乱用、アルコール依存症及び／又は薬物依存症及び／又は医薬依存症、性的機能障害、心臓血管疾患、低血圧症、高血圧症、耳鳴り、掻痒、偏頭痛、難聴、腸の運動性の不足、摂食障害、拒食症、肥満症、運動器官障害、下痢、悪液質、尿失禁の治療のため、筋弛緩剤、鎮痙剤又は麻酔剤として、又はオピオイド系鎮痛剤又は麻酔剤を用いた治療の際の同時投与のため、利尿又は抗ナトリウム利尿、抗不安のため、運動活力の調節のため、神経伝達物質放出の調節のため及びそれに関連する神経変性疾患の治療のため、禁断症状の治療のため及び／又はオピオイドの中毒能力の低減のための医薬の製造のための、本発明によるスピロ環状アザインドール誘導体の使用である。
Claims (1)
- 不安状態、ストレス及びストレスと関連する症候群、鬱病、てんかん、アルツハイマー病、老人性痴呆、カタレプシー、全般的認知機能障害、学習及び記憶障害（向精神薬として）、禁断症状、アルコール乱用及び／又はドラッグ乱用及び／又は薬物乱用、アルコール依存症及び／又は薬物依存症及び／又は医薬依存症、性的機能障害、心臓血管疾患、低血圧症、高血圧症、耳鳴り、掻痒、偏頭痛、難聴、腸の運動性の不足、摂食障害、拒食症、肥満症、運動器官障害、下痢、悪液質、尿失禁の治療のため、又は筋弛緩剤、鎮痙剤又は麻酔剤として、又はオピオイド系鎮痛剤又は麻酔剤を用いた治療の際の同時投与のため、利尿又は抗ナトリウム利尿、抗不安のため、運動活力の調節のため、神経伝達物質放出の調節のため及びそれに関連する神経変性疾患の治療のため、禁断症状の治療のため及び／又はオピオイドの中毒能力の低減のための医薬の製造への、請求項１記載の、一般式Ｉで表わされる置換されたアザインドール誘導体の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006033114A DE102006033114A1 (de) | 2006-07-18 | 2006-07-18 | Spirocyclische Azaindol-Derivate |
| DE102006033114.1 | 2006-07-18 | ||
| PCT/EP2007/006326 WO2008009416A1 (de) | 2006-07-18 | 2007-07-17 | Spirocyclische azaindol-derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009543825A JP2009543825A (ja) | 2009-12-10 |
| JP2009543825A5 true JP2009543825A5 (ja) | 2013-04-11 |
| JP5269784B2 JP5269784B2 (ja) | 2013-08-21 |
Family
ID=38704887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519861A Expired - Fee Related JP5269784B2 (ja) | 2006-07-18 | 2007-07-17 | スピロ環状アザインドール誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8399503B2 (ja) |
| EP (1) | EP2041142B1 (ja) |
| JP (1) | JP5269784B2 (ja) |
| KR (1) | KR101421034B1 (ja) |
| CN (1) | CN101490055B (ja) |
| AR (1) | AR062079A1 (ja) |
| AU (1) | AU2007276414B2 (ja) |
| BR (1) | BRPI0714650A2 (ja) |
| CA (1) | CA2658379C (ja) |
| CL (1) | CL2007001917A1 (ja) |
| DE (1) | DE102006033114A1 (ja) |
| ES (1) | ES2434114T3 (ja) |
| HK (1) | HK1129676A1 (ja) |
| IL (1) | IL196525A (ja) |
| MX (1) | MX2009000670A (ja) |
| NO (1) | NO342282B1 (ja) |
| NZ (1) | NZ573688A (ja) |
| PE (1) | PE20080277A1 (ja) |
| PL (1) | PL2041142T3 (ja) |
| RU (1) | RU2468028C2 (ja) |
| WO (1) | WO2008009416A1 (ja) |
| ZA (1) | ZA200901128B (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| ES2621407T3 (es) | 2008-03-27 | 2017-07-04 | Grünenthal GmbH | Ciclohexildiaminas sustituidas |
| NZ588779A (en) | 2008-03-27 | 2012-06-29 | Gruenenthal Chemie | Substituted 4-aminocyclohexane derivatives |
| DK2260042T3 (da) * | 2008-03-27 | 2011-10-31 | Gruenenthal Gmbh | Substituerede spirocykliske cyklohexan-derivater |
| MX2010010337A (es) | 2008-03-27 | 2010-10-07 | Gruenenthal Gmbh | Derivados de espiro(5.5)undecano. |
| JP5650637B2 (ja) | 2008-03-27 | 2015-01-07 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | （ヘテロ−）アリール−シクロヘキサン誘導体 |
| RU2514192C2 (ru) | 2008-03-27 | 2014-04-27 | Грюненталь Гмбх | Гидроксиметилциклогексиламины |
| WO2011153359A1 (en) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| US8658827B2 (en) | 2010-12-08 | 2014-02-25 | Gruenenthal Gmbh | Method for synthesizing substituted aminocyclohexanone compounds |
| JP6557674B2 (ja) * | 2014-03-12 | 2019-08-07 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 新規クラスのミュー−オピオイド受容体アゴニスト |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| WO2016008582A1 (en) | 2014-07-15 | 2016-01-21 | Grünenthal GmbH | Substituted azaspiro(4.5)decane derivatives |
| WO2017049158A1 (en) | 2015-09-16 | 2017-03-23 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065573A (en) | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| EP0738717A1 (en) | 1990-10-09 | 1996-10-23 | Neurogen Corporation | Certain substituted pyrimidines as intermediates for production of cycloalkyl and azacycloalkyl pyrrolopyrimidines |
| WO2000038720A1 (fr) * | 1998-12-24 | 2000-07-06 | Meiji Seika Kaisha, Ltd. | Remedes contre la douleur |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| KR20020087134A (ko) * | 2000-04-10 | 2002-11-21 | 화이자 프로덕츠 인크. | 벤조아미드 피페리딘 함유 화합물 및 관련 화합물 |
| DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| RU2216737C1 (ru) * | 2002-03-19 | 2003-11-20 | Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова | Способ оценки течения хронического воспалительного процесса в бронхолегочной системе больного муковисцидозом |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| EP1637521B1 (en) * | 2003-06-23 | 2013-06-19 | Ono Pharmaceutical Co., Ltd. | Novel tricyclic heterocycle compound |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| CN101072771B (zh) * | 2004-10-07 | 2010-09-29 | 默沙东公司 | Cgrp受体拮抗剂 |
| JP4997976B2 (ja) * | 2004-12-22 | 2012-08-15 | 小野薬品工業株式会社 | 三環式化合物およびその用途 |
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102007009235A1 (de) | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102007009319A1 (de) | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DK2260042T3 (da) | 2008-03-27 | 2011-10-31 | Gruenenthal Gmbh | Substituerede spirocykliske cyklohexan-derivater |
-
2006
- 2006-07-18 DE DE102006033114A patent/DE102006033114A1/de not_active Withdrawn
-
2007
- 2007-06-29 CL CL200701917A patent/CL2007001917A1/es unknown
- 2007-07-16 AR ARP070103151A patent/AR062079A1/es not_active Application Discontinuation
- 2007-07-16 PE PE2007000917A patent/PE20080277A1/es active IP Right Grant
- 2007-07-17 ES ES07786123T patent/ES2434114T3/es active Active
- 2007-07-17 BR BRPI0714650-7A patent/BRPI0714650A2/pt not_active Application Discontinuation
- 2007-07-17 JP JP2009519861A patent/JP5269784B2/ja not_active Expired - Fee Related
- 2007-07-17 NZ NZ573688A patent/NZ573688A/en not_active IP Right Cessation
- 2007-07-17 KR KR1020097003277A patent/KR101421034B1/ko active IP Right Grant
- 2007-07-17 PL PL07786123T patent/PL2041142T3/pl unknown
- 2007-07-17 WO PCT/EP2007/006326 patent/WO2008009416A1/de active Application Filing
- 2007-07-17 MX MX2009000670A patent/MX2009000670A/es active IP Right Grant
- 2007-07-17 CN CN2007800272998A patent/CN101490055B/zh not_active Expired - Fee Related
- 2007-07-17 AU AU2007276414A patent/AU2007276414B2/en not_active Ceased
- 2007-07-17 EP EP07786123.5A patent/EP2041142B1/de active Active
- 2007-07-17 CA CA2658379A patent/CA2658379C/en not_active Expired - Fee Related
- 2007-07-17 RU RU2009105399/04A patent/RU2468028C2/ru not_active IP Right Cessation
-
2009
- 2009-01-15 US US12/354,001 patent/US8399503B2/en not_active Expired - Fee Related
- 2009-01-15 IL IL196525A patent/IL196525A/en active IP Right Grant
- 2009-01-19 NO NO20090294A patent/NO342282B1/no not_active IP Right Cessation
- 2009-02-17 ZA ZA2009/01128A patent/ZA200901128B/en unknown
- 2009-09-29 HK HK09108973.5A patent/HK1129676A1/xx not_active IP Right Cessation
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