JP2012508275A5 - - Google Patents
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- Publication number
- JP2012508275A5 JP2012508275A5 JP2011536412A JP2011536412A JP2012508275A5 JP 2012508275 A5 JP2012508275 A5 JP 2012508275A5 JP 2011536412 A JP2011536412 A JP 2011536412A JP 2011536412 A JP2011536412 A JP 2011536412A JP 2012508275 A5 JP2012508275 A5 JP 2012508275A5
- Authority
- JP
- Japan
- Prior art keywords
- disorder
- disease
- composition
- disorders
- cognitive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 8
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 230000007278 cognition impairment Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- MAYQIFVKVAUMPD-UHFFFAOYSA-N 1-(benzenesulfonyl)-2-methyl-4-piperazin-1-ylbenzimidazole Chemical compound CC1=NC2=C(N3CCNCC3)C=CC=C2N1S(=O)(=O)C1=CC=CC=C1 MAYQIFVKVAUMPD-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 206010033664 Panic attack Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000005686 eating Nutrition 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000007514 neuronal growth Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11329608P | 2008-11-11 | 2008-11-11 | |
| US61/113,296 | 2008-11-11 | ||
| PCT/US2009/063816 WO2010056644A1 (en) | 2008-11-11 | 2009-11-10 | 1- (ARYLSULFONYL) -4- (PI PERAZIN-I -YL) -IH-BENZ IMIDAZOLES AS δ-HYDROXYTRYPTAMINE- 6 LIGANDS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508275A JP2012508275A (ja) | 2012-04-05 |
| JP2012508275A5 true JP2012508275A5 (enExample) | 2012-07-19 |
| JP5087171B2 JP5087171B2 (ja) | 2012-11-28 |
Family
ID=41404503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536412A Expired - Fee Related JP5087171B2 (ja) | 2008-11-11 | 2009-11-10 | ５−ヒドロキシトリプタミン−６リガンドとしての１−（アリールスルホニル）−４−（ピペラジン−１−イル）−１ｈ−ベンズイミダゾール類 |
Country Status (41)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2580857A1 (en) * | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| CA2580844A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
| JP5080256B2 (ja) * | 2004-09-20 | 2012-11-21 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 二環式複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼ（ＳＣＤ）のインヒビターとしてのそれらの使用 |
| TW200624427A (en) * | 2004-09-20 | 2006-07-16 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| CN104557726B (zh) * | 2013-10-19 | 2019-05-24 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
| WO2016004882A1 (en) | 2014-07-08 | 2016-01-14 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| WO2017052394A1 (en) | 2015-09-23 | 2017-03-30 | Uniwersytet Jagielloński | Imidazopyridine compounds and their use as 5-ht6 receptor ligands |
| EP3530651A1 (en) | 2018-02-21 | 2019-08-28 | Adamed sp. z o.o. | Indole and benzimidazole derivatives as dual 5-ht2a and 5-ht6 receptor antagonists |
| US12398097B2 (en) | 2019-07-29 | 2025-08-26 | Vanderbilt University | WDR5-MYC inhibitors |
| IL297448A (en) * | 2020-04-22 | 2022-12-01 | Recurium Ip Holdings Llc | Preparation of an selective estrogen receptor degrader |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3155008B2 (ja) * | 1994-07-26 | 2001-04-09 | ファイザー・インコーポレーテッド | セロトニンアゴニストおよびアンタゴニストとしての４−インドール誘導体 |
| US5849759A (en) * | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| WO1999002502A2 (en) | 1997-07-11 | 1999-01-21 | Smithkline Beecham Plc | Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation |
| GB9716656D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| SI0930302T1 (en) * | 1998-01-16 | 2003-10-31 | F. Hoffmann-La Roche Ag | Benzosulfone derivatives |
| US6251893B1 (en) * | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
| WO2000009498A1 (en) * | 1998-08-10 | 2000-02-24 | Partnership Of Michael E. Garst, George Sachs And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| GB9818916D0 (en) * | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| SE0002754D0 (sv) | 2000-07-21 | 2000-07-21 | Pharmacia & Upjohn Ab | New pharmaceutical combination formulation and method of treatment with the combination |
| NZ524675A (en) | 2000-10-20 | 2004-09-24 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-N1-(benzensulfonyl) indoles and their use in therapy |
| SE0003810D0 (sv) * | 2000-10-20 | 2000-10-20 | Pharmacia Ab | Novel compounds their use and preparations |
| HUP0303756A3 (en) * | 2000-11-02 | 2009-08-28 | Wyeth Corp | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands and process for their preparation and pharmaceutical compositions containing them |
| US7034029B2 (en) * | 2000-11-02 | 2006-04-25 | Wyeth | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands |
| CN1321110C (zh) * | 2001-06-15 | 2007-06-13 | 弗·哈夫曼-拉罗切有限公司 | 具有5－ht6受体亲和力的4－哌嗪基吲哚衍生物 |
| EP1401812B1 (en) * | 2001-06-15 | 2006-06-28 | F. Hoffmann-La Roche Ag | 4-piperazinylindole derivatives with 5-ht6 receptor affinity |
| WO2003026666A1 (en) | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors |
| AU2003284142A1 (en) | 2002-10-15 | 2004-05-04 | Synta Pharmaceuticals Corp | Aromatic bicyclic heterocyles to modulate 1L-12 production |
| WO2005112938A2 (en) | 2004-04-13 | 2005-12-01 | Synta Pharmaceuticals Corp. | Disalt inhibitors of il-12 production |
| WO2006015259A2 (en) | 2004-07-28 | 2006-02-09 | Irm Llc | Compounds and compositions as modulators of steroid hormone nuclear receptors |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
-
2009
- 2009-10-11 UA UAA201105862A patent/UA100192C2/uk unknown
- 2009-11-10 DK DK09752080.3T patent/DK2285784T3/da active
- 2009-11-10 PT PT09752080T patent/PT2285784E/pt unknown
- 2009-11-10 RS RS20120326A patent/RS52381B/sr unknown
- 2009-11-10 EP EP09752080A patent/EP2285784B1/en active Active
- 2009-11-10 AP AP2011005664A patent/AP2814A/xx active
- 2009-11-10 HR HRP20120561AT patent/HRP20120561T1/hr unknown
- 2009-11-10 EA EA201100696A patent/EA018369B1/ru not_active IP Right Cessation
- 2009-11-10 PE PE2011001015A patent/PE20120026A1/es not_active Application Discontinuation
- 2009-11-10 KR KR1020117010610A patent/KR101323417B1/ko not_active Expired - Fee Related
- 2009-11-10 GE GEAP200912221A patent/GEP20135805B/en unknown
- 2009-11-10 MY MYPI2011001681A patent/MY156324A/en unknown
- 2009-11-10 BR BRPI0920682A patent/BRPI0920682A2/pt not_active IP Right Cessation
- 2009-11-10 NZ NZ592563A patent/NZ592563A/xx not_active IP Right Cessation
- 2009-11-10 PL PL09752080T patent/PL2285784T3/pl unknown
- 2009-11-10 WO PCT/US2009/063816 patent/WO2010056644A1/en not_active Ceased
- 2009-11-10 CA CA2740262A patent/CA2740262C/en not_active Expired - Fee Related
- 2009-11-10 SI SI200930293T patent/SI2285784T1/sl unknown
- 2009-11-10 ME MEP-2011-75A patent/ME01129B/me unknown
- 2009-11-10 CN CN200980144578.1A patent/CN102209713B/zh not_active Expired - Fee Related
- 2009-11-10 AU AU2009314221A patent/AU2009314221B2/en not_active Ceased
- 2009-11-10 ES ES09752080T patent/ES2389694T3/es active Active
- 2009-11-10 MX MX2011004996A patent/MX2011004996A/es active IP Right Grant
- 2009-11-10 JP JP2011536412A patent/JP5087171B2/ja not_active Expired - Fee Related
- 2009-11-11 US US12/616,201 patent/US8063053B2/en not_active Expired - Fee Related
- 2009-11-11 SA SA109300673A patent/SA109300673B1/ar unknown
- 2009-11-11 TW TW098138260A patent/TWI481605B/zh not_active IP Right Cessation
- 2009-11-11 AR ARP090104372A patent/AR074325A1/es not_active Application Discontinuation
-
2011
- 2011-04-07 IL IL212213A patent/IL212213A0/en not_active IP Right Cessation
- 2011-04-22 TN TN2011000203A patent/TN2011000203A1/fr unknown
- 2011-05-05 ZA ZA2011/03283A patent/ZA201103283B/en unknown
- 2011-05-10 DO DO2011000130A patent/DOP2011000130A/es unknown
- 2011-05-10 CL CL2011001050A patent/CL2011001050A1/es unknown
- 2011-05-10 NI NI201100093A patent/NI201100093A/es unknown
- 2011-05-11 CR CR20110247A patent/CR20110247A/es unknown
- 2011-05-11 MA MA33836A patent/MA32788B1/fr unknown
- 2011-05-11 SV SV2011003902A patent/SV2011003902A/es unknown
- 2011-05-11 CU CU2011000101A patent/CU24020B1/es active IP Right Grant
- 2011-05-11 EC EC2011011045A patent/ECSP11011045A/es unknown
- 2011-05-12 CO CO11058600A patent/CO6440548A2/es active IP Right Grant
-
2012
- 2012-08-13 CY CY20121100721T patent/CY1113025T1/el unknown
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