EA201071083A1 - Арилсульфонилпиразолинкарбоксамидиновые производные в качестве антагонистов 5-нт - Google Patents

Арилсульфонилпиразолинкарбоксамидиновые производные в качестве антагонистов 5-нт

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EA201071083A1
EA201071083A1 EA201071083A EA201071083A EA201071083A1 EA 201071083 A1 EA201071083 A1 EA 201071083A1 EA 201071083 A EA201071083 A EA 201071083A EA 201071083 A EA201071083 A EA 201071083A EA 201071083 A1 EA201071083 A1 EA 201071083A1
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disorders
compounds
disease
eating
cognitive impairment
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EA201071083A
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EA023176B1 (ru
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Арнольд Ван Лувезейн
Баккер Ваутер И. Ивема
Аксел Стойт
Агата А.М. Ренсинк
Дженнифер Венхорст
Мартина А.В. Ван Дер Нэт
Мартин Де Хан
Корнелис Г. Крюсе
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Эбботт Хелткэа Продактс Б.В.
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Publication of EA201071083A1 publication Critical patent/EA201071083A1/ru
Publication of EA023176B1 publication Critical patent/EA023176B1/ru

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Abstract

Настоящее изобретение относится к арилсульфонилпиразолинкарбоксамидиновым производным в качестве антагонистов рецепторов 5-HT, к способам получения этих соединений и к новым промежуточным соединениям, применимым в их синтезе. Кроме того, настоящее изобретение относится к применениям указанных соединений и композиций, в частности их применению для введения пациентам с целью достижения терапевтического эффекта при лечении болезни Паркинсона, хореи Хантингтона, шизофрении, тревожности, депрессии, маниакально-депрессивного психоза, психозов, эпилепсии, обсессивно-компульсивных расстройств, аффективных расстройств, мигрени, болезни Альцгеймера, возрастного ослабления когнитивных способностей, умеренных когнитивных нарушений, расстройств сна, расстройств, связанных с питанием, анорексии, булимии, расстройств, связанных с перееданием, приступов панического расстройства, акатизии, синдрома дефицита внимания и гиперактивности, синдрома дефицита внимания, избавления от пагубных пристрастий к кокаину, этанолу, никотину или бензодиазепинам, боли, расстройств, связанных с травмами позвоночника и/или поражениями головы, гидроцефалии, расстройств деятельности кишечника, синдрома раздраженного кишечника, ожирения и диабета 2 типа. Указанные соединения имеют общую формулу (1), где символы имеют значения, приведенные в описании.
EA201071083A 2008-03-18 2009-03-17 Арилсульфонилпиразолинкарбоксамидиновые производные в качестве антагонистов 5-нт EA023176B1 (ru)

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US3746308P 2008-03-18 2008-03-18
EP08152873 2008-03-18
PCT/EP2009/053133 WO2009115515A1 (en) 2008-03-18 2009-03-17 Arylsulfonyl pyrazoline carboxamidine derivatives as 5-ht6 antagonists

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EA201071083A1 true EA201071083A1 (ru) 2011-04-29
EA023176B1 EA023176B1 (ru) 2016-05-31

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GB0422263D0 (en) 2004-10-07 2004-11-10 Glaxo Group Ltd Novel compounds
SA07280510B1 (ar) 2006-09-22 2012-02-07 سولفاي فارماسوتيكالز بي . في سلفونيل بيرازول ومشتقات سلفونيل كربوكساميدين كمضادات ht6-5

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