CO6290679A2 - Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht 6 - Google Patents

Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht 6

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Publication number
CO6290679A2
CO6290679A2 CO10113567A CO10113567A CO6290679A2 CO 6290679 A2 CO6290679 A2 CO 6290679A2 CO 10113567 A CO10113567 A CO 10113567A CO 10113567 A CO10113567 A CO 10113567A CO 6290679 A2 CO6290679 A2 CO 6290679A2
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CO
Colombia
Prior art keywords
disorders
compounds
disorder
disease
attention deficit
Prior art date
Application number
CO10113567A
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English (en)
Inventor
Arnold Van Loevezijn
Bakker Wouter Iwema
Axel Stoit
Aghata Rensink
Jennifer Venhorst
Der Neut Martina A W Van
Haan Martin De
Cornelis Kruse
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Abbott Healthcare Products Bv
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Publication date
Application filed by Abbott Healthcare Products Bv filed Critical Abbott Healthcare Products Bv
Publication of CO6290679A2 publication Critical patent/CO6290679A2/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invención se refiere a derivados de arilsulfonil pirazolin carboxamidina como antagonistas de receptores 5-HT6, a métodos para la preparación de estoscompuestos y a novedosos intermediarios útiles para su síntesis. La invención también se refiere a los usos de tales compuestos y composiciones particularmente su uso en la administración de los mismos a pacientes para lograr un efecto terapéutico en la enfermedad de Parkinson, corea de Huntington, esquizofrenia, ansiedad, depresión, depresión maníaca, psicosis, epilepsia, trastornos obsesivos compulsivos, trastornos del ánimo, migraña, enfermedad de Alzheimer, declinación cognitiva relacionada con la edad, deterioro cognitivo leve, trastornos del sueño, trastornos de la alimentación, anorexia, bulimia, trastornos de atracones en la alimentación, ataques de pánico, acatisia, trastorno de hiperactividad y déficit de atención, trastorno de déficit de atención, abstinencia del abuso de cocaína, etanol, nicotina o benzodiazepinas, dolor, trastornos asociados con trauma espinal o daño en la cabeza, hidrocefalia, trastorno funcional del intestino, Síndrome de Intestino Irritable, obesidad y diabetes tipo 2. Los compuestos tienen la fórmula general (1):en donde los símbolos tienen los significados dados en la descripción.
CO10113567A 2008-03-18 2010-09-14 Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht 6 CO6290679A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3746308P 2008-03-18 2008-03-18
EP08152873 2008-03-18

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EP (2) EP2610247B1 (es)
JP (1) JP5504252B2 (es)
KR (1) KR101623357B1 (es)
CN (2) CN104003937A (es)
AR (1) AR070898A1 (es)
AU (1) AU2009226956C1 (es)
BR (1) BRPI0908738A8 (es)
CA (1) CA2717922A1 (es)
CO (1) CO6290679A2 (es)
CR (1) CR11742A (es)
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DO (2) DOP2010000276A (es)
EA (1) EA023176B1 (es)
EC (1) ECSP10010476A (es)
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AR079935A1 (es) * 2010-01-29 2012-02-29 Abbott Healthcare Products Bv Sintesis de derivados de pirazolin carboxamidina sustituida
EA026389B1 (ru) * 2011-08-15 2017-04-28 Юниверсити Оф Юта Рисерч Фаундейшн Замещенные аналоги (e)-n'-(1-фенилэтилиден)бензогидразида в качестве ингибиторов деметилазы гистонов
AR104762A1 (es) * 2012-11-16 2017-08-16 Bristol Myers Squibb Co Moduladores de dihidropirazol gpr40
CN104812748B (zh) * 2012-11-16 2017-10-24 百时美施贵宝公司 二氢吡唑gpr40调节剂
US9656963B2 (en) 2012-11-16 2017-05-23 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
EP3140288B1 (en) * 2014-05-09 2023-01-25 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Pyrazole derivatives and their use as cannabinoid receptor mediators
EP3180312B1 (en) 2014-08-12 2019-10-16 Loyola University Of Chicago Indoline sulfonamide inhibitors of dape and ndm-1 and use of the same
EP3109237A1 (en) * 2015-06-22 2016-12-28 AnaMar AB Novel 5-ht2 antagonists
CN107460160A (zh) * 2017-08-23 2017-12-12 世贸天阶制药（江苏）有限责任公司 一种cho细胞无血清培养基
US10879709B2 (en) 2018-05-31 2020-12-29 National Taipei University Of Technology Power management system and operating method thereof
BR112022006791A2 (pt) 2019-10-09 2022-06-28 Bayer Ag Novos compostos heteroaril-triazol como pesticidas
CA3185968A1 (en) 2020-07-13 2022-01-20 Tony Lahoutte Antibody fragment against folr1
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

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WO2003026648A1 (en) * 2001-09-21 2003-04-03 Solvay Pharmaceuticals B.V. 4,5-dihydro-1h-pyrazole derivatives having potent cb1-antagonistic activity
GB0422263D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd Novel compounds
AR062907A1 (es) * 2006-09-22 2008-12-17 Solvay Pharm Bv Derivados de sulfonilpirazol y sulfonilpirazolincarboxamidina como antagonistas de 5-ht6

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MX2010010299A (es) 2010-12-15
AU2009226956A8 (en) 2010-09-23
TWI557110B (zh) 2016-11-11
US20140011775A1 (en) 2014-01-09
CN104003937A (zh) 2014-08-27
US20110046171A1 (en) 2011-02-24
EP2265589A1 (en) 2010-12-29
BRPI0908738A2 (pt) 2017-06-13
EA023176B1 (ru) 2016-05-31
IL207846A0 (en) 2010-12-30
HK1201823A1 (en) 2015-09-11
DOP2010000277A (es) 2011-01-31
PH12013502376B1 (en) 2015-01-12
BRPI0908738A8 (pt) 2017-10-10
DK2265589T3 (en) 2016-03-21
ES2565184T3 (es) 2016-04-01
ES2577867T3 (es) 2016-07-19
PL2265589T3 (pl) 2016-06-30
EA201071083A1 (ru) 2011-04-29
EP2610247A1 (en) 2013-07-03
ZA201006272B (en) 2011-05-25
PT2610247T (pt) 2016-07-07
AU2009226956C1 (en) 2014-03-06
PL2610247T3 (pl) 2017-02-28
US9126942B2 (en) 2015-09-08
AR070898A1 (es) 2010-05-12
EP2265589B1 (en) 2016-01-27
JP5504252B2 (ja) 2014-05-28
CN102036967A (zh) 2011-04-27
CR11742A (es) 2011-03-03
WO2009115515A1 (en) 2009-09-24
DOP2010000276A (es) 2010-11-15
CA2717922A1 (en) 2009-09-24
US20150051239A1 (en) 2015-02-19
NZ587743A (en) 2012-06-29
KR101623357B1 (ko) 2016-05-23
CN102036967B (zh) 2014-10-15
AU2009226956B2 (en) 2013-05-23
AU2009226956A1 (en) 2009-09-24
SG183688A1 (en) 2012-09-27
HK1152708A1 (en) 2012-03-09
MY155318A (en) 2015-09-30
EP2610247B1 (en) 2016-05-25
DK2610247T3 (en) 2016-06-13
TW200942519A (en) 2009-10-16
JP2011517443A (ja) 2011-06-09
UA105629C2 (uk) 2014-06-10
KR20100136504A (ko) 2010-12-28
US8563723B2 (en) 2013-10-22
PH12013502376A1 (en) 2015-01-12
ECSP10010476A (es) 2010-10-30
US8901108B2 (en) 2014-12-02

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