JP2009538870A5 - - Google Patents
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- Publication number
- JP2009538870A5 JP2009538870A5 JP2009512572A JP2009512572A JP2009538870A5 JP 2009538870 A5 JP2009538870 A5 JP 2009538870A5 JP 2009512572 A JP2009512572 A JP 2009512572A JP 2009512572 A JP2009512572 A JP 2009512572A JP 2009538870 A5 JP2009538870 A5 JP 2009538870A5
- Authority
- JP
- Japan
- Prior art keywords
- disorder
- pain
- disease
- syndrome
- diaza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000002193 Pain Diseases 0.000 claims 6
- -1 1,4-diaza-bicyclo [3.2.2] nonylpyrimidinyl Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 3
- 230000006735 deficit Effects 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 208000032841 Bulimia Diseases 0.000 claims 2
- 206010006550 Bulimia nervosa Diseases 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 108010009685 Cholinergic Receptors Proteins 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020651 Hyperkinesia Diseases 0.000 claims 1
- 208000000269 Hyperkinesis Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 claims 1
- 206010036600 Premature labour Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010041247 Social fear Diseases 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 102000034337 acetylcholine receptors Human genes 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 150000001557 benzodiazepines Chemical class 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 208000014617 hemorrhoid Diseases 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 201000009863 inflammatory diarrhea Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 230000000938 luteal effect Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- KFKFYOVMLCPCMT-UHFFFAOYSA-N n-[2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)pyrimidin-5-yl]-2-fluorobenzamide Chemical compound FC1=CC=CC=C1C(=O)NC1=CN=C(N2C3CCN(CC3)CC2)N=C1 KFKFYOVMLCPCMT-UHFFFAOYSA-N 0.000 claims 1
- OMGLTFYSOBZDLM-UHFFFAOYSA-N n-[2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)pyrimidin-5-yl]-2-fluorobenzamide;hydrochloride Chemical compound Cl.FC1=CC=CC=C1C(=O)NC1=CN=C(N2C3CCN(CC3)CC2)N=C1 OMGLTFYSOBZDLM-UHFFFAOYSA-N 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 208000026440 premature labor Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000016160 smooth muscle contraction Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80902306P | 2006-05-30 | 2006-05-30 | |
| DKPA200600730 | 2006-05-30 | ||
| PCT/EP2007/055172 WO2007138041A1 (en) | 2006-05-30 | 2007-05-29 | Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009538870A JP2009538870A (ja) | 2009-11-12 |
| JP2009538870A5 true JP2009538870A5 (enExample) | 2010-05-27 |
Family
ID=38258823
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512570A Abandoned JP2009538868A (ja) | 2006-05-30 | 2007-05-29 | 新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルピリミジニル誘導体及びその医学的使用 |
| JP2009512572A Abandoned JP2009538870A (ja) | 2006-05-30 | 2007-05-29 | 新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルピリミジニル誘導体及びその医学的使用 |
| JP2009512571A Abandoned JP2009538869A (ja) | 2006-05-30 | 2007-05-29 | 新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルピリミジニル誘導体及びその医学的使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512570A Abandoned JP2009538868A (ja) | 2006-05-30 | 2007-05-29 | 新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルピリミジニル誘導体及びその医学的使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512571A Abandoned JP2009538869A (ja) | 2006-05-30 | 2007-05-29 | 新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルピリミジニル誘導体及びその医学的使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7915272B2 (enExample) |
| EP (3) | EP2029595B1 (enExample) |
| JP (3) | JP2009538868A (enExample) |
| AU (3) | AU2007267176A1 (enExample) |
| CA (3) | CA2653460A1 (enExample) |
| MX (3) | MX2008014889A (enExample) |
| WO (3) | WO2007138039A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ548180A (en) * | 2004-02-04 | 2010-04-30 | Neurosearch As | Diazabicyclic aryl derivatives as cholinergic receptor modulators and nicotinic acetylcholine receptor ligands |
| US7915272B2 (en) | 2006-05-30 | 2011-03-29 | Neurosearch A/S | 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use |
| JP2010536726A (ja) | 2007-08-17 | 2010-12-02 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体リガンドとして有用な新規１，４−ジアザ−ビシクロ〔３．２．２〕ノニルヘテロアリール誘導体 |
| DE102007053771A1 (de) * | 2007-11-12 | 2009-05-14 | Merck Patent Gmbh | Organische Elektrolumineszenzvorrichtungen |
| WO2009062988A1 (en) * | 2007-11-14 | 2009-05-22 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use |
| CN101970438A (zh) * | 2007-11-14 | 2011-02-09 | 神经研究公司 | 新的1，4-二氮杂-二环[3.2.2]壬基嘧啶衍生物及它们的医药应用 |
| EP2209781A1 (en) * | 2007-11-14 | 2010-07-28 | NeuroSearch AS | Novel 1,4-diaza-bicycloý3.2.2¨nonyl pyrimidine derivatives and their medical use |
| WO2010026176A1 (en) * | 2008-09-05 | 2010-03-11 | Neurosearch A/S | 1,4 -diaza- bicyclo [3.2.2]n0nyl pyrimidine derivatives as nicotinic and monoamine receptor modulators |
| WO2010026177A1 (en) * | 2008-09-05 | 2010-03-11 | Neurosearch A/S | 1,4-diaza-bicyclo [3.2.2] nonyl pyridine derivatives as nicotinic and monoamine receptor modulators |
| US20110269778A1 (en) * | 2008-10-10 | 2011-11-03 | Neurosearch A/S | Novel diphenyl purine derivatives useful as modulators of nicotinic acetylcholine receptors |
| WO2010063784A1 (en) * | 2008-12-04 | 2010-06-10 | Neurosearch A/S | Novel diaza-bicyclononyl-phenyl derivatives and their medical use |
| US20120028967A1 (en) * | 2009-01-21 | 2012-02-02 | Neurosearch A/S | Novel diaza-bicyclononyl-pyrimidinyl derivatives and their medical use |
| US20120004214A1 (en) * | 2009-01-21 | 2012-01-05 | Neurosearch A/S | N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786770B1 (fr) * | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| WO2002064571A1 (en) * | 2001-02-14 | 2002-08-22 | Warner-Lambert Company Llc | Pyrimidine matrix metalloproteinase inhibitors |
| CA2450167A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| SE0202430D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| MXPA05002621A (es) * | 2002-09-10 | 2005-05-05 | Pfizer Prod Inc | Compuestos diazabiciclos utiles en el tratamiento de transtornos del sistema nervioso central y otros trastornos. |
| US7220741B2 (en) * | 2002-09-30 | 2007-05-22 | Neurosearch A/S | 1,4-diazabicycloalkane derivatives, their preparation and use |
| US7223753B2 (en) * | 2002-11-11 | 2007-05-29 | Neurosearch A/S | Diazabicyclic biaryl derivatives |
| WO2004043960A1 (en) | 2002-11-11 | 2004-05-27 | Neurosearch A/S | 1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof |
| CN100432075C (zh) * | 2004-02-04 | 2008-11-12 | 神经研究公司 | 作为烟碱样乙酰胆碱受体配体的二氮杂双环芳基衍生物 |
| NZ548180A (en) | 2004-02-04 | 2010-04-30 | Neurosearch As | Diazabicyclic aryl derivatives as cholinergic receptor modulators and nicotinic acetylcholine receptor ligands |
| EP1863819B1 (en) | 2005-02-16 | 2011-01-12 | NeuroSearch A/S | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at the nicotinic acetylcholine receptors |
| US7915272B2 (en) * | 2006-05-30 | 2011-03-29 | Neurosearch A/S | 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use |
| EP2190846A1 (en) | 2007-08-17 | 2010-06-02 | Neurosearch A/S | 1,4-diaza-bicycl0(3.2.2)n0nyl pyrimidinyl derivatives useful as nicotinic acetylcholine- receptor ligands |
| JP2010536726A (ja) | 2007-08-17 | 2010-12-02 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体リガンドとして有用な新規１，４−ジアザ−ビシクロ〔３．２．２〕ノニルヘテロアリール誘導体 |
| EP2209781A1 (en) * | 2007-11-14 | 2010-07-28 | NeuroSearch AS | Novel 1,4-diaza-bicycloý3.2.2¨nonyl pyrimidine derivatives and their medical use |
| CN101970438A (zh) * | 2007-11-14 | 2011-02-09 | 神经研究公司 | 新的1，4-二氮杂-二环[3.2.2]壬基嘧啶衍生物及它们的医药应用 |
-
2007
- 2007-05-29 US US12/299,114 patent/US7915272B2/en not_active Expired - Fee Related
- 2007-05-29 JP JP2009512570A patent/JP2009538868A/ja not_active Abandoned
- 2007-05-29 WO PCT/EP2007/055170 patent/WO2007138039A1/en not_active Ceased
- 2007-05-29 JP JP2009512572A patent/JP2009538870A/ja not_active Abandoned
- 2007-05-29 MX MX2008014889A patent/MX2008014889A/es not_active Application Discontinuation
- 2007-05-29 EP EP07729594A patent/EP2029595B1/en not_active Not-in-force
- 2007-05-29 EP EP07729593A patent/EP2049538A1/en not_active Withdrawn
- 2007-05-29 WO PCT/EP2007/055172 patent/WO2007138041A1/en not_active Ceased
- 2007-05-29 US US12/299,108 patent/US20090197872A1/en not_active Abandoned
- 2007-05-29 MX MX2008014890A patent/MX2008014890A/es not_active Application Discontinuation
- 2007-05-29 JP JP2009512571A patent/JP2009538869A/ja not_active Abandoned
- 2007-05-29 AU AU2007267176A patent/AU2007267176A1/en not_active Abandoned
- 2007-05-29 EP EP07729592A patent/EP2041134A1/en not_active Withdrawn
- 2007-05-29 CA CA002653460A patent/CA2653460A1/en not_active Abandoned
- 2007-05-29 CA CA002653681A patent/CA2653681A1/en not_active Abandoned
- 2007-05-29 MX MX2008014885A patent/MX2008014885A/es not_active Application Discontinuation
- 2007-05-29 AU AU2007267178A patent/AU2007267178A1/en not_active Abandoned
- 2007-05-29 US US12/299,106 patent/US8148365B2/en not_active Expired - Fee Related
- 2007-05-29 CA CA002653371A patent/CA2653371A1/en not_active Abandoned
- 2007-05-29 WO PCT/EP2007/055171 patent/WO2007138040A1/en not_active Ceased
- 2007-05-29 AU AU2007267177A patent/AU2007267177A1/en not_active Abandoned
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