JP2007530635A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007530635A5 JP2007530635A5 JP2007505537A JP2007505537A JP2007530635A5 JP 2007530635 A5 JP2007530635 A5 JP 2007530635A5 JP 2007505537 A JP2007505537 A JP 2007505537A JP 2007505537 A JP2007505537 A JP 2007505537A JP 2007530635 A5 JP2007530635 A5 JP 2007530635A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- hydroxy
- represents hydrogen
- halo
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 64
- 239000001257 hydrogen Substances 0.000 claims 64
- 150000002431 hydrogen Chemical class 0.000 claims 48
- 125000005843 halogen group Chemical group 0.000 claims 37
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 30
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 150000003672 ureas Chemical class 0.000 claims 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 22
- 125000001188 haloalkyl group Chemical group 0.000 claims 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
- 125000004438 haloalkoxy group Chemical group 0.000 claims 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 208000035475 disorder Diseases 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- -1 cyano, nitro, amino Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 4
- DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical class NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 208000004296 neuralgia Diseases 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000032841 Bulimia Diseases 0.000 claims 2
- 206010006550 Bulimia nervosa Diseases 0.000 claims 2
- 208000012661 Dyskinesia Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 208000013403 hyperactivity Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000003367 polycyclic group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- RKJVTQDJANQBCQ-UHFFFAOYSA-N 1-(2-amino-4,5-dichlorophenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea Chemical compound NC1=CC(Cl)=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl RKJVTQDJANQBCQ-UHFFFAOYSA-N 0.000 claims 1
- BNUHODYAAMQTJV-UHFFFAOYSA-N 1-(2-amino-6-hydroxyphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound NC1=CC=CC(O)=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 BNUHODYAAMQTJV-UHFFFAOYSA-N 0.000 claims 1
- ULOBWFQFTPJMGJ-UHFFFAOYSA-N 1-(2-hydroxy-6-nitrophenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound OC1=CC=CC([N+]([O-])=O)=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 ULOBWFQFTPJMGJ-UHFFFAOYSA-N 0.000 claims 1
- HNTMOGAMWRYMHA-UHFFFAOYSA-N 1-(3,5-dichloro-4-hydroxyphenyl)-3-(3-phenylphenyl)urea Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1NC(=O)NC1=CC=CC(C=2C=CC=CC=2)=C1 HNTMOGAMWRYMHA-UHFFFAOYSA-N 0.000 claims 1
- TXPYJBVRPJRUQL-UHFFFAOYSA-N 1-(3,5-dichloro-4-hydroxyphenyl)-3-(4-phenylphenyl)urea Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1NC(=O)NC1=CC=C(C=2C=CC=CC=2)C=C1 TXPYJBVRPJRUQL-UHFFFAOYSA-N 0.000 claims 1
- FAWIIPHQRGSJDT-UHFFFAOYSA-N 1-(3,5-dichloro-4-hydroxyphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 FAWIIPHQRGSJDT-UHFFFAOYSA-N 0.000 claims 1
- WQWQRFNJWNSZRT-UHFFFAOYSA-N 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea Chemical compound OC1=C(Br)C=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl WQWQRFNJWNSZRT-UHFFFAOYSA-N 0.000 claims 1
- DHTHORLNMVCEAU-UHFFFAOYSA-N 1-(3-chloro-4-hydroxyphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound C1=C(Cl)C(O)=CC=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 DHTHORLNMVCEAU-UHFFFAOYSA-N 0.000 claims 1
- REACISFIAOQOEW-UHFFFAOYSA-N 1-(3-hydroxy-5-methylphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound CC1=CC(O)=CC(NC(=O)NC=2C=C(C=CC=2)C(F)(F)F)=C1 REACISFIAOQOEW-UHFFFAOYSA-N 0.000 claims 1
- HDNTXGPZSHXXNF-UHFFFAOYSA-N 1-(4-hydroxy-2-methylphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound CC1=CC(O)=CC=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 HDNTXGPZSHXXNF-UHFFFAOYSA-N 0.000 claims 1
- OSRJFFDHMMTEOE-UHFFFAOYSA-N 1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxy-4-nitrophenyl)urea Chemical compound OC1=CC=C(Cl)C=C1NC(=O)NC1=CC=C([N+]([O-])=O)C=C1O OSRJFFDHMMTEOE-UHFFFAOYSA-N 0.000 claims 1
- UGBYWTFBYWRHHF-UHFFFAOYSA-N 1-(5-chloro-2-hydroxyphenyl)-3-(4-phenylphenyl)urea Chemical compound OC1=CC=C(Cl)C=C1NC(=O)NC1=CC=C(C=2C=CC=CC=2)C=C1 UGBYWTFBYWRHHF-UHFFFAOYSA-N 0.000 claims 1
- OUDXRNQPVSMGDW-UHFFFAOYSA-N 1-(5-chloro-2-hydroxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea Chemical compound OC1=CC=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl OUDXRNQPVSMGDW-UHFFFAOYSA-N 0.000 claims 1
- JYSGFTLBGUTNFL-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-3-(2-hydroxy-4-nitrophenyl)urea Chemical compound COC1=CC=C(Cl)C=C1NC(=O)NC1=CC=C([N+]([O-])=O)C=C1O JYSGFTLBGUTNFL-UHFFFAOYSA-N 0.000 claims 1
- HGTNAHXLPRRYOU-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea Chemical compound COC1=CC=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl HGTNAHXLPRRYOU-UHFFFAOYSA-N 0.000 claims 1
- PBKRQAUIJPXLKE-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(3,5-dichloro-2-hydroxyphenyl)urea Chemical compound OC1=C(Cl)C=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl PBKRQAUIJPXLKE-UHFFFAOYSA-N 0.000 claims 1
- AHNRQMGGVDYUHK-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(3,5-dichloro-4-hydroxyphenyl)urea Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl AHNRQMGGVDYUHK-UHFFFAOYSA-N 0.000 claims 1
- UHGHDJAPQFIHPC-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(3-hydroxy-5-methylphenyl)urea Chemical compound CC1=CC(O)=CC(NC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)=C1 UHGHDJAPQFIHPC-UHFFFAOYSA-N 0.000 claims 1
- DZIWWFOGOSMHGX-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(4-hydroxy-2-methylphenyl)urea Chemical compound CC1=CC(O)=CC=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl DZIWWFOGOSMHGX-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010002660 Anoxia Diseases 0.000 claims 1
- 241000976983 Anoxia Species 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000004547 Hallucinations Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 1
- 208000005374 Poisoning Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 claims 1
- 229960004373 acetylcholine Drugs 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000007953 anoxia Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 230000002920 convulsive effect Effects 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000001856 erectile effect Effects 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 206010020765 hypersomnia Diseases 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 201000009863 inflammatory diarrhea Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 230000005906 menstruation Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- UVHPKGYWIYNBJN-UHFFFAOYSA-N n-[4,5-dichloro-2-[[2-chloro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]acetamide Chemical compound CC(=O)NC1=CC(Cl)=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl UVHPKGYWIYNBJN-UHFFFAOYSA-N 0.000 claims 1
- 239000004081 narcotic agent Substances 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- CMUOJBJRZUHRMU-UHFFFAOYSA-N nitrourea Chemical class NC(=O)N[N+]([O-])=O CMUOJBJRZUHRMU-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 208000028591 pheochromocytoma Diseases 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000020341 sensory perception of pain Effects 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000016160 smooth muscle contraction Effects 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400498 | 2004-03-29 | ||
| US55769804P | 2004-03-31 | 2004-03-31 | |
| PCT/EP2005/051183 WO2005092843A1 (en) | 2004-03-29 | 2005-03-16 | Novel urea derivatives and their medical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007530635A JP2007530635A (ja) | 2007-11-01 |
| JP2007530635A5 true JP2007530635A5 (enExample) | 2008-04-24 |
Family
ID=37818161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505537A Abandoned JP2007530635A (ja) | 2004-03-29 | 2005-03-16 | 新規尿素誘導体群およびそれらの利用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070142450A1 (enExample) |
| EP (1) | EP1732883A1 (enExample) |
| JP (1) | JP2007530635A (enExample) |
| CN (1) | CN1926098A (enExample) |
| AU (1) | AU2005225559A1 (enExample) |
| BR (1) | BRPI0507296A (enExample) |
| CA (1) | CA2561639A1 (enExample) |
| RU (1) | RU2006131454A (enExample) |
| WO (1) | WO2005092843A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006089871A2 (en) * | 2005-02-23 | 2006-08-31 | Neurosearch A/S | Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias |
| WO2008028903A2 (en) * | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| US8618145B2 (en) | 2009-05-12 | 2013-12-31 | Mei Han | Small molecular compounds capable of accelerating proliferation of stem cells and use thereof |
| JP5835729B2 (ja) * | 2010-09-02 | 2015-12-24 | 国立大学法人京都大学 | 筋萎縮性側索硬化症の予防および治療用医薬組成物 |
| US20130310419A1 (en) | 2011-02-03 | 2013-11-21 | Lupin Limited | Pyrrole derivatives used as modulators of alpha7 nachr |
| MA34957B1 (fr) | 2011-02-23 | 2014-03-01 | Lupin Ltd | Derives heteroaryle a titre modulateurs des nachr alpha 7 |
| EP2691368A1 (en) | 2011-03-31 | 2014-02-05 | Lupin Limited | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease |
| EP2727604A4 (en) | 2011-06-30 | 2015-03-18 | Toray Industries | ANTIPRURIGINOUS AGENT |
| US8946432B2 (en) | 2011-07-05 | 2015-02-03 | Lupin Limited | Biaryl derivatives as nAChR modulators |
| US8541577B2 (en) * | 2011-11-10 | 2013-09-24 | Allergan, Inc. | Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators |
| CN103172543B (zh) * | 2011-12-21 | 2016-02-10 | 中国科学院上海药物研究所 | 一种脲类化合物、制备方法及其用途 |
| EP2822946A1 (en) | 2012-03-06 | 2015-01-14 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| EP2945936A1 (en) | 2012-11-12 | 2015-11-25 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| EP2945941B1 (en) | 2013-01-16 | 2016-12-07 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
| JP2016512225A (ja) | 2013-03-13 | 2016-04-25 | ルピン・リミテッドＬｕｐｉｎ Ｌｉｍｉｔｅｄ | アルファー７ｎａｃｈｒモジュレータとしてのピロール誘導体 |
| TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
| AU2014282886A1 (en) | 2013-06-17 | 2015-12-17 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3237479A1 (de) * | 1982-10-09 | 1984-04-12 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von substituierten tetrahydropyrimidinonderivaten |
| DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
| EP0705100B1 (en) * | 1993-05-27 | 2003-07-30 | CeNes Limited | Therapeutic substituted guanidines |
| JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| AU2962297A (en) * | 1996-05-24 | 1998-01-05 | Neurosearch A/S | Phenyl derivatives useful as blockers of chloride channels |
| AU1939999A (en) * | 1997-12-22 | 1999-07-12 | Bayer Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| CA2336361C (en) * | 1998-07-01 | 2011-09-06 | The Trustees Of The University Of Pennsylvania | Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same |
| WO2002064139A1 (en) * | 2001-02-15 | 2002-08-22 | Neurosearch A/S | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity |
| US20030236287A1 (en) | 2002-05-03 | 2003-12-25 | Piotrowski David W. | Positive allosteric modulators of the nicotinic acetylcholine receptor |
-
2005
- 2005-03-16 CA CA002561639A patent/CA2561639A1/en not_active Abandoned
- 2005-03-16 EP EP05717055A patent/EP1732883A1/en not_active Withdrawn
- 2005-03-16 RU RU2006131454/04A patent/RU2006131454A/ru not_active Application Discontinuation
- 2005-03-16 AU AU2005225559A patent/AU2005225559A1/en not_active Abandoned
- 2005-03-16 US US10/590,104 patent/US20070142450A1/en not_active Abandoned
- 2005-03-16 CN CNA200580006364XA patent/CN1926098A/zh active Pending
- 2005-03-16 WO PCT/EP2005/051183 patent/WO2005092843A1/en not_active Ceased
- 2005-03-16 JP JP2007505537A patent/JP2007530635A/ja not_active Abandoned
- 2005-03-16 BR BRPI0507296-4A patent/BRPI0507296A/pt not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007530635A5 (enExample) | ||
| RU2006131454A (ru) | Новые производные мочевины и их медицинское применение | |
| JP2006508109A5 (enExample) | ||
| JP2009538870A5 (enExample) | ||
| CA2570155C (en) | 3-(heteroaryl-oxy)-2-alkyl-1-aza-bicycloalkyl derivatives as alpha.7-nachr ligands for the treatment of cns diseases | |
| JP2009538869A5 (enExample) | ||
| JP2009538867A5 (enExample) | ||
| CN100432075C (zh) | 作为烟碱样乙酰胆碱受体配体的二氮杂双环芳基衍生物 | |
| JP2005524713A5 (enExample) | ||
| CA2566155C (en) | 1-aza-bicyclo[3.3.1]nonanes | |
| JP2009526814A5 (enExample) | ||
| JP2008530171A5 (enExample) | ||
| JP2009538866A5 (enExample) | ||
| RU2008139481A (ru) | Новые 1,4-диаза-бицикло[3.2.2]нонил-оксадиазолильные производные и их медицинское применение | |
| CA2409644A1 (en) | Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands | |
| JP2009537599A5 (enExample) | ||
| JP2010535738A5 (enExample) | ||
| JP2008533087A5 (enExample) | ||
| JP2007520525A5 (enExample) | ||
| JP2009526776A5 (enExample) | ||
| EP1966208B1 (en) | (1-AZA-BICYCLO[3.3.1]NON-4-YL)-[5-(1H-INDOL-5-YL)-HETEROARYL]-AMINES AS CHOLINERGIC LIGANDS OF THE N-AChR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS | |
| EP1599476B1 (en) | Novel diazabicyclic aryl derivatives | |
| JP2007538046A5 (enExample) | ||
| JP2006503062A5 (enExample) | ||
| JP2009526024A5 (enExample) |