RU2006131454A - Новые производные мочевины и их медицинское применение - Google Patents
Новые производные мочевины и их медицинское применение Download PDFInfo
- Publication number
- RU2006131454A RU2006131454A RU2006131454/04A RU2006131454A RU2006131454A RU 2006131454 A RU2006131454 A RU 2006131454A RU 2006131454/04 A RU2006131454/04 A RU 2006131454/04A RU 2006131454 A RU2006131454 A RU 2006131454A RU 2006131454 A RU2006131454 A RU 2006131454A
- Authority
- RU
- Russia
- Prior art keywords
- phenyl
- hydroxy
- hydrogen
- alkyl
- urea
- Prior art date
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- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 64
- 239000001257 hydrogen Substances 0.000 claims 64
- 150000002431 hydrogen Chemical class 0.000 claims 48
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 30
- 150000003672 ureas Chemical class 0.000 claims 30
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 24
- 125000005843 halogen group Chemical group 0.000 claims 24
- 125000001188 haloalkyl group Chemical group 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
- 125000004438 haloalkoxy group Chemical group 0.000 claims 17
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 17
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 12
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- -1 cyano, nitro, amino Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 208000032841 Bulimia Diseases 0.000 claims 2
- 206010006550 Bulimia nervosa Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 206010020651 Hyperkinesia Diseases 0.000 claims 2
- 208000000269 Hyperkinesis Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 claims 2
- 229960004373 acetylcholine Drugs 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003367 polycyclic group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- RKJVTQDJANQBCQ-UHFFFAOYSA-N 1-(2-amino-4,5-dichlorophenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea Chemical compound NC1=CC(Cl)=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl RKJVTQDJANQBCQ-UHFFFAOYSA-N 0.000 claims 1
- BNUHODYAAMQTJV-UHFFFAOYSA-N 1-(2-amino-6-hydroxyphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound NC1=CC=CC(O)=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 BNUHODYAAMQTJV-UHFFFAOYSA-N 0.000 claims 1
- ULOBWFQFTPJMGJ-UHFFFAOYSA-N 1-(2-hydroxy-6-nitrophenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound OC1=CC=CC([N+]([O-])=O)=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 ULOBWFQFTPJMGJ-UHFFFAOYSA-N 0.000 claims 1
- HNTMOGAMWRYMHA-UHFFFAOYSA-N 1-(3,5-dichloro-4-hydroxyphenyl)-3-(3-phenylphenyl)urea Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1NC(=O)NC1=CC=CC(C=2C=CC=CC=2)=C1 HNTMOGAMWRYMHA-UHFFFAOYSA-N 0.000 claims 1
- TXPYJBVRPJRUQL-UHFFFAOYSA-N 1-(3,5-dichloro-4-hydroxyphenyl)-3-(4-phenylphenyl)urea Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1NC(=O)NC1=CC=C(C=2C=CC=CC=2)C=C1 TXPYJBVRPJRUQL-UHFFFAOYSA-N 0.000 claims 1
- FAWIIPHQRGSJDT-UHFFFAOYSA-N 1-(3,5-dichloro-4-hydroxyphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 FAWIIPHQRGSJDT-UHFFFAOYSA-N 0.000 claims 1
- WQWQRFNJWNSZRT-UHFFFAOYSA-N 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea Chemical compound OC1=C(Br)C=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl WQWQRFNJWNSZRT-UHFFFAOYSA-N 0.000 claims 1
- DHTHORLNMVCEAU-UHFFFAOYSA-N 1-(3-chloro-4-hydroxyphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound C1=C(Cl)C(O)=CC=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 DHTHORLNMVCEAU-UHFFFAOYSA-N 0.000 claims 1
- REACISFIAOQOEW-UHFFFAOYSA-N 1-(3-hydroxy-5-methylphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound CC1=CC(O)=CC(NC(=O)NC=2C=C(C=CC=2)C(F)(F)F)=C1 REACISFIAOQOEW-UHFFFAOYSA-N 0.000 claims 1
- HDNTXGPZSHXXNF-UHFFFAOYSA-N 1-(4-hydroxy-2-methylphenyl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound CC1=CC(O)=CC=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 HDNTXGPZSHXXNF-UHFFFAOYSA-N 0.000 claims 1
- OSRJFFDHMMTEOE-UHFFFAOYSA-N 1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxy-4-nitrophenyl)urea Chemical compound OC1=CC=C(Cl)C=C1NC(=O)NC1=CC=C([N+]([O-])=O)C=C1O OSRJFFDHMMTEOE-UHFFFAOYSA-N 0.000 claims 1
- UGBYWTFBYWRHHF-UHFFFAOYSA-N 1-(5-chloro-2-hydroxyphenyl)-3-(4-phenylphenyl)urea Chemical compound OC1=CC=C(Cl)C=C1NC(=O)NC1=CC=C(C=2C=CC=CC=2)C=C1 UGBYWTFBYWRHHF-UHFFFAOYSA-N 0.000 claims 1
- OUDXRNQPVSMGDW-UHFFFAOYSA-N 1-(5-chloro-2-hydroxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea Chemical compound OC1=CC=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl OUDXRNQPVSMGDW-UHFFFAOYSA-N 0.000 claims 1
- JYSGFTLBGUTNFL-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-3-(2-hydroxy-4-nitrophenyl)urea Chemical compound COC1=CC=C(Cl)C=C1NC(=O)NC1=CC=C([N+]([O-])=O)C=C1O JYSGFTLBGUTNFL-UHFFFAOYSA-N 0.000 claims 1
- HGTNAHXLPRRYOU-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-3-[2-chloro-5-(trifluoromethyl)phenyl]urea Chemical compound COC1=CC=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl HGTNAHXLPRRYOU-UHFFFAOYSA-N 0.000 claims 1
- PBKRQAUIJPXLKE-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(3,5-dichloro-2-hydroxyphenyl)urea Chemical compound OC1=C(Cl)C=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl PBKRQAUIJPXLKE-UHFFFAOYSA-N 0.000 claims 1
- AHNRQMGGVDYUHK-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(3,5-dichloro-4-hydroxyphenyl)urea Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl AHNRQMGGVDYUHK-UHFFFAOYSA-N 0.000 claims 1
- UHGHDJAPQFIHPC-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(3-hydroxy-5-methylphenyl)urea Chemical compound CC1=CC(O)=CC(NC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)=C1 UHGHDJAPQFIHPC-UHFFFAOYSA-N 0.000 claims 1
- DZIWWFOGOSMHGX-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(4-hydroxy-2-methylphenyl)urea Chemical compound CC1=CC(O)=CC=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl DZIWWFOGOSMHGX-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 206010002660 Anoxia Diseases 0.000 claims 1
- 241000976983 Anoxia Species 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028403 Mutism Diseases 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
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- 208000006673 asthma Diseases 0.000 claims 1
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- 125000002883 imidazolyl group Chemical group 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 claims 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
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- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- UVHPKGYWIYNBJN-UHFFFAOYSA-N n-[4,5-dichloro-2-[[2-chloro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]acetamide Chemical compound CC(=O)NC1=CC(Cl)=C(Cl)C=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1Cl UVHPKGYWIYNBJN-UHFFFAOYSA-N 0.000 claims 1
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- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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| RU2627271C2 (ru) * | 2011-11-10 | 2017-08-04 | Аллерган, Инк. | Производные арилмочевины в качестве модуляторов n-формилпептидного-1 рецептора (fprl-1) |
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| WO2006089871A2 (en) * | 2005-02-23 | 2006-08-31 | Neurosearch A/S | Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias |
| WO2008028903A2 (en) * | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| WO2010130063A1 (zh) * | 2009-05-12 | 2010-11-18 | Han Mei | 具有促进干細胞增殖作用的小分子化合物及其用途 |
| US9856210B2 (en) | 2010-09-02 | 2018-01-02 | Kyoto University | Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis |
| EP2670744B1 (en) | 2011-02-03 | 2015-05-27 | Lupin Limited | Pyrrole derivatives used as modulators of alpha7 nachr |
| AU2012221800B2 (en) | 2011-02-23 | 2016-10-27 | Lupin Limited | Heteroaryl derivatives as alpha7 nAChR modulators |
| AU2012235779B2 (en) | 2011-03-31 | 2017-03-02 | Lupin Limited | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease |
| CN103619354A (zh) | 2011-06-30 | 2014-03-05 | 东丽株式会社 | 止痒剂 |
| ES2606043T3 (es) | 2011-07-05 | 2017-03-17 | Lupin Limited | Derivados de biarilo como moduladores de nAChR |
| CN103172543B (zh) * | 2011-12-21 | 2016-02-10 | 中国科学院上海药物研究所 | 一种脲类化合物、制备方法及其用途 |
| WO2013132380A1 (en) | 2012-03-06 | 2013-09-12 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| WO2014072957A1 (en) | 2012-11-12 | 2014-05-15 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
| US9617211B2 (en) | 2013-01-16 | 2017-04-11 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
| US9617210B2 (en) | 2013-03-13 | 2017-04-11 | Lupin Limited | Pyrrole derivatives as alpha 7 NACHR modulators |
| TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
| WO2014203150A1 (en) | 2013-06-17 | 2014-12-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
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| DE3237479A1 (de) * | 1982-10-09 | 1984-04-12 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von substituierten tetrahydropyrimidinonderivaten |
| DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
| JP3610368B2 (ja) * | 1993-05-27 | 2005-01-12 | セネス リミティド | 治療用置換グアニジン |
| JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| WO1997045111A1 (en) * | 1996-05-24 | 1997-12-04 | Neurosearch A/S | Phenyl derivatives useful as blockers of chloride channels |
| DE69830513T2 (de) * | 1997-12-22 | 2006-03-16 | Bayer Pharmaceuticals Corp., West Haven | HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN |
| EP2196930B1 (en) * | 1998-07-01 | 2011-03-23 | The Trustees of The University of Pennsylvania | Cavity induced allosteric modificatin of intermolecular interactions and methods of identifiying compounds that effect the same |
| US20040063742A1 (en) * | 2001-02-15 | 2004-04-01 | Dan Peters | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity |
| US20030236287A1 (en) | 2002-05-03 | 2003-12-25 | Piotrowski David W. | Positive allosteric modulators of the nicotinic acetylcholine receptor |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2627271C2 (ru) * | 2011-11-10 | 2017-08-04 | Аллерган, Инк. | Производные арилмочевины в качестве модуляторов n-формилпептидного-1 рецептора (fprl-1) |
Also Published As
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| JP2007530635A (ja) | 2007-11-01 |
| AU2005225559A1 (en) | 2005-10-06 |
| WO2005092843A1 (en) | 2005-10-06 |
| CN1926098A (zh) | 2007-03-07 |
| US20070142450A1 (en) | 2007-06-21 |
| CA2561639A1 (en) | 2005-10-06 |
| EP1732883A1 (en) | 2006-12-20 |
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