JP2005524712A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005524712A5 JP2005524712A5 JP2004502919A JP2004502919A JP2005524712A5 JP 2005524712 A5 JP2005524712 A5 JP 2005524712A5 JP 2004502919 A JP2004502919 A JP 2004502919A JP 2004502919 A JP2004502919 A JP 2004502919A JP 2005524712 A5 JP2005524712 A5 JP 2005524712A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- azacycloethynyl
- alkyl
- cycloalkyl
- cycloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- -1 cyano , Amino Chemical group 0.000 claims description 32
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 19
- 125000003545 alkoxy group Chemical group 0.000 claims description 18
- 125000000304 alkynyl group Chemical group 0.000 claims description 18
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 150000002367 halogens Chemical class 0.000 claims description 18
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 18
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 14
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 13
- 125000003118 aryl group Chemical group 0.000 claims description 13
- 125000004104 aryloxy group Chemical group 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 13
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 7
- 125000004973 1-butenyl group Chemical group C(=CCC)* 0.000 claims 4
- 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 claims 4
- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 claims 4
- 206010049119 Emotional distress Diseases 0.000 claims 4
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000002100 cyclohexa-1,3-dienyl group Chemical group [H]C1([*])C([H])=C([H])C([H])=C([H])C1([H])[H] 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 230000009429 distress Effects 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 125000003367 polycyclic group Chemical group 0.000 claims 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000006017 1-propenyl group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000032841 Bulimia Diseases 0.000 claims 2
- 206010006550 Bulimia nervosa Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 208000012661 Dyskinesia Diseases 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 208000013403 hyperactivity Diseases 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- HIMLFKSDWLBNLP-UHFFFAOYSA-N 3-[2-(2,4-difluorophenyl)ethynyl]-8-methyl-8-azabicyclo[3.2.1]oct-3-ene Chemical compound CN1C(C2)CCC1C=C2C#CC1=CC=C(F)C=C1F HIMLFKSDWLBNLP-UHFFFAOYSA-N 0.000 claims 1
- SFNWCCDLIGODBR-UHFFFAOYSA-N 3-[2-(4-methoxyphenyl)ethynyl]-8-methyl-8-azabicyclo[3.2.1]oct-3-ene Chemical compound C1=CC(OC)=CC=C1C#CC(C1)=CC2N(C)C1CC2 SFNWCCDLIGODBR-UHFFFAOYSA-N 0.000 claims 1
- YEEVKUTYVRZGRO-UHFFFAOYSA-N 5-(2-phenylethynyl)-1,2,3,6-tetrahydropyridine Chemical compound C1NCCC=C1C#CC1=CC=CC=C1 YEEVKUTYVRZGRO-UHFFFAOYSA-N 0.000 claims 1
- FYQFXHPDTCMLMY-UHFFFAOYSA-N 8-methyl-3-(2-methylbut-1-en-3-ynyl)-8-azabicyclo[3.2.1]oct-3-ene Chemical compound C1C(C=C(C)C#C)=CC2CCC1N2C FYQFXHPDTCMLMY-UHFFFAOYSA-N 0.000 claims 1
- PWGAVFOAURZTIJ-UHFFFAOYSA-N 8-methyl-3-(2-phenylethynyl)-8-azabicyclo[3.2.1]oct-3-ene Chemical compound CN1C(C2)CCC1C=C2C#CC1=CC=CC=C1 PWGAVFOAURZTIJ-UHFFFAOYSA-N 0.000 claims 1
- MKSXUVTXJXBGNV-UHFFFAOYSA-N 8-methyl-3-(3-phenylprop-1-ynyl)-8-azabicyclo[3.2.1]oct-3-ene Chemical compound CN1C(C2)CCC1C=C2C#CCC1=CC=CC=C1 MKSXUVTXJXBGNV-UHFFFAOYSA-N 0.000 claims 1
- CXSNNJRLRKJIGY-UHFFFAOYSA-N 8-methyl-3-[2-(4-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]oct-3-ene Chemical compound CN1C(C2)CCC1C=C2C#CC1=CC=C(C)C=C1 CXSNNJRLRKJIGY-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 206010002660 Anoxia Diseases 0.000 claims 1
- 241000976983 Anoxia Species 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- QIGDTSZGOURQSK-UHFFFAOYSA-N C1N(C)CCC=C1C#CC1=CC=CC=C1 Chemical compound C1N(C)CCC=C1C#CC1=CC=CC=C1 QIGDTSZGOURQSK-UHFFFAOYSA-N 0.000 claims 1
- 108010009685 Cholinergic Receptors Proteins 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 208000005374 Poisoning Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 208000022372 Reading disease Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010040981 Sleep attacks Diseases 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 102000034337 acetylcholine receptors Human genes 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000007953 anoxia Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000002650 habitual effect Effects 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 230000029849 luteinization Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 208000028591 pheochromocytoma Diseases 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000020341 sensory perception of pain Effects 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000016160 smooth muscle contraction Effects 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200200691 | 2002-05-07 | ||
| PCT/DK2003/000294 WO2003094830A2 (en) | 2002-05-07 | 2003-05-06 | Novel azacyclic ethynyl derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005524712A JP2005524712A (ja) | 2005-08-18 |
| JP2005524712A5 true JP2005524712A5 (enExample) | 2006-06-15 |
Family
ID=29414627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004502919A Ceased JP2005524712A (ja) | 2002-05-07 | 2003-05-06 | 新規アザシクロエチニル誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7378526B2 (enExample) |
| EP (1) | EP1506205B1 (enExample) |
| JP (1) | JP2005524712A (enExample) |
| CN (1) | CN100522976C (enExample) |
| AT (1) | ATE401334T1 (enExample) |
| AU (1) | AU2003222738B2 (enExample) |
| CA (1) | CA2480378A1 (enExample) |
| DE (1) | DE60322212D1 (enExample) |
| MX (1) | MXPA04010965A (enExample) |
| NZ (1) | NZ535641A (enExample) |
| WO (1) | WO2003094830A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| CA2499128C (en) | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| PL1697378T3 (pl) | 2003-12-22 | 2008-04-30 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzoizoksazole i 1,2-benzoizotiazole oraz ich wytwarzanie i zastosowania |
| WO2005092890A2 (en) | 2004-03-25 | 2005-10-06 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| DE602005024677D1 (de) | 2004-04-22 | 2010-12-23 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen |
| RU2386633C2 (ru) | 2004-05-07 | 2010-04-20 | Мемори Фармасьютиклз Корпорейшн | 1h-индазолы, бензотиазолы, 1, 2-бензоизоксазолы, 1, 2-бензоизотиазолы и хромоны и их получение и применения |
| JP2008525464A (ja) | 2004-12-22 | 2008-07-17 | メモリー・ファーマシューティカルズ・コーポレイション | α−７ニコチン性受容体リガンド並びにその製造及び使用 |
| AU2010319927B2 (en) * | 2009-10-29 | 2015-01-22 | Janssen Pharmaceutica Nv | Alkynyl derivatives useful as DPP-1 inhibitors |
| TWI519532B (zh) | 2010-05-17 | 2016-02-01 | 艾維沃製藥公司 | （Ｒ）－７－氯－Ｎ－（啶－３－基）苯並［b］噻吩－２－羧醯胺鹽酸鹽單水合物之結晶形體 |
| RU2017136693A (ru) | 2012-05-08 | 2019-02-08 | Форум Фармасьютикалз, Инк. | Способы поддержания, лечения или улучшения когнитивной функции |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9218334D0 (en) * | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
| GB9226573D0 (en) * | 1992-12-21 | 1993-02-17 | Ici Plc | Heterocyclic compounds |
| US5616712A (en) * | 1995-05-16 | 1997-04-01 | Allergan | Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity |
| HUP9802433A3 (en) * | 1995-10-13 | 2000-03-28 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use |
| KR100589872B1 (ko) * | 1997-05-30 | 2006-06-15 | 뉴로서치 에이/에스 | 8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법 |
| DE69914935T2 (de) * | 1998-11-27 | 2009-10-01 | Neurosearch A/S | 8-azabicyclo[3.2.1]okt-2-en- und -oktanderivate |
| UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| JP4815083B2 (ja) | 1999-08-31 | 2011-11-16 | メルク・シャープ・エンド・ドーム・コーポレイション | 複素環化合物およびそれの使用方法 |
| JP5154728B2 (ja) * | 2000-07-24 | 2013-02-27 | クレニツキー・ファーマシューティカルズ，インコーポレイテッド | 神経栄養活性を有する置換５−アルキニルピリミジン |
| US6624167B1 (en) * | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| EP1358177B1 (en) * | 2000-10-13 | 2006-08-02 | NeuroSearch A/S | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
| RU2288919C2 (ru) * | 2001-10-02 | 2006-12-10 | Акадиа Фармасьютикалз, Инк. | Производные бензимидазолидинона в качестве агентов мускариновых рецепторов |
| RU2004110717A (ru) | 2001-10-17 | 2005-10-20 | Юсиби, С.А. (Be) | Производные хинуклидина, способы их получения и их применение в качестве и нгибиторов м2- и/или м3- мускариновых рецепторов |
| KR100432283B1 (ko) * | 2001-10-27 | 2004-05-22 | 한국과학기술연구원 | 무스카린성 아세틸콜린 수용체에 작용하는테트라하이드로피리딘 유도체 |
-
2003
- 2003-05-06 AU AU2003222738A patent/AU2003222738B2/en not_active Ceased
- 2003-05-06 MX MXPA04010965A patent/MXPA04010965A/es active IP Right Grant
- 2003-05-06 DE DE60322212T patent/DE60322212D1/de not_active Expired - Lifetime
- 2003-05-06 NZ NZ535641A patent/NZ535641A/en not_active IP Right Cessation
- 2003-05-06 CN CNB03810184XA patent/CN100522976C/zh not_active Expired - Fee Related
- 2003-05-06 CA CA002480378A patent/CA2480378A1/en not_active Abandoned
- 2003-05-06 WO PCT/DK2003/000294 patent/WO2003094830A2/en not_active Ceased
- 2003-05-06 EP EP03718655A patent/EP1506205B1/en not_active Expired - Lifetime
- 2003-05-06 AT AT03718655T patent/ATE401334T1/de not_active IP Right Cessation
- 2003-05-06 US US10/513,416 patent/US7378526B2/en not_active Expired - Fee Related
- 2003-05-06 JP JP2004502919A patent/JP2005524712A/ja not_active Ceased
-
2008
- 2008-03-25 US US12/076,929 patent/US7667040B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005524713A5 (enExample) | ||
| EP1532144B1 (en) | quinuclidine derivatives and their use | |
| AU2003266222B2 (en) | Novel 1,4-diazabicycloalkane derivatives, their preparation and use | |
| JP2009538867A5 (enExample) | ||
| RU2008139481A (ru) | Новые 1,4-диаза-бицикло[3.2.2]нонил-оксадиазолильные производные и их медицинское применение | |
| EP1866314B1 (en) | Novel diazabicyclic aryl derivatives and their medical use | |
| EP1713810B1 (en) | Diazabicyclic aryl derivatives as nicotinic acetylcholine receptor ligands | |
| EP1599476B1 (en) | Novel diazabicyclic aryl derivatives | |
| JP2010535738A (ja) | ニコチン性アセチルコリン受容体の調節物質として有用な新規１，２，３−トリアゾール誘導体 | |
| JP2004538268A5 (enExample) | ||
| JP2009526814A (ja) | 鏡像異性的に純粋なキヌクリジニルオキシピリダジン、及びニコチン性アセチルコリン受容体リガンドとしてのその使用 | |
| JP2006508109A5 (enExample) | ||
| JP2009526814A5 (enExample) | ||
| EP1805183B1 (en) | Novel diazabicyclic aryl derivatives and their medical use | |
| JP2005530814A5 (enExample) | ||
| JP2009537599A5 (enExample) | ||
| EP1713809B1 (en) | Dimeric azacyclic compounds and their use | |
| JP2007520525A5 (enExample) | ||
| US20070142450A1 (en) | Novel urea derivatives and their medical use | |
| JP2009537599A (ja) | 新規８，１０−ジアザ−ビシクロ［４．３．１］デカン誘導体及びそれらの医学的使用 | |
| KR20050062575A (ko) | 신규한 1,4-디아자바이사이클로알칸 유도체, 이의 제법 및용도 | |
| JP2011530495A (ja) | ニコチン性アセチルコリン受容体のモジュレーターとして有用な新規のジフェニル１，２，３−トリアゾール誘導体 | |
| JP2006503062A5 (enExample) | ||
| JP2006517567A5 (enExample) | ||
| JP2009537598A (ja) | 新規１，４−ジアザ−ビシクロ［３．２．２］ノナン誘導体及びそれらの医学的使用 |