JP2004538268A5 - - Google Patents
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- Publication number
- JP2004538268A5 JP2004538268A5 JP2003500090A JP2003500090A JP2004538268A5 JP 2004538268 A5 JP2004538268 A5 JP 2004538268A5 JP 2003500090 A JP2003500090 A JP 2003500090A JP 2003500090 A JP2003500090 A JP 2003500090A JP 2004538268 A5 JP2004538268 A5 JP 2004538268A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- diazabicyclo
- alkyl
- pyridazinyl
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 19
- -1 methylenedioxy Chemical group 0.000 claims description 18
- 125000003342 alkenyl group Chemical group 0.000 claims description 16
- 125000002950 monocyclic group Chemical group 0.000 claims description 13
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 12
- 125000001424 substituent group Chemical group 0.000 claims description 12
- 125000000304 alkynyl group Chemical group 0.000 claims description 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 7
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims description 7
- 125000004104 aryloxy group Chemical group 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- 125000003367 polycyclic group Polymers 0.000 claims description 7
- 125000005309 thioalkoxy group Chemical group 0.000 claims description 7
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229940002612 prodrug Drugs 0.000 claims description 6
- 239000000651 prodrug Substances 0.000 claims description 6
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 4
- 125000004946 alkenylalkyl group Chemical group 0.000 claims description 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 3
- 125000005038 alkynylalkyl group Chemical group 0.000 claims description 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 201000010099 disease Diseases 0.000 claims 10
- 208000035475 disorder Diseases 0.000 claims 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- 125000003373 pyrazinyl group Chemical group 0.000 claims 5
- 125000002098 pyridazinyl group Chemical group 0.000 claims 5
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 5
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 208000026097 Factitious disease Diseases 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000020341 sensory perception of pain Effects 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- ALIZNLALDYRBPE-UHFFFAOYSA-N 2-(7-benzyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)-4-methylquinoline Chemical compound N=1C2=CC=CC=C2C(C)=CC=1N(C1)CC(C2)CC1CN2CC1=CC=CC=C1 ALIZNLALDYRBPE-UHFFFAOYSA-N 0.000 claims 1
- KVSXEDHWFIFXBR-UHFFFAOYSA-N 2-(7-benzyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)-6-nitroquinoline Chemical compound C1=CC2=CC([N+](=O)[O-])=CC=C2N=C1N(C1)CC(C2)CC1CN2CC1=CC=CC=C1 KVSXEDHWFIFXBR-UHFFFAOYSA-N 0.000 claims 1
- ILQIIKPMIYMAPY-UHFFFAOYSA-N 2-(7-benzyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)quinoline Chemical compound C1C(CN(C2)C=3N=C4C=CC=CC4=CC=3)CC2CN1CC1=CC=CC=C1 ILQIIKPMIYMAPY-UHFFFAOYSA-N 0.000 claims 1
- CDMNFLMDVUCYMJ-UHFFFAOYSA-N 2-(7-methyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)quinoline Chemical compound C1=CC=CC2=NC(N3CC4CC(C3)CN(C4)C)=CC=C21 CDMNFLMDVUCYMJ-UHFFFAOYSA-N 0.000 claims 1
- ZYZYDFVOVNJUNN-UHFFFAOYSA-N 4-benzyl-8-(6-chloropyridazin-3-yl)-4,8-diazabicyclo[4.3.1]decane Chemical compound N1=NC(Cl)=CC=C1N1CC(CN(CC=2C=CC=CC=2)CC2)CC2C1 ZYZYDFVOVNJUNN-UHFFFAOYSA-N 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- HVKPRTHYJIPAMY-UHFFFAOYSA-N 7-benzyl-3-(6-chloropyrazin-2-yl)-3,7-diazabicyclo[3.3.1]nonane Chemical compound ClC1=CN=CC(N2CC3CC(CN(CC=4C=CC=CC=4)C3)C2)=N1 HVKPRTHYJIPAMY-UHFFFAOYSA-N 0.000 claims 1
- HEVSILFGYDGLEY-UHFFFAOYSA-N 7-benzyl-3-(6-chloropyridazin-3-yl)-3,7-diazabicyclo[3.3.1]nonane Chemical compound N1=NC(Cl)=CC=C1N1CC(CN(CC=2C=CC=CC=2)C2)CC2C1 HEVSILFGYDGLEY-UHFFFAOYSA-N 0.000 claims 1
- JWTDGNZXXYAVGI-UHFFFAOYSA-N 7-benzyl-3-(6-chloropyridazin-3-yl)-3,7-diazabicyclo[3.3.2]decane Chemical compound N1=NC(Cl)=CC=C1N1CC(CN(CC=2C=CC=CC=2)C2)CCC2C1 JWTDGNZXXYAVGI-UHFFFAOYSA-N 0.000 claims 1
- HAVWFULQRNSLRW-UHFFFAOYSA-N 7-benzyl-3-(6-phenylpyridazin-3-yl)-3,7-diazabicyclo[3.3.1]nonane Chemical compound C=1C=CC=CC=1CN(C1)CC(C2)CC1CN2C(N=N1)=CC=C1C1=CC=CC=C1 HAVWFULQRNSLRW-UHFFFAOYSA-N 0.000 claims 1
- CRDRGVJUPMOEJB-UHFFFAOYSA-N 7-methyl-3-(6-phenylpyridazin-3-yl)-3,7-diazabicyclo[3.3.1]nonane Chemical compound C1N(C)CC(C2)CC1CN2C(N=N1)=CC=C1C1=CC=CC=C1 CRDRGVJUPMOEJB-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 206010002660 Anoxia Diseases 0.000 claims 1
- 241000976983 Anoxia Species 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010013754 Drug withdrawal syndrome Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000017701 Endocrine disease Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020651 Hyperkinesia Diseases 0.000 claims 1
- 208000000269 Hyperkinesis Diseases 0.000 claims 1
- 206010020710 Hyperphagia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 208000022372 Reading disease Diseases 0.000 claims 1
- 241001303601 Rosacea Species 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010040981 Sleep attacks Diseases 0.000 claims 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000007953 anoxia Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000001713 cholinergic effect Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 208000030172 endocrine system disease Diseases 0.000 claims 1
- 230000002650 habitual effect Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 230000029849 luteinization Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 235000020830 overeating Nutrition 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000028591 pheochromocytoma Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000016160 smooth muscle contraction Effects 0.000 claims 1
- 230000001148 spastic effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000005057 thyrotoxicosis Diseases 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 208000002271 trichotillomania Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100866 | 2001-06-01 | ||
| PCT/DK2002/000347 WO2002096911A1 (en) | 2001-06-01 | 2002-05-23 | Novel heteroaryl-diazabicyclo-alkanes as cns-modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004538268A JP2004538268A (ja) | 2004-12-24 |
| JP2004538268A5 true JP2004538268A5 (enExample) | 2006-01-12 |
Family
ID=8160542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003500090A Pending JP2004538268A (ja) | 2001-06-01 | 2002-05-23 | Ｃｎｓ−モジュレーターとしての新規ヘテロアリール−ジアザビシクロアルカン類 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040147505A1 (enExample) |
| EP (1) | EP1397365B1 (enExample) |
| JP (1) | JP2004538268A (enExample) |
| AT (1) | ATE289310T1 (enExample) |
| DE (1) | DE60203007T2 (enExample) |
| WO (1) | WO2002096911A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2499128C (en) | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| US20050065178A1 (en) * | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| US7396833B2 (en) | 2003-12-22 | 2008-07-08 | Memory Pharmaceuticals Corporation | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof |
| US7365193B2 (en) | 2004-02-04 | 2008-04-29 | Abbott Laboratories | Amino-substituted tricyclic derivatives and methods of use |
| US20050171079A1 (en) * | 2004-02-04 | 2005-08-04 | Schrimpf Michael R. | Amino-substituted tricyclic derivatives and methods of use |
| CN103724343A (zh) | 2004-03-25 | 2014-04-16 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途 |
| CA2567977A1 (en) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| KR20070015607A (ko) | 2004-05-07 | 2007-02-05 | 메모리 파마슈티칼스 코포레이션 | 1ｈ-인다졸, 벤조티아졸, 1,2-벤조이속사졸,1,2-벤조이소티아졸, 및 크로몬 및 그의 제조법 및 용도 |
| WO2006069097A2 (en) | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| ATE495178T1 (de) | 2005-02-16 | 2011-01-15 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| EP1963323B1 (en) * | 2005-12-06 | 2010-07-14 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
| US7700596B2 (en) | 2006-02-10 | 2010-04-20 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1987031A1 (en) | 2006-02-10 | 2008-11-05 | NeuroSearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| AU2007213670A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2007217370A (ja) * | 2006-02-17 | 2007-08-30 | Nard Inst Ltd | ポジトロン断層撮影法および該方法に用いるポジトロン放出化合物 |
| RU2333211C1 (ru) * | 2006-11-01 | 2008-09-10 | Институт физиологически активных веществ Российской Академии наук | N,n`-замещенные 3, 7-диазабицикло[3.3.1]нонаны, обладающие фармакологической активностью, фармацевтические композиции на их основе и способ их применения |
| TW201004963A (en) * | 2008-07-03 | 2010-02-01 | Targacept Inc | Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands |
| EP2344496A1 (en) * | 2008-09-05 | 2011-07-20 | Targacept Inc. | Amides of diazabicyclooctanes and uses thereof |
| WO2010028011A1 (en) * | 2008-09-05 | 2010-03-11 | Targacept, Inc. | Amides of diazabicyclononanes and uses thereof |
| RU2417082C2 (ru) * | 2009-07-14 | 2011-04-27 | Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) | Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n, n'-замещенных 3, 7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения |
| RU2480470C2 (ru) * | 2011-04-06 | 2013-04-27 | Максим Эдуардович Запольский | Трициклические производные n,n'-замещенных 3,7-диазабицикло[3.3.1]нонанов, обладающие фармакологической активностью, и лекарственные средства на их основе |
| RU2489436C2 (ru) * | 2011-04-26 | 2013-08-10 | Максим Эдуардович Запольский | Алициклические производные n, n'-замещенных 3,7-диазабицикло[3.3.1]нонанов, обладающие фармакологической активностью, и лекарственные средства на их основе |
| RU2613071C1 (ru) * | 2015-09-18 | 2017-03-15 | Общество с ограниченной ответственностью "Цикломеморин" | N, N'-замещенные 3, 7-диазабицикло[3.3.1]нонаны, фармацевтические композиции на их основе и их применение |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3196154A (en) * | 1962-05-17 | 1965-07-20 | Sterling Drug Inc | 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes |
| JP2585086B2 (ja) * | 1988-12-28 | 1997-02-26 | 大鵬薬品工業株式会社 | ジアザビシクロアルカン誘導体 |
| US5468742A (en) * | 1991-07-19 | 1995-11-21 | Bayer Aktiengesellschaft | 8-vinyl- and 9-ethinyl-quinolone-carboxylic acids |
| US5679673A (en) * | 1992-09-24 | 1997-10-21 | The United States Of America, Represented By The Department Of Health And Human Services | Aralkyl bridged diazabicycloalkane derivatives for CNS disorders |
| DE4408212A1 (de) * | 1994-03-11 | 1995-09-14 | Bayer Ag | 5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren |
| US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
| GB9519563D0 (en) * | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
| CN1205210C (zh) * | 1997-05-30 | 2005-06-08 | 神经研究公司 | 作为尼古丁ACh受体上胆碱能配体的9－氮杂双环(3.3.1)壬－2－烯衍生物 |
| SE9704709D0 (sv) * | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
| GB9726630D0 (en) * | 1997-12-18 | 1998-02-18 | Glaxo Group Ltd | Kv2.1 Antagonists |
| DE60006213T2 (de) * | 1999-01-29 | 2004-07-29 | Abbott Laboratories, Abbott Park | Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden |
| CA2365258A1 (en) * | 1999-05-04 | 2000-11-09 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| EP1274710B1 (en) * | 1999-12-14 | 2005-02-23 | NeuroSearch A/S | Novel heteroaryl-diazabicycloalkanes |
| US6852721B2 (en) * | 2000-05-25 | 2005-02-08 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| CN1185233C (zh) * | 2000-07-04 | 2005-01-19 | 神经研究公司 | 芳基和杂芳基－二氮杂双环烷烃,其制备和用途 |
-
2002
- 2002-05-23 US US10/479,348 patent/US20040147505A1/en not_active Abandoned
- 2002-05-23 AT AT02724151T patent/ATE289310T1/de not_active IP Right Cessation
- 2002-05-23 JP JP2003500090A patent/JP2004538268A/ja active Pending
- 2002-05-23 EP EP02724151A patent/EP1397365B1/en not_active Expired - Lifetime
- 2002-05-23 WO PCT/DK2002/000347 patent/WO2002096911A1/en not_active Ceased
- 2002-05-23 DE DE60203007T patent/DE60203007T2/de not_active Expired - Lifetime
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