DE60203007T2 - Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren - Google Patents
Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren Download PDFInfo
- Publication number
- DE60203007T2 DE60203007T2 DE60203007T DE60203007T DE60203007T2 DE 60203007 T2 DE60203007 T2 DE 60203007T2 DE 60203007 T DE60203007 T DE 60203007T DE 60203007 T DE60203007 T DE 60203007T DE 60203007 T2 DE60203007 T2 DE 60203007T2
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- Prior art keywords
- diazabicyclo
- disease
- disorder
- pyridazinyl
- nonane
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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| DKPA200100866 | 2001-06-01 | ||
| DK200100866 | 2001-06-01 | ||
| PCT/DK2002/000347 WO2002096911A1 (en) | 2001-06-01 | 2002-05-23 | Novel heteroaryl-diazabicyclo-alkanes as cns-modulators |
Publications (2)
| Publication Number | Publication Date |
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| DE60203007D1 DE60203007D1 (de) | 2005-03-24 |
| DE60203007T2 true DE60203007T2 (de) | 2005-07-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| DE60203007T Expired - Lifetime DE60203007T2 (de) | 2001-06-01 | 2002-05-23 | Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren |
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| EP (1) | EP1397365B1 (enExample) |
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| AT (1) | ATE289310T1 (enExample) |
| DE (1) | DE60203007T2 (enExample) |
| WO (1) | WO2002096911A1 (enExample) |
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| CA2499128C (en) | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| US20050065178A1 (en) * | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| US7396833B2 (en) | 2003-12-22 | 2008-07-08 | Memory Pharmaceuticals Corporation | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof |
| US7365193B2 (en) | 2004-02-04 | 2008-04-29 | Abbott Laboratories | Amino-substituted tricyclic derivatives and methods of use |
| US20050171079A1 (en) * | 2004-02-04 | 2005-08-04 | Schrimpf Michael R. | Amino-substituted tricyclic derivatives and methods of use |
| CN103724343A (zh) | 2004-03-25 | 2014-04-16 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途 |
| CA2567977A1 (en) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| KR20070015607A (ko) | 2004-05-07 | 2007-02-05 | 메모리 파마슈티칼스 코포레이션 | 1ｈ-인다졸, 벤조티아졸, 1,2-벤조이속사졸,1,2-벤조이소티아졸, 및 크로몬 및 그의 제조법 및 용도 |
| WO2006069097A2 (en) | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| ATE495178T1 (de) | 2005-02-16 | 2011-01-15 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| EP1963323B1 (en) * | 2005-12-06 | 2010-07-14 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
| US7700596B2 (en) | 2006-02-10 | 2010-04-20 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1987031A1 (en) | 2006-02-10 | 2008-11-05 | NeuroSearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| AU2007213670A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2007217370A (ja) * | 2006-02-17 | 2007-08-30 | Nard Inst Ltd | ポジトロン断層撮影法および該方法に用いるポジトロン放出化合物 |
| RU2333211C1 (ru) * | 2006-11-01 | 2008-09-10 | Институт физиологически активных веществ Российской Академии наук | N,n`-замещенные 3, 7-диазабицикло[3.3.1]нонаны, обладающие фармакологической активностью, фармацевтические композиции на их основе и способ их применения |
| TW201004963A (en) * | 2008-07-03 | 2010-02-01 | Targacept Inc | Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands |
| EP2344496A1 (en) * | 2008-09-05 | 2011-07-20 | Targacept Inc. | Amides of diazabicyclooctanes and uses thereof |
| WO2010028011A1 (en) * | 2008-09-05 | 2010-03-11 | Targacept, Inc. | Amides of diazabicyclononanes and uses thereof |
| RU2417082C2 (ru) * | 2009-07-14 | 2011-04-27 | Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) | Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n, n'-замещенных 3, 7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения |
| RU2480470C2 (ru) * | 2011-04-06 | 2013-04-27 | Максим Эдуардович Запольский | Трициклические производные n,n'-замещенных 3,7-диазабицикло[3.3.1]нонанов, обладающие фармакологической активностью, и лекарственные средства на их основе |
| RU2489436C2 (ru) * | 2011-04-26 | 2013-08-10 | Максим Эдуардович Запольский | Алициклические производные n, n'-замещенных 3,7-диазабицикло[3.3.1]нонанов, обладающие фармакологической активностью, и лекарственные средства на их основе |
| RU2613071C1 (ru) * | 2015-09-18 | 2017-03-15 | Общество с ограниченной ответственностью "Цикломеморин" | N, N'-замещенные 3, 7-диазабицикло[3.3.1]нонаны, фармацевтические композиции на их основе и их применение |
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| US3196154A (en) * | 1962-05-17 | 1965-07-20 | Sterling Drug Inc | 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes |
| JP2585086B2 (ja) * | 1988-12-28 | 1997-02-26 | 大鵬薬品工業株式会社 | ジアザビシクロアルカン誘導体 |
| US5468742A (en) * | 1991-07-19 | 1995-11-21 | Bayer Aktiengesellschaft | 8-vinyl- and 9-ethinyl-quinolone-carboxylic acids |
| US5679673A (en) * | 1992-09-24 | 1997-10-21 | The United States Of America, Represented By The Department Of Health And Human Services | Aralkyl bridged diazabicycloalkane derivatives for CNS disorders |
| DE4408212A1 (de) * | 1994-03-11 | 1995-09-14 | Bayer Ag | 5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren |
| US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
| GB9519563D0 (en) * | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
| CN1205210C (zh) * | 1997-05-30 | 2005-06-08 | 神经研究公司 | 作为尼古丁ACh受体上胆碱能配体的9－氮杂双环(3.3.1)壬－2－烯衍生物 |
| SE9704709D0 (sv) * | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
| GB9726630D0 (en) * | 1997-12-18 | 1998-02-18 | Glaxo Group Ltd | Kv2.1 Antagonists |
| DE60006213T2 (de) * | 1999-01-29 | 2004-07-29 | Abbott Laboratories, Abbott Park | Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden |
| CA2365258A1 (en) * | 1999-05-04 | 2000-11-09 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| EP1274710B1 (en) * | 1999-12-14 | 2005-02-23 | NeuroSearch A/S | Novel heteroaryl-diazabicycloalkanes |
| US6852721B2 (en) * | 2000-05-25 | 2005-02-08 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| CN1185233C (zh) * | 2000-07-04 | 2005-01-19 | 神经研究公司 | 芳基和杂芳基－二氮杂双环烷烃,其制备和用途 |
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- 2002-05-23 JP JP2003500090A patent/JP2004538268A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2002096911A1 (en) | 2002-12-05 |
| EP1397365B1 (en) | 2005-02-16 |
| DE60203007D1 (de) | 2005-03-24 |
| US20040147505A1 (en) | 2004-07-29 |
| ATE289310T1 (de) | 2005-03-15 |
| JP2004538268A (ja) | 2004-12-24 |
| EP1397365A1 (en) | 2004-03-17 |
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