JP2006508109A5 - - Google Patents
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- Publication number
- JP2006508109A5 JP2006508109A5 JP2004550659A JP2004550659A JP2006508109A5 JP 2006508109 A5 JP2006508109 A5 JP 2006508109A5 JP 2004550659 A JP2004550659 A JP 2004550659A JP 2004550659 A JP2004550659 A JP 2004550659A JP 2006508109 A5 JP2006508109 A5 JP 2006508109A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridazin
- nonane
- diazabicyclo
- disease
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 41
- 201000010099 disease Diseases 0.000 claims description 21
- 208000035475 disorder Diseases 0.000 claims description 20
- 208000002193 Pain Diseases 0.000 claims description 6
- 230000004770 neurodegeneration Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 3
- 230000016160 smooth muscle contraction Effects 0.000 claims description 3
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000004983 Phantom Limb Diseases 0.000 claims description 2
- 206010056238 Phantom pain Diseases 0.000 claims description 2
- 208000004550 Postoperative Pain Diseases 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 230000000306 recurrent effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 206010010904 Convulsion Diseases 0.000 claims 3
- -1 indol-2-yl- Chemical group 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000032841 Bulimia Diseases 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 208000012661 Dyskinesia Diseases 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000013403 hyperactivity Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- SPENYPHOPYNNMM-UHFFFAOYSA-N 2-[6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)pyridazin-3-yl]-1,3,4-oxadiazole Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=NN=CO1 SPENYPHOPYNNMM-UHFFFAOYSA-N 0.000 claims 1
- NWBQHUOIZCLTEN-UHFFFAOYSA-N 2-[6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)pyridazin-3-yl]-1,3,4-thiadiazole Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=NN=CS1 NWBQHUOIZCLTEN-UHFFFAOYSA-N 0.000 claims 1
- GQDZMLYERQCVCI-UHFFFAOYSA-N 2-[6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)pyridazin-3-yl]-1,3-oxazole Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=NC=CO1 GQDZMLYERQCVCI-UHFFFAOYSA-N 0.000 claims 1
- LWDIJZHGOFRRBY-UHFFFAOYSA-N 2-[6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)pyridazin-3-yl]-1,3-thiazole Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=NC=CS1 LWDIJZHGOFRRBY-UHFFFAOYSA-N 0.000 claims 1
- XGQNMFLIMAXOIY-UHFFFAOYSA-N 4-(6-pyridin-3-ylpyridazin-3-yl)-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=CC=CN=C1 XGQNMFLIMAXOIY-UHFFFAOYSA-N 0.000 claims 1
- DKHBMBRMHHQCDB-UHFFFAOYSA-N 4-(6-selenophen-2-ylpyridazin-3-yl)-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=CC=C[se]1 DKHBMBRMHHQCDB-UHFFFAOYSA-N 0.000 claims 1
- DOFUKSVDRJDFPT-UHFFFAOYSA-N 4-(6-selenophen-3-ylpyridazin-3-yl)-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C=1C=C[se]C=1 DOFUKSVDRJDFPT-UHFFFAOYSA-N 0.000 claims 1
- JZWLASCGBSGJJP-UHFFFAOYSA-N 4-(6-thiophen-2-ylpyridazin-3-yl)-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=CC=CS1 JZWLASCGBSGJJP-UHFFFAOYSA-N 0.000 claims 1
- GDHIPSSNCMRUGD-UHFFFAOYSA-N 4-(6-thiophen-3-ylpyridazin-3-yl)-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C=1C=CSC=1 GDHIPSSNCMRUGD-UHFFFAOYSA-N 0.000 claims 1
- UUMMBUCFQAZHOZ-UHFFFAOYSA-N 4-[6-(1h-indol-2-yl)pyridazin-3-yl]-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CC2CCN1CCN2C1=CC=C(C=2NC3=CC=CC=C3C=2)N=N1 UUMMBUCFQAZHOZ-UHFFFAOYSA-N 0.000 claims 1
- AAJWPKMRKNHGJB-UHFFFAOYSA-N 4-[6-(1h-indol-3-yl)pyridazin-3-yl]-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CC2CCN1CCN2C1=CC=C(C=2C3=CC=CC=C3NC=2)N=N1 AAJWPKMRKNHGJB-UHFFFAOYSA-N 0.000 claims 1
- VSQKKGSKQLKGLK-UHFFFAOYSA-N 4-[6-(1h-indol-5-yl)pyridazin-3-yl]-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CC2CCN1CCN2C1=CC=C(C=2C=C3C=CNC3=CC=2)N=N1 VSQKKGSKQLKGLK-UHFFFAOYSA-N 0.000 claims 1
- GQLYDXLVVUJUNQ-UHFFFAOYSA-N 4-[6-(1h-indol-6-yl)pyridazin-3-yl]-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CC2CCN1CCN2C1=CC=C(C=2C=C3NC=CC3=CC=2)N=N1 GQLYDXLVVUJUNQ-UHFFFAOYSA-N 0.000 claims 1
- PUSFZEHEZVTHLC-UHFFFAOYSA-N 4-[6-(furan-2-yl)pyridazin-3-yl]-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=CC=CO1 PUSFZEHEZVTHLC-UHFFFAOYSA-N 0.000 claims 1
- IPMBYUWDOKOAHU-UHFFFAOYSA-N 4-[6-(furan-3-yl)pyridazin-3-yl]-1,4-diazabicyclo[3.2.2]nonane Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C=1C=COC=1 IPMBYUWDOKOAHU-UHFFFAOYSA-N 0.000 claims 1
- YZICOXNXTNFTLQ-UHFFFAOYSA-N 5-[6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)pyridazin-3-yl]-1,3-oxazole Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=CN=CO1 YZICOXNXTNFTLQ-UHFFFAOYSA-N 0.000 claims 1
- VCXNGLKVCYWXLQ-UHFFFAOYSA-N 5-[6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)pyridazin-3-yl]-1,3-thiazole Chemical compound C1CN(CC2)CCC1N2C(N=N1)=CC=C1C1=CN=CS1 VCXNGLKVCYWXLQ-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 206010002660 Anoxia Diseases 0.000 claims 1
- 241000976983 Anoxia Species 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 206010004716 Binge eating Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 108010009685 Cholinergic Receptors Proteins 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000005374 Poisoning Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 208000022372 Reading disease Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 102000034337 acetylcholine receptors Human genes 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 238000001467 acupuncture Methods 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000007953 anoxia Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 208000014679 binge eating disease Diseases 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 230000029849 luteinization Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000028591 pheochromocytoma Diseases 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000020341 sensory perception of pain Effects 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 description 4
- 210000001428 peripheral nervous system Anatomy 0.000 description 4
- 230000001713 cholinergic effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 description 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200201737 | 2002-11-11 | ||
| PCT/DK2003/000769 WO2004043960A1 (en) | 2002-11-11 | 2003-11-10 | 1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508109A JP2006508109A (ja) | 2006-03-09 |
| JP2006508109A5 true JP2006508109A5 (enExample) | 2010-10-14 |
Family
ID=32309262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550659A Ceased JP2006508109A (ja) | 2002-11-11 | 2003-11-10 | １，４−ジアザビシクロ（３，２，２）ノナン誘導体、その製造方法及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1562945B1 (enExample) |
| JP (1) | JP2006508109A (enExample) |
| AT (1) | ATE345342T1 (enExample) |
| AU (1) | AU2003280309A1 (enExample) |
| DE (1) | DE60309740T2 (enExample) |
| DK (1) | DK1562945T3 (enExample) |
| WO (1) | WO2004043960A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| US7094572B2 (en) | 2003-03-14 | 2006-08-22 | Bristol-Myers Squibb | Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74 |
| SE0303075D0 (sv) * | 2003-11-19 | 2003-11-19 | Astrazeneca Ab | 4-substituted imidazoles |
| SE0303076D0 (sv) * | 2003-11-19 | 2003-11-19 | Astrazeneca Ab | 5-substituted imidazoles |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| WO2006058879A1 (en) * | 2004-11-30 | 2006-06-08 | Neurosearch A/S | Novel diazabicyclic aryl derivatives as cholinergy ligands |
| EP1866314B1 (en) | 2005-02-16 | 2010-09-15 | NeuroSearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
| DE602006019561D1 (de) | 2005-02-16 | 2011-02-24 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin-acetylcholin-rezeptoren |
| US8173658B2 (en) | 2005-12-06 | 2012-05-08 | Neurosearch A/S | Diazabicycylic aryl derivatives and their medical use |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| JP2009526777A (ja) | 2006-02-14 | 2009-07-23 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体作用薬としての３，９−ジアザビシクロ（３．３．１）ノナ−３−イル−アリールメタノン誘導体 |
| MX2008014890A (es) | 2006-05-30 | 2008-12-05 | Neurosearch As | Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil pirimidinilo y su uso medico. |
| ATE463497T1 (de) * | 2006-05-30 | 2010-04-15 | Neurosearch As | Neues 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivat und seine medizinische verwendung |
| US8778987B2 (en) | 2007-03-13 | 2014-07-15 | Symrise Ag | Use of 4-hydroxychalcone derivatives for masking an unpleasant taste |
| EP1977655B1 (de) | 2007-03-29 | 2011-05-18 | Symrise AG | Aromakompositionen von Alkamiden mit Hesperetin und/oder 4-Hydroxydihydrochalkonen und deren Salzen zur Verstärkung süßer sensorischer Eindrücke |
| BRPI0820259A2 (pt) | 2007-11-14 | 2015-06-16 | Neurosearch As | Derivado de 1,4-diaza-biciclo[3.2.2] nonil pirimidina, composição farmacêutica, uso do derivado de 1,4-diaza-biciclo[3.2.2] nonil pirimidina, e, método de tratamento, prevenção ou alívio de uma doença ou uma desordem ou uma condição de um corpo de animal vivo |
| US20110257161A1 (en) * | 2008-12-04 | 2011-10-20 | Neurosearch A/S | Novel diaza-bicyclononyl-phenyl derivatives and their medical use |
| MX357676B (es) | 2010-05-17 | 2018-07-18 | Forum Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin- 3-il)benzo[b]tiofeno-2-carboxamida monohidratado. |
| EP2559346B1 (en) | 2011-08-15 | 2014-03-26 | Symrise AG | Oleanene-type triterpene glycosides as masking agents |
| EP3666272A1 (en) | 2012-05-08 | 2020-06-17 | Forum Pharmaceuticals Inc. | Use of encenicline in the treatment of cognitive impairment, alzheimer's disease, memory deficit |
| US8729263B2 (en) * | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| KR102318727B1 (ko) | 2013-07-31 | 2021-10-28 | 노파르티스 아게 | 1,4-이치환된 피리다진 유사체 및 smn-결핍-관련 상태를 치료하기 위한 그의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786770B1 (fr) * | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| FR2809732B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE |
| FR2809731B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
| FR2809730B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique |
| US20020086871A1 (en) * | 2000-12-29 | 2002-07-04 | O'neill Brian Thomas | Pharmaceutical composition for the treatment of CNS and other disorders |
| FR2832713B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
| FR2832714B1 (fr) * | 2001-11-23 | 2004-07-16 | Sanofi Synthelabo | Derives de 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
| FR2832712B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
| DE10162442A1 (de) * | 2001-12-19 | 2003-07-03 | Bayer Ag | Monocyclische N-Aryl-amide |
-
2003
- 2003-11-10 EP EP03770918A patent/EP1562945B1/en not_active Expired - Lifetime
- 2003-11-10 DE DE60309740T patent/DE60309740T2/de not_active Expired - Lifetime
- 2003-11-10 DK DK03770918T patent/DK1562945T3/da active
- 2003-11-10 WO PCT/DK2003/000769 patent/WO2004043960A1/en not_active Ceased
- 2003-11-10 JP JP2004550659A patent/JP2006508109A/ja not_active Ceased
- 2003-11-10 AT AT03770918T patent/ATE345342T1/de active
- 2003-11-10 AU AU2003280309A patent/AU2003280309A1/en not_active Abandoned
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