CN1926098A - 新的脲衍生物及其医药应用 - Google Patents

新的脲衍生物及其医药应用 Download PDF

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Publication number
CN1926098A
CN1926098A CNA200580006364XA CN200580006364A CN1926098A CN 1926098 A CN1926098 A CN 1926098A CN A200580006364X A CNA200580006364X A CN A200580006364XA CN 200580006364 A CN200580006364 A CN 200580006364A CN 1926098 A CN1926098 A CN 1926098A
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phenyl
hydroxyl
halogen
expression hydrogen
nitro
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CNA200580006364XA
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English (en)
Chinese (zh)
Inventor
B·H·达尔
D·皮特斯
G·M·奥尔森
T·D·卓根森
D·B·逖米尔曼
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NTG Nordic Transport Group AS
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Neurosearch AS
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Publication of CN1926098A publication Critical patent/CN1926098A/zh
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    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
CNA200580006364XA 2004-03-29 2005-03-16 新的脲衍生物及其医药应用 Pending CN1926098A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200400498 2004-03-29
DKPA200400498 2004-03-29
US60/557,698 2004-03-31

Publications (1)

Publication Number Publication Date
CN1926098A true CN1926098A (zh) 2007-03-07

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CNA200580006364XA Pending CN1926098A (zh) 2004-03-29 2005-03-16 新的脲衍生物及其医药应用

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US (1) US20070142450A1 (enExample)
EP (1) EP1732883A1 (enExample)
JP (1) JP2007530635A (enExample)
CN (1) CN1926098A (enExample)
AU (1) AU2005225559A1 (enExample)
BR (1) BRPI0507296A (enExample)
CA (1) CA2561639A1 (enExample)
RU (1) RU2006131454A (enExample)
WO (1) WO2005092843A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103172543A (zh) * 2011-12-21 2013-06-26 中国科学院上海药物研究所 一种脲类化合物、制备方法及其用途

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WO2006089871A2 (en) * 2005-02-23 2006-08-31 Neurosearch A/S Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
WO2008028903A2 (en) * 2006-09-04 2008-03-13 Neurosearch A/S Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
WO2010130063A1 (zh) * 2009-05-12 2010-11-18 Han Mei 具有促进干細胞增殖作用的小分子化合物及其用途
US9856210B2 (en) 2010-09-02 2018-01-02 Kyoto University Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
EP2670744B1 (en) 2011-02-03 2015-05-27 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nachr
AU2012221800B2 (en) 2011-02-23 2016-10-27 Lupin Limited Heteroaryl derivatives as alpha7 nAChR modulators
AU2012235779B2 (en) 2011-03-31 2017-03-02 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease
CN103619354A (zh) 2011-06-30 2014-03-05 东丽株式会社 止痒剂
ES2606043T3 (es) 2011-07-05 2017-03-17 Lupin Limited Derivados de biarilo como moduladores de nAChR
US8541577B2 (en) * 2011-11-10 2013-09-24 Allergan, Inc. Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators
WO2013132380A1 (en) 2012-03-06 2013-09-12 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
WO2014072957A1 (en) 2012-11-12 2014-05-15 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
US9617211B2 (en) 2013-01-16 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
US9617210B2 (en) 2013-03-13 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 NACHR modulators
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
WO2014203150A1 (en) 2013-06-17 2014-12-24 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators

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DE3237479A1 (de) * 1982-10-09 1984-04-12 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von substituierten tetrahydropyrimidinonderivaten
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
JP3610368B2 (ja) * 1993-05-27 2005-01-12 セネス リミティド 治療用置換グアニジン
JPH11503110A (ja) * 1995-02-17 1999-03-23 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体拮抗剤
WO1997045111A1 (en) * 1996-05-24 1997-12-04 Neurosearch A/S Phenyl derivatives useful as blockers of chloride channels
DE69830513T2 (de) * 1997-12-22 2006-03-16 Bayer Pharmaceuticals Corp., West Haven HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN
EP2196930B1 (en) * 1998-07-01 2011-03-23 The Trustees of The University of Pennsylvania Cavity induced allosteric modificatin of intermolecular interactions and methods of identifiying compounds that effect the same
US20040063742A1 (en) * 2001-02-15 2004-04-01 Dan Peters Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
US20030236287A1 (en) 2002-05-03 2003-12-25 Piotrowski David W. Positive allosteric modulators of the nicotinic acetylcholine receptor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103172543A (zh) * 2011-12-21 2013-06-26 中国科学院上海药物研究所 一种脲类化合物、制备方法及其用途
WO2013091285A1 (zh) * 2011-12-21 2013-06-27 中国科学院上海药物研究所 一种脲类化合物、制备方法及其用途
CN103172543B (zh) * 2011-12-21 2016-02-10 中国科学院上海药物研究所 一种脲类化合物、制备方法及其用途

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AU2005225559A1 (en) 2005-10-06
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US20070142450A1 (en) 2007-06-21
CA2561639A1 (en) 2005-10-06
EP1732883A1 (en) 2006-12-20
BRPI0507296A (pt) 2007-07-03
RU2006131454A (ru) 2008-05-10

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