JP2009543544A - 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法 - Google Patents

置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法 Download PDF

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JP2009543544A
JP2009543544A JP2009511045A JP2009511045A JP2009543544A JP 2009543544 A JP2009543544 A JP 2009543544A JP 2009511045 A JP2009511045 A JP 2009511045A JP 2009511045 A JP2009511045 A JP 2009511045A JP 2009543544 A JP2009543544 A JP 2009543544A
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マーク エル. ネルソン,
マイケル ドレイパー,
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パラテック ファーマシューティカルズ インコーポレイテッド
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    • C12N15/635Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/001Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C12N2830/003Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible

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JP2009511045A 2006-05-15 2007-05-15 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法 Pending JP2009543544A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80066206P 2006-05-15 2006-05-15
PCT/US2007/011700 WO2007133798A2 (en) 2006-05-15 2007-05-15 Methods of regulating expression of genes or of gene products using substituted tetracycline compounds

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JP2010112699A Division JP2010193904A (ja) 2006-05-15 2010-05-14 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法

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JP2009543544A true JP2009543544A (ja) 2009-12-10
JP2009543544A5 JP2009543544A5 (enExample) 2010-07-01

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JP2009511045A Pending JP2009543544A (ja) 2006-05-15 2007-05-15 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法
JP2009511044A Pending JP2009537139A (ja) 2006-05-15 2007-05-15 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を制御する方法
JP2010112699A Pending JP2010193904A (ja) 2006-05-15 2010-05-14 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法

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JP2010112699A Pending JP2010193904A (ja) 2006-05-15 2010-05-14 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法

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US (2) US20080118979A1 (enExample)
EP (5) EP2537934A3 (enExample)
JP (3) JP2009543544A (enExample)
AU (2) AU2007249695A1 (enExample)
CA (2) CA2652347A1 (enExample)
WO (2) WO2007133798A2 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
JP2002501026A (ja) * 1998-01-23 2002-01-15 トルスティーズ オブ トゥフツ カレッジ 薬学的に活性の化合物及びその利用法
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
KR101027625B1 (ko) * 2000-07-07 2011-04-06 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
KR101228706B1 (ko) 2003-07-09 2013-02-01 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
EP2269978A3 (en) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
EP2537934A3 (en) * 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
CA2673486C (en) 2006-12-21 2015-09-08 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP3045449A1 (en) 2006-12-21 2016-07-20 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
WO2008127722A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
US20080283080A1 (en) * 2007-05-15 2008-11-20 Masood Habibi Hair styling device
BRPI0908951A2 (pt) 2008-03-05 2017-01-17 Paratek Pharm Innc compostos de minociclina e método de uso dos mesmos
EP2276342A4 (en) * 2008-04-14 2012-02-22 Paratek Pharm Innc SUBSTITUTED TETRACYCLIN COMPOUNDS
EP2307027A4 (en) * 2008-07-11 2012-08-15 Neumedics TETRACYCLINE DERIVATIVES WITH REDUCED ANTIBIOTIC ACTIVITY AND NEUROPROTECTIVE PROPERTIES
US8629334B2 (en) * 2008-07-16 2014-01-14 University Of Florida Research Foundation, Inc. Viral-based transient-expression vector system for trees
PL3000805T3 (pl) 2008-08-08 2018-04-30 Tetraphase Pharmaceuticals, Inc. C7-fluoro podstawione związki tetracyklinowe
WO2010033939A1 (en) * 2008-09-19 2010-03-25 Paratek Pharmaceuticals, Inc. Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment
WO2010037593A1 (en) 2008-10-01 2010-04-08 Tet Systems Holding Gmbh & Co.Kg Tetracycline inducible transcription control sequence
EP2364322A1 (en) 2008-10-28 2011-09-14 Pioneer Hi-Bred International Inc. Sulfonylurea-responsive repressor proteins
ES2627772T3 (es) 2009-05-08 2017-07-31 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina
WO2011025982A2 (en) * 2009-08-28 2011-03-03 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
WO2012071549A2 (en) 2010-11-24 2012-05-31 Clontech Laboratories, Inc. Inducible expression system transcription modulators comprising a distributed protein transduction domain and methods for using the same
ES2931180T3 (es) 2011-05-19 2022-12-27 Fund Publica Andaluza Progreso Y Salud Sistema de tipo Tet-on lentivírico de promotor dual muy inducible
AU2013308504B2 (en) 2012-08-31 2016-11-10 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
KR102880712B1 (ko) 2016-10-19 2025-11-03 테트라페이즈 파마슈티컬스, 인코포레이티드 에라바사이클린의 결정질 형태
WO2018085216A1 (en) 2016-11-01 2018-05-11 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp)
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas
TW202323529A (zh) 2021-10-18 2023-06-16 美商再生元醫藥公司 包括腺病毒相關病毒聚核苷酸的真核細胞
AU2022371200A1 (en) * 2021-10-18 2024-05-02 Regeneron Pharmaceuticals, Inc. Controlled transcription of polynucleotides

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11506901A (ja) * 1994-07-01 1999-06-22 ベーアーエスエフ アクツィエンゲゼルシャフト テトラサイクリン調節される転写モジュレーター
JP2004505012A (ja) * 2000-03-31 2004-02-19 トラスティーズ・オブ・タフツ・カレッジ 7−および9−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物
JP2005506291A (ja) * 2001-03-13 2005-03-03 パラテック ファーマシューティカルズ, インク. 7,9−置換テトラサイクリン化合物
WO2006047671A2 (en) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
WO2006047756A2 (en) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) * 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) * 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) * 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3862225A (en) 1961-08-18 1975-01-21 Pfizer D-ring substituted tetracyclines
US3165531A (en) * 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) * 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (enExample) * 1966-05-31 1967-12-01
US4066694A (en) 1971-02-09 1978-01-03 Pfizer Inc. 4-hydroxy-4-dedimethylamino-tetracyclines
US3622627A (en) 1967-09-13 1971-11-23 Pfizer 4-dedimethylaminatetracycline and 5a, 6-anhydro derivatives thereof
DE1767891C3 (de) * 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) * 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) * 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) * 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
EP0179127B1 (en) 1984-04-13 1989-12-13 Akzo N.V. Leukoregulin, an antitumor lymphokine, and its therapeutic uses
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US4806372A (en) * 1985-02-15 1989-02-21 Georgia Oil & Gas Co., Inc. Nitrite-free-curing of bacon and product thereof
EP0264166B1 (en) 1986-04-09 1996-08-21 Genzyme Corporation Transgenic animals secreting desired proteins into milk
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
EP0528810B1 (en) 1991-03-22 1996-02-07 CARSON, William S. Container and pickup assembly for collection of recyclable materials
AU1970892A (en) 1991-04-18 1992-11-17 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Identification of a new ehrlichia species from a patient suffering from ehrlichiosis
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DK0536515T3 (da) 1991-10-04 2002-04-08 American Cyanamid Co Nye 7-substitueret-9-substitueret amino-6-demethyl-6-deoxytetracycliner
US5281628A (en) 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5442059A (en) 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
DE4227616C2 (de) 1992-08-20 1995-04-13 Sigma Tau Ind Farmaceuti 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen
US5371076A (en) 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US20030022315A1 (en) * 1993-06-14 2003-01-30 Basf Aktiengesellschaft And Knoll Aktiengesellschaft Tetracycline-inducible transcriptional inhibitor fusion proteins
US5814618A (en) 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5888981A (en) * 1993-06-14 1999-03-30 Basf Aktiengesellschaft Methods for regulating gene expression
US5654168A (en) 1994-07-01 1997-08-05 Basf Aktiengesellschaft Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units
ES2140359T1 (es) * 1993-06-14 2000-03-01 Basf Ag Control preciso de expresion genetica en celulas eucarioticas mediante promotores que responden a la tetaciclina.
US5859310A (en) * 1993-06-14 1999-01-12 Basf Aktiengesellschaft Mice transgenic for a tetracycline-controlled transcriptional activator
US6004941A (en) 1993-06-14 1999-12-21 Basf Aktiengesellschaft Methods for regulating gene expression
US5789156A (en) 1993-06-14 1998-08-04 Basf Ag Tetracycline-regulated transcriptional inhibitors
US5912411A (en) * 1993-06-14 1999-06-15 University Of Heidelberg Mice transgenic for a tetracycline-inducible transcriptional activator
EP0656504B1 (de) * 1993-12-03 1998-08-05 Uhrig Kanaltechnik GmbH Vorrichtung zum Abdichten von Leckstellen in Rohren vom Rohrinnern her und Verfahren zum Abdichten der Leckstellen
MX9603508A (es) 1994-02-17 1997-03-29 Pfizer Analogos de la doxiciclina.
US5530557A (en) 1994-09-12 1996-06-25 International Business Machines Corporation Online placement of video files determined by a function of the bandwidth to space ratio of each of the storage devices in a server environment
US6165999A (en) 1995-05-03 2000-12-26 Pfizer Inc Tetracycline derivatives
US5888891A (en) * 1996-08-23 1999-03-30 International Rectifier Corporation Process for manufacturing a schottky diode with enhanced barrier height and high thermal stability
DE19640817A1 (de) * 1996-10-02 1998-05-14 Hermann Prof Dr Bujard Rekombinantes Herstellungsverfahren für ein vollständiges Malaria-Antigen gp190/MSP 1
US6087166A (en) * 1997-07-03 2000-07-11 Basf Aktiengesellschaft Transcriptional activators with graded transactivation potential
JP2002501026A (ja) 1998-01-23 2002-01-15 トルスティーズ オブ トゥフツ カレッジ 薬学的に活性の化合物及びその利用法
WO2000028983A1 (en) 1998-11-18 2000-05-25 Collagenex Pharmaceuticals, Inc. Novel 4-dedimethy laminotetra cycline derivatives
US6506740B1 (en) 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
DE60043889D1 (en) 1999-06-07 2010-04-08 Tet Systems Holding Gmbh & Co Tet repressor basierte transkriptionale regulatorische proteine
US6256365B1 (en) * 1999-08-16 2001-07-03 Analogic Corporation Apparatus and method for reconstruction of images in a computed tomography system using oblique slices
US6500812B2 (en) * 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6849615B2 (en) * 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EP1666454B1 (en) 1999-09-14 2011-09-07 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
AU3105801A (en) * 2000-01-24 2001-07-31 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
US20020015287A1 (en) * 2000-04-05 2002-02-07 Charles Shao Cooling system and method for a high density electronics enclosure
US6642270B2 (en) 2000-05-15 2003-11-04 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
AU2000257445A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-n-substituted phenyl tetracycline compounds
AU2000254942A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
DK1679305T3 (da) 2000-07-07 2012-05-29 Tufts College 9-substituerede minocyclinforbindelser
KR101027625B1 (ko) 2000-07-07 2011-04-06 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
EP1303479B1 (en) 2000-07-07 2011-04-06 Trustees Of Tufts College 7-, 8- and 9-substituted tetracycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
AU2000265203A1 (en) 2000-08-04 2002-02-18 Trustees Of Tufts College 8-substituted tetracycline compounds
JP3777301B2 (ja) * 2000-12-04 2006-05-24 本田技研工業株式会社 車両用多気筒エンジン
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
CA2440757A1 (en) * 2001-03-14 2002-09-19 Michael Draper Substituted tetracycline compounds as synergistic antifungal agents
JP2004530661A (ja) * 2001-03-14 2004-10-07 パラテック ファーマシューティカルズ インコーポレイテッド 抗真菌剤としての置換テトラサイクリン化合物
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003055441A2 (en) * 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
WO2003023568A2 (en) * 2001-09-10 2003-03-20 Paratek Pharmaceuticals, Inc. Computational method for determining oral bioavailability
DE10148195A1 (de) * 2001-09-28 2003-04-24 Rolf Gebhardt Nicht-menschliches Tiermodell zur Untersuchung der Entstehung und der Therapie von Organfibrose
EP1439843A4 (en) * 2001-10-05 2007-01-03 Tetragenex Pharmaceuticals Inc TETRACYCLINE DERIVATIVES AND METHODS OF USE
EP2311796A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
WO2003075857A2 (en) * 2002-03-08 2003-09-18 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EA200401232A1 (ru) 2002-03-21 2005-12-29 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
CA2497263A1 (en) * 2002-08-28 2004-03-11 Universitaet Heidelberg Chromosomal loci for the stringent control of gene activities via transcription activation systems
US7437446B2 (en) 2002-09-30 2008-10-14 Electronic Data Systems Corporation Reporting of abnormal computer resource utilization data
DE10249390A1 (de) * 2002-10-23 2004-05-13 Ruprecht-Karls-Universität Heidelberg Rekombinante MVA-Stämme als potentielle Impfstoffe gegen P.falciparum-Malaria
EP1562608A4 (en) * 2002-10-24 2010-09-01 Paratek Pharm Innc METHOD OF USE OF SUBSTITUTED TETRACYCLINE COMPOUNDS FOR MODULATING THE RNA
KR101228706B1 (ko) 2003-07-09 2013-02-01 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
US20060287283A1 (en) 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US7739737B2 (en) * 2003-07-29 2010-06-15 Wisconsin Alumni Research Foundation Method and apparatus to detect malicious software
US7672693B2 (en) 2003-11-10 2010-03-02 Nokia Corporation Controlling method, secondary unit and radio terminal equipment
EP1716101A1 (en) * 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
JP5024784B2 (ja) 2004-12-03 2012-09-12 独立行政法人科学技術振興機構 被検体生物の同定方法、この方法に使用する内部標準用dna組成物及びその製造方法
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
DE102005011719A1 (de) 2005-03-15 2006-09-28 Clariant Produkte (Deutschland) Gmbh Wasch- und Reinigungsmittel enthaltend Acetale als organische Lösemittel
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
CA2639406A1 (en) * 2006-01-24 2007-08-02 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
TW200808812A (en) 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
EP2537934A3 (en) * 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
WO2008127722A1 (en) * 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
WO2008134048A2 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EA201070048A1 (ru) * 2007-07-06 2010-10-29 Паратек Фармасьютикалс, Инк. Способы синтеза замещённых соединений тетрациклина (варианты)
US7787981B2 (en) 2008-05-16 2010-08-31 Xerox Corporation System for reliable collaborative assembly and maintenance of complex systems
KR101098447B1 (ko) 2009-12-04 2011-12-26 매그나칩 반도체 유한회사 반도체 장치
JP5706185B2 (ja) 2011-02-22 2015-04-22 富士レビオ株式会社 測定装置及び測定方法
US9713502B2 (en) 2014-03-09 2017-07-25 Gyrus Acmi, Inc. Narrow band imaging with surgical loupes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11506901A (ja) * 1994-07-01 1999-06-22 ベーアーエスエフ アクツィエンゲゼルシャフト テトラサイクリン調節される転写モジュレーター
JP2004505012A (ja) * 2000-03-31 2004-02-19 トラスティーズ・オブ・タフツ・カレッジ 7−および9−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物
JP2005506291A (ja) * 2001-03-13 2005-03-03 パラテック ファーマシューティカルズ, インク. 7,9−置換テトラサイクリン化合物
WO2006047671A2 (en) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
WO2006047756A2 (en) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6012054057; Gene Therapy vol.4, 1997, pp.993-997 *
JPN6012054058; Analytical Biochemistry vol.309, 2002, pp.79-84 *
JPN6012054059; Virus Research vol.115, 2006, pp.16-23 *

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