JP2009542225A - 組換え法によりｆｖｉｉｉタンパク質を生産する方法 - Google Patents

組換え法によりｆｖｉｉｉタンパク質を生産する方法 Download PDF

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JP2009542225A
JP2009542225A JP2009518576A JP2009518576A JP2009542225A JP 2009542225 A JP2009542225 A JP 2009542225A JP 2009518576 A JP2009518576 A JP 2009518576A JP 2009518576 A JP2009518576 A JP 2009518576A JP 2009542225 A JP2009542225 A JP 2009542225A
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factor viii
protein
amino acid
fviii
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ランダル， ジェイ． カウフマン，
スティーブン， ダブリュー パイプ，
ウィリアム グリフィス，
ウィリアム ドロハン，
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ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・ミシガン
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2009518576A 2006-06-30 2007-06-29 組換え法によりｆｖｉｉｉタンパク質を生産する方法 Pending JP2009542225A (ja)

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US81817706P 2006-06-30 2006-06-30
PCT/US2007/072506 WO2008005847A2 (en) 2006-06-30 2007-06-29 Method of producing factor viii proteins by recombinant methods

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JP2013161261A Division JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

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JP2009542225A true JP2009542225A (ja) 2009-12-03
JP2009542225A5 JP2009542225A5 (https=) 2013-09-19

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US (2) US20080070251A1 (https=)
EP (2) EP2520586A1 (https=)
JP (2) JP2009542225A (https=)
AU (1) AU2007269233B2 (https=)
CA (1) CA2656558A1 (https=)
WO (1) WO2008005847A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015519313A (ja) * 2012-04-24 2015-07-09 ノヴォ ノルディスク アー／エス 血友病の治療に適する医薬組成物
JP2016513697A (ja) * 2013-03-15 2016-05-16 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 変異体第ｖｉｉｉ因子ポリペプチドならびにそれらの製造方法および使用方法
JP2019527541A (ja) * 2016-06-24 2019-10-03 モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート
JP2021052769A (ja) * 2015-02-06 2021-04-08 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 最適化されたヒト凝固第ｖｉｉｉ因子遺伝子発現カセットおよびその使用
JP2023542132A (ja) * 2020-09-16 2023-10-05 ジェネレーション バイオ カンパニー Ｆｖｉｉｉ治療薬を発現させるための非ウイルス性ｄｎａベクター及びその使用

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US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
US20120028900A1 (en) * 2006-06-30 2012-02-02 Kaufman Randal J Method of producing factor viii proteins by recombinant methods
CA2837995A1 (en) * 2011-06-03 2012-12-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
KR20140084208A (ko) 2011-10-18 2014-07-04 시에스엘 리미티드 정제된 인자 ｖｉｉｉ의 재구성 후의 안정성을 향상시키는 방법
DK2971005T3 (da) * 2013-03-12 2020-08-24 Agc Biologics Inc Forbedret rekombinant proteinekspression ved anvendelse af en hybrid CHEF1-promotor
RU2711322C1 (ru) 2013-12-20 2020-01-16 Ф. Хоффманн-Ля Рош Аг Улучшенные способы получения рекомбинантного полипептида
WO2015091130A1 (en) * 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Method for improving the recombinant production of soluble fusion polypeptides
WO2015132724A1 (en) 2014-03-05 2015-09-11 Pfizer Inc. Improved muteins of clotting factor viii
WO2015143512A2 (en) * 2014-03-23 2015-10-01 Advantech Bioscience Farmacêutica Ltda. Enhancement of recombinant protein expression with copper
US9855319B2 (en) 2014-04-01 2018-01-02 Advantech Bioscience Farmacêutica Ltda Stabilization of factor VIII without calcium as an excipient
JP2017509659A (ja) 2014-04-01 2017-04-06 アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ 低糖−低グリシンの安定な第ｖｉｉｉ因子製剤
HUE057952T2 (hu) 2015-06-24 2022-06-28 Hoffmann La Roche Anti-transzferrin receptor antitestek testreszabott affinitással
TWI873952B (zh) 2015-10-02 2025-02-21 瑞士商赫孚孟拉羅股份公司 雙特異性抗‐人類cd20/人類轉鐵蛋白受體抗體及使用方法
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
WO2024110426A1 (en) 2022-11-23 2024-05-30 F. Hoffmann-La Roche Ag Method for increasing recombinant protein expression

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015519313A (ja) * 2012-04-24 2015-07-09 ノヴォ ノルディスク アー／エス 血友病の治療に適する医薬組成物
JP2016513697A (ja) * 2013-03-15 2016-05-16 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 変異体第ｖｉｉｉ因子ポリペプチドならびにそれらの製造方法および使用方法
JP2021052769A (ja) * 2015-02-06 2021-04-08 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 最適化されたヒト凝固第ｖｉｉｉ因子遺伝子発現カセットおよびその使用
JP7437035B2 (ja) 2015-02-06 2024-02-22 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 最適化されたヒト凝固第ｖｉｉｉ因子遺伝子発現カセットおよびその使用
US12116398B2 (en) 2015-02-06 2024-10-15 The University Of North Carolina At Chapel Hill Optimized human clotting factor VIII gene expression cassettes and their use
JP2019527541A (ja) * 2016-06-24 2019-10-03 モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート
JP2021118696A (ja) * 2016-06-24 2021-08-12 モガム・インスティテュート・フォー・バイオメディカル・リサーチMogam Institute For Biomedical Research 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート
JP7235511B2 (ja) 2016-06-24 2023-03-08 モガム・インスティテュート・フォー・バイオメディカル・リサーチ 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート
JP2023542132A (ja) * 2020-09-16 2023-10-05 ジェネレーション バイオ カンパニー Ｆｖｉｉｉ治療薬を発現させるための非ウイルス性ｄｎａベクター及びその使用

Also Published As

Publication number Publication date
US20110039302A1 (en) 2011-02-17
EP2520586A1 (en) 2012-11-07
JP2014000080A (ja) 2014-01-09
EP2035572A2 (en) 2009-03-18
US20080070251A1 (en) 2008-03-20
CA2656558A1 (en) 2008-01-10
AU2007269233A1 (en) 2008-01-10
EP2035572A4 (en) 2010-01-06
WO2008005847A3 (en) 2008-10-16
AU2007269233B2 (en) 2011-06-09
WO2008005847A2 (en) 2008-01-10

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