AU2007269233B2 - Method of producing Factor VIII proteins by recombinant methods - Google Patents

Method of producing Factor VIII proteins by recombinant methods Download PDF

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Publication number
AU2007269233B2
AU2007269233B2 AU2007269233A AU2007269233A AU2007269233B2 AU 2007269233 B2 AU2007269233 B2 AU 2007269233B2 AU 2007269233 A AU2007269233 A AU 2007269233A AU 2007269233 A AU2007269233 A AU 2007269233A AU 2007269233 B2 AU2007269233 B2 AU 2007269233B2
Authority
AU
Australia
Prior art keywords
fviii
protein
nucleic acid
domain
factor viii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007269233A
Other languages
English (en)
Other versions
AU2007269233A1 (en
Inventor
William Drohan
Michael Griffith
Randal J. Kaufman
Steven W. Pipe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CNJ Holdings Inc
University of Michigan System
Original Assignee
CNJ Holdings Inc
University of Michigan System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CNJ Holdings Inc, University of Michigan System filed Critical CNJ Holdings Inc
Publication of AU2007269233A1 publication Critical patent/AU2007269233A1/en
Assigned to THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INSPIRATION BIOPHARMACEUTICALS, INC. reassignment THE REGENTS OF THE UNIVERSITY OF MICHIGAN Alteration of Name(s) of Applicant(s) under S113 Assignors: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Application granted granted Critical
Publication of AU2007269233B2 publication Critical patent/AU2007269233B2/en
Assigned to THE REGENTS OF THE UNIVERSITY OF MICHIGAN, CNJ HOLDINGS, INC. reassignment THE REGENTS OF THE UNIVERSITY OF MICHIGAN Request for Assignment Assignors: INSPIRATION BIOPHARMACEUTICALS, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2007269233A 2006-06-30 2007-06-29 Method of producing Factor VIII proteins by recombinant methods Ceased AU2007269233B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81817706P 2006-06-30 2006-06-30
US60/818,177 2006-06-30
PCT/US2007/072506 WO2008005847A2 (en) 2006-06-30 2007-06-29 Method of producing factor viii proteins by recombinant methods

Publications (2)

Publication Number Publication Date
AU2007269233A1 AU2007269233A1 (en) 2008-01-10
AU2007269233B2 true AU2007269233B2 (en) 2011-06-09

Family

ID=38895363

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007269233A Ceased AU2007269233B2 (en) 2006-06-30 2007-06-29 Method of producing Factor VIII proteins by recombinant methods

Country Status (6)

Country Link
US (2) US20080070251A1 (https=)
EP (2) EP2520586A1 (https=)
JP (2) JP2009542225A (https=)
AU (1) AU2007269233B2 (https=)
CA (1) CA2656558A1 (https=)
WO (1) WO2008005847A2 (https=)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
US20120028900A1 (en) * 2006-06-30 2012-02-02 Kaufman Randal J Method of producing factor viii proteins by recombinant methods
CA2837995A1 (en) * 2011-06-03 2012-12-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
KR20140084208A (ko) 2011-10-18 2014-07-04 시에스엘 리미티드 정제된 인자 ｖｉｉｉ의 재구성 후의 안정성을 향상시키는 방법
WO2013160005A1 (en) * 2012-04-24 2013-10-31 Novo Nordisk A/S Pharmaceutical composition suitable for treatment of haemophilia
DK2971005T3 (da) * 2013-03-12 2020-08-24 Agc Biologics Inc Forbedret rekombinant proteinekspression ved anvendelse af en hybrid CHEF1-promotor
CA2906602A1 (en) * 2013-03-15 2014-09-25 Bayer Healthcare Llc Variant factor viii polypeptides and methods of their production and use
RU2711322C1 (ru) 2013-12-20 2020-01-16 Ф. Хоффманн-Ля Рош Аг Улучшенные способы получения рекомбинантного полипептида
WO2015091130A1 (en) * 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Method for improving the recombinant production of soluble fusion polypeptides
WO2015132724A1 (en) 2014-03-05 2015-09-11 Pfizer Inc. Improved muteins of clotting factor viii
WO2015143512A2 (en) * 2014-03-23 2015-10-01 Advantech Bioscience Farmacêutica Ltda. Enhancement of recombinant protein expression with copper
US9855319B2 (en) 2014-04-01 2018-01-02 Advantech Bioscience Farmacêutica Ltda Stabilization of factor VIII without calcium as an excipient
JP2017509659A (ja) 2014-04-01 2017-04-06 アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ 低糖−低グリシンの安定な第ｖｉｉｉ因子製剤
MX388739B (es) * 2015-02-06 2025-03-20 Univ North Carolina Chapel Hill Casetes optimizados de expresión del gen humano del factor viii de coagulación y su uso.
HUE057952T2 (hu) 2015-06-24 2022-06-28 Hoffmann La Roche Anti-transzferrin receptor antitestek testreszabott affinitással
TWI873952B (zh) 2015-10-02 2025-02-21 瑞士商赫孚孟拉羅股份公司 雙特異性抗‐人類cd20/人類轉鐵蛋白受體抗體及使用方法
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
JP7235511B2 (ja) * 2016-06-24 2023-03-08 モガム・インスティテュート・フォー・バイオメディカル・リサーチ 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート
CA3191743A1 (en) * 2020-09-16 2022-03-24 Generation Bio Co. Non-viral dna vectors and uses thereof for expressing fviii therapeutics
WO2024110426A1 (en) 2022-11-23 2024-05-30 F. Hoffmann-La Roche Ag Method for increasing recombinant protein expression

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20040147436A1 (en) * 2003-01-28 2004-07-29 Hun-Taek Kim Factor VIII polypeptide
US20060014683A1 (en) * 1996-04-24 2006-01-19 University Of Michigan Inactivation resistant factor VIII

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US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4599308A (en) 1981-10-06 1986-07-08 Hamer Dean H Protein from SV40 recombinants
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
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US5214033A (en) * 1983-03-31 1993-05-25 Scripps Clinic & Research Foundation Factor VIII coagulant polypeptides
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4757006A (en) * 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
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US4879236A (en) 1984-05-16 1989-11-07 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4745057A (en) * 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
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US4879224A (en) * 1985-01-10 1989-11-07 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor polypeptides
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ES8801674A1 (es) * 1985-04-12 1988-02-16 Genetics Inst Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.
DE3785102T2 (de) 1986-01-03 1993-07-22 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
US5250421A (en) 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
AT388079B (de) 1986-04-18 1989-04-25 Helmut Ing Koenig Backofen
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ES2182501T3 (es) * 1998-03-12 2003-03-01 Inst Genetics Llc Metodos mejorados para producir proteinas del factor viii.
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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060014683A1 (en) * 1996-04-24 2006-01-19 University Of Michigan Inactivation resistant factor VIII
US20040147436A1 (en) * 2003-01-28 2004-07-29 Hun-Taek Kim Factor VIII polypeptide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIAO HONGZHI Z ET AL: "Bioengineering of coagulation factor VIII for improved secretion", Blood, vol. 103, no. 9, 2004, pages 3412-3419. *

Also Published As

Publication number Publication date
US20110039302A1 (en) 2011-02-17
EP2520586A1 (en) 2012-11-07
JP2014000080A (ja) 2014-01-09
EP2035572A2 (en) 2009-03-18
US20080070251A1 (en) 2008-03-20
CA2656558A1 (en) 2008-01-10
AU2007269233A1 (en) 2008-01-10
JP2009542225A (ja) 2009-12-03
EP2035572A4 (en) 2010-01-06
WO2008005847A3 (en) 2008-10-16
WO2008005847A2 (en) 2008-01-10

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE CO-INVENTOR NAME FROM GRIFFITH, WILLIAM TO GRIFFITH, MICHAEL

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PC Assignment registered

Owner name: THE REGENTS OF THE UNIVERSITY OF MICHIGAN; CNJ HOL

Free format text: FORMER OWNER WAS: THE REGENTS OF THE UNIVERSITY OF MICHIGAN; INSPIRATION BIOPHARMACEUTICALS, INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired